Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19
Hoffman, Robert L, Kania, Robert S, Brothers, Mary A, Davies, Jay F, Ferre, Rose A, Gajiwala, Ketan S, He, Mingying, Hogan, Robert J, Kozminski, Kirk, Li, Lilian Y, Lockner, Jonathan W, Lou, Jihong, Marra, Michelle T, Mitchell, Lennert J, Murray, Brion W, Nieman, James A, Noell, Stephen, Planken, Simon P, Rowe, Thomas, Ryan, Kevin, Smith, George J, Solowiej, James E, Steppan, Claire M, Taggart, Barbara
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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Journal Article
Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer
Freeman-Cook, Kevin D, Hoffman, Robert L, Behenna, Douglas C, Boras, Britton, Carelli, Jordan, Diehl, Wade, Ferre, Rose Ann, He, You-Ai, Hui, Andrea, Huang, Buwen, Huser, Nanni, Jones, Rhys, Kephart, Susan E, Lapek, John, McTigue, Michele, Miller, Nichol, Murray, Brion W, Nagata, Asako, Nguyen, Lisa, Niessen, Sherry, Ninkovic, Sacha, O’Doherty, Inish, Ornelas, Martha A, Solowiej, James, Sutton, Scott C, Tran, Khanh, Tseng, Elaine, Visswanathan, Ravi, Xu, Meirong, Zehnder, Luke, Zhang, Qin, Zhang, Cathy, Dann, Stephen
Published in Journal of medicinal chemistry (08.07.2021)
Published in Journal of medicinal chemistry (08.07.2021)
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Journal Article
Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib
Huang, Qinhua, Johnson, Ted W, Bailey, Simon, Brooun, Alexei, Bunker, Kevin D, Burke, Benjamin J, Collins, Michael R, Cook, Andrew S, Cui, J. Jean, Dack, Kevin N, Deal, Judith G, Deng, Ya-Li, Dinh, Dac, Engstrom, Lars D, He, Mingying, Hoffman, Jacqui, Hoffman, Robert L, Johnson, Patrick S, Kania, Robert S, Lam, Hieu, Lam, Justine L, Le, Phuong T, Li, Qiuhua, Lingardo, Laura, Liu, Wei, Lu, Melissa West, McTigue, Michele, Palmer, Cynthia L, Richardson, Paul F, Sach, Neal W, Shen, Hong, Smeal, Tod, Smith, Graham L, Stewart, Albert E, Timofeevski, Sergei, Tsaparikos, Konstantinos, Wang, Hui, Zhu, Huichun, Zhu, Jinjiang, Zou, Helen Y, Edwards, Martin P
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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Journal Article
Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility
Martinez, Ricardo, Blasina, Alessandra, Hallin, Jill F, Hu, Wenyue, Rymer, Isha, Fan, Jeffery, Hoffman, Robert L, Murphy, Sean, Marx, Matthew, Yanochko, Gina, Trajkovic, Dusko, Dinh, Dac, Timofeevski, Sergei, Zhu, Zhou, Sun, Peiquing, Lappin, Patrick B, Murray, Brion W
Published in PloS one (23.09.2015)
Published in PloS one (23.09.2015)
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Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations
Johnson, Ted W., Richardson, Paul F., Bailey, Simon, Brooun, Alexei, Burke, Benjamin J., Collins, Michael R., Cui, J. Jean, Deal, Judith G., Deng, Ya-Li, Dinh, Dac, Engstrom, Lars D., He, Mingying, Hoffman, Jacqui, Hoffman, Robert L., Huang, Qinhua, Kania, Robert S., Kath, John C., Lam, Hieu, Lam, Justine L., Le, Phuong T., Lingardo, Laura, Liu, Wei, McTigue, Michele, Palmer, Cynthia L., Sach, Neal W., Smeal, Tod, Smith, Graham L., Stewart, Albert E., Timofeevski, Sergei, Zhu, Huichun, Zhu, Jinjiang, Zou, Helen Y., Edwards, Martin P.
Published in Journal of medicinal chemistry (12.06.2014)
Published in Journal of medicinal chemistry (12.06.2014)
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Journal Article
Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
Freeman-Cook, Kevin, Hoffman, Robert L., Miller, Nichol, Almaden, Jonathan, Chionis, John, Zhang, Qin, Eisele, Koleen, Liu, Chaoting, Zhang, Cathy, Huser, Nanni, Nguyen, Lisa, Costa-Jones, Cinthia, Niessen, Sherry, Carelli, Jordan, Lapek, John, Weinrich, Scott L., Wei, Ping, McMillan, Elizabeth, Wilson, Elizabeth, Wang, Tim S., McTigue, Michele, Ferre, Rose Ann, He, You-Ai, Ninkovic, Sacha, Behenna, Douglas, Tran, Khanh T., Sutton, Scott, Nagata, Asako, Ornelas, Martha A., Kephart, Susan E., Zehnder, Luke R., Murray, Brion, Xu, Meirong, Solowiej, James E., Visswanathan, Ravi, Boras, Britton, Looper, David, Lee, Nathan, Bienkowska, Jadwiga R., Zhu, Zhou, Kan, Zhengyan, Ding, Ying, Mu, Xinmeng Jasmine, Oderup, Cecilia, Salek-Ardakani, Shahram, White, Michael A., VanArsdale, Todd, Dann, Stephen G.
Published in Cancer cell (11.10.2021)
Published in Cancer cell (11.10.2021)
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Journal Article
Lipophilic efficiency: the most important efficiency metric in medicinal chemistry
Freeman-Cook, Kevin D, Hoffman, Robert L, Johnson, Ted W
Published in Future medicinal chemistry (01.02.2013)
Published in Future medicinal chemistry (01.02.2013)
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Journal Article
Heteroatom-linked indanylpyrazines are corticotropin releasing factor type-1 receptor antagonists
Corbett, Jeffrey W., Rauckhorst, Mark R., Qian, Fang, Hoffman, Robert L., Knauer, Christopher S., Fitzgerald, Lawrence W.
Published in Bioorganic & medicinal chemistry (15.11.2007)
Published in Bioorganic & medicinal chemistry (15.11.2007)
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Journal Article
아제티딘 및 피롤리딘 PARP1 저해제, 및 이의 용도
KALDOR STEPHEN W, TRZOSS LYNNIE, DONG QING, HOFFMAN ROBERT L, VA PORINO JINJO
Year of Publication 20.05.2024
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Year of Publication 20.05.2024
Patent
PARP1 저해제 및 이의 용도
PINCHMAN JOSEPH ROBERT, KALDOR STEPHEN W, TRZOSS LYNNIE, DONG QING, HOFFMAN ROBERT L, VA PORINO JINJO
Year of Publication 23.09.2024
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Year of Publication 23.09.2024
Patent
PARP1 저해제 및 이의 용도
PINCHMAN JOSEPH ROBERT, KALDOR STEPHEN W, TRZOSS LYNNIE, DONG QING, HOFFMAN ROBERT L, VA PORINO JINJO
Year of Publication 23.09.2024
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Year of Publication 23.09.2024
Patent
PARP1 저해제 및 이의 용도
PINCHMAN JOSEPH ROBERT, KALDOR STEPHEN W, TRZOSS LYNNIE, DONG QING, HOFFMAN ROBERT L, VA PORINO JINJO
Year of Publication 04.09.2024
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Year of Publication 04.09.2024
Patent
Predicting Secchi disk depth from average beam attenuation in a deep, ultra-clear lake
Larson, Gary L, Hoffman, Robert L, Hargreaves, Bruce R, Collier, Robert W
Published in Hydrobiologia (01.01.2007)
Published in Hydrobiologia (01.01.2007)
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Journal Article
Thermal, chemical, and optical properties of Crater Lake, Oregon
Larson, Gary L., Hoffman, Robert L., McIntire, David C., Buktenica, Mark W., Girdner, Scott F.
Published in Hydrobiologia (01.01.2007)
Published in Hydrobiologia (01.01.2007)
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Journal Article
Structure-Activity Relationships in the 8-Amino-6,7,8,9-tetrahydro-3H-benz[e]indole Ring System. Part 2: Effect of 8-Amino Nitrogen Substitution on Serotonin Receptor Binding and Pharmacology
Ennis, Michael D, Stjernloef, Peter, Hoffman, Robert L, Ghazal, Nabil B, Smith, Martin W, Svensson, Kjell, Wikstroem, Haakan, Haadsma-Svensson, Susanne R, Lin, Chiu-Hong
Published in Journal of medicinal chemistry (01.06.1995)
Published in Journal of medicinal chemistry (01.06.1995)
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Journal Article
Isochroman-6-carboxamides as Highly Selective 5-HT1D Agonists: Potential New Treatment for Migraine without Cardiovascular Side Effects
Ennis, Michael D, Ghazal, Nabil B, Hoffman, Robert L, Smith, Martin W, Schlachter, Siusaidh K, Lawson, Charles F, Im, Wha Bin, Pregenzer, Jeffrey F, Svensson, Kjell A, Lewis, Richard A, Hall, Edward D, Sutter, Dorothy M, Harris, Lorri T, McCall, Robert B
Published in Journal of medicinal chemistry (18.06.1998)
Published in Journal of medicinal chemistry (18.06.1998)
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