Search Results - "HORIGUCHI, TOHRU" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists

Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists

by Kai, Hiroyuki, Horiguchi, Tohru, Kameyma, Takayuki, Onodera, Naohiro, Itoh, Naohiro, Fujii, Yasuhiko, Ichihashi, Yusuke, Hirai, Keiichiro, Shintani, Takuya, Nakamura, Kenichiroh, Minami, Kazuhisa, Kasai, Erika, Yoneda, Sosuke, Murakami, Yuki, Ogawa, Hiroko, Sekimoto, Ryouko, Shinohara, Shunji, Yoshida, Osamu, Kurose, Noriyuki
Published in Bioorganic & medicinal chemistry letters (15.11.2021)

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Journal Article

Dioxotriazine derivatives as a new class of P2X3 receptor antagonists: Identification of a lead and initial SAR studies

Dioxotriazine derivatives as a new class of P2X3 receptor antagonists: Identification of a lead and initial SAR studies

by Kai, Hiroyuki, Horiguchi, Tohru, Kameyama, Takayuki, Asahi, Kentaro, Endoh, Takeshi, Jikihara, Sae, Hasegawa, Tsuyoshi, Tanaka, Satoru, Nozu, Azusa, Takeyama, Chie, Tomari, Maki, Takahashi, Fumiyo, Tamura, Naomi, Yagi, Shigenori, Itoh, Tetsuji, Isou, Yasuyoshi
Published in Bioorganic & medicinal chemistry letters (01.04.2021)

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Relationship between the Structures of Taxane Derivatives and Their Microtubule Polymerization Activity

Relationship between the Structures of Taxane Derivatives and Their Microtubule Polymerization Activity

by HIDAKA, Masafumi, KOGA, Tomoe, KIYOTA, Hiromasa, HORIGUCHI, Tohru, SHI, Qing-Wen, HIROSE, Keiko, UCHIDA, Takafumi
Published in Bioscience, biotechnology, and biochemistry (2012)

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Studies on Taxol biosynthesis: preparation of taxadiene-diol and triol derivatives by deoxygenation of taxusin

Studies on Taxol biosynthesis: preparation of taxadiene-diol and triol derivatives by deoxygenation of taxusin

by Li, Hui, Horiguchi, Tohru, Croteau, Rodney, Williams, Robert M.
Published in Tetrahedron (01.01.2008)

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Dioxotriazine derivatives as a new class of P2X(3) receptor antagonists: Identification of a lead and initial SAR studies

Dioxotriazine derivatives as a new class of P2X(3) receptor antagonists: Identification of a lead and initial SAR studies

by Kai, Hiroyuki, Horiguchi, Tohru, Kameyama, Takayuki, Asahi, Kentaro, Endoh, Takeshi, Jikihara, Sae, Hasegawa, Tsuyoshi, Tanaka, Satoru, Nozu, Azusa, Takeyama, Chie, Tomari, Maki, Takahashi, Fumiyo, Tamura, Naomi, Yagi, Shigenori, Itoh, Tetsuji, Isou, Yasuyoshi
Published in Bioorganic & medicinal chemistry letters (01.04.2021)

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Two novel taxane diterpenoids from the needles of Japanese yew, Taxus cuspidata

Two novel taxane diterpenoids from the needles of Japanese yew, Taxus cuspidata

by Cheng, Q. (Tohoku Univ., Sendai (Japan)), Oritani, T, Horiguchi, T
Published in Bioscience, biotechnology, and biochemistry (01.04.2000)

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Four novel taxane diterpenoids from the needles of Japanese yew, Taxus cuspidata

Four novel taxane diterpenoids from the needles of Japanese yew, Taxus cuspidata

by Shi, Q.W. (Tohoku Univ., Sendai (Japan)), Oritani, T, Horiguchi, T, Sugiyama, T, Murakami, R, Yamada, T
Published in Bioscience, biotechnology, and biochemistry (1999)

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A novel rearranged taxoid from needles of the Japanese yew, Taxus cuspidata Sieb. et Zucc

A novel rearranged taxoid from needles of the Japanese yew, Taxus cuspidata Sieb. et Zucc

by Murakami, R. (Tohoku Univ., Sendai (Japan)), Shi, Q.W, Horiguchi, T, Oritani, T
Published in Bioscience, biotechnology, and biochemistry (01.01.1999)

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Journal Article

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives

by Tobinaga, Hiroyuki, Kameyama, Takayuki, Asahi, Kentarou, Horiguchi, Tohru, Oohara, Miho, Taoda, Yoshiyuki, Hata, Kayoko, Hasegawa, Tsuyoshi, Tada, Yukio, Kurihara, Naoko, Kanda, Yasuhiko, Yagi, Shigenori, Tomari, Maki, Tanaka, Yoshikazu, Takahashi, Fumiyo, Taniguchi, Emiko, Takahara, Yukio, Shimada, Shinji, Takeyama, Chie, Yamamoto, Shoichi, Shinohara, Shunji, Kai, Hiroyuki
Published in Bioorganic & medicinal chemistry letters (15.12.2020)

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Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds

by Tobinaga, Hiroyuki, Kameyama, Takayuki, Asahi, Kentarou, Horiguchi, Tohru, Oohara, Miho, Tada, Yukio, Fuchino, Kouki, Jikihara, Sae, Endoh, Takeshi, Kurihara, Naoko, Kanda, Yasuhiko, Ogawa, Masayoshi, Tamura, Naomi, Yagi, Shigenori, Taniguchi, Emiko, Takahara, Yukio, Shimada, Shinji, Takeyama, Chie, Yamamoto, Shoichi, Shinohara, Shunji, Kai, Hiroyuki
Published in Bioorganic & medicinal chemistry letters (01.03.2019)

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Journal Article

Three new rearranged taxane diterpenoids from the bark of Taxus chinensis var. mairei and the needles of Taxus cuspidata

Three new rearranged taxane diterpenoids from the bark of Taxus chinensis var. mairei and the needles of Taxus cuspidata

by Shi, QW, Oritani, T, Sugiyama, T, Kiyota, H, Horiguchi, T
Published in Heterocycles (01.04.1999)

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Et2AlCl-Mediated Reaction of α-4(20)-Epoxy-5α -hydroxy Taxinine B

Et2AlCl-Mediated Reaction of α-4(20)-Epoxy-5α -hydroxy Taxinine B

by Qian CHENG, Takayuki ORITANI, Tohru HORIGUCHI
Published in 中国化学快报 (01.03.2000)

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Journal Article

Imaging of Digital Versatile Rewritable Disc using the Reflection-Mode Scattering-Type Scanning Near-Field Optical Microscope

Imaging of Digital Versatile Rewritable Disc using the Reflection-Mode Scattering-Type Scanning Near-Field Optical Microscope

by Yamaguchi, Mitsushiro, Sasaki, Yasuo, Sasaki, Hiroko, Konada, Takeshi, Ebina, Atsushi, Umezawa, Tomokazu, Horiguchi, Tohru
Published in Japanese Journal of Applied Physics (01.03.2001)

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Journal Article

FUSED HETEROCYCLE HAVING TRKA INHIBITORY ACTIVITY AND FUSED CARBOCYCLE DERIVATIVE

FUSED HETEROCYCLE HAVING TRKA INHIBITORY ACTIVITY AND FUSED CARBOCYCLE DERIVATIVE

by YASUO, Kazuya, HORIGUCHI, Tohru, YAMAGUCHI, Hiroki, HATA, Kayoko, KANO, Kazuya
Year of Publication 03.05.2018

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Patent

Dioxotriazine derivatives as a new class of P2X 3 receptor antagonists: Identification of a lead and initial SAR studies

Dioxotriazine derivatives as a new class of P2X 3 receptor antagonists: Identification of a lead and initial SAR studies

by Kai, Hiroyuki, Horiguchi, Tohru, Kameyama, Takayuki, Asahi, Kentaro, Endoh, Takeshi, Jikihara, Sae, Hasegawa, Tsuyoshi, Tanaka, Satoru, Nozu, Azusa, Takeyama, Chie, Tomari, Maki, Takahashi, Fumiyo, Tamura, Naomi, Yagi, Shigenori, Itoh, Tetsuji, Isou, Yasuyoshi
Published in Bioorganic & medicinal chemistry letters (01.04.2021)

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Journal Article

NITROGEN-CONTAINING HETEROCYCLE HAVING TRKA INHIBITORY ACTIVITY, AND CARBOCYCLIC DERIVATIVE

NITROGEN-CONTAINING HETEROCYCLE HAVING TRKA INHIBITORY ACTIVITY, AND CARBOCYCLIC DERIVATIVE

by NAKAMURA, Kenichiroh, FUJIU, Motohiro, HORIGUCHI, Tohru, YUKIMASA, Akira, YAMAGUCHI, Hiroki, INOUE, Takatsugu, KANO, Kazuya
Year of Publication 10.08.2017

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Patent

HETEROCYCLIC AND CARBOCYCLIC DERIVATIVE HAVING TRKA-INHIBITING ACTIVITY

HETEROCYCLIC AND CARBOCYCLIC DERIVATIVE HAVING TRKA-INHIBITING ACTIVITY

by YUKIMASA, AKIRA, KANO, KAZUYA, KOZONO, IORI, NAKAMURA, KENICHIROH, HORIGUCHI, TOHRU, INOUE, TAKATSUGU
Year of Publication 11.02.2016

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Patent

SUBSTITUTED TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

SUBSTITUTED TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

by KAI, HIROYUKI, NAKAMURA, KEN'ICHIROH, HORIGUCHI, TOHRU, FUJII, YASUHIKO, ASAHI, KENTARO
Year of Publication 20.06.2013

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Patent

Administering cultured Taxus cells with early precursors reveals bifurcations in the taxoid biosynthetic pathway

Administering cultured Taxus cells with early precursors reveals bifurcations in the taxoid biosynthetic pathway

by Ketchum, Raymond E.B., Horiguchi, Tohru, Qiu, Deyou, Williams, Robert M., Croteau, Rodney B.
Published in Phytochemistry (Oxford) (01.02.2007)

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Journal Article

A study on the mechanism of enhanced diuresis following direct hemoperfusion with polymyxin B-immobilized fiber

A study on the mechanism of enhanced diuresis following direct hemoperfusion with polymyxin B-immobilized fiber

by TERAWAKI, Hiroyuki, KASAI, Kenji, KOBAYASHI, Hideyuki, HIRANO, Keita, HAMAGUCHI, Akihiko, KASE, Yoichi, HORIGUCHI, Tohru, YOKOYAMA, Keitaro, YAMAMOTO, Hiroyasu, NAKAYAMA, Masaaki, KAWAGUCHI, Yoshindo, HOSOYA, Tatsuo
Published in Nihon Jinzo Gakkai shi (01.07.2000)

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Journal Article