A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding
Jefferies, Harold B J, Cooke, Frank T, Jat, Parmjit, Boucheron, Christine, Koizumi, Tomonobu, Hayakawa, Masahiko, Kaizawa, Hiroyuki, Ohishi, Takahide, Workman, Paul, Waterfield, Michael D, Parker, Peter J
Published in EMBO reports (01.02.2008)
Published in EMBO reports (01.02.2008)
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Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases
RAYNAUD, Florence I, ECCLES, Suzanne, BJERKE, Lynn M, KELLAND, Lloyd, VALENTI, Melanie, PATTERSON, Lisa, GOWAN, Sharon, DE HAVEN BRANDON, Alexis, HAYAKAWA, Masahiko, KAIZAWA, Hiroyuki, KOIZUMI, Tomonubu, OHISHI, Takahide, CLARKE, Paul A, PATEL, Sonal, SAGHIR, Nahid, PARKER, Peter, WATERFIELD, Mike, WORKMAN, Paul, HAYES, Angela, NUTLEY, Bernard, ALIX, Sonia, HENLEY, Alan, DI-STEFANO, Francesca, AHMAD, Zahida, GUILLARD, Sandrine
Published in Cancer research (Chicago, Ill.) (15.06.2007)
Published in Cancer research (Chicago, Ill.) (15.06.2007)
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PIKfyve Negatively Regulates Exocytosis in Neurosecretory Cells
Osborne, Shona L., Wen, Peter J., Boucheron, Christine, Nguyen, Hao N., Hayakawa, Masahiko, Kaizawa, Hiroyuki, Parker, Peter J., Vitale, Nicolas, Meunier, Frederic A.
Published in The Journal of biological chemistry (01.02.2008)
Published in The Journal of biological chemistry (01.02.2008)
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Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives
Koshio, Hiroyuki, Hirayama, Fukushi, Ishihara, Tsukasa, Kaizawa, Hiroyuki, Shigenaga, Takeshi, Taniuchi, Yuta, Sato, Kazuo, Moritani, Yumiko, Iwatsuki, Yoshiyuki, Uemura, Toshio, Kaku, Seiji, Kawasaki, Tomihisa, Matsumoto, Yuzo, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (15.10.2004)
Published in Bioorganic & medicinal chemistry (15.10.2004)
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Design, synthesis and biological activity of YM-60828 derivatives. Part 2: potent and orally-bioavailable factor Xa inhibitors based on benzothiadiazine-4-one template
Hirayama, Fukushi, Koshio, Hiroyuki, Katayama, Naoko, Ishihara, Tsukasa, Kaizawa, Hiroyuki, Taniuchi, Yuta, Sato, Kazuo, Sakai-Moritani, Yumiko, Kaku, Seiji, Kurihara, Hiroyuki, Kawasaki, Tomihisa, Matsumoto, Yuzo, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (06.02.2003)
Published in Bioorganic & medicinal chemistry (06.02.2003)
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Design, synthesis and biological activity of YM-60828 derivatives: Potent and orally-bioavailable factor Xa inhibitors based on naphthoanilide and naphthalensulfonanilide templates
HIRAYAMA, Fukushi, KOSHIO, Hiroyuki, SATO, Kazuo, SAKAI-MORITANI, Yumiko, KAKU, Seiji, KAWASAKI, Tomihisa, MATSUMOTO, Yuzo, SAKAMOTO, Shuichi, TSUKAMOTO, Shin-Ichi, ISHIHARA, Tsukasa, WATANUKI, Susumu, HACHIYA, Shunichiro, KAIZAWA, Hiroyuki, KURAMOCHI, Takahiro, KATAYAMA, Naoko, KURIHARA, Hiroyuki, TANIUCHI, Yuta
Published in Bioorganic & medicinal chemistry (01.08.2002)
Published in Bioorganic & medicinal chemistry (01.08.2002)
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A selective PIKfyve inhibitor blocks PtdIns(3,5)P 2 production and disrupts endomembrane transport and retroviral budding
Parker, Peter J, Jefferies, Harold B J, Cooke, Frank T, Jat, Parmjit, Boucheron, Christine, Koizumi, Tomonobu, Hayakawa, Masahiko, Kaizawa, Hiroyuki, Ohishi, Takahide, Workman, Paul, Waterfield, Michael D
Published in EMBO reports (01.02.2008)
Published in EMBO reports (01.02.2008)
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Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors
Hayakawa, Masahiko, Kaizawa, Hiroyuki, Moritomo, Hiroyuki, Koizumi, Tomonobu, Ohishi, Takahide, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Parker, Peter, Workman, Paul, Waterfield, Mike
Published in Bioorganic & medicinal chemistry (15.10.2006)
Published in Bioorganic & medicinal chemistry (15.10.2006)
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Boller, Danielle, Doepfner, Kathrin T, Laurentiis, Angela DE, Guerreiro, Ana S, Marinov, Marin, Shalaby, Tarek, Depledge, Paul, Robson, Anthony, Saghir, Nahid, Hayakawa, Masahiko, Kaizawa, Hiroyuki, Koizumi, Tomonobu, Ohishi, Takahide, Fattet, Sarah, Delattre, Olivier, Schweri-Olac, Anelia, Höland, Katrin, Grotzer, Michael A, Frei, Karl, Spertini, Olivier, Waterfield, Michael D, Arcaro, Alexandre
Published in Anticancer research (01.06.2022)
Published in Anticancer research (01.06.2022)
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Synthesis and biological evaluation of pyrido[3′,2′:4,5]furo[3,2- d]pyrimidine derivatives as novel PI3 kinase p110α inhibitors
Hayakawa, Masahiko, Kaizawa, Hiroyuki, Moritomo, Hiroyuki, Koizumi, Tomonobu, Ohishi, Takahide, Yamano, Mayumi, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Raynaud, Florence I., Workman, Paul, Waterfield, Michael D., Parker, Peter
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
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Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2- a]pyridines as novel PI3 kinase p110α inhibitors
Hayakawa, Masahiko, Kawaguchi, Ken-ichi, Kaizawa, Hiroyuki, Koizumi, Tomonobu, Ohishi, Takahide, Yamano, Mayumi, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Raynaud, Florence I., Parker, Peter, Workman, Paul, Waterfield, Michael D.
Published in Bioorganic & medicinal chemistry (01.09.2007)
Published in Bioorganic & medicinal chemistry (01.09.2007)
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Synthesis and biological evaluation of imidazo[1,2- a]pyridine derivatives as novel PI3 kinase p110α inhibitors
Hayakawa, Masahiko, Kaizawa, Hiroyuki, Kawaguchi, Ken-ichi, Ishikawa, Noriko, Koizumi, Tomonobu, Ohishi, Takahide, Yamano, Mayumi, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Raynaud, Florence I., Waterfield, Michael D., Parker, Peter, Workman, Paul
Published in Bioorganic & medicinal chemistry (2007)
Published in Bioorganic & medicinal chemistry (2007)
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Targeting PI3KC2β Impairs Proliferation and Survival in Acute Leukemia, Brain Tumours and Neuroendocrine Tumours
BOLLER, Danielle, DOEPFNER, Kathrin T, KAIZAWA, Hiroyuki, KOIZUMI, Tomonobu, OHISHI, Takahide, FATTET, Sarah, DELATTRE, Olivier, SCHWERI-OLAC, Anelia, HÖLAND, Katrin, GROTZER, Michael A, FREI, Karl, SPERTINI, Olivier, DE LAURENTIIS, Angela, WATERFIELD, Michael D, ARCARO, Alexandre, GUERREIRO, Ana S, MARINOV, Marin, SHALABY, Tarek, DEPLEDGE, Paul, ROBSON, Anthony, SAGHIR, Nahid, HAYAKAWA, Masahiko
Published in Anticancer research (01.08.2012)
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Published in Anticancer research (01.08.2012)
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A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding
Jefferies, Harold B J, Cooke, Frank T, Jat, Parmjit, Boucheron, Christine, Koizumi, Tomonobu, Hayakawa, Masahiko, Kaizawa, Hiroyuki, Ohishi, Takahide, Workman, Paul, Waterfield, Michael D, Parker, Peter J
Published in EMBO reports (01.02.2008)
Published in EMBO reports (01.02.2008)
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Journal Article
A selective PIKfyve inhibitor blocks PtdIns(3,5)P sub(2) production and disrupts endomembrane transport and retroviral budding
Jefferies, Harold B J, Cooke, Frank T, Jat, Parmjit, Boucheron, Christine, Koizumi, Tomonobu, Hayakawa, Masahiko, Kaizawa, Hiroyuki, Ohishi, Takahide, Workman, Paul, Waterfield, Michael D, Parker, Peter J
Published in EMBO reports (01.02.2008)
Published in EMBO reports (01.02.2008)
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Journal Article
Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors
Hayakawa, Masahiko, Kaizawa, Hiroyuki, Moritomo, Hiroyuki, Koizumi, Tomonobu, Ohishi, Takahide, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Parker, Peter, Workman, Paul, Waterfield, Mike
Published in Bioorganic & medicinal chemistry (15.10.2006)
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Published in Bioorganic & medicinal chemistry (15.10.2006)
Journal Article
Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors
Hayakawa, Masahiko, Kawaguchi, Ken-Ichi, Kaizawa, Hiroyuki, Koizumi, Tomonobu, Ohishi, Takahide, Yamano, Mayumi, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-Ichi, Raynaud, Florence I, Parker, Peter, Workman, Paul, Waterfield, Michael D
Published in Bioorganic & medicinal chemistry (01.09.2007)
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Published in Bioorganic & medicinal chemistry (01.09.2007)
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Synthesis and biological evaluation of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors
Hayakawa, Masahiko, Kaizawa, Hiroyuki, Moritomo, Hiroyuki, Koizumi, Tomonobu, Ohishi, Takahide, Yamano, Mayumi, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Raynaud, Florence I, Workman, Paul, Waterfield, Michael D, Parker, Peter
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
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Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Journal Article
Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors
Hayakawa, Masahiko, Kaizawa, Hiroyuki, Kawaguchi, Ken-Ichi, Ishikawa, Noriko, Koizumi, Tomonobu, Ohishi, Takahide, Yamano, Mayumi, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-Ichi, Raynaud, Florence I, Waterfield, Michael D, Parker, Peter, Workman, Paul
Published in Bioorganic & medicinal chemistry (01.01.2007)
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Published in Bioorganic & medicinal chemistry (01.01.2007)
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PYRIDINE DERIVATIVE FOR THE TREATMENT OF NOCTURIA
TAKAMATSU, HAJIME, KAIZAWA, HIROYUKI, HIRAMOTO, MASASHI, KANAI, AKIRA, ISHIHATA, AKIHIRO, MORIKAWA, HIROSHI, HANADATE, TADAATSU, KAZAMI, JUNICHI, ENJO, KENTARO, KAWAGUCHI, KENICHI, TSUCHIYA, KAZUYUKI, INAGAKI, YUSUKE
Year of Publication 23.08.2022
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Year of Publication 23.08.2022
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