Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial
Thomas, Huw D, Calabrese, Christopher R, Batey, Michael A, Canan, Stacie, Hostomsky, Zdenek, Kyle, Suzanne, Maegley, Karen A, Newell, David R, Skalitzky, Donald, Wang, Lan-Zhen, Webber, Stephen E, Curtin, Nicola J
Published in Molecular cancer therapeutics (01.03.2007)
Published in Molecular cancer therapeutics (01.03.2007)
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Inhibition of Poly(ADP-Ribose) Polymerase-1 Enhances Temozolomide and Topotecan Activity against Childhood Neuroblastoma
DANIEL, Rachel A, ROZANSKA, Agata L, CURTIN, Nicola J, CLIFFORD, Steven C, THOMAS, Huw D, MULLIGAN, Evan A, DREW, Yvette, CASTELBUONO, Deborah J, HOSTOMSKY, Zdenek, PLUMMER, E. Ruth, BODDY, Alan V, TWEDDLE, Deborah A
Published in Clinical cancer research (15.02.2009)
Published in Clinical cancer research (15.02.2009)
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Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells
CURTIN, Nicola J, WANG, Lan-Zhen, NEWELL, David R, YIAKOUVAKI, Anthie, KYLE, Suzanne, ARRIS, Christine A, CANAN-KOCH, Stacie, WEBBER, Stephen E, DURKACZ, Barbara W, CALVERT, Hilary A, HOSTOMSKY, Zdenek
Published in Clinical cancer research (01.02.2004)
Published in Clinical cancer research (01.02.2004)
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Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase
White, Alex W, Almassy, Robert, Calvert, A. Hilary, Curtin, Nicola J, Griffin, Roger J, Hostomsky, Zdenek, Maegley, Karen, Newell, David R, Srinivasan, Sheila, Golding, Bernard T
Published in Journal of medicinal chemistry (02.11.2000)
Published in Journal of medicinal chemistry (02.11.2000)
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The Crystal Structure of Hepatitis C Virus NS3 Proteinase Reveals a Trypsin-like Fold and a Structural Zinc Binding Site
Love, Robert A, Parge, Hans E, Wickersham, John A, Hostomsky, Zdenek, Habuka, Noriyuki, Moomaw, Ellen W, Adachi, Tsuyoshi, Hostomska, Zuzana
Published in Cell (18.10.1996)
Published in Cell (18.10.1996)
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Potentiation of Temozolomide and Topotecan Growth Inhibition and Cytotoxicity by Novel Poly(adenosine Diphosphoribose) Polymerase Inhibitors in a Panel of Human Tumor Cell Lines
DELANEY, C. A, WANG, L.-Z, KYLE, S, WHITE, A. W, CALVERT, A. H, CURTIN, N. J, DURKACZ, B. W, HOSTOMSKY, Z, NEWELL, D. R
Published in Clinical cancer research (01.07.2000)
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Published in Clinical cancer research (01.07.2000)
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Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors
Mukhopadhyay, Asima, Elattar, Ahmed, Cerbinskaite, Aiste, Wilkinson, Sarah J, Drew, Yvette, Kyle, Suzanne, Los, Gerrit, Hostomsky, Zdenek, Edmondson, Richard J, Curtin, Nicola J
Published in Clinical cancer research (15.04.2010)
Published in Clinical cancer research (15.04.2010)
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Therapeutic Potential of Poly(ADP-ribose) Polymerase Inhibitor AG014699 in Human Cancers With Mutated or Methylated BRCA1 or BRCA2
DREW, Yvette, MULLIGAN, Evan A, EDMONDSON, Richard J, CURTIN, Nicola J, VONG, Wan-Tse, THOMAS, Huw D, KAHN, Samra, KYLE, Suzanne, MUKHOPADHYAY, Asima, LOS, Gerrit, HOSTOMSKY, Zdenek, PLUMMER, Elizabeth R
Published in JNCI : Journal of the National Cancer Institute (16.02.2011)
Published in JNCI : Journal of the National Cancer Institute (16.02.2011)
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Anticancer chemosensitization and radiosensitization by the novel Poly(ADP-ribose) polymerase-1 inhibitor AG14361
CALABRESE, Christopher R, ALMASSY, Robert, LI, Jianke, MAEGLEY, Karen, NEWELL, David R, NOTARIANNI, Elena, STRATFORD, Ian J, SKALITZKY, Donald, THOMAS, Huw D, WANG, Ian-Zhen, WEBBER, Stephen E, WILLIAMS, Kaye J, BARTON, Stephanie, CURTIN, Nicola J, BATEY, Michael A, CALVERT, A. Hilary, CANAN-KOCH, Stacie, DURKACZ, Barbara W, HOSTOMSKY, Zdenek, KUMPF, Robert A, KYLE, Suzanne
Published in JNCI : Journal of the National Cancer Institute (07.01.2004)
Published in JNCI : Journal of the National Cancer Institute (07.01.2004)
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NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699
Hunter, J E, Willmore, E, Irving, J A E, Hostomsky, Z, Veuger, S J, Durkacz, B W
Published in Oncogene (12.01.2012)
Published in Oncogene (12.01.2012)
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Tricyclic Benzimidazoles as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors
Skalitzky, Donald J, Marakovits, Joseph T, Maegley, Karen A, Ekker, Anne, Yu, Xiao-Hong, Hostomsky, Zdenek, Webber, Stephen E, Eastman, Brian W, Almassy, Robert, Li, Jianke, Curtin, Nicola J, Newell, David R, Calvert, A. Hilary, Griffin, Roger J, Golding, Bernard T
Published in Journal of medicinal chemistry (16.01.2003)
Published in Journal of medicinal chemistry (16.01.2003)
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Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity: Design, Synthesis, and X-ray Cocrystal Structure
Canan Koch, Stacie S, Thoresen, Lars H, Tikhe, Jayashree G, Maegley, Karen A, Almassy, Robert J, Li, Jianke, Yu, Xiao-Hong, Zook, Scott E, Kumpf, Robert A, Zhang, Cathy, Boritzki, Theodore J, Mansour, Rena N, Zhang, Kanyin E, Ekker, Anne, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R, Webber, Stephen E, Hostomsky, Zdenek
Published in Journal of medicinal chemistry (07.11.2002)
Published in Journal of medicinal chemistry (07.11.2002)
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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like cells enriched with tumor spheroids from a non-small cell lung cancer cell line
Fang, Douglas D., Cao, Joan, Jani, Jitesh P., Tsaparikos, Konstantinos, Blasina, Alessandra, Kornmann, Jill, Lira, Maruja E., Wang, Jianying, Jirout, Zuzana, Bingham, Justin, Zhu, Zhou, Gu, Yin, Los, Gerrit, Hostomsky, Zdenek, VanArsdale, Todd
Published in Frontiers of medicine (01.12.2013)
Published in Frontiers of medicine (01.12.2013)
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Identification of potent nontoxic poly(ADP-ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies
CALABRESE, Christopher R, BATEY, Michael A, MAEGLEY, Karen, CALVERT, Alan H, HOSTOMSKY, Zdenek, NEWELL, David R, CURTIN, Nicola J, THOMAS, Huw D, DURKACZ, Barbara W, WANG, Lan-Zhen, KYLE, Suzanne, SKALITZKY, Donald, LI, Janke, ZHANG, Catherine, BORITZKI, Theodore
Published in Clinical cancer research (01.07.2003)
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Published in Clinical cancer research (01.07.2003)
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Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors
White, Alex W., Curtin, Nicola J., Eastman, Brian W., Golding, Bernard T., Hostomsky, Zdenek, Kyle, Suzanne, Li, Jianke, Maegley, Karen A., Skalitzky, Donald J., Webber, Stephen E., Yu, Xiao-Hong, Griffin, Roger J.
Published in Bioorganic & medicinal chemistry letters (17.05.2004)
Published in Bioorganic & medicinal chemistry letters (17.05.2004)
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High-affinity ssDNA inhibitors of the reverse transcriptase of type 1 human immunodeficiency virus
Schneider, Daniel J, Feigon, Juli, Hostomsky, Zdenek, Gold, Larry
Published in Biochemistry (Easton) (25.07.1995)
Published in Biochemistry (Easton) (25.07.1995)
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