Search Results - "HOLENZ Jörg" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Synthesis and Biological Evaluation of the 1‑Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4‑{2-[5-Methyl-1-(naphthalen-2-yl)‑1H‑pyrazol-3-yloxy]ethyl}morpholine (S1RA, E‑52862)

Synthesis and Biological Evaluation of the 1‑Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4‑{2-[5-Methyl-1-(naphthalen-2-yl)‑1H‑pyrazol-3-yloxy]ethyl}morpholine (S1RA, E‑52862)

by Díaz, José Luis, Cuberes, Rosa, Berrocal, Joana, Contijoch, Montserrat, Christmann, Ute, Fernández, Ariadna, Port, Adriana, Holenz, Jörg, Buschmann, Helmut, Laggner, Christian, Serafini, Maria Teresa, Burgueño, Javier, Zamanillo, Daniel, Merlos, Manuel, Vela, José Miguel, Almansa, Carmen
Published in Journal of medicinal chemistry (11.10.2012)

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Toward β‑Secretase‑1 Inhibitors with Improved Isoform Selectivity

Toward β‑Secretase‑1 Inhibitors with Improved Isoform Selectivity

by Johansson, Patrik, Kaspersson, Karin, Gurrell, Ian K, Bäck, Elisabeth, Eketjäll, Susanna, Scott, Clay W, Cebers, Gvido, Thorne, Philip, McKenzie, Michael J, Beaton, Haydn, Davey, Paul, Kolmodin, Karin, Holenz, Jörg, Duggan, Mark E, Budd Haeberlein, Samantha, Bürli, Roland W
Published in Journal of medicinal chemistry (26.04.2018)

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Design and Synthesis of β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β‑Amyloid Peptides

Design and Synthesis of β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β‑Amyloid Peptides

by Swahn, Britt-Marie, Kolmodin, Karin, Karlström, Sofia, von Berg, Stefan, Söderman, Peter, Holenz, Jörg, Berg, Stefan, Lindström, Johan, Sundström, Marie, Turek, Dominika, Kihlström, Jacob, Slivo, Can, Andersson, Lars, Pyring, David, Rotticci, Didier, Öhberg, Liselotte, Kers, Annika, Bogar, Krisztian, von Kieseritzky, Fredrik, Bergh, Margareta, Olsson, Lise-Lotte, Janson, Juliette, Eketjäll, Susanna, Georgievska, Biljana, Jeppsson, Fredrik, Fälting, Johanna
Published in Journal of medicinal chemistry (08.11.2012)

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The small molecule CLP257 does not modify activity of the K + -Cl - co-transporter KCC2 but does potentiate GABA A receptor activity

The small molecule CLP257 does not modify activity of the K + -Cl - co-transporter KCC2 but does potentiate GABA A receptor activity

by Cardarelli, Ross A, Jones, Karen, Pisella, Lucie I, Wobst, Heike J, McWilliams, Lisa J, Sharpe, Paul M, Burnham, Matthew P, Baker, David J, Chudotvorova, Ilona, Guyot, Justine, Silayeva, Liliya, Morrow, Danielle H, Dekker, Niek, Zicha, Stephen, Davies, Paul A, Holenz, Jörg, Duggan, Mark E, Dunlop, John, Mather, Robert J, Wang, Qi, Medina, Igor, Brandon, Nicholas J, Deeb, Tarek Z, Moss, Stephen J
Published in Nature medicine (07.12.2017)

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Thiophene Bioisosteres of Spirocyclic σ Receptor Ligands. 1. N-Substituted Spiro[piperidine-4,4′-thieno[3,2-c]pyrans]

Thiophene Bioisosteres of Spirocyclic σ Receptor Ligands. 1. N-Substituted Spiro[piperidine-4,4′-thieno[3,2-c]pyrans]

by Oberdorf, Christoph, Schepmann, Dirk, Vela, Jose Miguel, Diaz, Jose Luis, Holenz, Jörg, Wünsch, Bernhard
Published in Journal of medicinal chemistry (23.10.2008)

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Thiophene Bioisosteres of Spirocyclic σ Receptor Ligands: Relationships between Substitution Pattern and σ Receptor Affinity

Thiophene Bioisosteres of Spirocyclic σ Receptor Ligands: Relationships between Substitution Pattern and σ Receptor Affinity

by Oberdorf, Christoph, Schepmann, Dirk, Vela, Jose Miguel, Buschmann, Helmut, Holenz, Jörg, Wünsch, Bernhard
Published in Journal of medicinal chemistry (14.06.2012)

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Biotransformation of two β-secretase inhibitors including ring opening and contraction of a pyrimidine ring

Biotransformation of two β-secretase inhibitors including ring opening and contraction of a pyrimidine ring

by Lindgren, Anders, Eklund, Göran, Turek, Dominika, Malmquist, Jonas, Swahn, Britt-Marie, Holenz, Jörg, von Berg, Stefan, Karlström, Sofia, Bueters, Tjerk
Published in Drug metabolism and disposition (01.05.2013)

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Efficacy of selective 5‐HT6 receptor ligands determined by monitoring 5‐HT6 receptor‐mediated cAMP signaling pathways

Efficacy of selective 5‐HT6 receptor ligands determined by monitoring 5‐HT6 receptor‐mediated cAMP signaling pathways

by Romero, Gonzalo, Sánchez, Elisabeth, Pujol, Marta, Pérez, Pilar, Codony, Xavier, Holenz, Jörg, Buschmann, Helmut, Pauwels, Petrus J
Published in British journal of pharmacology (01.08.2006)

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Combination of Two Pharmacophoric Systems: Synthesis and Pharmacological Evaluation of Spirocyclic Pyranopyrazoles with High σ1 Receptor Affinity

Combination of Two Pharmacophoric Systems: Synthesis and Pharmacological Evaluation of Spirocyclic Pyranopyrazoles with High σ1 Receptor Affinity

by Schläger, Torsten, Schepmann, Dirk, Lehmkuhl, Kirstin, Holenz, Jörg, Vela, Jose Miguel, Buschmann, Helmut, Wünsch, Bernhard
Published in Journal of medicinal chemistry (13.10.2011)

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Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy

Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy

by Swahn, Britt-Marie, Holenz, Jörg, Kihlström, Jacob, Kolmodin, Karin, Lindström, Johan, Plobeck, Niklas, Rotticci, Didier, Sehgelmeble, Fernando, Sundström, Marie, Berg, Stefan von, Fälting, Johanna, Georgievska, Biljana, Gustavsson, Susanne, Neelissen, Jan, Ek, Margareta, Olsson, Lise-Lotte, Berg, Stefan
Published in Bioorganic & medicinal chemistry letters (01.03.2012)

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Identification of Novel Indanylsulfonamide Guanylhydrazones as Potent 5-HT6 Serotonin Receptor Antagonists

Identification of Novel Indanylsulfonamide Guanylhydrazones as Potent 5-HT6 Serotonin Receptor Antagonists

by Mesquida, Neus, López-Pérez, Sara, Dinarès, Immaculada, Frigola, Jordi, Mercè, Ramon, Holenz, Jörg, Pérez, Raquel, Burgueño, Javier, Alcalde, Ermitas
Published in Journal of medicinal chemistry (08.10.2009)

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Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of sigma(1) Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of sigma(1) Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

by Luis Diaz, Jose, Cuberes, Rosa, Berrocal, Joana, Contijoch, Montserrat, Christmann, Ute, Fernandez, Ariadna, Port, Adriana, Holenz, Jorg, Buschmann, Helmut, Laggner, Christian, Teresa Serafini, Maria, Burgueno, Javier, Zamanillo, Daniel, Merlos, Manuel, Miguel Vela, Jose, Almansa, Carmen
Published in Journal of medicinal chemistry (11.10.2012)

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Epigenetic Drug Discovery

Epigenetic Drug Discovery

by Sippl, Wolfgang, Jung, Manfred, Mannhold, Raimund, Buschmann, Helmut, Holenz, Jörg
Year of Publication 2019

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Drug Selectivity: An Evolving Concept in Medicinal Chemistry

Drug Selectivity: An Evolving Concept in Medicinal Chemistry

by Handler, Norbert, Buschmann, Helmut, Mannhold, Raimund, Holenz, Jörg
Year of Publication 2018

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Sulfonimidamides as Sulfonamides Bioisosteres: Rational Evaluation through Synthetic, in Vitro, and in Vivo Studies with γ-Secretase Inhibitors

Sulfonimidamides as Sulfonamides Bioisosteres: Rational Evaluation through Synthetic, in Vitro, and in Vivo Studies with γ-Secretase Inhibitors

by Sehgelmeble, Fernando, Janson, Juliette, Ray, Colin, Rosqvist, Susanne, Gustavsson, Susanne, Nilsson, Linda I., Minidis, Alexander, Holenz, Jörg, Rotticci, Didier, Lundkvist, Johan, Arvidsson, Per I.
Published in ChemMedChem (05.03.2012)

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First synthesis of the antimalarial naphthylisoquinoline alkaloid dioncophylline C, and its unnatural anti-HIV dimer, jozimine C

First synthesis of the antimalarial naphthylisoquinoline alkaloid dioncophylline C, and its unnatural anti-HIV dimer, jozimine C

by Bringmann, Gerhard, Holenz, Jörg, Weirich, Ralf, Rübenacker, Martin, Funke, Christian, Boyd, Michael R., Gulakowski, Robert J., François, Guido
Published in Tetrahedron (01.01.1998)

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Combination of Two Pharmacophoric Systems: Synthesis and Pharmacological Evaluation of Spirocyclic Pyranopyrazoles with High σ 1 Receptor Affinity

Combination of Two Pharmacophoric Systems: Synthesis and Pharmacological Evaluation of Spirocyclic Pyranopyrazoles with High σ 1 Receptor Affinity

by Schläger, Torsten, Schepmann, Dirk, Lehmkuhl, Kirstin, Holenz, Jörg, Vela, Jose Miguel, Buschmann, Helmut, Wünsch, Bernhard
Published in Journal of medicinal chemistry (13.10.2011)

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Vismione H and structurally related anthranoid compounds of natural and synthetic origin as promising drugs against the human malaria parasite Plasmodium falciparum : structure-activity relationships

Vismione H and structurally related anthranoid compounds of natural and synthetic origin as promising drugs against the human malaria parasite Plasmodium falciparum : structure-activity relationships

by FRANCOIS, G, STEENACKERS, T, AKE ASSI, L, STEGLICH, W, LAMOTTKE, K, HOLENZ, J, BRINGMANN, G
Published in Parasitology research (1987) (01.07.1999)

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Medicinal chemistry strategies to 5-HT6 receptor ligands as potential cognitive enhancers and antiobesity agents

Medicinal chemistry strategies to 5-HT6 receptor ligands as potential cognitive enhancers and antiobesity agents

by HOLENZ, Jörg, PAUWELS, Petrus J, DIAZ, José Luis, MERCE, Ramon, CODONY, Xavier, BUSCHMANN, Helmut
Published in Drug discovery today (01.04.2006)

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Journal Article

Target Discovery and Validation: Methods and Strategies for Drug Discovery

Target Discovery and Validation: Methods and Strategies for Drug Discovery

by Plowright, Alleyn T, Mannhold, Raimund, Buschmann, Helmut, Holenz, Jörg
Year of Publication 2020

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