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Duplantier, Allen J, Becker, Stacey L, Bohanon, Michael J, Borzilleri, Kris A, Chrunyk, Boris A, Downs, James T, Hu, Lain-Yen, El-Kattan, Ayman, James, Larry C, Liu, Shenping, Lu, Jiemin, Maklad, Noha, Mansour, Mahmoud N, Mente, Scot, Piotrowski, Mary A, Sakya, Subas M, Sheehan, Susan, Steyn, Stefanus J, Strick, Christine A, Williams, Victoria A, Zhang, Lei
Published in Journal of medicinal chemistry (11.06.2009)
Published in Journal of medicinal chemistry (11.06.2009)
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4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production
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Published in Bioorganic & medicinal chemistry letters (01.03.2009)
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Role of specific aminotransferases in de novo glutamate synthesis and redox shuttling in the retina
LaNoue, Kathyrn F., Berkich, Deborah A., Conway, Myra, Barber, Alistair J., Hu, Lain-Yen, Taylor, Charles, Hutson, Susan
Published in Journal of neuroscience research (01.12.2001)
Published in Journal of neuroscience research (01.12.2001)
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Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications
Li, Jie Jack, Iula, Donna M, Nguyen, Maria N, Hu, Lain-Yen, Dettling, Danielle, Johnson, Theodore R, Du, Daniel Y, Shanmugasundaram, Veerabahu, Van Camp, Jennifer A, Wang, Zhi, Harter, William G, Yue, Wen-Song, Boys, Mark L, Wade, Kimberly J, Drummond, Elena M, Samas, Brian M, Lefker, Bruce A, Hoge, Garrett S, Lovdahl, Mark J, Asbill, Jeffrey, Carroll, Matthew, Meade, Mary Ann, Ciotti, Susan M, Krieger-Burke, Theresa
Published in Journal of medicinal chemistry (13.11.2008)
Published in Journal of medicinal chemistry (13.11.2008)
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Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production
Mitchell, Lorna H., Hu, Lain-Yen, Nguyen, Maria, Fakhoury, Stephen, Smith, Yvonne, Iula, Donna, Kostlan, Catherine, Carroll, Matthew, Dettling, Danielle, Du, Daniel, Pocalyko, David, Wade, Kimberly, Lefker, Bruce
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
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Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production
Van Camp, Jennifer A., Hu, Lain-Yen, Kostlan, Catherine, Lefker, Bruce, Li, Jie, Mitchell, Lorna, Wang, Zhi, Yue, Wen-Song, Carroll, Matthew, Dettling, Danielle, Du, Daniel, Pocalyko, David, Wade, Kimberly
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases
Hu, Lain-Yen, Boxer, Peter A., Kesten, Suzanne R., Lei, Huangshu J., Wustrow, David J., Moreland, David W., Zhang, Liming, Ahn, Kay, Ryder, Todd R., Liu, Xiaohong, Rubin, John R., Fahnoe, Kelly, Carroll, Richard T., Dutta, Satavisha, Fahnoe, Douglass C., Probert, Albert W., Roof, Robin L., Rafferty, Michael F., Kostlan, Catherine R., Scholten, Jeffrey D., Hood, Molly, Ren, Xiao-Dan, Schielke, Gerald P., Su, Ti-Zhi, Taylor, Charles P., Mistry, Anil, McConnell, Patrick, Hasemann, Charles, Ohren, Jeffrey
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Comparison of artificial sebum with human and hamster sebum samples
Lu, Guang Wei, Valiveti, Satyanarayana, Spence, Julie, Zhuang, Christine, Robosky, Lora, Wade, Kimberly, Love, Ann, Hu, Lain-Yen, Pole, David, Mollan, Matt
Published in International journal of pharmaceutics (09.02.2009)
Published in International journal of pharmaceutics (09.02.2009)
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Synthesis and Pharmacological Evaluation of N-(2,5-Disubstituted phenyl)-N‘-(3-substituted phenyl)-N‘-methylguanidines As N-Methyl-d-aspartate Receptor Ion-Channel Blockers
Hu, Lain-Yen, Guo, Junqing, Magar, Sharad S, Fischer, James B, Burke-Howie, Kathleen J, Durant, Graham J
Published in Journal of medicinal chemistry (19.12.1997)
Published in Journal of medicinal chemistry (19.12.1997)
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Pantolactams as androgen receptor antagonists for the topical suppression of sebum production
Sexton, Karen E., Barrett, Stephen, Bridgwood, Katy, Carroll, Matthew, Dettling, Danielle, Du, Daniel, Fakhoury, Stephen, Fedij, Victor, Hu, Lain-Yen, Kostlan, Catherine, Pocalyko, David, Raheja, Neil, Smith, Yvonne, Shanmugasundaram, Veerabahu, Wade, Kimberly
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery
Mitchell, Lorna H, Johnson, Theodore R, Lu, Guang Wei, Du, Daniel, Datta, Kaushik, Grzemski, Felicity, Shanmugasundaram, Veerabahu, Spence, Julie, Wade, Kim, Wang, Zhi, Sun, Kevin, Lin, Kristin, Hu, Lain-Yen, Sexton, Karen, Raheja, Neil, Kostlan, Catherine, Pocalyko, David
Published in Journal of medicinal chemistry (10.06.2010)
Published in Journal of medicinal chemistry (10.06.2010)
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Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist
Reddy, N. L, Hu, Lain-Yen, Cotter, R. E, Fischer, J. B, Wong, W. J, McBurney, R. N, Weber, E, Holmes, D. L, Wong, S. T
Published in Journal of medicinal chemistry (01.01.1994)
Published in Journal of medicinal chemistry (01.01.1994)
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Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production
Hu, Lain-Yen, Lei, Huangshu John, Du, Daniel, Johnson, Theodore R., Fedij, Victor, Kostlan, Catherine, Yue, Wen Song, Lovdahl, Mark, Li, Jie Jack, Carroll, Mathew, Dettling, Danielle, Asbill, Jeffrey, Fan, Conglin, Wade, Kimberly, Pocalyko, David, Lapham, Kimberly, Yalamanchili, Radhika, Samas, Brian, Vrieze, Derek, Ciotti, Susan, Krieger-Burke, Teresa, Sliskovic, Drago, Welgus, Howard
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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(1 R ,2 S )-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production
Hu, Lain-Yen, Du, Daniel, Hoffman, Jennifer, Smith, Yvonne, Fedij, Victor, Kostlan, Catherine, Johnson, Theodore R., Huang, Yun, Kesten, Steve, Harter, William, Yue, Wen Song, Li, Jie Jack, Barvian, Nicole, Mitchell, Lorna, Lei, Huangshu John, Lefker, Bruce, Carroll, Mathew, Dettling, Danielle, Krieger-Burke, Teresa, Samas, Brian, Yalamanchili, Radhika, Lapham, Kimberly, Pocalyko, David, Sliskovic, Drago, Ciotti, Susan, Stoller, Brenda, Hena, Mostofa A., Ding, Qizhu, Maiti, Samarendra N., Stier, Michael, Welgus, Howard
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
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Synthesis and characterization of N-(acenaphth-5-yl)-N'-(4-methoxynaphth-1-yl)guanidine as a glutamate release inhibitor and potential anti-ischemic agent
Laxma Reddy, N., Connaughton, Sonia, Daly, Deborah, Fischer, James B., Goldin, Stanley M., Hu, Lain-Yen, Subbarao, Katragadda, Durant, Graham J.
Published in Bioorganic & medicinal chemistry letters (01.10.1995)
Published in Bioorganic & medicinal chemistry letters (01.10.1995)
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Synthesis and biological evaluation of substituted 4-(OBz)phenylalanine derivatives as novel N-type calcium channel blockers
Hu, Lain-Yen, Ryder, Todd R., Nikam, Sham S., Millerman, Elizabeth, Szoke, Balazs G., Rafferty, Michael F.
Published in Bioorganic & medicinal chemistry letters (19.04.1999)
Published in Bioorganic & medicinal chemistry letters (19.04.1999)
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Multiple parallel synthesis of N, N-dialkyldipeptidylamines as N-type calcium channel blockers
Ryder, Todd R., Hu, Lain-Yen, Rafferty, Michael F., Millerman, Elizabeth, Szoke, Balazs G., Tarczy-Hornoch, Katalin
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
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N, N-Dialkyl-dipeptidylamines as novel N-type calcium channel blockers
Hu, Lain-Yen, Ryder, Todd R, Rafferty, Michael F, Cody, Wayne L, Lotarski, Susan M, Miljanich, George P, Millerman, Elizabeth, Rock, David M, Song, Yuntao, Stoehr, Sally J, Taylor, Charles P, Weber, Mark L, Szoke, Balazs G, Vartanian, Mark G
Published in Bioorganic & medicinal chemistry letters (22.03.1999)
Published in Bioorganic & medicinal chemistry letters (22.03.1999)
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Structure-activity relationship at the proximal phenyl group in a series of non-peptidyl N-type calcium channel antagonists
Ryder, Todd R., Hu, Lain-Yen, Rafferty, Michael F., Lotarski, Susan M., Rock, David M., Stoehr, Sally J., Taylor, Charles P., Weber, Mark L., Miljanich, George P., Millerman, Elizabeth, Szoke, Balazs G.
Published in Bioorganic & medicinal chemistry letters (16.08.1999)
Published in Bioorganic & medicinal chemistry letters (16.08.1999)
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