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Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines

by Hunt, Thomas, Atherton-Watson, Hazel C., Axford, Jake, Collingwood, Stephen P., Coote, Kevin J., Cox, Brian, Czarnecki, Sarah, Danahay, Henry, Devereux, Nick, Howsham, Catherine, Hunt, Peter, Paddock, Victoria, Paisley, Derek, Young, Alice
Published in Bioorganic & medicinal chemistry letters (15.01.2012)

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Journal Article

Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease

Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease

by Grand, Darren Le, Gosling, Martin, Baettig, Urs, Bahra, Parmjit, Bala, Kamlesh, Brocklehurst, Cara, Budd, Emma, Butler, Rebecca, Cheung, Atwood K, Choudhury, Hedaythul, Collingwood, Stephen P, Cox, Brian, Danahay, Henry, Edwards, Lee, Everatt, Brian, Glaenzel, Ulrike, Glotin, Anne-Lise, Groot-Kormelink, Paul, Hall, Edward, Hatto, Julia, Howsham, Catherine, Hughes, Glyn, King, Anna, Koehler, Julia, Kulkarni, Swarupa, Lightfoot, Megan, Nicholls, Ian, Page, Christopher, Pergl-Wilson, Giles, Popa, Mariana Oana, Robinson, Richard, Rowlands, David, Sharp, Tom, Spendiff, Matthew, Stanley, Emily, Steward, Oliver, Taylor, Roger J, Tranter, Pamela, Wagner, Trixie, Watson, Hazel, Williams, Gareth, Wright, Penny, Young, Alice, Sandham, David A
Published in Journal of medicinal chemistry (10.06.2021)

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Journal Article

Synthesis of a Novel Type of 2,3′‐BIMs via Platinum‐Catalysed Reaction of Indolylallenes with Indoles

Synthesis of a Novel Type of 2,3′‐BIMs via Platinum‐Catalysed Reaction of Indolylallenes with Indoles

by Cooper, Lisa, Alonso, José Miguel, Eagling, Louise, Newson, Helen, Herath, Sachini, Thomson, Christopher, Lister, Andrew, Howsham, Catherine, Cox, Brian, Muñoz, María Paz
Published in Chemistry : a European journal (20.04.2018)

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Journal Article

Cover Feature: Synthesis of a Novel Type of 2,3′‐BIMs via Platinum‐Catalysed Reaction of Indolylallenes with Indoles (Chem. Eur. J. 23/2018)

Cover Feature: Synthesis of a Novel Type of 2,3′‐BIMs via Platinum‐Catalysed Reaction of Indolylallenes with Indoles (Chem. Eur. J. 23/2018)

by Cooper, Lisa, Alonso, José Miguel, Eagling, Louise, Newson, Helen, Herath, Sachini, Thomson, Christopher, Lister, Andrew, Howsham, Catherine, Cox, Brian, Muñoz, María Paz
Published in Chemistry : a European journal (20.04.2018)

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Journal Article

Biomimetic Synthesis of Resorcylate Natural Products Utilizing Late Stage Aromatization: Concise Total Syntheses of the Marine Antifungal Agents 15G256ι and 15G256β

Biomimetic Synthesis of Resorcylate Natural Products Utilizing Late Stage Aromatization: Concise Total Syntheses of the Marine Antifungal Agents 15G256ι and 15G256β

by Navarro, Ismael, Basset, Jean-François, Hebbe, Séverine, Major, Sarah M, Werner, Thomas, Howsham, Catherine, Bräckow, Jan, Barrett, Anthony G. M
Published in Journal of the American Chemical Society (06.08.2008)

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Journal Article

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: α-Branched quaternary amines

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: α-Branched quaternary amines

by Hunt, Thomas, Atherton-Watson, Hazel C., Collingwood, Stephen P., Coote, Kevin J., Czarnecki, Sarah, Danahay, Henry, Howsham, Catherine, Hunt, Peter, Paisley, Derek, Young, Alice
Published in Bioorganic & medicinal chemistry letters (15.04.2012)

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Journal Article

PYRAZINE DERIVATIVES AS ENAC BLOCKERS

PYRAZINE DERIVATIVES AS ENAC BLOCKERS

by SMITH NICHOLA, EDWARDS LEE, HUNT PETER, BHALAY GURDIP, HOWSHAM CATHERINE
Year of Publication 28.12.2015

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Patent

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: [alpha]-Branched quaternary amines

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: [alpha]-Branched quaternary amines

by Hunt, Thomas, Atherton-Watson, Hazel C, Collingwood, Stephen P, Coote, Kevin J, Czarnecki, Sarah, Danahay, Henry, Howsham, Catherine, Hunt, Peter, Paisley, Derek, Young, Alice
Published in Bioorganic & medicinal chemistry letters (15.04.2012)

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Journal Article

CRYSTALLINE FORM OF A SUCCINATE SALT

CRYSTALLINE FORM OF A SUCCINATE SALT

by LINDENBERG CHRISTIAN, TUFILLI NICOLA, PERLBERG ANETT, HOWSHAM CATHERINE
Year of Publication 17.10.2014

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Patent

PYRAZINE DERIVATIVES AS ENAC BLOCKERS

PYRAZINE DERIVATIVES AS ENAC BLOCKERS

by SMITH NICHOLA, EDWARDS LEE, HUNT PETER, BHALAY GURDIP, HOWSHAM CATHERINE
Year of Publication 26.06.2013

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Patent

3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF AIRWAY DISEASES

3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF AIRWAY DISEASES

by HUNT THOMAS ANTHONY, COLLINGWOOD STEPHEN PAUL, HOWSHAM CATHERINE
Year of Publication 08.02.2011

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Patent

PYRIDINES AND PYRAZINES AS INHIBITORS OF PI3K

PYRIDINES AND PYRAZINES AS INHIBITORS OF PI3K

by EDWARDS LEE, BRUCE IAN, BUDD EMMA, HOWSHAM CATHERINE
Year of Publication 21.12.2010

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Patent

PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATORY OR ALLERGIC CONDITIONS

PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATORY OR ALLERGIC CONDITIONS

by HUNT THOMAS ANTHONY, DUNSTAN ANDREW, BRUCE IAN, HOWSHAM CATHERINE
Year of Publication 08.03.2010

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Patent

PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF

PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF

by BAETTIG URS, EDWARDS LEE, LEGRAND DARREN MARK, BUDD EMMA, SPIEGEL KATRIN, HUGHES GLYN, BALA KAMLESH JAGDIS, HOWSHAM CATHERINE
Year of Publication 25.01.2013

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Patent

PYRAZINE DERIVATIVES AS EPITHELIAL SODIUM CHANNEL BLOCKERS

PYRAZINE DERIVATIVES AS EPITHELIAL SODIUM CHANNEL BLOCKERS

by DEVEREUX NICHOLAS JAMES, HUNT THOMAS ANTHONY, HUNT PETER, COLLINGWOOD STEPHEN PAUL, HOWSHAM CATHERINE
Year of Publication 20.04.2011

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Patent

Pyridine and pyrazine derivative for the treatment of chronic bronchitis

Pyridine and pyrazine derivative for the treatment of chronic bronchitis

by Howsham, Catherine, Baettig, Urs, Budd, Emma, Spiegel, Katrin, Bala, Kamlesh Jagdis, Edwards, Lee, Hughes, Glyn Alan, Le Grand, Darren Mark
Year of Publication 27.02.2024

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Patent

OARGANIC COMPOUNDS

OARGANIC COMPOUNDS

by GEDECK PETER, HUNT THOMAS ANTHONY, SMITH NICHOLA, EDWARDS LEE, HUNT PETER, DUNSTAN ANDREW, BUDD EMMA, BHALAY GURDIP, BLOOMFIELD GRAHAM CHARLES, COLLINGWOOD STEPHEN PAUL, OAKLEY PAUL, HOWSHAM CATHERINE
Year of Publication 08.09.2010

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Patent

CRYSTALLINE FORM OF A SUCCINATE SALT

CRYSTALLINE FORM OF A SUCCINATE SALT

by TUFILLI, NICOLA, HOWSHAM, CATHERINE, LINDENBERG, CHRISTIAN, PERLBERG, ANETT
Year of Publication 02.06.2020

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Patent

Biomimetic synthesis of resorcylate natural products utilizing late stage aromatization: concise total syntheses of the marine antifungal agents 15G256iota and 15G256beta

Biomimetic synthesis of resorcylate natural products utilizing late stage aromatization: concise total syntheses of the marine antifungal agents 15G256iota and 15G256beta

by Navarro, Ismael, Basset, Jean-François, Hebbe, Séverine, Major, Sarah M, Werner, Thomas, Howsham, Catherine, Bräckow, Jan, Barrett, Anthony G M
Published in Journal of the American Chemical Society (06.08.2008)

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Journal Article

N-SUBSTITUTED HETEROCYCLYL CARBOXAMIDES

N-SUBSTITUTED HETEROCYCLYL CARBOXAMIDES

by BUDD, Emma, TAYLOR, Roger, John, EDWARDS, Lee, HOWSHAM, Catherine, BALA, Kamlesh, Jagdis, LEGRAND, Darren, Mark
Year of Publication 02.06.2021

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Patent

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