3-Cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: Synthesis and initial structure-activity relationships
MURALI DHAR, T. G, ZHONGQI SHEN, TOWNSEND, Robert, HOLLENBAUGH, Diane L, IWANOWICZ, Edwin J, GU, Henry H, PING CHEN, NORRIS, Derek, WATTERSON, Scott H, BALLENTINE, Shelley K, FLEENER, Catherine A, ROULEAU, Katherine A, BARRISH, Joel C
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
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Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3
Watterson, Scott H., Dhar, T.G.Murali, Ballentine, Shelley K., Shen, Zhongqi, Barrish, Joel C., Cheney, Daniel, Fleener, Catherine A., Rouleau, Katherine A., Townsend, Robert, Hollenbaugh, Diane L., Iwanowicz, Edwin J.
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
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Discovery of N-[2-[2-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a Novel and Potent Inhibitor of Inosine Monophosphate Dehydrogenase with Excellent in Vivo Activity
Dhar, T. G. Murali, Shen, Zhongqi, Guo, Junqing, Liu, Chunjian, Watterson, Scott H, Gu, Henry H, Pitts, William J, Fleener, Catherine A, Rouleau, Katherine A, Sherbina, N. Z, McIntyre, Kim W, Witmer, Mark R, Tredup, Jeffrey A, Chen, Bang-Chi, Zhao, Rulin, Bednarz, Mark S, Cheney, Daniel L, MacMaster, John F, Miller, Laura M, Berry, Karen K, Harper, Timothy W, Barrish, Joel C, Hollenbaugh, Diane L, Iwanowicz, Edwin J
Published in Journal of medicinal chemistry (23.05.2002)
Published in Journal of medicinal chemistry (23.05.2002)
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De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold
Potin, Dominique, Launay, Michele, Nicolai, Eric, Fabreguette, Maud, Malabre, Patrice, Caussade, François, Besse, Dominique, Skala, Stacey, Stetsko, Dawn K., Todderud, Gordon, Beno, Brett R., Cheney, Daniel L., Chang, Chiehying J., Sheriff, Steven, Hollenbaugh, Diane L., Barrish, Joel C., Iwanowicz, Edwin J., Suchard, Suzanne J., Dhar, T.G. Murali
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
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Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase
Pitts, William J., Guo, Junqing, Dhar, T.G.Murali, Shen, Zhongqi, Gu, Henry H., Watterson, Scott H., Bednarz, Mark S., Chen, Bang-Chi, Barrish, Joel C., Bassolino, Donna, Cheney, Daniel, Fleener, Catherine A., Rouleau, Katherine A., Hollenbaugh, Diane L., Iwanowicz, Edwin J.
Published in Bioorganic & medicinal chemistry letters (19.08.2002)
Published in Bioorganic & medicinal chemistry letters (19.08.2002)
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Identification of novel and potent isoquinoline aminooxazole-Based IMPDH inhibitors
Chen, Ping, Norris, Derek, Haslow, Kristin D., Murali Dhar, T.G., Pitts, William J., Watterson, Scott H., Cheney, Daniel L., Bassolino, Donna A., Fleener, Catherine A., Rouleau, Katherine A., Hollenbaugh, Diane L., Townsend, Robert M., Barrish, Joel C., Iwanowicz, Edwin J.
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
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The TosMIC approach to 3-(Oxazol-5-yl) indoles: application to the synthesis of indole-based IMPDH inhibitors
Dhar, T.G.Murali, Shen, Zhongqi, Fleener, Catherine A., Rouleau, Katherine A., Barrish, Joel C., Hollenbaugh, Diane L., Iwanowicz, Edwin J.
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
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Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety
Iwanowicz, Edwin J., Watterson, Scott H., Guo, Junqing, Pitts, William J., Murali Dhar, T.G., Shen, Zhongqi, Chen, Ping, Gu, Henry H., Fleener, Catherine A., Rouleau, Katherine A., Cheney, Daniel L., Townsend, Robert M., Hollenbaugh, Diane L.
Published in Bioorganic & medicinal chemistry letters (16.06.2003)
Published in Bioorganic & medicinal chemistry letters (16.06.2003)
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Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase
IWANOWICZ, Edwin J, WATTERSON, Scott H, HOLLENBAUGH, Diane L, CHUNJIAN LIU, GU, Henry H, MITT, Toomas, LEFTHERIS, Katerina, BARRISH, Joel C, FLEENER, Catherine A, ROULEAU, Katherine, SHERBINA, N. Z
Published in Bioorganic & medicinal chemistry letters (21.10.2002)
Published in Bioorganic & medicinal chemistry letters (21.10.2002)
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Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series
Watterson, Scott H., Carlsen, Marianne, Murali Dhar, T.G., Shen, Zhongqi, Pitts, William J., Guo, Junqing, Gu, Henry H., Norris, Derek, Chorba, John, Chen, Ping, Cheney, Daniel, Witmer, Mark, Fleener, Catherine A., Rouleau, Katherine, Townsend, Robert, Hollenbaugh, Diane L., Iwanowicz, Edwin J.
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
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Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase
WATTERSON, Scott H, CHUNJIAN LIU, IWANOWICZ, Edwin J, MURALI DHAR, T. G, GU, Henry H, PITTS, William J, BARRISH, Joel C, FLEENER, Catherine A, ROULEAU, Katherine, SHERBINA, N. Z, HOLLENBAUGH, Diane L
Published in Bioorganic & medicinal chemistry letters (21.10.2002)
Published in Bioorganic & medicinal chemistry letters (21.10.2002)
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Journal Article
Discovery of N-[2-[2-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4-morpholineacetamide as a Novel and Potent Inhibitor of Inosine Monophosphate Dehydrogenase (IMPDH) with Excellent in Vivo Activity
Murali Dhar, T. G, Shen, Zhongqi, Guo, Junqing, Liu, Chunjian, Watterson, Scott H, Gu, Henry H, Pitts, William J, Fleener, Catherine A, Rouleau, Katherine A, Sherbina, N. Z, McIntyre, Kim W, Shuster, David J, Witmer, Mark R, Tredup, Jeffrey A, Chen, Bang-Chi, Zhao, Rulin, Bednarz, Mark S, Cheney, Daniel L, MacMaster, John F, Miller, Laura M, Berry, Karen K, Harper, Timothy W, Barrish, Joel C, Hollenbaugh, Diane L, Iwanowicz, Edwin J
Published in Journal of medicinal chemistry (07.11.2002)
Published in Journal of medicinal chemistry (07.11.2002)
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Journal Article
Novel inhibitors of IMPDH
Watterson, Scott H., Carlsen, Marianne, Murali Dhar, T.G., Shen, Zhongqi, Pitts, William J., Guo, Junqing, Gu, Henry H., Norris, Derek, Chorba, John, Chen, Ping, Cheney, Daniel, Witmer, Mark, Fleener, Catherine A., Rouleau, Katherine, Townsend, Robert, Hollenbaugh, Diane L., Iwanowicz, Edwin J.
Published in Bioorganic & medicinal chemistry letters (01.02.2003)
Published in Bioorganic & medicinal chemistry letters (01.02.2003)
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METHODS FOR INHIBITING AN IMMUNE RESPONSE BY BLOCKING THE GP39/CD40 AND CTLA4/CD28/B7 PATHWAYS AND COMPOSITIONS FOR USE THEREWITH
ARUFFO, ALEJANDRO A, HOLLENBAUGH, DIANE L, LARSEN, CHRISTIAN P, LEDBETTER, JEFFREY A, PEARSON, THOMAS C, LINSLEY, PETER S
Year of Publication 08.11.2011
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Year of Publication 08.11.2011
Patent
METHODS FOR INHIBITING AN IMMUNE RESPONSE BY BLOCKING THE GP39/CD40 AND CTLA4/CD28/B7 PATHWAYS AND COMPOSITIONS FOR USE THEREWITH
LINSLEY, PETER, S, PEARSON, THOMAS, C, LARSEN, CHRISTIAN, P, HOLLENBAUGH, DIANE, L, LEDBETTER, JEFFREY, A, ARUFFO, ALEJANDRO, A
Year of Publication 02.09.2009
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Year of Publication 02.09.2009
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Polynucleotides encoding humanized antibodies against human 4-1BB
Kunkel, Maria Jure, Ganguly, Subinay, Abraham, Ralph, Hollenbaugh, Diane L, Rillema, Jill, Thorne, Barbara, Shuford, Walter W, Mittler, Robert S
Year of Publication 08.05.2007
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Year of Publication 08.05.2007
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Polynucleotides encoding humanized antibodies against human 4-1BB
KUNKEL MARIA JURE, ABRAHAM RALPH, RILLEMA JILL, SHUFORD WALTER W, GANGULY SUBINAY, HOLLENBAUGH DIANE L, MITTLER ROBERT S, THORNE BARBARA
Year of Publication 08.05.2007
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Year of Publication 08.05.2007
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