Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice
Kenjo, Eriya, Hozumi, Hiroyuki, Makita, Yukimasa, Iwabuchi, Kumiko A., Fujimoto, Naoko, Matsumoto, Satoru, Kimura, Maya, Amano, Yuichiro, Ifuku, Masataka, Naoe, Youichi, Inukai, Naoto, Hotta, Akitsu
Published in Nature communications (08.12.2021)
Published in Nature communications (08.12.2021)
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Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping
Gee, Peter, Lung, Mandy S. Y., Okuzaki, Yuya, Sasakawa, Noriko, Iguchi, Takahiro, Makita, Yukimasa, Hozumi, Hiroyuki, Miura, Yasutomo, Yang, Lucy F., Iwasaki, Mio, Wang, Xiou H., Waller, Matthew A., Shirai, Nanako, Abe, Yasuko O., Fujita, Yoko, Watanabe, Kei, Kagita, Akihiro, Iwabuchi, Kumiko A., Yasuda, Masahiko, Xu, Huaigeng, Noda, Takeshi, Komano, Jun, Sakurai, Hidetoshi, Inukai, Naoto, Hotta, Akitsu
Published in Nature communications (13.03.2020)
Published in Nature communications (13.03.2020)
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CRISPR-Cas3 induces broad and unidirectional genome editing in human cells
Morisaka, Hiroyuki, Yoshimi, Kazuto, Okuzaki, Yuya, Gee, Peter, Kunihiro, Yayoi, Sonpho, Ekasit, Xu, Huaigeng, Sasakawa, Noriko, Naito, Yuki, Nakada, Shinichiro, Yamamoto, Takashi, Sano, Shigetoshi, Hotta, Akitsu, Takeda, Junji, Mashimo, Tomoji
Published in Nature communications (06.12.2019)
Published in Nature communications (06.12.2019)
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Journal Article
Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type
Rahmani, Waleed, Abbasi, Sepideh, Hagner, Andrew, Raharjo, Eko, Kumar, Ranjan, Hotta, Akitsu, Magness, Scott, Metzger, Daniel, Biernaskie, Jeff
Published in Developmental cell (08.12.2014)
Published in Developmental cell (08.12.2014)
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PKD1 -Dependent Renal Cystogenesis in Human Induced Pluripotent Stem Cell-Derived Ureteric Bud/Collecting Duct Organoids
Kuraoka, Shohei, Tanigawa, Shunsuke, Taguchi, Atsuhiro, Hotta, Akitsu, Nakazato, Hitoshi, Osafune, Kenji, Kobayashi, Akio, Nishinakamura, Ryuichi
Published in Journal of the American Society of Nephrology (01.10.2020)
Published in Journal of the American Society of Nephrology (01.10.2020)
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Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells
Kojima, Yoji, Sasaki, Kotaro, Yokobayashi, Shihori, Sakai, Yoshitake, Nakamura, Tomonori, Yabuta, Yukihiro, Nakaki, Fumio, Nagaoka, So, Woltjen, Knut, Hotta, Akitsu, Yamamoto, Takuya, Saitou, Mitinori
Published in Cell stem cell (05.10.2017)
Published in Cell stem cell (05.10.2017)
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Stage-Specific Optimization of Activin/Nodal and BMP Signaling Promotes Cardiac Differentiation of Mouse and Human Pluripotent Stem Cell Lines
Kattman, Steven J., Witty, Alec D., Gagliardi, Mark, Dubois, Nicole C., Niapour, Maryam, Hotta, Akitsu, Ellis, James, Keller, Gordon
Published in Cell stem cell (04.02.2011)
Published in Cell stem cell (04.02.2011)
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The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis
Imamura, Keiko, Izumi, Yuishin, Watanabe, Akira, Tsukita, Kayoko, Woltjen, Knut, Yamamoto, Takuya, Hotta, Akitsu, Kondo, Takayuki, Kitaoka, Shiho, Ohta, Akira, Tanaka, Akito, Watanabe, Dai, Morita, Mitsuya, Takuma, Hiroshi, Tamaoka, Akira, Kunath, Tilo, Wray, Selina, Furuya, Hirokazu, Era, Takumi, Makioka, Kouki, Okamoto, Koichi, Fujisawa, Takao, Nishitoh, Hideki, Homma, Kengo, Ichijo, Hidenori, Julien, Jean-Pierre, Obata, Nanako, Hosokawa, Masato, Akiyama, Haruhiko, Kaneko, Satoshi, Ayaki, Takashi, Ito, Hidefumi, Kaji, Ryuji, Takahashi, Ryosuke, Yamanaka, Shinya, Inoue, Haruhisa
Published in Science translational medicine (24.05.2017)
Published in Science translational medicine (24.05.2017)
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Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9
Li, Hongmei Lisa, Fujimoto, Naoko, Sasakawa, Noriko, Shirai, Saya, Ohkame, Tokiko, Sakuma, Tetsushi, Tanaka, Michihiro, Amano, Naoki, Watanabe, Akira, Sakurai, Hidetoshi, Yamamoto, Takashi, Yamanaka, Shinya, Hotta, Akitsu
Published in Stem cell reports (13.01.2015)
Published in Stem cell reports (13.01.2015)
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Efficient genomic correction methods in human iPS cells using CRISPR–Cas9 system
Li, Hongmei Lisa, Gee, Peter, Ishida, Kentaro, Hotta, Akitsu
Published in Methods (San Diego, Calif.) (15.05.2016)
Published in Methods (San Diego, Calif.) (15.05.2016)
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Isolation of MECP2-nuLl Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation
CHEUNG, Aaron Y. L, HORVATH, Lindsay M, GRAFODATSKAYA, Daria, PASCERI, Peter, WEKSBERG, Rosanna, HOTTA, Akitsu, CARREL, Laura, ELLIS, James
Published in Human molecular genetics (01.06.2011)
Published in Human molecular genetics (01.06.2011)
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Dual inhibition of TMPRSS2 and Cathepsin Bprevents SARS-CoV-2 infection in iPS cells
Hashimoto, Rina, Sakamoto, Ayaka, Deguchi, Sayaka, Yi, Renxing, Sano, Emi, Hotta, Akitsu, Takahashi, Kazutoshi, Yamanaka, Shinya, Takayama, Kazuo
Published in Molecular therapy. Nucleic acids (03.12.2021)
Published in Molecular therapy. Nucleic acids (03.12.2021)
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Efficient and reproducible myogenic differentiation from human iPS cells: prospects for modeling Miyoshi Myopathy in vitro
Tanaka, Akihito, Woltjen, Knut, Miyake, Katsuya, Hotta, Akitsu, Ikeya, Makoto, Yamamoto, Takuya, Nishino, Tokiko, Shoji, Emi, Sehara-Fujisawa, Atsuko, Manabe, Yasuko, Fujii, Nobuharu, Hanaoka, Kazunori, Era, Takumi, Yamashita, Satoshi, Isobe, Ken-Ichi, Kimura, En, Sakurai, Hidetoshi
Published in PloS one (23.04.2013)
Published in PloS one (23.04.2013)
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Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells
Wang, Bo, Iriguchi, Shoichi, Waseda, Masazumi, Ueda, Norihiro, Ueda, Tatsuki, Xu, Huaigeng, Minagawa, Atsutaka, Ishikawa, Akihiro, Yano, Hisashi, Ishi, Tomoko, Ito, Ryoji, Goto, Motohito, Takahashi, Riichi, Uemura, Yasushi, Hotta, Akitsu, Kaneko, Shin
Published in Nature biomedical engineering (01.05.2021)
Published in Nature biomedical engineering (01.05.2021)
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Minimizing off-Target Mutagenesis Risks Caused by Programmable Nucleases
Ishida, Kentaro, Gee, Peter, Hotta, Akitsu
Published in International Journal of Molecular Sciences (16.10.2015)
Published in International Journal of Molecular Sciences (16.10.2015)
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Book Review
Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate
Morizane, Asuka, Doi, Daisuke, Kikuchi, Tetsuhiro, Okita, Keisuke, Hotta, Akitsu, Kawasaki, Toshiyuki, Hayashi, Takuya, Onoe, Hirotaka, Shiina, Takashi, Yamanaka, Shinya, Takahashi, Jun
Published in Stem cell reports (15.10.2013)
Published in Stem cell reports (15.10.2013)
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Establishment of quantitative and consistent in vitro skeletal muscle pathological models of myotonic dystrophy type 1 using patient-derived iPSCs
Kawada, Ryu, Jonouchi, Tatsuya, Kagita, Akihiro, Sato, Masae, Hotta, Akitsu, Sakurai, Hidetoshi
Published in Scientific reports (11.01.2023)
Published in Scientific reports (11.01.2023)
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