Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors
Sakurada, Isao, Endo, Toshiya, Hikita, Katsuyoshi, Hirabayashi, Tomokazu, Hosaka, Yoshitaka, Kato, Yutaka, Maeda, Yoshitaka, Matsumoto, Shigeki, Mizuno, Takashi, Nagasue, Hiroshi, Nishimura, Teruyuki, Shimada, Shunsuke, Shinozaki, Mikihiko, Taguchi, Keiko, Takeuchi, Katsutoshi, Yokoyama, Tooru, Hruza, Alan, Reichert, Paul, Zhang, Ting, Wood, Harold B., Nakao, Kazunari, Furusako, Shoji
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
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Structure of the Insulin Receptor in Complex with Insulin using Single Particle CryoEM Analysis
Scapin, Giovanna, Dandey, Venkata, Zhang, Zhening, Prosise, Winifred, Hruza, Alan, Strickland, Corey, Potter, Clinton S., Carragher, Bridget
Published in Microscopy and microanalysis (01.07.2017)
Published in Microscopy and microanalysis (01.07.2017)
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Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor
Yu, Tao, Zhang, Yonglian, Kerekes, Angela D., Tagat, Jayaram R., Doll, Ronald J., Xiao, Yushi, Esposite, Sara, Hruza, Alan, Belanger, David B., Voss, Matthew, Rainka, Matthew P., Basso, Andrea, Liu, Ming, Liang, Lianzhu, Sui, Ning, Prelusky, Daniel, Rindgen, Diane, Zhang, Likang
Published in Bioorganic & medicinal chemistry letters (01.05.2018)
Published in Bioorganic & medicinal chemistry letters (01.05.2018)
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Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia
Yang, Shu-Wei, Smotryski, Jennifer, McElroy, William T., Tan, Zheng, Ho, Ginny, Tulshian, Deen, Greenlee, William J., Guzzi, Mario, Zhang, Xiaoping, Mullins, Deborra, Xiao, Li, Hruza, Alan, Chan, Tze-Ming, Rindgen, Diane, Bleickardt, Carina, Hodgson, Robert
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Abstract 4788: Discovery of potent and selective inhibitors of ERK1/2 with a unique mechanism of action
Deng, Yongqi, Samatar, Ahmed, Shipps, Gerald, Cooper, Alan, Long, Brian, Carr, Donnar, Xiao, Li, Hruza, Alan, Wang, Tong, Zhu, Liang, Nan, Yang, Patel, Mehul, Muppalla, Kiran, Zhu, Hugh, Boga, Babu Sobhana, Gao, Xiaolei
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases
Paruch, Kamil, Dwyer, Michael P, Alvarez, Carmen, Brown, Courtney, Chan, Tin-Yau, Doll, Ronald J, Keertikar, Kerry, Knutson, Chad, McKittrick, Brian, Rivera, Jocelyn, Rossman, Randall, Tucker, Greg, Fischmann, Thierry, Hruza, Alan, Madison, Vincent, Nomeir, Amin A, Wang, Yaolin, Kirschmeier, Paul, Lees, Emma, Parry, David, Sgambellone, Nicole, Seghezzi, Wolfgang, Schultz, Lesley, Shanahan, Frances, Wiswell, Derek, Xu, Xiaoying, Zhou, Quiao, James, Ray A, Paradkar, Vidyadhar M, Park, Haengsoon, Rokosz, Laura R, Stauffer, Tara M, Guzi, Timothy J
Published in ACS medicinal chemistry letters (12.08.2010)
Published in ACS medicinal chemistry letters (12.08.2010)
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Rapid development of two factor IXa inhibitors from hit to lead
Parker, Dann L., Walsh, Shawn, Li, Bing, Kim, Esther, Sharipour, Aurash, Smith, Cameron, Chen, Yi-Heng, Berger, Richard, Harper, Bart, Zhang, Ting, Park, Min, Shu, Min, Wu, Jane, Xu, Jiayi, Dewnani, Sunita, Sherer, Edward C., Hruza, Alan, Reichert, Paul, Geissler, Wayne, Sonatore, Lisa, Ellsworth, Kenneth, Balkovec, James, Greenlee, William, Wood, Harold B.
Published in Bioorganic & medicinal chemistry letters (01.06.2015)
Published in Bioorganic & medicinal chemistry letters (01.06.2015)
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Discovery of imidazo[1,2- a]pyrazine-based Aurora kinase inhibitors
Belanger, David B., Curran, Patrick J., Hruza, Alan, Voigt, Johannes, Meng, Zhaoyang, Mandal, Amit K., Siddiqui, M. Arshad, Basso, Andrea D., Gray, Kimberly
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Development of a novel class of potent and selective FIXa inhibitors
Zhang, Ting, Andre, Patrick, Bateman, Thomas J., Chen, Yi-Heng, Desai, Kunal, Ellsworth, Kenneth, Geissler, Wayne M., Guo, Liangqin, Hruza, Alan, Jian, Tianying, Meng, Dongfang, Parker, Dann L., Qian, Xiaoxia, Reichert, Paul, Sherer, Edward C., Shu, Min, Smith, Cameron J., Sonatore, Lisa M., Tschirret-Guth, Richard, Nolting, Andrew F., Orr, Robert, Campeau, Louis-Charles, Araki, Kazuto, Nishimura, Teruyuki, Sakurada, Isao, Wood, Harold B.
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
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Journal Article
Development of a novel tricyclic class of potent and selective FIXa inhibitors
Meng, Dongfang, Andre, Patrick, Bateman, Thomas J., Berger, Richard, Chen, Yi-Heng, Desai, Kunal, Dewnani, Sunita, Ellsworth, Kenneth, Feng, Daming, Geissler, Wayne M., Guo, Liangqin, Hruza, Alan, Jian, Tianying, Li, Hong, Metzger, Joe, Parker, Dann L., Reichert, Paul, Sherer, Edward C., Smith, Cameron J., Sonatore, Lisa M., Tschirret-Guth, Richard, Wu, Jane, Xu, Jiayi, Zhang, Ting, Campeau, Louis-Charles, Orr, Robert, Poirier, Marc, McCabe-Dunn, Jamie, Araki, Kazuto, Nishimura, Teruyuki, Sakurada, Isao, Hirabayashi, Tomokazu, Wood, Harold B.
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia
Ho, Ginny D., Yang, Shu-Wei, Smotryski, Jennifer, Bercovici, Ana, Nechuta, Terry, Smith, Elizabeth M., McElroy, William, Tan, Zheng, Tulshian, Deen, McKittrick, Brian, Greenlee, William J., Hruza, Alan, Xiao, Li, Rindgen, Diane, Mullins, Deborra, Guzzi, Mario, Zhang, Xiaoping, Bleickardt, Carina, Hodgson, Robert
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia
Ho, Ginny D., Michael Seganish, W., Bercovici, Ana, Tulshian, Deen, Greenlee, William J., Van Rijn, Rachel, Hruza, Alan, Xiao, Li, Rindgen, Diane, Mullins, Deborra, Guzzi, Mario, Zhang, Xiaoping, Bleickardt, Carina, Hodgson, Robert
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
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Structure-based drug design of clinical compound MK-8353, a novel inhibitor of ERK
Hruza, Alan, Boga, Sobhana Babu, Alhassan, Abdul-Basit, Cooper, Alan B., Doll, Ronald, Shih, Neng-Yang, Shipps, Gerald, Deng, Yongqi, Zhu, Hugh, Nan, Yang, Sun, Robert, Zhu, Liang, Desai, Jagdish, Patel, Mehul, Muppalla, Kiran, Gao, Xiaolei, Wang, James, Kelly, Joseph, Gudipati, Subrahmanyam, Paliwal, Sunil, Tsui, Hon-Chung, Wang, Tong, Sherborne, Bradley, Xiao, Li, Buevich, Alexei, Hesk, David, Samatar, Ahmed A., Carr, Donna, Long, Brian, Black, Stuart, Dayananth, Priya, Windsor, William, Kirschmeier, Paul, Bishop, Robert
Published in Acta crystallographica. Section A, Foundations and advances (20.07.2018)
Published in Acta crystallographica. Section A, Foundations and advances (20.07.2018)
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Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity
Voss, Matthew E., Rainka, Matthew P., Fleming, Mike, Peterson, Lisa H., Belanger, David B., Siddiqui, M. Arshad, Hruza, Alan, Voigt, Johannes, Gray, Kimberly, Basso, Andrea D.
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
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Pyrazolo[1,5- a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2
Paruch, Kamil, Dwyer, Michael P., Alvarez, Carmen, Brown, Courtney, Chan, Tin-Yau, Doll, Ronald J., Keertikar, Kerry, Knutson, Chad, McKittrick, Brian, Rivera, Jocelyn, Rossman, Randall, Tucker, Greg, Fischmann, Thierry O., Hruza, Alan, Madison, Vincent, Nomeir, Amin A., Wang, Yaolin, Lees, Emma, Parry, David, Sgambellone, Nicole, Seghezzi, Wolfgang, Schultz, Lesley, Shanahan, Fran, Wiswell, Derek, Xu, Xiaoying, Zhou, Quiao, James, Ray A., Paradkar, Vidyadhar M., Park, Haengsoon, Rokosz, Laura R., Stauffer, Tara M., Guzi, Timothy J.
Published in Bioorganic & medicinal chemistry (15.11.2007)
Published in Bioorganic & medicinal chemistry (15.11.2007)
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Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors
Dwyer, Michael P., Paruch, Kamil, Alvarez, Carmen, Doll, Ronald J., Keertikar, Kerry, Duca, Jose, Fischmann, Thierry O., Hruza, Alan, Madison, Vincent, Lees, Emma, Parry, David, Seghezzi, Wolfgang, Sgambellone, Nicole, Shanahan, Frances, Wiswell, Derek, Guzi, Timothy J.
Published in Bioorganic & medicinal chemistry (15.11.2007)
Published in Bioorganic & medicinal chemistry (15.11.2007)
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Abstract 2785: Modulating the interaction between cdk2 and cyclin A: Screening, synthesis and characterization of a quinoline-based inhibitor
Windsor, William T., Deng, Yongqi, Shipps, Gerald W., Zhao, Lianyun, Siddiqui, Arshad, Popovici-Muller, Janeta, Curran, Patrick, Fischmann, Thierry, Duca, Jose S., Hruza, Alan, Zhang, Rumin, McNemar, Charles, Mayhood, Todd, Syto, Rosalinda, Parry, David A., Lees, Emma, Kirschmeier, Paul
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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HRUZA ALAN, GAO YING DUO, MONINGKA REMOND, MERTZ ERIC, LIU WEIGUO, ALI AMJAD, EDMONDSON SCOTT D, NEELAMKAVIL SANTHOSH F, SO SUNG SAU, SUN WANYING, BROCKUNIER LINDA L
Year of Publication 13.09.2017
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Year of Publication 13.09.2017
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Discovery of C-imidazole azaheptapyridine FPT inhibitors
Zhu, Hugh Y., Cooper, Alan B., Desai, Jagdish, Njoroge, George, Kirschmeier, Paul, Bishop, W. Robert, Strickland, Corey, Hruza, Alan, Doll, Ronald J., Girijavallabhan, Viyyoor M.
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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DEBENHAM, John S, NIZNER, Peter, TATOSIAN, Daniel A, KUANG, Rongze, ALI, Amjad, HICKS, Jacqueline D, GAO, Ying-Duo, YANG, Dexi, HRUZA, Alan, WEI, Lan
Year of Publication 19.06.2024
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Year of Publication 19.06.2024
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