Validation of Human MDR1-MDCK and BCRP-MDCK Cell Lines to Improve the Prediction of Brain Penetration
Feng, Bo, West, Mark, Patel, Nandini C., Wager, Travis, Hou, Xinjun, Johnson, Jillian, Tremaine, Larry, Liras, Jennifer
Published in Journal of pharmaceutical sciences (01.07.2019)
Published in Journal of pharmaceutical sciences (01.07.2019)
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Optimal designs for pairwise calculation: An application to free energy perturbation in minimizing prediction variability
Yang, Qingyi, Burchett, Woodrow, Steeno, Gregory S., Liu, Shuai, Yang, Mingjun, Mobley, David L., Hou, Xinjun
Published in Journal of computational chemistry (30.01.2020)
Published in Journal of computational chemistry (30.01.2020)
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Current Landscape of Phosphodiesterase 10A (PDE10A) Inhibition
Chappie, Thomas A, Helal, Christopher J, Hou, Xinjun
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes
Wager, Travis T, Chandrasekaran, Ramalakshmi Y, Hou, Xinjun, Troutman, Matthew D, Verhoest, Patrick R, Villalobos, Anabella, Will, Yvonne
Published in ACS chemical neuroscience (16.06.2010)
Published in ACS chemical neuroscience (16.06.2010)
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Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia
Verhoest, Patrick R., Chapin, Douglas S., Corman, Michael, Fonseca, Kari, Harms, John F., Hou, Xinjun, Marr, Eric S., Menniti, Frank S., Nelson, Frederick, O'Connor, Rebecca, Pandit, Jayvardhan, Proulx-LaFrance, Caroline, Schmidt, Anne W., Schmidt, Christopher J., Suiciak, Judith A., Liras, Spiros
Published in Journal of medicinal chemistry (27.08.2009)
Published in Journal of medicinal chemistry (27.08.2009)
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Journal Article
Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
Ferruz, Noelia, Doerr, Stefan, Vanase-Frawley, Michelle A, Zou, Yaozhong, Chen, Xiaomin, Marr, Eric S, Nelson, Robin T, Kormos, Bethany L, Wager, Travis T, Hou, Xinjun, Villalobos, Anabella, Sciabola, Simone, De Fabritiis, Gianni
Published in Scientific reports (17.01.2018)
Published in Scientific reports (17.01.2018)
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Different mechanisms of X-ray irradiation-induced male and female sterility in Aedes aegypti
Zhang, Heng, Trueman, Emma, Hou, Xinjun, Chew, De Xian, Deng, Lu, Liew, Jonathan, Chia, Tania, Xi, Zhiyong, Tan, Cheong Huat, Cai, Yu
Published in BMC biology (27.11.2023)
Published in BMC biology (27.11.2023)
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Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy
Verhoest, Patrick R, Proulx-Lafrance, Caroline, Corman, Michael, Chenard, Lois, Helal, Christopher J, Hou, Xinjun, Kleiman, Robin, Liu, Shenping, Marr, Eric, Menniti, Frank S, Schmidt, Christopher J, Vanase-Frawley, Michelle, Schmidt, Anne W, Williams, Robert D, Nelson, Frederick R, Fonseca, Kari R, Liras, Spiros
Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
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Attenuation of neurovirulence of chikungunya virus by a single amino acid mutation in viral E2 envelope protein
Chen, Huixin, Phuektes, Patchara, Yeo, Li Sze, Wong, Yi Hao, Lee, Regina Ching Hua, Yi, Bowen, Hou, Xinjun, Liu, Sen, Cai, Yu, Chu, Justin Jang Hann
Published in Journal of biomedical science (17.01.2024)
Published in Journal of biomedical science (17.01.2024)
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Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors
Zuhl, Andrea M, Nolan, Charles E, Brodney, Michael A, Niessen, Sherry, Atchison, Kevin, Houle, Christopher, Karanian, David A, Ambroise, Claude, Brulet, Jeffrey W, Beck, Elizabeth M, Doran, Shawn D, O'Neill, Brian T, Am Ende, Christopher W, Chang, Cheng, Geoghegan, Kieran F, West, Graham M, Judkins, Joshua C, Hou, Xinjun, Riddell, David R, Johnson, Douglas S
Published in Nature communications (11.10.2016)
Published in Nature communications (11.10.2016)
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Hierarchical Lamellar Aluminophosphate Inorganic Materials for Medium Density Fiberboard with Good Fire Performance
Wu, Zhenzeng, Chen, Tingjie, Aladejana, John Tosin, Kouomo Guelifack, Yves, Li, Dehong, Hou, Xinjun, Wang, Xiaodong(Alice), Niu, Min, Xie, Yongqun
Published in Journal of industrial and engineering chemistry (Seoul, Korea) (25.06.2021)
Published in Journal of industrial and engineering chemistry (Seoul, Korea) (25.06.2021)
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Structure-based design of novel human Pin1 inhibitors (III): Optimizing affinity beyond the phosphate recognition pocket
Guo, Chuangxing, Hou, Xinjun, Dong, Liming, Marakovits, Joseph, Greasley, Samantha, Dagostino, Eleanor, Ferre, RoseAnn, Catherine Johnson, M., Humphries, Paul S., Li, Haitao, Paderes, Genevieve D., Piraino, Joseph, Kraynov, Eugenia, Murray, Brion W.
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
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Author Correction: Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
Ferruz, Noelia, Doerr, Stefan, Vanase-Frawley, Michelle A, Zou, Yaozhong, Chen, Xiaomin, Marr, Eric S, Nelson, Robin T, Kormos, Bethany L, Wager, Travis T, Hou, Xinjun, Villalobos, Anabella, Sciabola, Simone, De Fabritiis, Gianni
Published in Scientific reports (10.04.2019)
Published in Scientific reports (10.04.2019)
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Structure-based design of novel human Pin1 inhibitors (I)
Guo, Chuangxing, Hou, Xinjun, Dong, Liming, Dagostino, Eleanor, Greasley, Samantha, Ferre, RoseAnn, Marakovits, Joseph, Johnson, M. Catherine, Matthews, David, Mroczkowski, Barbara, Parge, Hans, VanArsdale, Todd, Popoff, Ian, Piraino, Joseph, Margosiak, Stephen, Thomson, James, Los, Gerrit, Murray, Brion W.
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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Structure-based design of novel human Pin1 inhibitors (II)
Dong, Liming, Marakovits, Joseph, Hou, Xinjun, Guo, Chuangxing, Greasley, Samantha, Dagostino, Eleanor, Ferre, RoseAnn, Johnson, M. Catherine, Kraynov, Eugenia, Thomson, James, Pathak, Ved, Murray, Brion W.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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The Discovery and Characterization of the α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N‑{(3S,4S)‑4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242)
Shaffer, Christopher L, Patel, Nandini C, Schwarz, Jacob, Scialis, Renato J, Wei, Yunjing, Hou, Xinjun J, Xie, Longfei, Karki, Kapil, Bryce, Dianne K, Osgood, Sarah M, Hoffmann, William E, Lazzaro, John T, Chang, Cheng, McGinnis, Dina F, Lotarski, Susan M, Liu, JianHua, Obach, R. Scott, Weber, Mark L, Chen, Laigao, Zasadny, Kenneth R, Seymour, Patricia A, Schmidt, Christopher J, Hajós, Mihály, Hurst, Raymond S, Pandit, Jayvardhan, O’Donnell, Christopher J
Published in Journal of medicinal chemistry (28.05.2015)
Published in Journal of medicinal chemistry (28.05.2015)
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Discovery and Characterization of a Novel Dihydroisoxazole Class of α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators
Patel, Nandini C, Schwarz, Jacob, Hou, Xinjun J, Hoover, Dennis J, Xie, Longfei, Fliri, Anton J, Gallaschun, Randall J, Lazzaro, John T, Bryce, Dianne K, Hoffmann, William E, Hanks, Ashley N, McGinnis, Dina, Marr, Eric S, Gazard, Justin L, Hajós, Mihály, Scialis, Renato J, Hurst, Raymond S, Shaffer, Christopher L, Pandit, Jayvardhan, O’Donnell, Christopher J
Published in Journal of medicinal chemistry (27.11.2013)
Published in Journal of medicinal chemistry (27.11.2013)
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The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter
Lowe, John A., Hou, Xinjun, Schmidt, Christopher, David Tingley, F., McHardy, Stan, Kalman, Monica, DeNinno, Shari, Sanner, Mark, Ward, Karen, Lebel, Lorraine, Tunucci, Don, Valentine, James
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
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