Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS
Hodges, Timothy R, Abbott, Jason R, Little, Andrew J, Sarkar, Dhruba, Salovich, James M, Howes, Jennifer E, Akan, Denis T, Sai, Jiqing, Arnold, Allison L, Browning, Carrie, Burns, Michael C, Sobolik, Tammy, Sun, Qi, Beesetty, Yugandhar, Coker, Jesse A, Scharn, Dirk, Stadtmueller, Heinz, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, McConnell, Darryl B, Fesik, Stephen W
Published in Journal of medicinal chemistry (11.10.2018)
Published in Journal of medicinal chemistry (11.10.2018)
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Journal Article
Small Molecule-Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1
Howes, Jennifer E, Akan, Denis T, Burns, Michael C, Rossanese, Olivia W, Waterson, Alex G, Fesik, Stephen W
Published in Molecular cancer therapeutics (01.05.2018)
Published in Molecular cancer therapeutics (01.05.2018)
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High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling
Burns, Michael C., Howes, Jennifer E., Sun, Qi, Little, Andrew J., Camper, DeMarco V., Abbott, Jason R., Phan, Jason, Lee, Taekyu, Waterson, Alex G., Rossanese, Olivia W., Fesik, Stephen W.
Published in Analytical biochemistry (01.05.2018)
Published in Analytical biochemistry (01.05.2018)
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Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5–MYC Protein–Protein Interaction
Macdonald, Jonathan D, Chacón Simon, Selena, Han, Changho, Wang, Feng, Shaw, J. Grace, Howes, Jennifer E, Sai, Jiqing, Yuh, Joannes P, Camper, Demarco, Alicie, Bethany M, Alvarado, Joseph, Nikhar, Sameer, Payne, William, Aho, Erin R, Bauer, Joshua A, Zhao, Bin, Phan, Jason, Thomas, Lance R, Rossanese, Olivia W, Tansey, William P, Waterson, Alex G, Stauffer, Shaun R, Fesik, Stephen W
Published in Journal of medicinal chemistry (26.12.2019)
Published in Journal of medicinal chemistry (26.12.2019)
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Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling
Abbott, Jason R, Hodges, Timothy R, Daniels, R. Nathan, Patel, Pratiq A, Kennedy, J. Phillip, Howes, Jennifer E, Akan, Denis T, Burns, Michael C, Sai, Jiqing, Sobolik, Tammy, Beesetty, Yugandhar, Lee, Taekyu, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, Fesik, Stephen W
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
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Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses
Akan, Denis T, Howes, Jennifer E, Sai, Jiqing, Arnold, Allison L, Beesetty, Yugandhar, Phan, Jason, Olejniczak, Edward T, Waterson, Alex G, Fesik, Stephen W
Published in ACS chemical biology (15.03.2019)
Published in ACS chemical biology (15.03.2019)
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C-terminal Mutations Destabilize SIL1/BAP and Can Cause Marinesco-Sjögren Syndrome
Howes, Jennifer, Shimizu, Yuichiro, Feige, Matthias J., Hendershot, Linda M.
Published in The Journal of biological chemistry (09.03.2012)
Published in The Journal of biological chemistry (09.03.2012)
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Journal Article
Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling
AKERFELDT, Mia C, HOWES, Jennifer, JENG YIE CHAN, STEVENS, Veronica A, BOUBENNA, Nacer, MCGUIRE, Helen M, KING, Cecile, BIDEN, Trevor J, ROSS LAYBUTT, D
Published in Diabetes (New York, N.Y.) (01.11.2008)
Published in Diabetes (New York, N.Y.) (01.11.2008)
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Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS
Abbott, Jason R, Patel, Pratiq A, Howes, Jennifer E, Akan, Denis T, Kennedy, J. Phillip, Burns, Michael C, Browning, Carrie F, Sun, Qi, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, Fesik, Stephen W
Published in ACS medicinal chemistry letters (13.09.2018)
Published in ACS medicinal chemistry letters (13.09.2018)
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Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
ZAMO, Alberto, CHIARLE, Roberto, PIVA, Roberto, HOWES, Jennifer, YAN FAN, CHILOSI, Marco, LEVY, David E, INGHIRAMI, Giorgio
Published in Oncogene (07.02.2002)
Published in Oncogene (07.02.2002)
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Let's Talk Critical. Development and Evaluation of a Communication Skills Training Program for Critical Care Fellows
Hope, Aluko A, Hsieh, S Jean, Howes, Jennifer M, Keene, Adam B, Fausto, James A, Pinto, Priya A, Gong, Michelle Ng
Published in Annals of the American Thoracic Society (01.04.2015)
Published in Annals of the American Thoracic Society (01.04.2015)
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One-year audit of complaints made against a University Hospital Surgical Department
Mann, Chris D., Howes, Jennifer A., Buchanan, Alex, Bowrey, David J.
Published in ANZ journal of surgery (01.10.2012)
Published in ANZ journal of surgery (01.10.2012)
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A rare paediatric case of Klippel-Trenaunay-Weber syndrome
Howes, Jennifer A, Setty, Guru, Khan, Arif, Hussain, Nahin
Published in Journal of pediatric neurosciences (01.01.2015)
Published in Journal of pediatric neurosciences (01.01.2015)
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Henri Schildt: The Traditional Kerala Manor: Architecture of a South Indian Catuḥśāla House. (Institut Français de Pondichéry and Ecole Française D'Extrême Orient, Collection Indologie 117.) xiv, 473 pp. Pondicherry: All India Press, 2012. ISBN (IFP) 978 81 8470 189 0. ISBN (EFEO) 978 2 85539 126 7
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