Development of a Manufacturing Process toward the Convergent Synthesis of the COVID-19 Antiviral Ensitrelvir
Kawajiri, Takahiro, Kijima, Akihito, Iimuro, Atsuhiro, Ohashi, Eisaku, Yamakawa, Katsuya, Agura, Kazushi, Masuda, Kengo, Kouki, Kensuke, Kasamatsu, Koji, Yanagisawa, Shuichi, Nakashima, Sho, Shibahara, Setsuya, Toyota, Takashi, Higuchi, Takafumi, Suto, Takahiro, Oohara, Tadashi, Maki, Toshikatsu, Sahara, Naoto, Fukui, Nobuaki, Wakamori, Hisayuki, Ikemoto, Hidaka, Murakami, Hiroaki, Ando, Hiroyasu, Hosoya, Masahiro, Sato, Mizuki, Suzuki, Yusuke, Nakagawa, Yuta, Unoh, Yuto, Hirano, Yoichi, Nagasawa, Yoshitomo, Goda, Satoshi, Ohara, Takafumi, Tsuritani, Takayuki
Published in ACS central science (26.04.2023)
Published in ACS central science (26.04.2023)
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Investigation into an Unexpected Impurity: A Practical Approach to Process Development for the Addition of Grignard Reagents to Aldehydes Using Continuous Flow Synthesis
Hosoya, Masahiro, Nishijima, Shogo, Kurose, Noriyuki
Published in Organic process research & development (20.03.2020)
Published in Organic process research & development (20.03.2020)
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Catalytic Activity of Triphenylphosphine for Electrophilic Aromatic Bromination Using N‑Bromosuccinimide and Process Safety Evaluation
Hosoya, Masahiro, Ishibashi, Kenichi, Ohara, Takafumi, Mori, Atsunori, Okano, Kentaro
Published in Organic process research & development (18.10.2024)
Published in Organic process research & development (18.10.2024)
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Development of an Optimized Synthetic Process for an Antiobesity Drug Candidate (S-234462) Featuring Mild Chlorination of Benzoxazolone and In Situ IR Monitoring of a Mitsunobu Reaction
Oda, Shinichi, Fukui, Yuki, Hozumi, Yasuyuki, Takeuchi, Yoshiyuki, Hosoya, Masahiro
Published in Organic process research & development (19.08.2022)
Published in Organic process research & development (19.08.2022)
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An Effective Additive for Introducing the Triazole Unit of Ensitrelvir: Combination of LiCl and Et3N to Easily Generate Lithium Triazinolate
Ohashi, Eisaku, Sahara, Naoto, Hirano, Yoichi, Hosoya, Masahiro, Takahashi, Yusaku, Tsuno, Naoki
Published in Synthesis (Stuttgart) (01.02.2024)
Published in Synthesis (Stuttgart) (01.02.2024)
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Addition Reaction of Alcohol to Isocyanate Catalyzed by Copper Present in Tap Water: Robust Manufacturing Process of Naldemedine Tosylate
Oda, Shinichi, Masui, Yoshiyuki, Omura, Sohei, Imamura, Yoshiaki, Takeuchi, Yoshiyuki, Hosoya, Masahiro
Published in Organic process research & development (19.08.2022)
Published in Organic process research & development (19.08.2022)
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