Human Fatty Liver Disease: Old Questions and New Insights
Cohen, Jonathan C., Horton, Jay D., Hobbs, Helen H.
Published in Science (American Association for the Advancement of Science) (24.06.2011)
Published in Science (American Association for the Advancement of Science) (24.06.2011)
Get full text
Journal Article
Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: A Scientific Statement From the American Heart Association
Duell, P Barton, Welty, Francine K, Miller, Michael, Chait, Alan, Hammond, Gmerice, Ahmad, Zahid, Cohen, David E, Horton, Jay D, Pressman, Gregg S, Toth, Peter P
Published in Arteriosclerosis, thrombosis, and vascular biology (01.06.2022)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.06.2022)
Get full text
Journal Article
A Highly Durable RNAi Therapeutic Inhibitor of PCSK9
Fitzgerald, Kevin, White, Suellen, Borodovsky, Anna, Bettencourt, Brian R, Strahs, Andrew, Clausen, Valerie, Wijngaard, Peter, Horton, Jay D, Taubel, Jorg, Brooks, Ashley, Fernando, Chamikara, Kauffman, Robert S, Kallend, David, Vaishnaw, Akshay, Simon, Amy
Published in The New England journal of medicine (05.01.2017)
Published in The New England journal of medicine (05.01.2017)
Get full text
Journal Article
PCSK9: a convertase that coordinates LDL catabolism
Horton, Jay D., Cohen, Jonathan C., Hobbs, Helen H.
Published in Journal of lipid research (01.04.2009)
Published in Journal of lipid research (01.04.2009)
Get full text
Journal Article
The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals
Moon, Young-Ah, Liang, Guosheng, Xie, Xuefen, Frank-Kamenetsky, Maria, Fitzgerald, Kevin, Koteliansky, Victor, Brown, Michael S., Goldstein, Joseph L., Horton, Jay D.
Published in Cell metabolism (08.02.2012)
Published in Cell metabolism (08.02.2012)
Get full text
Journal Article
Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation
Kim, Chai-Wan, Addy, Carol, Kusunoki, Jun, Anderson, Norma N., Deja, Stanislaw, Fu, Xiaorong, Burgess, Shawn C., Li, Cai, Ruddy, Marcie, Chakravarthy, Manu, Previs, Steve, Milstein, Stuart, Fitzgerald, Kevin, Kelley, David E., Horton, Jay D.
Published in Cell metabolism (01.08.2017)
Published in Cell metabolism (01.08.2017)
Get full text
Journal Article
Acetate Dependence of Tumors
Comerford, Sarah A., Huang, Zhiguang, Du, Xinlin, Wang, Yun, Cai, Ling, Witkiewicz, Agnes K., Walters, Holly, Tantawy, Mohammed N., Fu, Allie, Manning, H. Charles, Horton, Jay D., Hammer, Robert E., McKnight, Steven L., Tu, Benjamin P.
Published in Cell (18.12.2014)
Published in Cell (18.12.2014)
Get full text
Journal Article
Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice[S]
Linden, Albert G., Li, Shili, Choi, Hwa Y., Fang, Fei, Fukasawa, Masashi, Uyeda, Kosaku, Hammer, Robert E., Horton, Jay D., Engelking, Luke J., Liang, Guosheng
Published in Journal of lipid research (01.03.2018)
Published in Journal of lipid research (01.03.2018)
Get full text
Journal Article
Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism
Ferris, Heather A., Perry, Rachel J., Moreira, Gabriela V., Shulman, Gerald I., Horton, Jay D., Kahn, C. Ronald
Published in Proceedings of the National Academy of Sciences - PNAS (31.01.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (31.01.2017)
Get full text
Journal Article
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels
Goedeke, Leigh, Rotllan, Noemi, Canfrán-Duque, Alberto, Aranda, Juan F, Ramírez, Cristina M, Araldi, Elisa, Lin, Chin-Sheng, Anderson, Norma N, Wagschal, Alexandre, de Cabo, Rafael, Horton, Jay D, Lasunción, Miguel A, Näär, Anders M, Suárez, Yajaira, Fernández-Hernando, Carlos
Published in Nature medicine (01.11.2015)
Published in Nature medicine (01.11.2015)
Get full text
Journal Article
A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice[S]
Duarte, Joao A.G., Carvalho, Filipa, Pearson, Mackenzie, Horton, Jay D., Browning, Jeffrey D., Jones, John G., Burgess, Shawn C.
Published in Journal of lipid research (01.12.2014)
Published in Journal of lipid research (01.12.2014)
Get full text
Journal Article
Genetic and Metabolic Determinants of Plasma PCSK9 Levels
Lakoski, Susan G, Lagace, Thomas A, Cohen, Jonathan C, Horton, Jay D, Hobbs, Helen H
Published in The journal of clinical endocrinology and metabolism (01.07.2009)
Published in The journal of clinical endocrinology and metabolism (01.07.2009)
Get full text
Journal Article
Molecular basis for LDL receptor recognition by PCSK9
Kwon, Hyock Joo, Lagace, Thomas A, McNutt, Markey C, Horton, Jay D, Deisenhofer, Johann
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2008)
Get full text
Journal Article
Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation
Zhang, Da-Wei, Lagace, Thomas A., Garuti, Rita, Zhao, Zhenze, McDonald, Meghan, Horton, Jay D., Cohen, Jonathan C., Hobbs, Helen H.
Published in The Journal of biological chemistry (22.06.2007)
Published in The Journal of biological chemistry (22.06.2007)
Get full text
Journal Article
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
Bartuzi, Paulina, Billadeau, Daniel D, Favier, Robert, Rong, Shunxing, Dekker, Daphne, Fedoseienko, Alina, Fieten, Hille, Wijers, Melinde, Levels, Johannes H, Huijkman, Nicolette, Kloosterhuis, Niels, van der Molen, Henk, Brufau, Gemma, Groen, Albert K, Elliott, Alison M, Kuivenhoven, Jan Albert, Plecko, Barbara, Grangl, Gernot, McGaughran, Julie, Horton, Jay D, Burstein, Ezra, Hofker, Marten H, van de Sluis, Bart
Published in Nature communications (11.03.2016)
Published in Nature communications (11.03.2016)
Get full text
Journal Article
The impact of endotrophin on the progression of chronic liver disease
Kim, Min, Lee, Changhu, Seo, Dae Yun, Lee, Hyojung, Horton, Jay D, Park, Jiyoung, Scherer, Philipp E
Published in Experimental & molecular medicine (01.10.2020)
Published in Experimental & molecular medicine (01.10.2020)
Get full text
Journal Article