Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate
Sleiman, Sama F, Henry, Jeffrey, Al-Haddad, Rami, El Hayek, Lauretta, Abou Haidar, Edwina, Stringer, Thomas, Ulja, Devyani, Karuppagounder, Saravanan S, Holson, Edward B, Ratan, Rajiv R, Ninan, Ipe, Chao, Moses V
Published in eLife (02.06.2016)
Published in eLife (02.06.2016)
Get full text
Journal Article
Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases
Karnib, Nabil, El-Ghandour, Rim, El Hayek, Lauretta, Nasrallah, Patrick, Khalifeh, Mohamad, Barmo, Nour, Jabre, Vanessa, Ibrahim, Pascale, Bilen, Maria, Stephan, Joseph S, Holson, Edward B, Ratan, Rajiv R, Sleiman, Sama F
Published in Neuropsychopharmacology (New York, N.Y.) (01.05.2019)
Published in Neuropsychopharmacology (New York, N.Y.) (01.05.2019)
Get full text
Journal Article
Selective HDAC inhibition for the disruption of latent HIV-1 infection
Barton, Kirston M, Archin, Nancie M, Keedy, Kara S, Espeseth, Amy S, Zhang, Yan-ling, Gale, Jennifer, Wagner, Florence F, Holson, Edward B, Margolis, David M
Published in PloS one (19.08.2014)
Published in PloS one (19.08.2014)
Get full text
Journal Article
EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression
Renneville, Aline, Van Galen, Peter, Canver, Matthew C., McConkey, Marie, Krill-Burger, John M., Dorfman, David M., Holson, Edward B., Bernstein, Bradley E., Orkin, Stuart H., Bauer, Daniel E., Ebert, Benjamin L.
Published in Blood (15.10.2015)
Published in Blood (15.10.2015)
Get full text
Journal Article
Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability
Bhaskara, Srividya, Knutson, Sarah K., Jiang, Guochun, Chandrasekharan, Mahesh B., Wilson, Andrew J., Zheng, Siyuan, Yenamandra, Ashwini, Locke, Kimberly, Yuan, Jia-ling, Bonine-Summers, Alyssa R., Wells, Christina E., Kaiser, Jonathan F., Washington, M. Kay, Zhao, Zhongming, Wagner, Florence F., Sun, Zu-Wen, Xia, Fen, Holson, Edward B., Khabele, Dineo, Hiebert, Scott W.
Published in Cancer cell (16.11.2010)
Published in Cancer cell (16.11.2010)
Get full text
Journal Article
Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia
Wagner, Florence F, Benajiba, Lina, Campbell, Arthur J, Weïwer, Michel, Sacher, Joshua R, Gale, Jennifer P, Ross, Linda, Puissant, Alexandre, Alexe, Gabriela, Conway, Amy, Back, Morgan, Pikman, Yana, Galinsky, Ilene, DeAngelo, Daniel J, Stone, Richard M, Kaya, Taner, Shi, Xi, Robers, Matthew B, Machleidt, Thomas, Wilkinson, Jennifer, Hermine, Olivier, Kung, Andrew, Stein, Adam J, Lakshminarasimhan, Damodharan, Hemann, Michael T, Scolnick, Edward, Zhang, Yan-Ling, Pan, Jen Q, Stegmaier, Kimberly, Holson, Edward B
Published in Science translational medicine (07.03.2018)
Published in Science translational medicine (07.03.2018)
Get more information
Journal Article
Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories
Gräff, Johannes, Joseph, Nadine F., Horn, Meryl E., Samiei, Alireza, Meng, Jia, Seo, Jinsoo, Rei, Damien, Bero, Adam W., Phan, Trongha X., Wagner, Florence, Holson, Edward, Xu, Jinbin, Sun, Jianjun, Neve, Rachael L., Mach, Robert H., Haggarty, Stephen J., Tsai, Li-Huei
Published in Cell (16.01.2014)
Published in Cell (16.01.2014)
Get full text
Journal Article
In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs
Wang, Changning, Schroeder, Frederick A, Wey, Hsiao-Ying, Borra, Ronald, Wagner, Florence F, Reis, Surya, Kim, Sung Won, Holson, Edward B, Haggarty, Stephen J, Hooker, Jacob M
Published in Journal of medicinal chemistry (09.10.2014)
Published in Journal of medicinal chemistry (09.10.2014)
Get full text
Journal Article
Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes
Dirice, Ercument, Ng, Raymond W.S., Martinez, Rachael, Hu, Jiang, Wagner, Florence F., Holson, Edward B., Wagner, Bridget K., Kulkarni, Rohit N.
Published in The Journal of biological chemistry (27.10.2017)
Published in The Journal of biological chemistry (27.10.2017)
Get full text
Journal Article
Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy
Ferguson, Bradley S., Harrison, Brooke C., Jeong, Mark Y., Reid, Brian G., Wempe, Michael F., Wagner, Florence F., Holson, Edward B., McKinsey, Timothy A.
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
Get full text
Journal Article
Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro
Algate, Kent, Haynes, David, Fitzsimmons, Tracy, Romeo, Ornella, Wagner, Florence, Holson, Edward, Reid, Robert, Fairlie, David, Bartold, Peter, Cantley, Melissa
Published in Journal of cellular biochemistry (01.01.2020)
Published in Journal of cellular biochemistry (01.01.2020)
Get full text
Journal Article
Small Molecule Inhibitors of Zinc-dependent Histone Deacetylases
Wagner, Florence F., Weїwer, Michel, Lewis, Michael C., Holson, Edward B.
Published in Neurotherapeutics (01.10.2013)
Published in Neurotherapeutics (01.10.2013)
Get full text
Journal Article
A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests
Schroeder, Frederick A, Lewis, Michael C, Fass, Daniel M, Wagner, Florence F, Zhang, Yan-Ling, Hennig, Krista M, Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D, Berry-Scott, Erin, Kim, Sung Won, Clore, Elizabeth L, Hooker, Jacob M, Holson, Edward B, Haggarty, Stephen J, Petryshen, Tracey L
Published in PloS one (14.08.2013)
Published in PloS one (14.08.2013)
Get full text
Journal Article
Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome
McCamphill, Patrick K, Stoppel, Laura J, Senter, Rebecca K, Lewis, Michael C, Heynen, Arnold J, Stoppel, David C, Sridhar, Vinay, Collins, Katie A, Shi, Xi, Pan, Jen Q, Madison, Jon, Cottrell, Jeffrey R, Huber, Kimberly M, Scolnick, Edward M, Holson, Edward B, Wagner, Florence F, Bear, Mark F
Published in Science translational medicine (20.05.2020)
Published in Science translational medicine (20.05.2020)
Get more information
Journal Article
Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif
Wagner, Florence F, Olson, David E, Gale, Jennifer P, Kaya, Taner, Weïwer, Michel, Aidoud, Nadia, Thomas, Méryl, Davoine, Emeline L, Lemercier, Bérénice C, Zhang, Yan-Ling, Holson, Edward B
Published in Journal of medicinal chemistry (28.02.2013)
Published in Journal of medicinal chemistry (28.02.2013)
Get full text
Journal Article
Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries
Lowe, Jason T, Lee, Maurice D, Akella, Lakshmi B, Davoine, Emeline, Donckele, Etienne J, Durak, Landon, Duvall, Jeremy R, Gerard, Baudouin, Holson, Edward B, Joliton, Adrien, Kesavan, Sarathy, Lemercier, Berenice C, Liu, Haibo, Marié, Jean-Charles, Mulrooney, Carol A, Muncipinto, Giovanni, Welzel-O’Shea, Morgan, Panko, Laura M, Rowley, Ann, Suh, Byung-Chul, Thomas, Meryl, Wagner, Florence F, Wei, Jingqiang, Foley, Michael A, Marcaurelle, Lisa A
Published in Journal of organic chemistry (07.09.2012)
Published in Journal of organic chemistry (07.09.2012)
Get full text
Journal Article
HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury
Aufhauser, David D., Hernandez, Paul, Concors, Seth J., O’Brien, Ciaran, Wang, Zhonglin, Murken, Douglas R., Samanta, Arabinda, Beier, Ulf H., Krumeich, Lauren, Bhatti, Tricia R., Wang, Yanfeng, Ge, Guanghui, Wang, Liqing, Cheraghlou, Shayan, Wagner, Florence F., Holson, Edward B., Kalin, Jay H., Cole, Philip A., Hancock, Wayne W., Levine, Matthew H.
Published in Scientific reports (27.04.2021)
Published in Scientific reports (27.04.2021)
Get full text
Journal Article
Discovery of the First Histone Deacetylase 6/8 Dual Inhibitors
Olson, David E, Wagner, Florence F, Kaya, Taner, Gale, Jennifer P, Aidoud, Nadia, Davoine, Emeline L, Lazzaro, Fanny, Weïwer, Michel, Zhang, Yan-Ling, Holson, Edward B
Published in Journal of medicinal chemistry (13.06.2013)
Published in Journal of medicinal chemistry (13.06.2013)
Get full text
Journal Article
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors
Wagner, Florence F., Weïwer, Michel, Steinbacher, Stefan, Schomburg, Adrian, Reinemer, Peter, Gale, Jennifer P., Campbell, Arthur J., Fisher, Stewart L., Zhao, Wen-Ning, Reis, Surya A., Hennig, Krista M., Thomas, Méryl, Müller, Peter, Jefson, Martin R., Fass, Daniel M., Haggarty, Stephen J., Zhang, Yan-Ling, Holson, Edward B.
Published in Bioorganic & medicinal chemistry (15.09.2016)
Published in Bioorganic & medicinal chemistry (15.09.2016)
Get full text
Journal Article
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging
Liang, Steven H., Chen, Jinshan Michael, Normandin, Marc D., Chang, Jeanne S., Chang, George C., Taylor, Christine K., Trapa, Patrick, Plummer, Mark S., Para, Kimberly S., Conn, Edward L., Lopresti-Morrow, Lori, Lanyon, Lorraine F., Cook, James M., Richter, Karl E. G., Nolan, Charlie E., Schachter, Joel B., Janat, Fouad, Che, Ye, Shanmugasundaram, Veerabahu, Lefker, Bruce A., Enerson, Bradley E., Livni, Elijahu, Wang, Lu, Guehl, Nicolas J., Patnaik, Debasis, Wagner, Florence F., Perlis, Roy, Holson, Edward B., Haggarty, Stephen J., El Fakhri, Georges, Kurumbail, Ravi G., Vasdev, Neil
Published in Angewandte Chemie (International ed.) (08.08.2016)
Published in Angewandte Chemie (International ed.) (08.08.2016)
Get full text
Journal Article