Search Results - "HIROYUKI HISAMICHI" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives

by Hisamichi, Hiroyuki, Naito, Ryo, Toyoshima, Akira, Kawano, Noriyuki, Ichikawa, Atsushi, Orita, Akiko, Orita, Masaya, Hamada, Noritaka, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (15.08.2005)

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Journal Article

YM-359445, an Orally Bioavailable Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor, Has Highly Potent Antitumor Activity against Established Tumors

YM-359445, an Orally Bioavailable Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor, Has Highly Potent Antitumor Activity against Established Tumors

by Amino, Nobuaki, Ideyama, Yukitaka, Yamano, Mayumi, Kuromitsu, Sadao, Tajinda, Katsuinori, Samizu, Kiyohiro, Hisamichi, Hiroyuki, Matsuhisa, Akira, Shirasuna, Kenna, Kudoh, Masafumi, Shibasaki, Masayuki
Published in Clinical cancer research (01.03.2006)

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Journal Article

Synthetic Studies on Selective Type 4 Phosphodiesterase (PDE 4) Inhibitors. 1. Structure–Activity Relationships and Pharmacological Evaluation of 1,8-Naphthyridin-2(1H)-one Derivatives

Synthetic Studies on Selective Type 4 Phosphodiesterase (PDE 4) Inhibitors. 1. Structure–Activity Relationships and Pharmacological Evaluation of 1,8-Naphthyridin-2(1H)-one Derivatives

by Takayama, Kazuhisa, Iwata, Masahiro, Hisamichi, Hiroyuki, Okamoto, Yoshinori, Aoki, Motonori, Niwa, Akira
Published in Chemical & pharmaceutical bulletin (01.08.2002)

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Journal Article

Discovery of ASP5878: Synthesis and structure–activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity

Discovery of ASP5878: Synthesis and structure–activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity

by Kuriwaki, Ikumi, Kameda, Minoru, Iikubo, Kazuhiko, Hisamichi, Hiroyuki, Kawamoto, Yuichiro, Kikuchi, Shigetoshi, Moritomo, Hiroyuki, Terasaka, Tadashi, Iwai, Yoshinori, Noda, Atsushi, Tomiyama, Hiroshi, Kikuchi, Aya, Hirano, Masaaki
Published in Bioorganic & medicinal chemistry (01.04.2022)

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Journal Article

Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2

Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2

by Kuriwaki, Ikumi, Kameda, Minoru, Hisamichi, Hiroyuki, Kikuchi, Shigetoshi, Iikubo, Kazuhiko, Kawamoto, Yuichiro, Moritomo, Hiroyuki, Kondoh, Yutaka, Amano, Yasushi, Tateishi, Yukihiro, Echizen, Yuka, Iwai, Yoshinori, Noda, Atsushi, Tomiyama, Hiroshi, Suzuki, Tomoyuki, Hirano, Masaaki
Published in Bioorganic & medicinal chemistry (15.05.2020)

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Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

by Kuriwaki, Ikumi, Kameda, Minoru, Iikubo, Kazuhiko, Hisamichi, Hiroyuki, Kawamoto, Yuichiro, Kikuchi, Shigetoshi, Moritomo, Hiroyuki, Kondoh, Yutaka, Terasaka, Tadashi, Amano, Yasushi, Tateishi, Yukihiro, Echizen, Yuka, Iwai, Yoshinori, Noda, Atsushi, Tomiyama, Hiroshi, Nakazawa, Taisuke, Hirano, Masaaki
Published in Bioorganic & medicinal chemistry (01.03.2021)

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Journal Article

Structure-activity Relationships of Cephalosporins Having a (Dimethylisoxazolidinio)vinyl Moiety at Their 3-Position

Structure-activity Relationships of Cephalosporins Having a (Dimethylisoxazolidinio)vinyl Moiety at Their 3-Position

by HARAI, RYUICHIRO, SAKAMOTO, KENICHIRO, HISAMICHI, HIROYUKI, NAGANO, NORIAKI
Published in Journal of antibiotics (01.11.1996)

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Journal Article

Synthesis and Biological Activity of New Cephem Compounds with a 3-(2-Butenyl)- and a 3-(1,3-Butadienyl)groupat Their 3-Position

Synthesis and Biological Activity of New Cephem Compounds with a 3-(2-Butenyl)- and a 3-(1,3-Butadienyl)groupat Their 3-Position

by HARA, RYUICHIRO, ITAHANA, HIROTSUNE, HISAMICHI, HIROYUKI, FUKUOKA, SUMIE, NAGANO, NORIAKI
Published in Journal of antibiotics (1996)

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Journal Article

Cycloaddition reactions of a 3-(1,3-butadienyl)cephalosporin and antibacterial activity of new cephem derivatives

Cycloaddition reactions of a 3-(1,3-butadienyl)cephalosporin and antibacterial activity of new cephem derivatives

by Hara, R, Itahana, H, Sakamoto, K, Hisamichi, H, Nagano, N
Published in Journal of antibiotics (01.11.1996)

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Journal Article

Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors

Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors

by Katayama, Naoko, Orita, Masaya, Yamaguchi, Tomohiko, Hisamichi, Hiroyuki, Kuromitsu, Sadao, Kurihara, Hiroyuki, Sakashita, Hitoshi, Matsumoto, Yuzo, Fujita, Shigeo, Niimi, Tatsuya
Published in Proteins, structure, function, and bioinformatics (01.12.2008)

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Journal Article

STUDIES ON β-LACTAM ANTIBIOTICS: IV. AN IMPROVED SYNTHESIS OF 3-(ISOTHIAZOLYLTHIOMETHYL)CEPHALOSPORINS AND ITS APPLICATION TO NEW DERIVATIVES

STUDIES ON β-LACTAM ANTIBIOTICS: IV. AN IMPROVED SYNTHESIS OF 3-(ISOTHIAZOLYLTHIOMETHYL)CEPHALOSPORINS AND ITS APPLICATION TO NEW DERIVATIVES

by HARA, RYUICHIRO, NAKAI, EI-ICHI, HISAMICHI, HIROYUKI, NAGANO, NORIAKI
Published in Journal of antibiotics (1994)

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Journal Article

YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine klinase inhibitor, has highly potent antitumor activity against established tumors

YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine klinase inhibitor, has highly potent antitumor activity against established tumors

by AMINO, Nobuaki, IDEYAMA, Yukitaka, SHIBASAKI, Masayuki, YAMANO, Mayumi, KUROMITSU, Sadao, TAJINDA, Katsuinori, SAMIZU, Kiyohiro, HISAMICHI, Hiroyuki, MATSUHISA, Akira, SHIRASUNA, Kenna, KUDOH, Masafumi
Published in Clinical cancer research (2006)

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Journal Article

Corrigendum to “Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives” [Bioorg. Med. Chem. 13 (2005) 4936–4951]

Corrigendum to “Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives” [Bioorg. Med. Chem. 13 (2005) 4936–4951]

by Hisamichi, Hiroyuki, Naito, Ryo, Toyoshima, Akira, Kawano, Noriyuki, Ichikawa, Atsushi, Orita, Akiko, Orita, Masaya, Hamada, Noritaka, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (01.11.2005)

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Journal Article

BENZOTHIOPHENE COMPOUND

BENZOTHIOPHENE COMPOUND

by ISHIHARA, TSUKASA, KURIWAKI, IKUMI, HISAMICHI, HIROYUKI, TAKEZAWA, RYUICHI, TAKESHITA, NOBUAKI, IKEGAI, KAZUHIRO
Year of Publication 23.03.2021

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Patent

Tetrahydroisoquinolin-1-one derivative or salt thereof

Tetrahydroisoquinolin-1-one derivative or salt thereof

by Ishihara, Tsukasa, Takuwa, Tomofumi, Maeno, Kyoichi, Shimizu, Takafumi, Hisamichi, Hiroyuki, Shimada, Itsuro, Ishikawa, Noriko, Seki, Norio
Year of Publication 14.01.2020

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Patent

TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF

TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF

by Ishihara, Tsukasa, Takuwa, Tomofumi, Maeno, Kyoichi, Shimizu, Takafumi, Hisamichi, Hiroyuki, Shimada, Itsuro, Ishikawa, Noriko, Seki, Norio
Year of Publication 03.01.2019

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Patent

BENZOTHIOPHENE COMPOUND

BENZOTHIOPHENE COMPOUND

by IKEGAI, Kazuhiro, TAKESHITA, Nobuaki, ISHIHARA, Tsukasa, TAKEZAWA, Ryuichi, HISAMICHI, Hiroyuki, KURIWAKI, Ikumi
Year of Publication 28.12.2018

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Patent

BENZOTHIOPHENE COMPOUND

BENZOTHIOPHENE COMPOUND

by ISHIHARA, TSUKASA, KURIWAKI, IKUMI, HISAMICHI, HIROYUKI, TAKEZAWA, RYUICHI, TAKESHITA, NOBUAKI, IKEGAI, KAZUHIRO
Year of Publication 28.09.2018

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Patent

BENZOTHIOPHENE COMPOUND

BENZOTHIOPHENE COMPOUND

by HISAMICHI Hiroyuki, IKEGAI Kazuhiro, KURIWAKI Ikumi, ISHIHARA Tsukasa, TAKESHITA Nobuaki, TAKEZAWA Ryuichi
Year of Publication 31.08.2018

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Patent

BENZOTHIOPHENE COMPOUND

BENZOTHIOPHENE COMPOUND

by ISHIHARA, TSUKASA, KURIWAKI, IKUMI, HISAMICHI, HIROYUKI, TAKEZAWA, RYUICHI, TAKESHITA, NOBUAKI, IKEGAI, KAZUHIRO
Year of Publication 31.07.2018

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Patent

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