Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression
Qin, Chong, Hu, Yang, Zhou, Bing, Fernandez-Salas, Ester, Yang, Chao-Yie, Liu, Liu, McEachern, Donna, Przybranowski, Sally, Wang, Mi, Stuckey, Jeanne, Meagher, Jennifer, Bai, Longchuan, Chen, Zhuo, Lin, Mei, Yang, Jiuling, Ziazadeh, Danya N, Xu, Fuming, Hu, Jiantao, Xiang, Weiguo, Huang, Liyue, Li, Siwei, Wen, Bo, Sun, Duxin, Wang, Shaomeng
Published in Journal of medicinal chemistry (09.08.2018)
Published in Journal of medicinal chemistry (09.08.2018)
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Journal Article
A narrative review: The pharmaceutical evolution of phenolic syringaldehyde
Wu, Jingyi, Fu, Yaw-Syan, Lin, Kaihuang, Huang, Xin, Chen, Yi-jing, Lai, Dong, Kang, Ning, Huang, Liyue, Weng, Ching-Feng
Published in Biomedicine & pharmacotherapy (01.09.2022)
Published in Biomedicine & pharmacotherapy (01.09.2022)
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Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)–Mixed Lineage Leukemia (MLL) Protein–Protein Interaction
Karatas, Hacer, Li, Yangbing, Liu, Liu, Ji, Jiao, Lee, Shirley, Chen, Yong, Yang, Jiuling, Huang, Liyue, Bernard, Denzil, Xu, Jing, Townsend, Elizabeth C, Cao, Fang, Ran, Xu, Li, Xiaoqin, Wen, Bo, Sun, Duxin, Stuckey, Jeanne A, Lei, Ming, Dou, Yali, Wang, Shaomeng
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
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Syringaldehyde promoting intestinal motility with suppressing α-amylase hinders starch digestion in diabetic mice
Weng, Lebin, Chen, Ting-Hsu, Zheng, Qingyan, Weng, Wei-Hao, Huang, Liyue, Lai, Dong, Fu, Yaw-Syan, Weng, Ching-Feng
Published in Biomedicine & pharmacotherapy (01.09.2021)
Published in Biomedicine & pharmacotherapy (01.09.2021)
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Combination of plant metabolites hinders starch digestion and glucose absorption while facilitating insulin sensitivity to diabetes
Huang, Xin, Lin, Kaihuang, Liu, Sinian, Yang, Junxiong, Zhao, Haowei, Zheng, Xiao-Hui, Tsai, May-Jywan, Chang, Chun-Sheng, Huang, Liyue, Weng, Ching-Feng
Published in Frontiers in pharmacology (05.06.2024)
Published in Frontiers in pharmacology (05.06.2024)
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Pharmaceutical Prospects of Curcuminoids for the Remedy of COVID-19: Truth or Myth
Fu, Yaw-Syan, Ho, Wan-Yi, Kang, Ning, Tsai, May-Jywan, Wu, Jingyi, Huang, Liyue, Weng, Ching-Feng
Published in Frontiers in pharmacology (14.04.2022)
Published in Frontiers in pharmacology (14.04.2022)
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Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors
Bregman, Howard, Chakka, Nagasree, Guzman-Perez, Angel, Gunaydin, Hakan, Gu, Yan, Huang, Xin, Berry, Virginia, Liu, Jingzhou, Teffera, Yohannes, Huang, Liyue, Egge, Bryan, Mullady, Erin L, Schneider, Steve, Andrews, Paul S, Mishra, Ankita, Newcomb, John, Serafino, Randy, Strathdee, Craig A, Turci, Susan M, Wilson, Cindy, DiMauro, Erin F
Published in Journal of medicinal chemistry (13.06.2013)
Published in Journal of medicinal chemistry (13.06.2013)
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Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)
Liu, Longbin, Siegmund, Aaron, Xi, Ning, Kaplan-Lefko, Paula, Rex, Karen, Chen, April, Lin, Jasmine, Moriguchi, Jodi, Berry, Loren, Huang, Liyue, Teffera, Yohannes, Yang, Yajing, Zhang, Yihong, Bellon, Steven F, Lee, Matthew, Shimanovich, Roman, Bak, Annette, Dominguez, Celia, Norman, Mark H, Harmange, Jean-Christophe, Dussault, Isabelle, Kim, Tae-Seong
Published in Journal of medicinal chemistry (10.07.2008)
Published in Journal of medicinal chemistry (10.07.2008)
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Rational Use of in Vitro P-glycoprotein Assays in Drug Discovery
Joseph W. Polli, Stephen A. Wring, Joan E. Humphreys, Liyue Huang, Jonathon B. Morgan, Lindsey O. Webster, Cosette S. Serabjit-Singh
Published in The Journal of pharmacology and experimental therapeutics (01.11.2001)
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Published in The Journal of pharmacology and experimental therapeutics (01.11.2001)
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Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain
Matson, David J, Hamamoto, Darryl T, Bregman, Howard, Cooke, Melanie, DiMauro, Erin F, Huang, Liyue, Johnson, Danielle, Li, Xingwen, McDermott, Jeff, Morgan, Carrie, Wilenkin, Ben, Malmberg, Annika B, McDonough, Stefan I, Simone, Donald A
Published in PloS one (17.09.2015)
Published in PloS one (17.09.2015)
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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement
Marx, Isaac E, Dineen, Thomas A, Able, Jessica, Bode, Christiane, Bregman, Howard, Chu-Moyer, Margaret, DiMauro, Erin F, Du, Bingfan, Foti, Robert S, Fremeau, Robert T, Gao, Hua, Gunaydin, Hakan, Hall, Brian E, Huang, Liyue, Kornecook, Thomas, Kreiman, Charles R, La, Daniel S, Ligutti, Joseph, Lin, Min-Hwa Jasmine, Liu, Dong, McDermott, Jeff S, Moyer, Bryan D, Peterson, Emily A, Roberts, Jonathan T, Rose, Paul, Wang, Jean, Youngblood, Beth D, Yu, Violeta, Weiss, Matthew M
Published in ACS medicinal chemistry letters (08.12.2016)
Published in ACS medicinal chemistry letters (08.12.2016)
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Relationship between Passive Permeability, Efflux, and Predictability of Clearance from In Vitro Metabolic Intrinsic Clearance
LIYUE HUANG, BERRY, Loren, GANGA, Sindhura, JANOSKY, Brett, CHEN, April, ROBERTS, Jonathan, COLLETTI, Adria E, JASMINE LIN, Min-Hwa
Published in Drug metabolism and disposition (01.02.2010)
Published in Drug metabolism and disposition (01.02.2010)
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Journal Article
Structure-Based Design of 2‑Aminopyridine Oxazolidinones as Potent and Selective Tankyrase Inhibitors
Huang, Hongbing, Guzman-Perez, Angel, Acquaviva, Lisa, Berry, Virginia, Bregman, Howard, Dovey, Jennifer, Gunaydin, Hakan, Huang, Xin, Huang, Liyue, Saffran, Doug, Serafino, Randy, Schneider, Steve, Wilson, Cindy, DiMauro, Erin F
Published in ACS medicinal chemistry letters (12.12.2013)
Published in ACS medicinal chemistry letters (12.12.2013)
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Journal Article
Discovery and Optimization of a Novel Series of N-Arylamide Oxadiazoles as Potent, Highly Selective and Orally Bioavailable Cannabinoid Receptor 2 (CB2) Agonists
Cheng, Yuan, Albrecht, Brian K, Brown, James, Buchanan, John L, Buckner, William H, DiMauro, Erin F, Emkey, Renee, Fremeau, Robert T, Harmange, Jean-Christophe, Hoffman, Beth J, Huang, Liyue, Huang, Ming, Lee, Josie Han, Lin, Fen-Fen, Martin, Matthew W, Nguyen, Hung Q, Patel, Vinod F, Tomlinson, Susan A, White, Ryan D, Xia, Xiaoyang, Hitchcock, Stephen A
Published in Journal of medicinal chemistry (28.08.2008)
Published in Journal of medicinal chemistry (28.08.2008)
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Journal Article
Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists
Nguyen, Hanh Nho, Bregman, Howie, Buchanan, John L., Du, Bingfan, Feric, Elma, Huang, Liyue, Li, Xingwen, Ligutti, Joseph, Liu, Dong, Malmberg, Annika B., Matson, David J., McDermott, Jeff S., Patel, Vinod F., Wilenkin, Ben, Zou, Anruo, McDonough, Stefan I., DiMauro, Erin F.
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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