Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans
Wu, Lingyan, Xia, Mingfeng, Duan, Yanan, Zhang, Lina, Jiang, Haowen, Hu, Xiaobei, Yan, Hongmei, Zhang, Yiqiu, Gu, Yushen, Shi, Hongcheng, Li, Jia, Gao, Xin, Li, Jingya
Published in Cell death & disease (13.06.2019)
Published in Cell death & disease (13.06.2019)
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Targeting C/EBPα overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia
Wang, Hanlin, Luo, Guanghao, Hu, Xiaobei, Xu, Gaoya, Wang, Tao, Liu, Minmin, Qiu, Xiaohui, Li, Jianan, Fu, Jingfeng, Feng, Bo, Tu, Yutong, Kan, Weijuan, Wang, Chang, Xu, Ran, Zhou, Yubo, Yang, Jianmin, Li, Jia
Published in Nature communications (05.04.2023)
Published in Nature communications (05.04.2023)
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Disruption of the unfolded protein response (UPR) by lead compound selectively suppresses cancer cell growth
Huang, Hejing, Liu, Huanan, Liu, Changmei, Fan, Lixia, Zhang, Xinwen, Gao, Anhui, Hu, Xiaobei, Zhang, Kunzhi, Cao, Xianchao, Jiang, Kailong, Zhou, Yubo, Hou, Jian, Nan, Fajun, Li, Jia
Published in Cancer letters (01.05.2015)
Published in Cancer letters (01.05.2015)
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Identification of 2‑Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c‑KIT
Tong, Lexian, Wang, Peipei, Li, Xuemei, Dong, Xiaowu, Hu, Xiaobei, Wang, Chang, Liu, Tao, Li, Jia, Zhou, Yubo
Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
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Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders
Yang, Xiangbo, Wang, Zhijia, Pei, Yuan, Song, Ning, Xu, Lei, Feng, Bo, Wang, Hanlin, Luo, Xiaomin, Hu, Xiaobei, Qiu, Xiaohui, Feng, Huijin, Yang, Yaxi, Zhou, Yubo, Li, Jia, Zhou, Bing
Published in European journal of medicinal chemistry (05.06.2021)
Published in European journal of medicinal chemistry (05.06.2021)
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Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein–Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy
Cheng, Jing, Yan, Ziqin, Jiang, Kailong, Liu, Chen, Xu, Dehua, Lyu, Xilin, Hu, Xiaobei, Zhang, Shiyan, Zhou, Yubo, Li, Jia, Zhao, Yujun
Published in Journal of medicinal chemistry (28.12.2023)
Published in Journal of medicinal chemistry (28.12.2023)
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Design, synthesis, and biological evaluation of Wee1 kinase degraders
Zhu, Shulei, Liu, Jieyu, Xiao, Donghuai, Wang, Peipei, Ma, Jingkun, Hu, Xiaobei, Fu, Jingfeng, Zhou, Yubo, Li, Jia, Lu, Wei
Published in European journal of medicinal chemistry (05.12.2022)
Published in European journal of medicinal chemistry (05.12.2022)
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Discovery of 2‑Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities
Li, Xuemei, Wang, Peipei, Wang, Chang, Jin, Tingting, Xu, Ran, Tong, Lexian, Hu, Xiaobei, Shen, Liteng, Li, Jia, Zhou, Yubo, Liu, Tao
Published in Journal of medicinal chemistry (14.09.2023)
Published in Journal of medicinal chemistry (14.09.2023)
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Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5‑((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile
Jin, Tingting, Xu, Lei, Wang, Peipei, Hu, Xiaobei, Zhang, Runyuan, Wu, Zhiqi, Du, Wenxin, Kan, Weijuan, Li, Kun, Wang, Chang, Zhou, Yubo, Li, Jia, Liu, Tao
Published in Journal of medicinal chemistry (28.10.2021)
Published in Journal of medicinal chemistry (28.10.2021)
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fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
Zhan, Wenhu, Che, Jinxin, Xu, Lei, Wu, Yizhe, Hu, Xiaobei, Zhou, Yubo, Cheng, Gang, Hu, Yongzhou, Dong, Xiaowu, Li, Jia
Published in European journal of medicinal chemistry (15.10.2019)
Published in European journal of medicinal chemistry (15.10.2019)
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Discovery of Novel 2-Aminopyridine-Based and 2-Aminopyrimidine-Based Derivatives as Potent CDK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors and Hematological Malignancies
Saidahmatov, Abdusaid, Li, Jianan, Xu, Shihao, Hu, Xiaobei, Gao, Xiangqian, Kan, Weijuan, Gao, Lixin, Li, Cong, Shi, Yuqiang, Sheng, Li, Wang, Peipei, Zhou, Yubo, Liang, Xuewu, Li, Jia, Liu, Hong
Published in Journal of medicinal chemistry (12.09.2024)
Published in Journal of medicinal chemistry (12.09.2024)
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Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
Zhan, Wenhu, Che, Jinxin, Xu, Lei, Wu, Yizhe, Hu, Xiaobei, Zhou, Yubo, Cheng, Gang, Hu, Yongzhou, Dong, Xiaowu, Li, Jia
Published in European journal of medicinal chemistry (15.10.2019)
Published in European journal of medicinal chemistry (15.10.2019)
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Discovery of Preclinical Candidate AD1058 as a Highly Potent, Selective, and Brain-Penetrant ATR Inhibitor for the Treatment of Advanced Malignancies
Liu, Zhi, Jiang, Kailong, Liu, Yan, Li, Junfei, Huang, Siqi, Li, Ping, Xu, Lei, Xu, Xiaomin, Hu, Xiaobei, Zeng, Xia, Huang, Zehui, Zhou, Yubo, Li, Jia, Long, Kai, Wang, Mingliang
Published in Journal of medicinal chemistry (08.08.2024)
Published in Journal of medicinal chemistry (08.08.2024)
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Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia
Jiang, Kailong, Li, Xuemei, Wang, Chang, Hu, Xiaobei, Wang, Peipei, Tong, Lexian, Tu, Yutong, Chen, Beijing, Jin, Tingting, Wang, Tao, Wang, Hanlin, Han, Yubing, Gui, Renzhao, Yang, Jianmin, Liu, Tao, Li, Jia, Zhou, Yubo
Published in Leukemia (01.03.2023)
Published in Leukemia (01.03.2023)
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Mechanical Stress Affects Circadian Rhythm in Skeletal Muscle (C2C12 Myoblasts) by Reducing Per/Cry Gene Expression and Increasing Bmal1 Gene Expression
Wang, Mengjia, Yu, Da, Zheng, Lichun, Hong, Bing, Li, Houxuan, Hu, Xiaobei, Zhang, Kun, Mou, Yongbin
Published in Medical science monitor (14.01.2021)
Published in Medical science monitor (14.01.2021)
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Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia
Han, Xu, Song, Ning, Saidahmatov, Abdusaid, Wang, Peipei, Wang, Yong, Hu, Xiaobei, Kan, Weijuan, Zhu, Wei, Gao, Lixin, Zeng, Mingjie, Wang, Yujie, Li, Chunpu, Li, Jia, Liu, Hong, Zhou, Yubo, Wang, Jiang
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies
Tong, Lexian, Song, Pinrao, Jiang, Kailong, Xu, Lei, Jin, Tingting, Wang, Peipei, Hu, Xiaobei, Fang, Sui, Gao, Anhui, Zhou, Yubo, Liu, Tao, Li, Jia, Hu, Yongzhou
Published in European journal of medicinal chemistry (01.07.2019)
Published in European journal of medicinal chemistry (01.07.2019)
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Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors
Li, Daqiang, Zhang, Xiaotuan, Ma, Xiaodong, Xu, Lei, Yu, Jianjun, Gao, Lixin, Hu, Xiaobei, Zhang, Jiankang, Dong, Xiaowu, Li, Jia, Liu, Tao, Zhou, Yubo, Hu, Yongzhou
Published in Journal of medicinal chemistry (25.10.2018)
Published in Journal of medicinal chemistry (25.10.2018)
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Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals distinct cancer-associated fibroblasts in head and neck squamous cell carcinoma
Zhang, Qian, Wang, Yuxin, Xia, Chengwan, Ding, Liang, Pu, Yumei, Hu, Xiaobei, Cai, Huiming, Hu, Qingang
Published in Annals of translational medicine (01.06.2021)
Published in Annals of translational medicine (01.06.2021)
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Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
Che, Jinxin, Huang, Feng, Zhang, Mengmeng, Xu, Gaoya, Qu, Bingxue, Gao, Jian, Chen, Binhui, Zhang, Jianjun, Ying, Huazhou, Hu, Yongzhou, Hu, Xiaobei, Zhou, Yubo, Gao, Anhui, Li, Jia, Dong, Xiaowu
Published in European journal of medicinal chemistry (01.10.2020)
Published in European journal of medicinal chemistry (01.10.2020)
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