In vitro SAR of (5-(2 H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase
Lowe, Derek B., Magnuson, Steven, Qi, Ning, Campbell, Ann-Marie, Cook, James, Hong, Zhenqiu, Wang, Ming, Rodriguez, Mareli, Achebe, Furahi, Kluender, Harold, Wong, Wai C., Bullock, William H., Salhanick, Arthur I., Witman-Jones, Terri, Bowling, Mary E., Keiper, Christine, Clairmont, Kevin B.
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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SAR of a novel ‘Anthranilamide Like’ series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer
Wickens, Philip, Kluender, Harold, Dixon, Julie, Brennan, Catherine, Achebe, Furahi, Bacchiocchi, Antonella, Bankston, Don, Bierer, Donald, Brands, Michael, Braun, Debbie, Brown, Melissa S., Chuang, Chih-Yuan, Dumas, Jacques, Enyedy, Istvan, Hofilena, Gloria, Hong, Zhenqiu, Housley, Tim, Jones, Benjamin, Khire, Uday, Kreiman, Charles, Kumarasinghe, Ellalahewage, Lowinger, Timothy, Ott-Morgan, Ronda, Perkins, Louise, Phillips, Barton, Schoenleber, Robert, Scott, William J., Sheeler, Ryan, Redman, Anikó, Sun, Xiuying, Taylor, Ian, Wang, Lei, Wilhelm, Scott, Zhang, Xiaomei, Zhang, Mingbao, Sullivan, Elizabeth, Carter, Christopher, Miglarese, Mark, Levy, Joan
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates the cyclocondensation of ethyl 4-(dimethylamino)-3-nitro-2-oxobut-3-enoate with substituted hydrazines
Zhao, Rulin, Hong, Zhenqiu, Wang, Bei, Kempson, James, Cornelius, Lyndon, Li, Jianqing, Li, Yi-Xin, Mathur, Arvind
Published in Organic & biomolecular chemistry (14.12.2022)
Published in Organic & biomolecular chemistry (14.12.2022)
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Regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates via the cyclocondensation of ethyl 4-(dimethylamino)-3-nitro-2-oxobut-3-enoate with substituted hydrazines
Zhao, Rulin, Hong, Zhenqiu, Wang, Bei, Kempson, James, Cornelius, Lyndon, Li, Jianqing, Li, Yi-Xin, Mathur, Arvind
Published in Organic & biomolecular chemistry (14.12.2022)
Published in Organic & biomolecular chemistry (14.12.2022)
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Development of a Safe and Practical Synthesis of Enantiomerically Pure (S)- and (R)‑N‑Boc-3-(Trifluoromethyl)piperazines Enabled by Aza-Michael Addition of Optically Pure 4‑Phenyl-2-Oxazolidinone to 3,3,3-Trifluoro-1-Nitropropene
Darne, Chetan Padmakar, Li, Ning, Smith, Daniel, Zhang, Shasha, Neithnadka, Premsai Rai, Silamkoti, Arundutt, Arumugam, Arunachalam, Gupta, Anuradha, Hong, Zhenqiu, Krishnananthan, Subramaniam, Wang, Bei, Zhao, Rulin, Yip, Shiuhang, Wu, Dauh-Rurng, Kempson, James, Mortensen, Deborah S., Mathur, Arvind, Li, Jianqing
Published in Organic process research & development (16.08.2024)
Published in Organic process research & development (16.08.2024)
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A mild and readily scalable procedure for the N-1-difluoromethylation of ethyl 6-((tert-butyldiphenylsilyl)oxy)-1H-indazole-3-carboxylate and its applications to the N-difluoromethylation of indazole, benzotriazole, imidazole, indole and pyrazole derivatives
Hong, Zhenqiu, Hou, Xiaoping, Zhao, Rulin, Li, Jianqing, Pawluczyk, Joseph, Wang, Bei, Kempson, James, Khandelwal, Purnima, Smith, Leon M., Glunz, Peter, Mathur, Arvind
Published in Journal of fluorine chemistry (01.06.2020)
Published in Journal of fluorine chemistry (01.06.2020)
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A Stereocontrolled Synthesis of a Phosphorothioate Cyclic Dinucleotide-Based STING Agonist
Kempson, James, Zhang, Huiping, Hou, Xiaoping, Cornelius, Lyndon, Zhao, Rulin, Wang, Bei, Hong, Zhenqiu, Oderinde, Martins S, Pawluczyk, Joseph, Wu, Dauh-Rurng, Sun, Dawn, Li, Peng, Yip, Shiuhang, Smith, Aaron, Caceres-Cortes, Janet, Aulakh, Darpandeep, Sarjeant, Amy A, Park, Peter K, Harikrishnan, Lalgudi S, Qin, Lan-ying, Dodd, Dharmpal S, Fink, Brian, Vite, Gregory, Mathur, Arvind
Published in Journal of organic chemistry (02.07.2021)
Published in Journal of organic chemistry (02.07.2021)
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Development of a Stereoselective and Scalable Synthesis for the Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor, BMT-297376; N‑((R)‑1-((cis)‑4-(3-(Difluoromethyl)-2-methoxypyridin-4-yl)cyclohexyl)propyl)-6-methoxynicotinamide
Nimje, Roshan Y, Kuppusamy, Prakasam, Krishnamoorthy, Suresh, Shanmugam, Yoganand, Ramasamy, Duraisamy, Manoharan, Haridhas, Arunachalam, Pirama Nayagam, Balog, Aaron, Cherney, Emily C, Zhang, Liping, Borzilleri, Robert M, Hong, Zhenqiu, Kempson, James, Rampulla, Richard R, Mathur, Arvind, Gupta, Anuradha
Published in Organic process research & development (16.07.2021)
Published in Organic process research & development (16.07.2021)
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Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists
Shi, Jun, Gu, Zhengxiang, Jurica, Elizabeth Anne, Wu, Ximao, Haque, Lauren E, Williams, Kristin N, Hernandez, Andres S, Hong, Zhenqiu, Gao, Qi, Dabros, Marta, Davulcu, Akin H, Mathur, Arvind, Rampulla, Richard A, Gupta, Arun Kumar, Jayaram, Ramya, Apedo, Atsu, Moore, Douglas B, Liu, Heng, Kunselman, Lori K, Brady, Edward J, Wilkes, Jason J, Zinker, Bradley A, Cai, Hong, Shu, Yue-Zhong, Sun, Qin, Dierks, Elizabeth A, Foster, Kimberly A, Xu, Carrie, Wang, Tao, Panemangalore, Reshma, Cvijic, Mary Ellen, Xie, Chunshan, Cao, Gary G, Zhou, Min, Krupinski, John, Whaley, Jean M, Robl, Jeffrey A, Ewing, William R, Ellsworth, Bruce Alan
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Discovery of 5‑Chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)‑one (BMS-903452), an Antidiabetic Clinical Candidate Targeting GPR119
Wacker, Dean A, Wang, Ying, Broekema, Matthias, Rossi, Karen, O’Connor, Steven, Hong, Zhenqiu, Wu, Ginger, Malmstrom, Sarah E, Hung, Chen-Pin, LaMarre, Linda, Chimalakonda, Anjaneya, Zhang, Lisa, Xin, Li, Cai, Hong, Chu, Cuixia, Boehm, Stephanie, Zalaznick, Jacob, Ponticiello, Randolph, Sereda, Larisa, Han, Song-Ping, Zebo, Rachel, Zinker, Bradley, Luk, Chiuwa Emily, Wong, Richard, Everlof, Gerry, Li, Yi-Xin, Wu, Chunyu K, Lee, Michelle, Griffen, Steven, Miller, Keith J, Krupinski, John, Robl, Jeffrey A
Published in Journal of medicinal chemistry (25.09.2014)
Published in Journal of medicinal chemistry (25.09.2014)
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Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3 '-hydroxyazetidin-1-yl)ethanone [BMS-8163361, an Orally Active Novel Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor
Ye, Xiang-Yang, Chen, Stephanie Y., Wu, Shung, Yoon, David S., Wang, Haixia, Hong, Zhenqiu, O'Connor, Stephen P., Li, Jun, Li, James J., Kennedy, Lawrence J., Walker, Steven J., Nayeem, Akbar, Sheriff, Steven, Camac, Daniel M., Ramamurthy, Vidyhashankar, Morin, Paul E., Zebo, Rachel, Taylor, Joseph R., Morgan, Nathan N., Ponticiello, Randolph P., Harrity, Thomas, Apedo, Atsu, Golla, Rajasree, Seethala, Ramakrishna, Wang, Mengmeng, Harper, Timothy W., Sleczka, Bogdan G., He, Bin, Kirby, Mark, Leahy, David K., Li, Jianqing, Hanson, Ronald L., Guo, Zhiwei, Li, Yi-Xin, DiMarco, John D., Scaringe, Raymond, Maxwell, Brad, Moulin, Frederick, Barrish, Joel C., Gordon, David A., Robl, Jeffrey A.
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
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Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors
Cherney, Emily C, Zhang, Liping, Guo, Weiwei, Huang, Audris, Williams, David, Seitz, Steven, Shan, Weifang, Zhu, Xiao, Gullo-Brown, Johnni, Maley, Derrick, Lin, Tai-an, Hunt, John T, Huang, Christine, Yang, Zheng, D’Arienzo, Celia J, Discenza, Lorell N, Ranasinghe, Asoka, Grubb, Mary F, Traeger, Sarah C, Li, Xin, Johnston, Kathy A, Kopcho, Lisa, Fereshteh, Mark, Foster, Kimberly A, Stefanski, Kevin, Delpy, Diane, Dhar, Gopal, Anandam, Aravind, Mahankali, Sandeep, Padmanabhan, Shweta, Rajanna, Prabhakar, Murali, Venkata, Mariappan, T. Thanga, Pattasseri, Shabeerali, Nimje, Roshan Y, Hong, Zhenqiu, Kempson, James, Rampulla, Richard, Mathur, Arvind, Gupta, Anuradha, Borzilleri, Robert, Vite, Gregory, Balog, Aaron
Published in ACS medicinal chemistry letters (08.07.2021)
Published in ACS medicinal chemistry letters (08.07.2021)
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Journal Article
Discovery of Clinical Candidate 2‑((2S,6S)‑2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3′-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor
Ye, Xiang-Yang, Chen, Stephanie Y, Wu, Shung, Yoon, David S, Wang, Haixia, Hong, Zhenqiu, O’Connor, Stephen P, Li, Jun, Li, James J, Kennedy, Lawrence J, Walker, Steven J, Nayeem, Akbar, Sheriff, Steven, Camac, Daniel M, Ramamurthy, Vidyhashankar, Morin, Paul E, Zebo, Rachel, Taylor, Joseph R, Morgan, Nathan N, Ponticiello, Randolph P, Harrity, Thomas, Apedo, Atsu, Golla, Rajasree, Seethala, Ramakrishna, Wang, Mengmeng, Harper, Timothy W, Sleczka, Bogdan G, He, Bin, Kirby, Mark, Leahy, David K, Li, Jianqing, Hanson, Ronald L, Guo, Zhiwei, Li, Yi-Xin, DiMarco, John D, Scaringe, Raymond, Maxwell, Brad, Moulin, Frederick, Barrish, Joel C, Gordon, David A, Robl, Jeffrey A
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
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Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)
Li, Jun, Kennedy, Lawrence J, Walker, Steven J, Wang, Haixia, Li, James J, Hong, Zhenqiu, O’Connor, Stephen P, Ye, Xiang-yang, Chen, Stephanie, Wu, Shung, Yoon, David S, Nayeem, Akbar, Camac, Daniel M, Ramamurthy, Vidhyashankar, Morin, Paul E, Sheriff, Steven, Wang, Mengmeng, Harper, Timothy W, Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P, Morgan, Nathan N, Taylor, Joseph R, Zebo, Rachel, Maxwell, Brad, Moulin, Frederick, Gordon, David A, Robl, Jeffrey A
Published in ACS medicinal chemistry letters (13.12.2018)
Published in ACS medicinal chemistry letters (13.12.2018)
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Journal Article
Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)
Li, Jun, Kennedy, Lawrence J, Wang, Haixia, Li, James J, Walker, Steven J, Hong, Zhenqiu, O’Connor, Stephen P, Nayeem, Akbar, Camac, Daniel M, Morin, Paul E, Sheriff, Steven, Wang, Mengmeng, Harper, Timothy, Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P, Morgan, Nathan N, Taylor, Joseph R, Zebo, Rachel, Gordon, David A, Robl, Jeffrey A
Published in ACS medicinal chemistry letters (10.07.2014)
Published in ACS medicinal chemistry letters (10.07.2014)
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Journal Article
DIHYDROPYRAZOLE GPR40 MODULATORS
O'CONNOR STEPHEN P, JURICA ELIZABETH A, ELLSWORTH BRUCE A, HERNANDEZ ANDRES S, SHI JUN, EWING WILLIAM R, WU XIMAO, GU ZHENGXIANG, HONG ZHENQIU
Year of Publication 15.07.2015
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Year of Publication 15.07.2015
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