Safety, efficacy and renal effect of febuxostat in patients with moderate-to-severe kidney dysfunction
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Published in Hypertension research (01.10.2014)
Published in Hypertension research (01.10.2014)
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Comparative study of a novel selective urate reabsorption inhibitor “dotinurad” among patient groups with different stages of renal dysfunction
Takahashi, Toshinari, Beppu, Takanobu, Hidaka, Yuji, Hosoya, Tatsuo
Published in Clinical and experimental nephrology (01.12.2021)
Published in Clinical and experimental nephrology (01.12.2021)
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Uric acid-lowering effect of dotinurad, a novel selective urate reabsorption inhibitor, in hypertensive patients with gout or asymptomatic hyperuricemia: a pooled analysis of individual participant data in phase II and III trials
Takahashi, Toshinari, Beppu, Takanobu, Hidaka, Yuji, Hosoya, Tatsuo
Published in Clinical and experimental hypertension (1993) (17.11.2021)
Published in Clinical and experimental hypertension (1993) (17.11.2021)
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Decreased extra-renal urate excretion is a common cause of hyperuricemia
Ichida, Kimiyoshi, Matsuo, Hirotaka, Takada, Tappei, Nakayama, Akiyoshi, Murakami, Keizo, Shimizu, Toru, Yamanashi, Yoshihide, Kasuga, Hiroshi, Nakashima, Hiroshi, Nakamura, Takahiro, Takada, Yuzo, Kawamura, Yusuke, Inoue, Hiroki, Okada, Chisa, Utsumi, Yoshitaka, Ikebuchi, Yuki, Ito, Kousei, Nakamura, Makiko, Shinohara, Yoshihiko, Hosoyamada, Makoto, Sakurai, Yutaka, Shinomiya, Nariyoshi, Hosoya, Tatsuo, Suzuki, Hiroshi
Published in Nature communications (03.04.2012)
Published in Nature communications (03.04.2012)
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Dotinurad versus benzbromarone in Japanese hyperuricemic patient with or without gout: a randomized, double-blind, parallel-group, phase 3 study
Hosoya, Tatsuo, Sano, Takafumi, Sasaki, Tomomitsu, Fushimi, Masahiko, Ohashi, Tetsuo
Published in Clinical and experimental nephrology (01.03.2020)
Published in Clinical and experimental nephrology (01.03.2020)
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Low Glomerular Density with Glomerulomegaly in Obesity-Related Glomerulopathy
Tsuboi, Nobuo, Utsunomiya, Yasunori, Kanzaki, Go, Koike, Kentaro, Ikegami, Masahiro, Kawamura, Tetsuya, Hosoya, Tatsuo
Published in Clinical journal of the American Society of Nephrology (01.05.2012)
Published in Clinical journal of the American Society of Nephrology (01.05.2012)
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Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout
Hosoya, Tatsuo, Ohno, Iwao, Nomura, Shinsuke, Hisatome, Ichiro, Uchida, Shunya, Fujimori, Shin, Yamamoto, Tetsuya, Hara, Shigeko
Published in Clinical and experimental nephrology (01.12.2014)
Published in Clinical and experimental nephrology (01.12.2014)
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Clinical efficacy and safety of dotinurad, a novel selective urate reabsorption inhibitor, in Japanese hyperuricemic patients with or without gout: randomized, multicenter, double-blind, placebo-controlled, parallel-group, confirmatory phase 2 study
Hosoya, Tatsuo, Sano, Takafumi, Sasaki, Tomomitsu, Fushimi, Masahiko, Ohashi, Tetsuo
Published in Clinical and experimental nephrology (01.03.2020)
Published in Clinical and experimental nephrology (01.03.2020)
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Clinical efficacy and safety of dotinurad, a novel selective urate reabsorption inhibitor, in Japanese hyperuricemic patients with or without gout: an exploratory, randomized, multicenter, double-blind, placebo-controlled, parallel-group early phase 2 study
Hosoya, Tatsuo, Sano, Takafumi, Sasaki, Tomomitsu, Fushimi, Masahiko, Ohashi, Tetsuo
Published in Clinical and experimental nephrology (01.03.2020)
Published in Clinical and experimental nephrology (01.03.2020)
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Effects of mild and moderate renal dysfunction on pharmacokinetics, pharmacodynamics, and safety of dotinurad: a novel selective urate reabsorption inhibitor
Fukase, Hiroyuki, Okui, Daisuke, Sasaki, Tomomitsu, Fushimi, Masahiko, Ohashi, Tetsuo, Hosoya, Tatsuo
Published in Clinical and experimental nephrology (01.03.2020)
Published in Clinical and experimental nephrology (01.03.2020)
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Common dysfunctional variants in ABCG2 are a major cause of early-onset gout
Matsuo, Hirotaka, Ichida, Kimiyoshi, Takada, Tappei, Nakayama, Akiyoshi, Nakashima, Hiroshi, Nakamura, Takahiro, Kawamura, Yusuke, Takada, Yuzo, Yamamoto, Ken, Inoue, Hiroki, Oikawa, Yuji, Naito, Mariko, Hishida, Asahi, Wakai, Kenji, Okada, Chisa, Shimizu, Seiko, Sakiyama, Masayuki, Chiba, Toshinori, Ogata, Hiraku, Niwa, Kazuki, Hosoyamada, Makoto, Mori, Atsuyoshi, Hamajima, Nobuyuki, Suzuki, Hiroshi, Kanai, Yoshikatsu, Sakurai, Yutaka, Hosoya, Tatsuo, Shimizu, Toru, Shinomiya, Nariyoshi
Published in Scientific reports (18.06.2013)
Published in Scientific reports (18.06.2013)
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Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study)
Wada, Takashi, Hosoya, Tatsuo, Honda, Daisuke, Sakamoto, Ryusuke, Narita, Kazutaka, Sasaki, Tomomitsu, Okui, Daisuke, Kimura, Kenjiro
Published in Clinical and experimental nephrology (01.08.2018)
Published in Clinical and experimental nephrology (01.08.2018)
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Serum uric acid and the incidence of CKD and hypertension
Kuriyama, Satoru, Maruyama, Yukio, Nishio, Shinichiro, Takahashi, Yasuhito, Kidoguchi, Satoshi, Kobayashi, Chisa, Takahashi, Daisuke, Sugano, Naoki, Hosoya, Tatsuo, Yokoo, Takashi
Published in Clinical and experimental nephrology (01.12.2015)
Published in Clinical and experimental nephrology (01.12.2015)
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Clinical feasibility of transfer to combined therapy with peritoneal dialysis and hemodialysis for patients on peritoneal dialysis: A prospective multicenter study in Japan
Maruyama, Yukio, Yokoyama, Keitaro, Higuchi, Chieko, Sanaka, Tsutomu, Tanaka, Yoshihide, Sakai, Ken, Kanno, Yoshihiko, Ryuzaki, Munekazu, Sakurada, Tsutomu, Hosoya, Tatsuo, Nakayama, Masaaki
Published in Therapeutic apheresis and dialysis (01.12.2022)
Published in Therapeutic apheresis and dialysis (01.12.2022)
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Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors
Nakayama, Akiyoshi, Matsuo, Hirotaka, Nakaoka, Hirofumi, Nakamura, Takahiro, Nakashima, Hiroshi, Takada, Yuzo, Oikawa, Yuji, Takada, Tappei, Sakiyama, Masayuki, Shimizu, Seiko, Kawamura, Yusuke, Chiba, Toshinori, Abe, Junko, Wakai, Kenji, Kawai, Sayo, Okada, Rieko, Tamura, Takashi, Shichijo, Yuka, Akashi, Airi, Suzuki, Hiroshi, Hosoya, Tatsuo, Sakurai, Yutaka, Ichida, Kimiyoshi, Shinomiya, Nariyoshi
Published in Scientific reports (09.06.2014)
Published in Scientific reports (09.06.2014)
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Gender interaction of uric acid in the development of hypertension
Nishio, Shinichiro, Maruyama, Yukio, Sugano, Naoki, Hosoya, Tatsuo, Yokoo, Takashi, Kuriyama, Satoru
Published in Clinical and experimental hypertension (1993) (01.01.2018)
Published in Clinical and experimental hypertension (1993) (01.01.2018)
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