Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies
Makino, Chie, Watanabe, Akiko, Kato, Manabu, Shiozawa, Hideyuki, Takakusa, Hideo, Nakai, Daisuke, Honda, Tomoyo, Watanabe, Nobuaki
Published in Drug metabolism and pharmacokinetics (01.08.2022)
Published in Drug metabolism and pharmacokinetics (01.08.2022)
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Bioactivation of loxoprofen to a pharmacologically active metabolite and its disposition kinetics in human skin
Sawamura, Ryoko, Sakurai, Hidetaka, Wada, Naoya, Nishiya, Yumi, Honda, Tomoyo, Kazui, Miho, Kurihara, Atsushi, Shinagawa, Akira, Izumi, Takashi
Published in Biopharmaceutics & drug disposition (01.09.2015)
Published in Biopharmaceutics & drug disposition (01.09.2015)
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CYP2D6-Mediated Metabolism of a Novel Acyl Coenzyme A:Cholesterol Acyltransferase Inhibitor, Pactimibe, and Its Unique Plasma Metabolite, R-125528
KOTSUMA, Masakatsu, TOKUI, Taro, ISHIZUKA-OZEKI, Tomoko, HONDA, Tomoyo, IWABUCHI, Haruo, MURAI, Takahiro, IKEDA, Toshihiko, SAJI, Hideo
Published in Drug metabolism and disposition (01.03.2008)
Published in Drug metabolism and disposition (01.03.2008)
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A Comparison of the Effects of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors on the CYP3A4-Dependent Oxidation of Mexazolam in Vitro
ISHIGAMI, Michi, HONDA, Tomoyo, TAKASAKI, Wataru, IKEDA, Toshihiko, KOMAI, Toru, ITO, Kiyomi, SUGIYAMA, Yuichi
Published in Drug metabolism and disposition (01.03.2001)
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Published in Drug metabolism and disposition (01.03.2001)
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Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells
Okajima, Daisuke, Yasuda, Satoru, Maejima, Takanori, Karibe, Tsuyoshi, Sakurai, Ken, Aida, Tetsuo, Toki, Tadashi, Yamaguchi, Junko, Kitamura, Michiko, Kamei, Reiko, Fujitani, Tomomichi, Honda, Tomoyo, Shibutani, Tomoko, Muramatsu, Sumie, Nakada, Takashi, Goto, Riki, Takahashi, Shu, Yamaguchi, Miki, Hamada, Hirofumi, Noguchi, Yutaka, Murakami, Masato, Abe, Yuki, Agatsuma, Toshinori
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Pharmacokinetics and metabolism of mirogabalin, a novel α 2 δ ligand, in rats and monkeys
Yamamura, Naotoshi, Uchiyama, Minoru, Takahashi, Makoto, Honda, Tomoyo, Nishiya, Yumi
Published in Xenobiotica (02.01.2022)
Published in Xenobiotica (02.01.2022)
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Estimation of fraction of drug metabolism by a single UDP‐glucuronosyl transferase enzyme using relative expression factor
Honda, Tomoyo, Obuchi, Wataru, Nishiya, Yumi, Shibayama, Takahiro, Watanabe, Kengo, Watanabe, Nobuaki
Published in Biopharmaceutics & drug disposition (01.10.2022)
Published in Biopharmaceutics & drug disposition (01.10.2022)
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Abstract 4891: Ifinatamab deruxtecan (I-DXd), a novel B7-H3-targeting antibody-drug conjugate, demonstrates efficient payload delivery into tumor through target-dependent internalization
Katsumata, Len, Deguchi, Tsuneo, Hasegawa, Jun, Yamato, Michiko, Nishiya, Yumi, Watanabe, Akiko, Honda, Tomoyo, Minami, Megumi, Kasanuki, Naomi, Maejima, Takanori, Muramatsu, Sumie, Herrmann, Monika, Schulte, Nina, Polier, Gernot, Wang, Xuya, Yoshida, Takanori, Izumi, Nanae, Qian, Xiaozhong, Agatsuma, Toshinori, Nakamaru, Kenji
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Structure Elucidation of Novel Metabolites of Gemfibrozil in Dog
ISHIKAWA, Minoru, HONDA, Tomoyo, YOSHII, Hidefumi, IKEDA, Toshihiko, IWABUCHI, Haruo
Published in Journal of the Mass Spectrometry Society of Japan (01.01.2004)
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Published in Journal of the Mass Spectrometry Society of Japan (01.01.2004)
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