mGluR2-음성 알로스테릭 조정제로서의 크로만, 이소크로만 및 디히드로이소벤조푸란 유도체, 조성물, 및 그의 용도
ARASAPPAN ASHOK, HOYT SCOTT B, SEBHAT IYASSU K, DEMONG DUANE, WILKENING ROBERT R
Year of Publication 24.05.2019
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Year of Publication 24.05.2019
Patent
Inhibition of Both IRAK1 and IRAK4 Is Required for Complete Suppression of NF-Kb Signaling across Multiple Receptor-Mediated Pathways in MDS and AML
Rosenbaum, Jan S, Hoyt, Scott B., Kolt, Amal S., Luedtke, Daniel A, Thomas, Craig J., Starczynowski, Daniel T.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Kme-0584, a Highly Potent IRAK1/IRAK4/panFLT3 Inhibitor, Is a Promising Clinical Candidate for Hypomethylating Agent Plus Venetoclax Resistant AML/MDS Patients
Rosenbaum, Jan S., Kolt, Amal S., Hoyt, Scott B., Hayes, Gregory M., Soldo, Brandi L., Thomas, Craig J., Starczynowski, Daniel T.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
IRAK1 Contributes to IRAK4 Inhibitor Resistance Via Non-Canonical Signaling Mechanisms in MDS/AML
Bennett, Josh, Yeung, Jennifer, Sampson, Avery, Hueneman, Kathleen, Wunderlich, Mark, Choi, Kwangmin, Volk, Andrew, Hoyt, Scott B., Thomas, Craig J., Starczynowski, Daniel T.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Discovery of IRAK1/4/pan-FLT3 Kinase Inhibitors as Treatments for Acute Myeloid Leukemia
Hoyt, Scott B., Finocchio, Chris J., Croll, Elizabeth, Tawa, Gregory J., Li, Huixu, Ma, Li, Li, Kaikai, Liu, Li, Li, Ranran, Zhang, Xiaohu, Wilson, Kelli, Xu, Xin, Shah, Pranav, Williams, Jordan, Fang, Yuhong, Bolanos, Lyndsey C., Gracia-Maldonado, Gabriel, Kolt, Amal, Robinson, Christina, Free, Jessica, Edmondson, Elijah F., Difilippantonio, Simone, Jones, LaQuita M., Culver-Cochran, Ashley E., Rosenbaum, Jan S., Starczynowski, Daniel T., Thomas, Craig J.
Published in ACS medicinal chemistry letters (23.10.2024)
Published in ACS medicinal chemistry letters (23.10.2024)
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Journal Article
Imidazopyridines: A novel class of hNav1.7 channel blockers
London, Clare, Hoyt, Scott B., Parsons, William H., Williams, Brande S., Warren, Vivien A., Tschirret-Guth, Richard, Smith, McHardy M., Priest, Birgit T., McGowan, Erin, Martin, William J., Lyons, Kathryn A., Li, Xiaohua, Karanam, Bindhu V., Jochnowitz, Nina, Garcia, Maria L., Felix, John P., Dean, Brian, Abbadie, Catherine, Kaczorowski, Gregory J., Duffy, Joseph L.
Published in Bioorganic & medicinal chemistry letters (01.03.2008)
Published in Bioorganic & medicinal chemistry letters (01.03.2008)
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Journal Article
Characterization of the Substituted N -Triazole Oxindole TROX-1, a Small-Molecule, State-Dependent Inhibitor of Ca v 2 Calcium Channels
Swensen, Andrew M., Herrington, James, Bugianesi, Randal M., Dai, Ge, Haedo, Rodolfo J., Ratliff, Kevin S., Smith, McHardy M., Warren, Vivien A., Arneric, Stephen P., Eduljee, Cyrus, Parker, David, Snutch, Terrance P., Hoyt, Scott B., London, Clare, Duffy, Joseph L., Kaczorowski, Gregory J., McManus, Owen B.
Published in Molecular pharmacology (01.03.2012)
Published in Molecular pharmacology (01.03.2012)
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Journal Article
Characterization of the Substituted N-Triazole Oxindole TROX-1, a Small-Molecule, State-Dependent Inhibitor of Cav2 Calcium Channels
Swensen, Andrew M, Herrington, James, Bugianesi, Randal M, Dai, Ge, Haedo, Rodolfo J, Ratliff, Kevin S, Smith, McHardy M, Warren, Vivien A, Arneric, Stephen P, Eduljee, Cyrus, Parker, David, Snutch, Terrance P, Hoyt, Scott B, London, Clare, Duffy, Joseph L, Kaczorowski, Gregory J, McManus, Owen B
Published in Molecular pharmacology (01.01.2012)
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Published in Molecular pharmacology (01.01.2012)
Journal Article
Characterization of a New Class of Potent Inhibitors of the Voltage-Gated Sodium Channel Nav1.7
Williams, Bre S, Felix, John P, Priest, Birgit T, Brochu, Richard M, Dai, Kefei, Hoyt, Scott B, London, Clare, Tang, Yui S, Duffy, Joseph L, Parsons, William H, Kaczorowski, Gregory J, Garcia, Maria L
Published in Biochemistry (Easton) (01.12.2007)
Published in Biochemistry (Easton) (01.12.2007)
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Journal Article
Imidazopyridines: A novel class of hNa sub(v)1.7 channel blockers
London, Clare, Hoyt, Scott B, Parsons, William H, Williams, Brande S, Warren, Vivien A, Tschirret-Guth, Richard, Smith, McHardy M, Priest, Birgit T, McGowan, Erin, Martin, William J, Lyons, Kathryn A, Li, Xiaohua, Karanam, Bindhu V, Jochnowitz, Nina, Garcia, Maria L, Felix, John P, Dean, Brian, Abbadie, Catherine, Kaczorowski, Gregory J, Duffy, Joseph L
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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Journal Article
Imidazopyridines: A novel class of hNa v1.7 channel blockers
London, Clare, Hoyt, Scott B., Parsons, William H., Williams, Brande S., Warren, Vivien A., Tschirret-Guth, Richard, Smith, McHardy M., Priest, Birgit T., McGowan, Erin, Martin, William J., Lyons, Kathryn A., Li, Xiaohua, Karanam, Bindhu V., Jochnowitz, Nina, Garcia, Maria L., Felix, John P., Dean, Brian, Abbadie, Catherine, Kaczorowski, Gregory J., Duffy, Joseph L.
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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Journal Article
Benzazepinone Na sub(v)1.7 blockers: Potential treatments for neuropathic pain
Hoyt, Scott B, London, Clare, Ok, Hyun, Gonzalez, Edward, Duffy, Joseph L, Abbadie, Catherine, Dean, Brian, Felix, John P, Garcia, Maria L, Jochnowitz, Nina, Karanam, Bindhu V, Li, Xiaohua, Lyons, Kathryn A, McGowan, Erin, MacIntyre, DEuan, Martin, William J, Priest, Birgit T, Smith, McHardy M, Tschirret-Guth, Richard, Warren, Vivien A, Williams, Brande S, Kaczorowski, Gregory J, Parsons, William H
Published in Bioorganic & medicinal chemistry (01.11.2007)
Published in Bioorganic & medicinal chemistry (01.11.2007)
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Journal Article
Discovery of a novel class of benzazepinone Na sub(v)1.7 blockers: Potential treatments for neuropathic pain
Hoyt, Scott B, London, Clare, Gorin, David, Wyvratt, Matthew J, Fisher, Michael H, Abbadie, Catherine, Felix, John P, Garcia, Maria L, Li, Xiaohua, Lyons, Kathryn A, McGowan, Erin, MacIntyre, DEuan, Martin, William J, Priest, Birgit T, Ritter, Amy, Smith, McHardy M, Warren, Vivien A, Williams, Brande S, Kaczorowski, Gregory J, Parsons, William H
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Journal Article
Benzazepinone Na v1.7 blockers: Potential treatments for neuropathic pain
Hoyt, Scott B., London, Clare, Ok, Hyun, Gonzalez, Edward, Duffy, Joseph L., Abbadie, Catherine, Dean, Brian, Felix, John P., Garcia, Maria L., Jochnowitz, Nina, Karanam, Bindhu V., Li, Xiaohua, Lyons, Kathryn A., McGowan, Erin, MacIntyre, D. Euan, Martin, William J., Priest, Birgit T., Smith, McHardy M., Tschirret-Guth, Richard, Warren, Vivien A., Williams, Brande S., Kaczorowski, Gregory J., Parsons, William H.
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Journal Article