Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors
Semmrich, Monika, Marchand, Jean-Baptiste, Fend, Laetitia, Rehn, Matilda, Remy, Christelle, Holmkvist, Petra, Silvestre, Nathalie, Svensson, Carolin, Kleinpeter, Patricia, Deforges, Jules, Junghus, Fred, Cleary, Kirstie L, Bodén, Mimoza, Mårtensson, Linda, Foloppe, Johann, Teige, Ingrid, Quéméneur, Eric, Frendéus, Björn
Published in Journal for immunotherapy of cancer (01.01.2022)
Published in Journal for immunotherapy of cancer (01.01.2022)
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Journal Article
1368 Preclinical development of an agonistic anti-TNFR2 antibody (BI-1910) for cancer immunotherapy
Martensson, Linda, Holmkvist, Petra, Kovacek, Mathilda, Svensson, Carolin, Bodén, Mimoza, Cleary, Kirstie, Dadas, Osman, Blidberg, Therese, Duell, Benjamin, Semmrich, Monika, Nilsson, Jan Anders, Beers, Stephen, Lim, Sean, Wallin, Johan E, Borggren, Marie, McAllister, Andres, Cragg, Mark, Karlsson, Ingrid, Frendeus, Bjorn, Teige, Ingrid
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
757 Phase 1/2a clinical trial of BI-1808, a monoclonal antibody to tumor necrosis factor receptor 2 (TNFR2) as single agent and in combination with pembrolizumab
Kristoffer Staahl Rohrberg, Papai, Zsuzsanna, Carneiro, Ana, Lang, Istvan, Yachnin, Jeffrey, Lim, Sean, Ny, Lars, Rikke H Lovendahl Eefsen, Walter, Harriet, Abel, Edvard, Cleary, Kirstie, Oldham, Robert, Cragg, Mark, Borggren, Marie, Gertsson, Susanne, Holmkvist, Petra, Karlsson, Ingrid, Martensson, Linda, Nilsson, Jan Anders, Wallin, Johan E, Chisamore, Michael, Frendeus, Bjorn, Teige, Ingrid, McAllister, Andres
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
725 Pre-clinical development of TNFR2 ligand-blocking BI-1808 for cancer immunotherapy
Mårtensson, Linda, Kovacek, Mathilda, Holmkvist, Petra, Semmrich, Monika, Svensson, Carolin, Blidberg, Therese, Roos, Carl, McAllister, Andres, Demiri, Mimoza, Borggren, Marie, Karlsson, Ingrid, Frendeus, Björn, Teige, Ingrid
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
IL-18Rα-deficient CD4(+) T cells induce intestinal inflammation in the CD45RB(hi) transfer model of colitis despite impaired innate responsiveness
Holmkvist, Petra, Pool, Lieneke, Hägerbrand, Karin, Agace, William W, Rivollier, Aymeric
Published in European journal of immunology (01.06.2016)
Published in European journal of immunology (01.06.2016)
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Journal Article
Abstract 936: Targeting TNFR2 for cancer immunotherapy: Ligand blocking depletors versus receptor agonists
Mårtensson, Linda, Cleary, Kirstie, Semmrich, Monika, Kovacek, Mathilda, Holmkvist, Petra, Svensson, Caroline, Demiri, Mimoza, Blidberg, Therese, Thornberg, Ulla-Carin, Pitic, Vincentiu, Dadas, Osman, Lim, Sean H., Beers, Stephen A., Cragg, Mark S., Frendéus, Björn, Teige, Ingrid
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
IL-18R alpha -deficient CD4 super(+) T cells induce intestinal inflammation in the CD45RB super(hi) transfer model of colitis despite impaired innate responsiveness
Holmkvist, Petra, Pool, Lieneke, Haegerbrand, Karin, Agace, William W, Rivollier, Aymeric
Published in European journal of immunology (01.06.2016)
Published in European journal of immunology (01.06.2016)
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Journal Article
IL‐18Rα‐deficient CD4 + T cells induce intestinal inflammation in the CD45RB hi transfer model of colitis despite impaired innate responsiveness
Holmkvist, Petra, Pool, Lieneke, Hägerbrand, Karin, Agace, William W., Rivollier, Aymeric
Published in European journal of immunology (01.06.2016)
Published in European journal of immunology (01.06.2016)
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Journal Article
IL-18R[alpha]-deficient CD4+ T cells induce intestinal inflammation in the CD45RBhi transfer model of colitis despite impaired innate responsiveness
Holmkvist, Petra, Pool, Lieneke, Hagerbrand, Karin, Agace, William W, Rivollier, Aymeric
Published in European journal of immunology (01.06.2016)
Published in European journal of immunology (01.06.2016)
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Journal Article
IL‐18Rα‐deficient CD4+ T cells induce intestinal inflammation in the CD45RBhi transfer model of colitis despite impaired innate responsiveness
Holmkvist, Petra, Pool, Lieneke, Hägerbrand, Karin, Agace, William W., Rivollier, Aymeric
Published in European journal of immunology (01.06.2016)
Published in European journal of immunology (01.06.2016)
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Journal Article
신규한 효능작용 항 TNFR2 항체 분자
HOLMKVIST PETRA, SEMMRICH MONIKA, FRENDEUS BJORN, MARTENSSON LINDA, TEIGE INGRID
Year of Publication 12.07.2021
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Year of Publication 12.07.2021
Patent
신규한 길항작용 항 TNFR2 항체 분자
HOLMKVIST PETRA, SEMMRICH MONIKA, FRENDEUS BJORN, MARTENSSON LINDA, TEIGE INGRID
Year of Publication 09.07.2021
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Year of Publication 09.07.2021
Patent
Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3 + CD8 + T regs
Joeris, Thorsten, Gomez-Casado, Cristina, Holmkvist, Petra, Tavernier, Simon J, Silva-Sanchez, Aaron, Klotz, Luisa, Randall, Troy D, Mowat, Allan M, Kotarsky, Knut, Malissen, Bernard, Agace, William W
Published in Science immunology (15.06.2021)
Published in Science immunology (15.06.2021)
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Journal Article
신규 항체 및 뉴클레오티드 서열 및 이의 용도
MARCHAND JEAN BAPTISTE, HOLMKVIST PETRA, SEMMRICH MONIKA, FRENDEUS BJORN, MARTENSSON LINDA, TEIGE INGRID, SILVESTRE NATHALIE
Year of Publication 17.05.2021
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Year of Publication 17.05.2021
Patent
Abstract 3567: Comprehensive preclinical studies of BT-001: An oncolytic vaccinia virus armed with Treg-depleting @CTLA4 and GM-CSF
Marchand, Jean-Baptiste, Semmrich, Monika, Ziller, Christelle, Rehn, Matilda, Fend, Laetitia, Holmkvist, Petra, Silvestre, Nathalie, Svensson, Carolin, Patricia, Kleinpeter, Deforges, Jules, Junghus, Fred, Mårtensson, Linda, Foloppe, Johann, Teige, Ingrid, Frendéus, Björn, Quéméneur, Eric
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
A major population of mucosal memory CD4+ T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality
Holmkvist, P, Roepstorff, K, Uronen-Hansson, H, Sandén, C, Gudjonsson, S, Patschan, O, Grip, O, Marsal, J, Schmidtchen, A, Hornum, L, Erjefält, J S, Håkansson, K, Agace, W W
Published in Mucosal immunology (01.05.2015)
Published in Mucosal immunology (01.05.2015)
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Journal Article
Abstract 4156: BI-1808 - a first in class ligand-blocking αTNFR2 antibody for cancer immunotherapy
Mårtensson, Linda, Cleary, Kirsty, Holmkvist, Petra, Kovacek, Mathilda, Svensson, Carolin, Semmrich, Monika, Blidberg, Therese, Demiri, Mimoza, Dadas, Osman, Borggren, Marie, Pitic, Vici, Lim, Sean H., Beers, Stephen A., Gertsson, Susanne, Rohrberg, Kristoffer S., Karlsson, Ingrid, McAllister, Andres, Cragg, Mark S., Frendeus, Björn, Teige, Ingrid
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
NOVEL AGONISTIC ANTI TNFR2 ANTIBODY MOLECULES
TEIGE, Ingrid, SEMMRICH, Monika, HOLMKVIST, Petra, FRENDÉUS, Björn, MÅRTENSSON, Linda
Year of Publication 10.03.2022
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Year of Publication 10.03.2022
Patent
NOVEL AGONISTIC ANTI TNFR2 ANTIBODY MOLECULES
TEIGE, Ingrid, SEMMRICH, Monika, HOLMKVIST, Petra, FRENDÉUS, Björn, MÅRTENSSON, Linda
Year of Publication 06.01.2022
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Year of Publication 06.01.2022
Patent
NOVEL ANTAGONISTIC ANTI TNFR2 ANTIBODY MOLECULES
TEIGE, Ingrid, SEMMRICH, Monika, HOLMKVIST, Petra, FRENDÉUS, Björn, MÅRTENSSON, Linda
Year of Publication 08.09.2021
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Year of Publication 08.09.2021
Patent