The Vasopressin 1b Receptor Antagonist A-988315 Blocks Stress Effects on the Retrieval of Object-Recognition Memory
Barsegyan, Areg, Atsak, Piray, Hornberger, Wilfried B, Jacobson, Peer B, van Gaalen, Marcel M, Roozendaal, Benno
Published in Neuropsychopharmacology (New York, N.Y.) (01.07.2015)
Published in Neuropsychopharmacology (New York, N.Y.) (01.07.2015)
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Journal Article
Label-free detection of small-molecule binding to a GPCR in the membrane environment
Heym, Roland G., Hornberger, Wilfried B., Lakics, Viktor, Terstappen, Georg C.
Published in Biochimica et biophysica acta (01.08.2015)
Published in Biochimica et biophysica acta (01.08.2015)
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Journal Article
Inhibitors of GlyT1 Affect Glycine Transport via Discrete Binding Sites
Mezler, Mario, Hornberger, Wilfried, Mueller, Reinhold, Schmidt, Martin, Amberg, Martin Schmidt Willi, Amberg, Willi, Braje, Wilfried, Ochse, Michael, Schoemaker, Hans, Behl, Berthold
Published in Molecular pharmacology (01.12.2008)
Published in Molecular pharmacology (01.12.2008)
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Journal Article
Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability
Jantos, Katja, Kling, Andreas, Mack, Helmut, Hornberger, Wilfried, Moeller, Achim, Nimmrich, Volker, Lao, Yanbin, Nijsen, Marjoleen
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
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Journal Article
Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer’s Disease: 2‑(3-Phenyl‑1H‑pyrazol-1-yl)-nicotinamides
Kling, Andreas, Jantos, Katja, Mack, Helmut, Hornberger, Wilfried, Drescher, Karla, Nimmrich, Volker, Relo, Ana, Wicke, Karsten, Hutchins, Charles W, Lao, Yanbin, Marsh, Kennan, Moeller, Achim
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Journal Article
De Novo Design, Synthesis, and Biological Evaluation of 3,4-Disubstituted Pyrrolidine Sulfonamides as Potent and Selective Glycine Transporter 1 Competitive Inhibitors
Wang, Ying, Zhao, Hongyu, Brewer, Jason T, Li, Huanqiu, Lao, Yanbin, Amberg, Willi, Behl, Berthold, Akritopoulou-Zanze, Irini, Dietrich, Justin, Lange, Udo E. W, Pohlki, Frauke, Hoft, Carolin, Hornberger, Wilfried, Djuric, Stevan W, Sydor, Jens, Mezler, Mario, Relo, Ana Lucia, Vasudevan, Anil
Published in Journal of medicinal chemistry (13.09.2018)
Published in Journal of medicinal chemistry (13.09.2018)
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Journal Article
Novel, potent, selective and brain penetrant vasopressin 1b receptor antagonists
Geneste, Hervé, Bhowmik, Swati, van Gaalen, Marcel M., Hornberger, Wilfried, Hutchins, Charles W., Netz, Astrid, Oost, Thorsten, Unger, Liliane
Published in Bioorganic & medicinal chemistry letters (15.10.2018)
Published in Bioorganic & medicinal chemistry letters (15.10.2018)
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Journal Article
Discovery of Novel Aminotetralines and Aminochromanes as Selective and Competitive Glycine Transporter 1 (GlyT1) Inhibitors
Amberg, Willi, Lange, Udo E. W, Ochse, Michael, Pohlki, Frauke, Behl, Berthold, Relo, Ana Lucia, Hornberger, Wilfried, Hoft, Carolin, Mezler, Mario, Sydor, Jens, Wang, Ying, Zhao, Hongyu, Brewer, Jason T, Dietrich, Justin, Li, Huanqiu, Akritopoulou-Zanze, Irini, Lao, Yanbin, Hannick, Steven M, Ku, Yi-Yin, Vasudevan, Anil
Published in Journal of medicinal chemistry (13.09.2018)
Published in Journal of medicinal chemistry (13.09.2018)
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Journal Article
Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties
Oost, Thorsten, Backfisch, Gisela, Bhowmik, Swati, van Gaalen, Marcel M., Geneste, Hervé, Hornberger, Wilfried, Lubisch, Wilfried, Netz, Astrid, Unger, Liliane, Wernet, Wolfgang
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Journal Article
Mitigating the Metabolic Liability of Carbonyl Reduction: Novel Calpain Inhibitors with P1′ Extension
Kling, Andreas, Jantos, Katja, Mack, Helmut, Hornberger, Wilfried, Backfisch, Gisela, Lao, Yanbin, Nijsen, Marjoleen, Rendenbach-Mueller, Beatrice, Moeller, Achim
Published in ACS medicinal chemistry letters (08.03.2018)
Published in ACS medicinal chemistry letters (08.03.2018)
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Journal Article
Successful attenuation of venous thrombus growth in rabbits after the administration of a novel oral thrombin inhibitor
Friederich, P W, Keller, T T, Biemond, B J, Peters, R J, Hornberger, W, Büller, H R, Levi, M
Published in Thrombosis and haemostasis (01.11.2000)
Published in Thrombosis and haemostasis (01.11.2000)
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Journal Article
Acute Inhibition of 11β-Hydroxysteroid Dehydrogenase Type-1 Improves Memory in Rodent Models of Cognition
Mohler, Eric G., Browman, Kaitlin E., Roderwald, Victoria A., Cronin, Elizabeth A., Markosyan, Stella, Scott Bitner, R., Strakhova, Marina I., Drescher, Karla U., Hornberger, Wilfried, Rohde, Jeffrey J., Brune, Michael E., Jacobson, Peer B., Rueter, Lynne E.
Published in The Journal of neuroscience (06.04.2011)
Published in The Journal of neuroscience (06.04.2011)
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Journal Article
CENTRAL CATHEPSIN B INHIBITION BY CA074 DOES NOT ALTER THE LEVELS OF NEUROTOXIC Aβ SPECIES IN THE BRAIN OF HAPP-LON MICE
Heym, Roland Gerhard, Awwad, Khader, Giaisi, Simone, Weiss, Sabine, Wieland, Heike, Schulz, Michael, Jantos, Katja, Kling, Andreas, Fang, Zhizhou, Louise van der Kam, Elizabeth, Hornberger, Wilfried, Buck, Kerstin
Published in Alzheimer's & dementia (01.07.2016)
Published in Alzheimer's & dementia (01.07.2016)
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Journal Article
P3‐039: Central Cathepsin B Inhibition by CA074 Does Not Alter the Levels of Neurotoxic Aβ Species in the Brain of Happ‐Lon Mice
Heym, Roland Gerhard, Awwad, Khader, Giaisi, Simone, Weiss, Sabine, Wieland, Heike, Schulz, Michael, Jantos, Katja, Kling, Andreas, Fang, Zhizhou, Louise van der Kam, Elizabeth, Hornberger, Wilfried, Buck, Kerstin
Published in Alzheimer's & dementia (01.07.2016)
Published in Alzheimer's & dementia (01.07.2016)
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Journal Article
Design and synthesis of novel potent and selective integrin αvβ3 antagonists—Novel synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates
Seitz, Werner, Geneste, Hervé, Backfisch, Gisela, Delzer, Jürgen, Graef, Claudia, Hornberger, Wilfried, Kling, Andreas, Subkowski, Thomas, Zimmermann, Norbert
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
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Journal Article
CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS
SEEMANN DIETMAR, NIMMRICH VOLKER, MACK HELMUT, KLING ANDREAS, MOELLER ACHIM, HORNBERGER WILFRIED, LUBISCH WILFRIED
Year of Publication 05.08.2015
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Year of Publication 05.08.2015
Patent
CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS
SEEMANN DIETMAR, NIMMRICH VOLKER, MACK HELMUT, KLING ANDREAS, MOELLER ACHIM, HORNBERGER WILFRIED, LUBISCH WILFRIED
Year of Publication 05.08.2015
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Year of Publication 05.08.2015
Patent
CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS
HUTCHINS CHARLES W, MACK HELMUT, KLING ANDREAS, MOELLER ACHIM, HORNBERGER WILFRIED, JANTOS KATJA
Year of Publication 06.02.2014
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Year of Publication 06.02.2014
Patent
HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE-3 INHIBITORS
HOFT CAROLIN, MACK HELMUT, TURNER SEAN COLM, HORNBERGER WILFRIED, VAN GAALEN MARCEL, BAKKER MARGARETHA HENRICA MARIA
Year of Publication 09.01.2014
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Year of Publication 09.01.2014
Patent
Design and synthesis of novel potent and selective integrin alpha sub(v) beta sub(3) antagonists - Novel synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates
Seitz, Werner, Geneste, Herve, Backfisch, Gisela, Delzer, Juergen, Graef, Claudia, Hornberger, Wilfried, Kling, Andreas, Subkowski, Thomas, Zimmermann, Norbert
Published in Bioorganic & medicinal chemistry (01.01.2008)
Published in Bioorganic & medicinal chemistry (01.01.2008)
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Journal Article