Antitumor effects of eribulin depend on modulation of the tumor microenvironment by vascular remodeling in mouse models
Ito, Ken, Hamamichi, Shusei, Abe, Takanori, Akagi, Tsuyoshi, Shirota, Hiroshi, Kawano, Satoshi, Asano, Makoto, Asano, Osamu, Yokoi, Akira, Matsui, Junji, Umeda, Izumi O., Fujii, Hirofumi
Published in Cancer science (01.11.2017)
Published in Cancer science (01.11.2017)
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E6201 [(3S,4R,5Z,8S,9S,11E)-14-(Ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a Novel Kinase Inhibitor of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase (MEK)-1 and MEK Kinase-1: In Vitro Characterization of Its Anti-Inflammatory and Antihyperproliferative Activities
Goto, Masaki, Chow, Jesse, Muramoto, Kenzo, Chiba, Ken-ichi, Yamamoto, Satoshi, Fujita, Masanori, Obaishi, Hiroshi, Tai, Kenji, Mizui, Yoshiharu, Tanaka, Isao, Young, Donna, Yang, Hua, Wang, Yuan J, Shirota, Hiroshi, Gusovsky, Fabian
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
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Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III
Shen, Yongchun, Boivin, Roch, Yoneda, Naoki, Du, Hong, Schiller, Shawn, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Lemelin, Charles, Jiang, Yimin, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Schnaderbeck, Matthew, Wang, Yuan
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead, II
Shen, Yongchun, Du, Hong, Kotake, Makoto, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Li, Xiangyi, Jiang, Yimin, Schiller, Shawn, Spyvee, Mark, Davis, Heather, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Wang, Yuan
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Abstract 5927: Eribulin modulates tumor microenvironment through vascular remodeling for antitumor effect in multiple mouse xenograft models
Ito, Ken, Hamamichi, Shusei, Abe, Takanori, Akagi, Tsuyoshi, Shirota, Hiroshi, Kawano, Satoshi, Asano, Makoto, Asano, Osamu, Yokoi, Akira, Matsui, Junji, Umeda, Izumi O., Fujii, Hirofumi
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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E6201, a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-1 and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase-1: in vivo effects on cutaneous inflammatory responses by topical administration
Muramoto, Kenzo, Goto, Masaki, Inoue, Yoko, Ishii, Naoto, Chiba, Ken-ichi, Kuboi, Yoshikazu, Omae, Takao, Wang, Yuan J, Gusovsky, Fabian, Shirota, Hiroshi
Published in The Journal of pharmacology and experimental therapeutics (01.10.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2010)
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Characterization of sepsis pathogenesis using molecular biomarkers and drug treatments in the mouse CLP model (56.6)
Bender, Andrew, Wu, Yin, Burgess, Laurette, Teceno, Tyler, Skokanova, Eva, Cao, Qiongfang, Wilcoxen, Keith, Ishizaka, Sally, Shirota, Hiroshi
Published in The Journal of immunology (1950) (01.04.2011)
Published in The Journal of immunology (1950) (01.04.2011)
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ESOPHAGEAL PERFORATION DUE TO REFLUX ESOPHAGITIS TREATED BY CONSERVATIVE THERAPY-A CASE REPORT
FUJITA, Tomoyuki, MOCHIDUKI, Yasuhiro, USHIYAMA, Toshiki, OHASHI, Masahiko, SHIROTA, Hiroshi, SAKURAI, Michio, SHIMADA, Makoto
Published in Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) (2000)
Published in Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) (2000)
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Journal Article
Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead
Shen, Yongchun, Du, Hong, Kotake, Makoto, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Li, Xiangyi, Jiang, Yimin, Schiller, Shawn, Spyvee, Mark, Davis, Heather, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Wang, Yuan
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Journal Article
Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2
Shen, Yongchun, Boivin, Roch, Yoneda, Naoki, Du, Hong, Schiller, Shawn, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Lemelin, Charles, Jiang, Yimin, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Schnaderbeck, Matthew, Wang, Yuan
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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A case of intraabdominal penetration of bleeding in a pancreatic retention cyst
SUEYOSHI, Koichiro, KAJIKAWA, Shoji, SHIMADA, Kou, MIHARA, Motohiro, YAZAWA, Kazuyuki, SHIROTA, Hiroshi
Published in Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) (2011)
Published in Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) (2011)
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A case of breast metastasis mimicking inflammatory breast cancer from colon cancer
GOMI, Kuniyuki, KAJIKAWA, Syoji, SHIMADA, Kou, YAZAWA, Kazuyuki, SHIROTA, Hiroshi, NAKAMURA, Tomotsugu
Published in Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) (2010)
Published in Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) (2010)
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A case of pedunculated gastrointestinal stromal tumor of the lesser omentum presenting preoperatively as a hemoperitoneum
GOMI, Kuniyuki, SHIROTA, Hiroshi, SHIMADA, Kou, YAZAWA, Kazuyuki, KAJIKAWA, Shoji, NAKAMURA, Tomotsugu
Published in Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) (2010)
Published in Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) (2010)
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A Case of Giant Brunner's Gland Hyperplasia in the Duodenum resected by Incising the Gastric Wall
Gomi, Kuniyuki, Kajikawa, Shoji, Nishiyama, Kazutaka, Shimada, Kou, Yazawa, Kazuyuki, Shirota, Hiroshi, Nakamura, Tomotsugu
Published in Nippon Shokaki Geka Gakkai zasshi (2009)
Published in Nippon Shokaki Geka Gakkai zasshi (2009)
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3D-DIC-CT was useful to change from nonoperative management to laparotomy for hepatic injury (IIIb type): report of a case
Yazawa, Kazuyuki, Kajikawa, Shoji, Ogawa, Yoshihito, Kiguchi, Takeyuki, Kono, Michio, Shirota, Hiroshi
Published in Nihon Kyukyu Igakukai Zasshi (15.06.2009)
Published in Nihon Kyukyu Igakukai Zasshi (15.06.2009)
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Stimulation of prostaglandin synthesis in cultured rat synovial cells by a factor derived from polymorphonuclear leukocytes
Hashida, Ryoichi, Kobayashi, Seiichi, Shirota, Hiroshi, Yoshimatsu, Kentaro, Ohsawa, Suguru, Hori, Hisae, Nagai, Yutaka
Published in Prostaglandins (01.05.1984)
Published in Prostaglandins (01.05.1984)
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