Overcoming adaptive therapy resistance in AML by targeting immune response pathways
Melgar, Katelyn, Walker, Morgan M, Jones, LaQuita M, Bolanos, Lyndsey C, Hueneman, Kathleen, Wunderlich, Mark, Jiang, Jian-Kang, Wilson, Kelli M, Zhang, Xiaohu, Sutter, Patrick, Wang, Amy, Xu, Xin, Choi, Kwangmin, Tawa, Gregory, Lorimer, Donald, Abendroth, Jan, O'Brien, Eric, Hoyt, Scott B, Berman, Ellin, Famulare, Christopher A, Mulloy, James C, Levine, Ross L, Perentesis, John P, Thomas, Craig J, Starczynowski, Daniel T
Published in Science translational medicine (04.09.2019)
Published in Science translational medicine (04.09.2019)
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Journal Article
Characterization of a New Class of Potent Inhibitors of the Voltage-Gated Sodium Channel Nav1.7
Williams, Brande S, Felix, John P, Priest, Birgit T, Brochu, Richard M, Dai, Kefei, Hoyt, Scott B, London, Clare, Tang, Yui S, Duffy, Joseph L, Parsons, William H, Kaczorowski, Gregory J, Garcia, Maria L
Published in Biochemistry (Easton) (18.12.2007)
Published in Biochemistry (Easton) (18.12.2007)
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Journal Article
Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain
Hoyt, Scott B., London, Clare, Gorin, David, Wyvratt, Matthew J., Fisher, Michael H., Abbadie, Catherine, Felix, John P., Garcia, Maria L., Li, Xiaohua, Lyons, Kathryn A., McGowan, Erin, MacIntyre, D. Euan, Martin, William J., Priest, Birgit T., Ritter, Amy, Smith, McHardy M., Warren, Vivien A., Williams, Brande S., Kaczorowski, Gregory J., Parsons, William H.
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Journal Article
Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML
Bennett, Joshua, Ishikawa, Chiharu, Agarwal, Puneet, Yeung, Jennifer, Sampson, Avery, Uible, Emma, Vick, Eric, Bolanos, Lyndsey C., Hueneman, Kathleen, Wunderlich, Mark, Kolt, Amal, Choi, Kwangmin, Volk, Andrew, Greis, Kenneth D., Rosenbaum, Jan, Hoyt, Scott B., Thomas, Craig J., Starczynowski, Daniel T.
Published in Blood (14.09.2023)
Published in Blood (14.09.2023)
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Journal Article
Targeting AML-associated FLT3 mutations with a type I kinase inhibitor
Jones, LaQuita M, Melgar, Katelyn, Bolanos, Lyndsey, Hueneman, Kathleen, Walker, Morgan M, Jiang, Jian-Kang, Wilson, Kelli M, Zhang, Xiaohu, Shen, Jian, Jiang, Fan, Sutter, Patrick, Wang, Amy, Xu, Xin, Tawa, Gregory J, Hoyt, Scott B, Wunderlich, Mark, O'Brien, Eric, Perentesis, John P, Starczynowski, Daniel T, Thomas, Craig J
Published in The Journal of clinical investigation (01.04.2020)
Published in The Journal of clinical investigation (01.04.2020)
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Journal Article
A peripherally acting Na(v)1.7 sodium channel blocker reverses hyperalgesia and allodynia on rat models of inflammatory and neuropathic pain
McGowan, Erin, Hoyt, Scott B, Li, Xiaohua, Lyons, Kathryn A, Abbadie, Catherine
Published in Anesthesia and analgesia (01.09.2009)
Published in Anesthesia and analgesia (01.09.2009)
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Journal Article
Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension
Hoyt, Scott B., Taylor, Jerry, London, Clare, Ali, Amjad, Ujjainwalla, Feroze, Tata, Jim, Struthers, Mary, Cully, Doris, Wisniewski, Tom, Ren, Ning, Bopp, Charlene, Sok, Andrea, Verras, Andreas, McMasters, Daniel, Chen, Qing, Tung, Elaine, Tang, Wei, Salituro, Gino, Clemas, Joe, Zhou, Gaochao, MacNeil, Douglas, Duffy, Ruth, Xiong, Yusheng
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
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Journal Article
Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker
Abbadie, Catherine, McManus, Owen B, Sun, Shu-Yu, Bugianesi, Randal M, Dai, Ge, Haedo, Rodolfo J, Herrington, James B, Kaczorowski, Gregory J, Smith, McHardy M, Swensen, Andrew M, Warren, Vivien A, Williams, Brande, Arneric, Stephen P, Eduljee, Cyrus, Snutch, Terrance P, Tringham, Elizabeth W, Jochnowitz, Nina, Liang, Annie, Euan MacIntyre, D, McGowan, Erin, Mistry, Shruti, White, Valerie V, Hoyt, Scott B, London, Clare, Lyons, Kathryn A, Bunting, Patricia B, Volksdorf, Sylvia, Duffy, Joseph L
Published in The Journal of pharmacology and experimental therapeutics (01.08.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2010)
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Journal Article
Imidazopyridyl compounds as aldosterone synthase inhibitors
Whitehead, Brent R., Lo, Michael M.-C., Ali, Amjad, Park, Min K., Hoyt, Scott B., Xiong, Yusheng, Cai, Jiaqiang, Carswell, Emma, Cooke, Andrew, MacLean, John, Ratcliffe, Paul, Robinson, John, Bennett, D. Jonathan, Clemas, Joseph A., Wisniewski, Tom, Struthers, Mary, Cully, Doris, MacNeil, Douglas J.
Published in Bioorganic & medicinal chemistry letters (15.01.2017)
Published in Bioorganic & medicinal chemistry letters (15.01.2017)
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Journal Article
Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels
Swensen, Andrew M, Herrington, James, Bugianesi, Randal M, Dai, Ge, Haedo, Rodolfo J, Ratliff, Kevin S, Smith, McHardy M, Warren, Vivien A, Arneric, Stephen P, Eduljee, Cyrus, Parker, David, Snutch, Terrance P, Hoyt, Scott B, London, Clare, Duffy, Joseph L, Kaczorowski, Gregory J, McManus, Owen B
Published in Molecular pharmacology (01.03.2012)
Published in Molecular pharmacology (01.03.2012)
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Journal Article
Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension
Petrilli, Whitney L, Hoyt, Scott B, London, Clare, McMasters, Daniel, Verras, Andreas, Struthers, Mary, Cully, Doris, Wisniewski, Thomas, Ren, Ning, Bopp, Charlene, Sok, Andrea, Chen, Qing, Li, Ying, Tung, Elaine, Tang, Wei, Salituro, Gino, Knemeyer, Ian, Karanam, Bindhu, Clemas, Joseph, Zhou, Gaochao, Gibson, Jack, Shipley, Carrie Ann, MacNeil, Douglas J, Duffy, Ruth, Tata, James R, Ujjainwalla, Feroze, Ali, Amjad, Xiong, Yusheng
Published in ACS medicinal chemistry letters (12.01.2017)
Published in ACS medicinal chemistry letters (12.01.2017)
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Journal Article
A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain
Hoyt, Scott B., London, Clare, Abbadie, Catherine, Felix, John P., Garcia, Maria L., Jochnowitz, Nina, Karanam, Bindhu V., Li, Xiaohua, Lyons, Kathryn A., McGowan, Erin, Priest, Birgit T., Smith, McHardy M., Warren, Vivien A., Thomas-Fowlkes, Brande S., Kaczorowski, Gregory J., Duffy, Joseph L.
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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Journal Article
Discovery of a novel class of benzazepinone Na(v)1.7 blockers: potential treatments for neuropathic pain
Hoyt, Scott B, London, Clare, Gorin, David, Wyvratt, Matthew J, Fisher, Michael H, Abbadie, Catherine, Felix, John P, Garcia, Maria L, Li, Xiaohua, Lyons, Kathryn A, McGowan, Erin, MacIntyre, D Euan, Martin, William J, Priest, Birgit T, Ritter, Amy, Smith, McHardy M, Warren, Vivien A, Williams, Brande S, Kaczorowski, Gregory J, Parsons, William H
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Journal Article
Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys
Hoyt, Scott B, Petrilli, Whitney, London, Clare, Liang, Gui-Bai, Tata, Jim, Hu, Qingzhong, Yin, Lina, van Koppen, Chris J, Hartmann, Rolf W, Struthers, Mary, Wisniewski, Tom, Ren, Ning, Bopp, Charlene, Sok, Andrea, Cai, Tian-Quan, Stribling, Sloan, Pai, Lee-Yuh, Ma, Xiuying, Metzger, Joe, Verras, Andreas, McMasters, Daniel, Chen, Qing, Tung, Elaine, Tang, Wei, Salituro, Gino, Buist, Nicole, Clemas, Joe, Zhou, Gaochao, Gibson, Jack, Maxwell, Carrie Ann, Lassman, Mike, McLaughlin, Theresa, Castro-Perez, Jose, Szeto, Daphne, Forrest, Gail, Hajdu, Richard, Rosenbach, Mark, Xiong, Yusheng
Published in ACS medicinal chemistry letters (13.08.2015)
Published in ACS medicinal chemistry letters (13.08.2015)
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Journal Article
Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys
Hoyt, Scott B, Park, Min K, London, Clare, Xiong, Yusheng, Tata, Jim, Bennett, D. Jonathan, Cooke, Andrew, Cai, Jiaqiang, Carswell, Emma, Robinson, John, MacLean, John, Brown, Lindsay, Belshaw, Simone, Clarkson, Thomas R, Liu, Kun, Liang, Gui-Bai, Struthers, Mary, Cully, Doris, Wisniewski, Tom, Ren, Ning, Bopp, Charlene, Sok, Andrea, Cai, Tian-Quan, Stribling, Sloan, Pai, Lee-Yuh, Ma, Xiuying, Metzger, Joe, Verras, Andreas, McMasters, Daniel, Chen, Qing, Tung, Elaine, Tang, Wei, Salituro, Gino, Buist, Nicole, Kuethe, Jeff, Rivera, Nelo, Clemas, Joe, Zhou, Gaochao, Gibson, Jack, Maxwell, Carrie Ann, Lassman, Mike, McLaughlin, Theresa, Castro-Perez, Jose, Szeto, Daphne, Forrest, Gail, Hajdu, Richard, Rosenbach, Mark, Ali, Amjad
Published in ACS medicinal chemistry letters (14.05.2015)
Published in ACS medicinal chemistry letters (14.05.2015)
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Journal Article
Benzazepinone Nav1.7 blockers : Potential treatments for neuropathic pain
HOYT, Scott B, LONDON, Clare, KARANAM, Bindhu V, XIAOHUA LI, LYONS, Kathryn A, MCGOWAN, Erin, EUAN MACINTYRE, D, MARTIN, William J, PRIEST, Birgit T, SMITH, Mchardy M, TSCHIRRET-GUTH, Richard, WARREN, Vivien A, OK, Hyun, WILLIAMS, Brande S, KACZOROWSKI, Gregory J, PARSONS, William H, GONZALEZ, Edward, DUFFY, Joseph L, ABBADIE, Catherine, DEAN, Brian, FELIX, John P, GARCIA, Maria L, JOCHNOWITZ, Nina
Published in Bioorganic & medicinal chemistry letters (15.11.2007)
Published in Bioorganic & medicinal chemistry letters (15.11.2007)
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Journal Article
Imidazopyridines : A novel class of hNav1.7 channel blockers
LONDON, Clare, HOYT, Scott B, LYONS, Kathryn A, XIAOHUA LI, KARANAM, Bindhu V, JOCHNOWITZ, Nina, GARCIA, Maria L, FELIX, John P, DEAN, Brian, ABBADIE, Catherine, KACZOROWSKI, Gregory J, DUFFY, Joseph L, PARSONS, William H, WILLIAMS, Brande S, WARREN, Vivien A, TSCHIRRET-GUTH, Richard, SMITH, Mchardy M, PRIEST, Birgit T, MCGOWAN, Erin, MARTIN, William J
Published in Bioorganic & medicinal chemistry letters (01.03.2008)
Published in Bioorganic & medicinal chemistry letters (01.03.2008)
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Journal Article
3-Amino-1,5-benzodiazepinones: Potent, state-dependent sodium channel blockers with anti-epileptic activity
Hoyt, Scott B., London, Clare, Wyvratt, Matthew J., Fisher, Michael H., Cashen, Doreen E., Felix, John P., Garcia, Maria L., Li, Xiaohua, Lyons, Kathryn A., Euan MacIntyre, D., Martin, William J., Priest, Birgit T., Smith, McHardy M., Warren, Vivien A., Williams, Brande S., Kaczorowski, Gregory J., Parsons, William H.
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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