The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
Canon, Jude, Rex, Karen, Saiki, Anne Y., Mohr, Christopher, Cooke, Keegan, Bagal, Dhanashri, Gaida, Kevin, Holt, Tyler, Knutson, Charles G., Koppada, Neelima, Lanman, Brian A., Werner, Jonathan, Rapaport, Aaron S., San Miguel, Tisha, Ortiz, Roberto, Osgood, Tao, Sun, Ji-Rong, Zhu, Xiaochun, McCarter, John D., Volak, Laurie P., Houk, Brett E., Fakih, Marwan G., O’Neil, Bert H., Price, Timothy J., Falchook, Gerald S., Desai, Jayesh, Kuo, James, Govindan, Ramaswamy, Hong, David S., Ouyang, Wenjun, Henary, Haby, Arvedson, Tara, Cee, Victor J., Lipford, J. Russell
Published in Nature (London) (01.11.2019)
Published in Nature (London) (01.11.2019)
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Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodynamic meta-analysis
Houk, Brett E, Bello, Carlo L, Poland, Bill, Rosen, Lee S, Demetri, George D, Motzer, Robert J
Published in Cancer chemotherapy and pharmacology (01.07.2010)
Published in Cancer chemotherapy and pharmacology (01.07.2010)
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Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Properties of Rozibafusp Alfa, a Bispecific Inhibitor of BAFF and ICOSL: Analyses of Phase I Clinical Trials
Abuqayyas, Lubna, Chen, Po‐Wei, Santos, Marcia Teixeira, Parnes, Jane R., Doshi, Sameer, Dutta, Sandeep, Houk, Brett E.
Published in Clinical pharmacology and therapeutics (01.08.2023)
Published in Clinical pharmacology and therapeutics (01.08.2023)
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Standard Error of Empirical Bayes Estimate in NONMEM® VI
Kang, Dongwoo, Bae, Kyun-Seop, Houk, Brett E, Savic, Radojka M, Karlsson, Mats O
Published in The Korean journal of physiology & pharmacology (01.04.2012)
Published in The Korean journal of physiology & pharmacology (01.04.2012)
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Determination of PF-04928473 in human plasma using liquid chromatography with tandem mass spectrometry
Jain, Lokesh, Gardner, Erin R., Venitz, Jürgen, Giaccone, Giuseppe, Houk, Brett E., Figg, William D.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.11.2010)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.11.2010)
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First-in-Human Study of PF-05212384 (PKI-587), a Small-Molecule, Intravenous, Dual Inhibitor of PI3K and mTOR in Patients with Advanced Cancer
Shapiro, Geoffrey I, Bell-McGuinn, Katherine M, Molina, Julian R, Bendell, Johanna, Spicer, James, Kwak, Eunice L, Pandya, Susan S, Millham, Robert, Borzillo, Gary, Pierce, Kristen J, Han, Lixin, Houk, Brett E, Gallo, Jorge D, Alsina, Maria, Braña, Irene, Tabernero, Josep
Published in Clinical cancer research (15.04.2015)
Published in Clinical cancer research (15.04.2015)
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A Phase I Study of PF-04929113 (SNX-5422), an Orally Bioavailable Heat Shock Protein 90 Inhibitor, in Patients with Refractory Solid Tumor Malignancies and Lymphomas
RAJAN, Arun, KELLY, Ronan J, MANNARGUDI, Baskar, FIGG, William D, HOUK, Brett E, SHNAIDMAN, Michael, BREGA, Nicoletta, GIACCONE, Giuseppe, TREPEL, Jane B, YEONG SANG KIM, ALARCON, Sylvia V, KUMMAR, Shivaani, GUTIERREZ, Martin, CRANDON, Sonja, ZEIN, Wadih M, JAIN, Lokesh
Published in Clinical cancer research (01.11.2011)
Published in Clinical cancer research (01.11.2011)
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Phase I study of PF-04691502, a small-molecule, oral, dual inhibitor of PI3K and mTOR, in patients with advanced cancer
Britten, Carolyn D., Adjei, Alex A., Millham, Robert, Houk, Brett E., Borzillo, Gary, Pierce, Kristen, Wainberg, Zev A., LoRusso, Patricia M.
Published in Investigational new drugs (01.06.2014)
Published in Investigational new drugs (01.06.2014)
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Journal Article
KRAS G12C Inhibition with Sotorasib in Advanced Solid Tumors
Hong, David S, Fakih, Marwan G, Strickler, John H, Desai, Jayesh, Durm, Gregory A, Shapiro, Geoffrey I, Falchook, Gerald S, Price, Timothy J, Sacher, Adrian, Denlinger, Crystal S, Bang, Yung-Jue, Dy, Grace K, Krauss, John C, Kuboki, Yasutoshi, Kuo, James C, Coveler, Andrew L, Park, Keunchil, Kim, Tae Won, Barlesi, Fabrice, Munster, Pamela N, Ramalingam, Suresh S, Burns, Timothy F, Meric-Bernstam, Funda, Henary, Haby, Ngang, Jude, Ngarmchamnanrith, Gataree, Kim, June, Houk, Brett E, Canon, Jude, Lipford, J Russell, Friberg, Gregory, Lito, Piro, Govindan, Ramaswamy, Li, Bob T
Published in The New England journal of medicine (24.09.2020)
Published in The New England journal of medicine (24.09.2020)
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Effect of axitinib on the QT interval in healthy volunteers
Ruiz-Garcia, Ana, Houk, Brett E., Pithavala, Yazdi K., Toh, Melvin, Sarapa, Nenad, Tortorici, Michael A.
Published in Cancer chemotherapy and pharmacology (01.03.2015)
Published in Cancer chemotherapy and pharmacology (01.03.2015)
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Phase I Trial of the HSP90 Inhibitor PF-04929113 (SNX5422) in Adult Patients With Recurrent, Refractory Hematologic Malignancies
Reddy, Nishitha, Voorhees, Peter M, Houk, Brett E, Brega, Nicoletta, Hinson, James M, Jillela, Anand
Published in Clinical lymphoma, myeloma and leukemia (01.08.2013)
Published in Clinical lymphoma, myeloma and leukemia (01.08.2013)
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Distribution, Metabolism, and Excretion of Gedatolisib in Healthy Male Volunteers After a Single Intravenous Infusion
Houk, Brett E., Alvey, Christine W., Visswanathan, Ravi, Kirkovsky, Leonid, Matschke, Kyle T., Kimoto, Emi, Ryder, Tim, Obach, R. Scott, Durairaj, Chandrasekar
Published in Clinical pharmacology in drug development (01.01.2019)
Published in Clinical pharmacology in drug development (01.01.2019)
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KRAS G12C 돌연변이를 포함하는 암의 치료를 위한 소토라십 및 EGFR 항체
NGARMCHAMNANRITH GATAREE, HENARY HABY, CHAN EMILY, FRIBERG GREGORY, HOUK BRETT E, DUTTA SANDEEP, MATHER OMAR
Year of Publication 11.06.2024
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Year of Publication 11.06.2024
Patent
Erratum to: Phase I study of PF-04691502, a small-molecule, oral, dual inhibitor of PI3K and mTOR, in patients with advanced cancer
Britten, Carolyn D., Adjei, Alex A., Millham, Robert, Houk, Brett E., Borzillo, Gary, Pierce, Kristen, Wainberg, Zev A., LoRusso, Patricia M.
Published in Investigational new drugs (2014)
Published in Investigational new drugs (2014)
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Journal Article
소토라십 투약 요법
NGARMCHAMNANRITH GATAREE, HENARY HABY, FRIBERG GREGORY, HOUK BRETT E, DUTTA SANDEEP, MATHER OMAR A
Year of Publication 16.11.2023
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Year of Publication 16.11.2023
Patent
Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors
Buchanan, John L., Newcomb, John R., Carney, David P., Chaffee, Stuart C., Chai, Lilly, Cupples, Rod, Epstein, Linda F., Gallant, Paul, Gu, Yan, Harmange, Jean-Christophe, Hodge, Kathy, Houk, Brett E., Huang, Xin, Jona, Janan, Joseph, Smriti, Jun, H. Toni, Kumar, Rakesh, Li, Chun, Lu, John, Menges, Tom, Morrison, Michael J., Novak, Perry M., van der Plas, Simon, Radinsky, Robert, Rose, Paul E., Sawant, Satin, Sun, Ji-Rong, Surapaneni, Sekhar, Turci, Susan M., Xu, Keyang, Yanez, Evelyn, Zhao, Huilin, Zhu, Xiaotian
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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