Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery
Pipal, Robert W., Stout, Kenneth T., Musacchio, Patricia Z., Ren, Sumei, Graham, Thomas J. A., Verhoog, Stefan, Gantert, Liza, Lohith, Talakad G., Schmitz, Alexander, Lee, Hsiaoju S., Hesk, David, Hostetler, Eric D., Davies, Ian W., MacMillan, David W. C.
Published in Nature (London) (28.01.2021)
Published in Nature (London) (28.01.2021)
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Discovery of 6‑(Fluoro-18 F)‑3-(1H‑pyrrolo[2,3‑c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)
Walji, Abbas M, Hostetler, Eric D, Selnick, Harold, Zeng, Zhizhen, Miller, Patricia, Bennacef, Idriss, Salinas, Cristian, Connolly, Brett, Gantert, Liza, Holahan, Marie, O’Malley, Stacey, Purcell, Mona, Riffel, Kerry, Li, Jing, Balsells, Jaume, OBrien, Julie A, Melquist, Stacey, Soriano, Aileen, Zhang, Xiaoping, Ogawa, Aimie, Xu, Serena, Joshi, Elizabeth, Della Rocca, Joseph, Hess, Fred J, Schachter, Joel, Hesk, David, Schenk, David, Struyk, Arie, Babaoglu, Kerim, Lohith, Talakad G, Wang, Yaode, Yang, Kun, Fu, Jianmin, Evelhoch, Jeffrey L, Coleman, Paul J
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232
Hostetler, Eric D, Joshi, Aniket D, Sanabria-Bohórquez, Sandra, Fan, Hong, Zeng, Zhizhen, Purcell, Mona, Gantert, Liza, Riffel, Kerry, Williams, Mangay, O'Malley, Stacey, Miller, Patricia, Selnick, Harold G, Gallicchio, Steven N, Bell, Ian M, Salvatore, Christopher A, Kane, Stefanie A, Li, Chi-Chung, Hargreaves, Richard J, de Groot, Tjibbe, Bormans, Guy, Van Hecken, Anne, Derdelinckx, Inge, de Hoon, Jan, Reynders, Tom, Declercq, Ruben, De Lepeleire, Inge, Kennedy, W P, Blanchard, Rebecca, Marcantonio, Eugene E, Sur, Cyrille, Cook, Jacquelynn J, Van Laere, Koen, Evelhoch, Jeffrey L
Published in The Journal of pharmacology and experimental therapeutics (01.11.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2013)
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In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1
Rubins, Daniel J, Meng, Xiangjun, McQuade, Paul, Klimas, Michael, Getty, Krista, Lin, Shu-An, Connolly, Brett M., O’Malley, Stacey S., Haley, Hyking, Purcell, Mona, Gantert, Liza, Holahan, Marie, Lindgren, Joel, Eklund, Pär, Ekblad, Caroline, Frejd, Fredrik Y., Hostetler, Eric D., González Trotter, Dinko E., Evelhoch, Jeffrey L.
Published in Molecular imaging and biology (01.04.2021)
Published in Molecular imaging and biology (01.04.2021)
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The PET tracer [ 11 C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer's disease
Li, Wenping, Wang, Yuchuan, Lohith, Talakad G, Zeng, Zhizhen, Tong, Ling, Mazzola, Robert, Riffel, Kerry, Miller, Patricia, Purcell, Mona, Holahan, Marie, Haley, Hyking, Gantert, Liza, Hesk, David, Ren, Sumei, Morrow, John, Uslaner, Jason, Struyk, Arie, Wai, Jenny Miu-Chun, Rudd, Michael T, Tellers, David M, McAvoy, Thomas, Bormans, Guy, Koole, Michel, Van Laere, Koen, Serdons, Kim, de Hoon, Jan, Declercq, Ruben, De Lepeleire, Inge, Pascual, Maria B, Zanotti-Fregonara, Paolo, Yu, Meixiang, Arbones, Victoria, Masdeu, Joseph C, Cheng, Amy, Hussain, Azher, Bueters, Tjerk, Anderson, Matt S, Hostetler, Eric D, Basile, Anthony S
Published in Science translational medicine (12.01.2022)
Published in Science translational medicine (12.01.2022)
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Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles
Koole, Michel, Lohith, Talakad G., Valentine, John L., Bennacef, Idriss, Declercq, Ruben, Reynders, Tom, Riffel, Kerry, Celen, Sofie, Serdons, Kim, Bormans, Guy, Ferry-Martin, Sandrine, Laroque, Philippe, Walji, Abbas, Hostetler, Eric D., Briscoe, Richard J., de Hoon, Jan, Sur, Cyrille, Van Laere, Koen, Struyk, Arie
Published in Molecular imaging and biology (01.02.2020)
Published in Molecular imaging and biology (01.02.2020)
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A dual-time-window protocol to reduce acquisition time of dynamic tau PET imaging using [18F]MK-6240
Kolinger, Guilherme D., Vállez García, David, Lohith, Talakad G., Hostetler, Eric D., Sur, Cyrille, Struyk, Arie, Boellaard, Ronald, Koole, Michel
Published in EJNMMI research (27.05.2021)
Published in EJNMMI research (27.05.2021)
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Continuous Microwave-Assisted Gas–Liquid Segmented Flow Reactor for Controlled Nucleation and Growth of Nanocrystals
Kim, Ki-Joong, Oleksak, Richard P, Hostetler, Eric B, Peterson, Daniel A, Chandran, Padmavathi, Schut, David M, Paul, Brian K, Herman, Gregory S, Chang, Chih-Hung
Published in Crystal growth & design (05.11.2014)
Published in Crystal growth & design (05.11.2014)
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cGMP production of the radiopharmaceutical [18F]MK‐6240 for PET imaging of human neurofibrillary tangles
Collier, Thomas Lee, Yokell, Daniel L., Livni, Eli, Rice, Peter A., Celen, Sofie, Serdons, Kim, Neelamegam, Ramesh, Bormans, Guy, Harris, Dawn, Walji, Abbas, Hostetler, Eric D., Bennacef, Idriss, Vasdev, Neil
Published in Journal of labelled compounds & radiopharmaceuticals (15.05.2017)
Published in Journal of labelled compounds & radiopharmaceuticals (15.05.2017)
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Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia
Raheem, Izzat T., Schreier, John D., Fuerst, Joy, Gantert, Liza, Hostetler, Eric D., Huszar, Sarah, Joshi, Aniket, Kandebo, Monika, Kim, Somang H., Li, Jing, Ma, Bennett, McGaughey, Georgia, Sharma, Sujata, Shipe, William D., Uslaner, Jason, Vandeveer, George H., Yan, Youwei, Renger, John J., Smith, Sean M., Coleman, Paul J., Cox, Christopher D.
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
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Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with 18 F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles
Lohith, Talakad G, Bennacef, Idriss, Vandenberghe, Rik, Vandenbulcke, Mathieu, Salinas, Cristian A, Declercq, Ruben, Reynders, Tom, Telan-Choing, N Florestina, Riffel, Kerry, Celen, Sofie, Serdons, Kim, Bormans, Guy, Tsai, Kuenhi, Walji, Abbas, Hostetler, Eric D, Evelhoch, Jeffrey L, Van Laere, Koen, Forman, Mark, Stoch, Aubrey, Sur, Cyrille, Struyk, Arie
Published in Journal of Nuclear Medicine (01.01.2019)
Published in Journal of Nuclear Medicine (01.01.2019)
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Discovery of [11C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors
Cox, Christopher D., Hostetler, Eric D., Flores, Broc A., Evelhoch, Jeffrey L., Fan, Hong, Gantert, Liza, Holahan, Marie, Eng, Waisi, Joshi, Aniket, McGaughey, Georgia, Meng, Xiangjun, Purcell, Mona, Raheem, Izzat T., Riffel, Kerry, Yan, Youwei, Renger, John J., Smith, Sean M., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
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Training the next generation of radiopharmaceutical scientists
Gee, Antony D., Andersson, Jan, Bhalla, Rajiv, Choe, Yearn Seong, Dick, David W., Herth, Matthias M., Hostetler, Eric D., Jáuregui-Haza, Ulises J., Huang, Ya-Yao, James, Michelle L., Jeong, Jae Min, Korde, Aruna, Kuge, Yuji, Kung, Hank F., Lapi, Suzanne E., Osso, Joao Alberto, Parent, Ephraim, Patt, Marianne, Pricile, Ekoume Fany, Riss, Patrick J., Santos-Oliveira, Ralph, Taylor, Stephen, Vasdev, Neil, Vercouillie, Johnny, Wadsak, Wolfgang, Yang, Zhi, Zhu, Hua, Scott, Peter J.H.
Published in Nuclear medicine and biology (01.09.2020)
Published in Nuclear medicine and biology (01.09.2020)
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MK-8719, a Novel and Selective O -GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy
Wang, Xiaohai, Li, Wenping, Marcus, Jacob, Pearson, Michelle, Song, Lixin, Smith, Karen, Terracina, Giuseppe, Lee, Julie, Hong, Kwok-Lam Karen, Lu, Sherry X., Hyde, Lynn, Chen, Shu-Cheng, Kinsley, David, Melchor, Jerry P., Rubins, Daniel J., Meng, Xiangjun, Hostetler, Eric, Sur, Cyrille, Zhang, Lili, Schachter, Joel B., Hess, J. Fred, Selnick, Harold G., Vocadlo, David J., McEachern, Ernest J., Uslaner, Jason M., Duffy, Joseph L., Smith, Sean M.
Published in The Journal of pharmacology and experimental therapeutics (01.08.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2020)
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PET/CT Imaging of 89Zr-N-sucDf-Pembrolizumab in Healthy Cynomolgus Monkeys
Li, Wenping, Wang, Yuchuan, Rubins, Daniel, Bennacef, Idriss, Holahan, Marie, Haley, Hyking, Purcell, Mona, Gantert, Liza, Hseih, SuChun, Judo, Michael, Seghezzi, Wolfgang, Zhang, Shuli, van der Veen, Elly L., Lub-de Hooge, Marjolijn N., de Vries, Elisabeth G.E., Evelhoch, Jeffrey L., Klimas, Michael, Hostetler, Eric D.
Published in Molecular imaging and biology (01.04.2021)
Published in Molecular imaging and biology (01.04.2021)
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Preclinical evaluation of [11C]L‐235 as a radioligand for Positron Emission Tomography cathepsin K imaging in bone
Bennacef, Idriss, Rubins, Daniel, Riffel, Kerry, Williams, Mangay, Posavec, Diane J., Holahan, Marie A., Purcell, Mona L., Haley, Hyking D., Wolf, Mary, Stachel, Shawn J., Lubbers, Laura S., Wesolowski, Gregg A., Duong, Le T., Hamill, Terence G., Evelhoch, Jeffrey L., Hostetler, Eric D.
Published in Journal of labelled compounds & radiopharmaceuticals (01.04.2021)
Published in Journal of labelled compounds & radiopharmaceuticals (01.04.2021)
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In Vivo Imaging of the Programmed Death Ligand 1 by 18 F PET
González Trotter, Dinko E, Meng, Xiangjun, McQuade, Paul, Rubins, Daniel, Klimas, Michael, Zeng, Zhizhen, Connolly, Brett M, Miller, Patricia J, O'Malley, Stacey S, Lin, Shu-An, Getty, Krista L, Fayadat-Dilman, Laurence, Liang, Linda, Wahlberg, Elisabet, Widmark, Olof, Ekblad, Caroline, Frejd, Fredrik Y, Hostetler, Eric D, Evelhoch, Jeffrey L
Published in Journal of Nuclear Medicine (01.11.2017)
Published in Journal of Nuclear Medicine (01.11.2017)
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The role of MRI and PET/SPECT in Alzheimer's disease
Coimbra, Alexandre, Williams, Donald S, Hostetler, Eric D
Published in Current topics in medicinal chemistry (01.03.2006)
Published in Current topics in medicinal chemistry (01.03.2006)
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Synthesis, characterization, and monkey PET studies of [18F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435
Hostetler, Eric D., Eng, Waisi, Joshi, Aniket D., Sanabria-Bohórquez, Sandra, Kawamoto, Hiroshi, Ito, Satoru, O'Malley, Stacey, Krause, Stephen, Ryan, Christine, Patel, Shil, Williams, Mangay, Riffel, Kerry, Suzuki, Gentaroh, Ozaki, Satoshi, Ohta, Hisashi, Cook, Jacquelynn, Burns, H. Donald, Hargreaves, Richard
Published in Synapse (New York, N.Y.) (01.02.2011)
Published in Synapse (New York, N.Y.) (01.02.2011)
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Evaluation of [18F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human
Hostetler, Eric D., Sanabria-Bohórquez, Sandra, Eng, Waisi, Joshi, Aniket D., Patel, Shailendra, Gibson, Raymond E., O'Malley, Stacey, Krause, Stephen M., Ryan, Christine, Riffel, Kerry, Bi, Sheng, Okamoto, Osamu, Kawamoto, Hiroshi, Ozaki, Satoshi, Ohta, Hisashi, de Groot, Tjibbe, Bormans, Guy, Depré, Marleen, de Hoon, Jan, De Lepeleire, Inge, Reynders, Tom, Cook, Jacquelynn J., Burns, H. Donald, Egan, Michael, Cho, William, van Laere, Koen, Hargreaves, Richard J.
Published in NeuroImage (Orlando, Fla.) (01.03.2013)
Published in NeuroImage (Orlando, Fla.) (01.03.2013)
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