Modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice
Yamada, Daisuke, Takahashi, Junpei, Iio, Keita, Nagase, Hiroshi, Saitoh, Akiyoshi
Published in Biochemical and biophysical research communications (30.06.2021)
Published in Biochemical and biophysical research communications (30.06.2021)
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Delta Opioid Receptor Agonists Ameliorate Colonic Inflammation by Modulating Immune Responses
Nagata, Kazuki, Nagase, Hiroshi, Okuzumi, Ayumi, Nishiyama, Chiharu
Published in Frontiers in immunology (22.09.2021)
Published in Frontiers in immunology (22.09.2021)
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Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models
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Published in Proceedings of the National Academy of Sciences - PNAS (30.05.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (30.05.2017)
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KNT-127, a selective delta opioid receptor agonist, shows beneficial effects in the hippocampal dentate gyrus of a chronic vicarious social defeat stress mouse model
Yoshioka, Toshinori, Yamada, Daisuke, Segi-Nishida, Eri, Nagase, Hiroshi, Saitoh, Akiyoshi
Published in Neuropharmacology (01.07.2023)
Published in Neuropharmacology (01.07.2023)
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Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord
Kardon, Adam P., Polgár, Erika, Hachisuka, Junichi, Snyder, Lindsey M., Cameron, Darren, Savage, Sinead, Cai, Xiaoyun, Karnup, Sergei, Fan, Christopher R., Hemenway, Gregory M., Bernard, Carcha S., Schwartz, Erica S., Nagase, Hiroshi, Schwarzer, Christoph, Watanabe, Masahiko, Furuta, Takahiro, Kaneko, Takeshi, Koerber, H. Richard, Todd, Andrew J., Ross, Sarah E.
Published in Neuron (Cambridge, Mass.) (07.05.2014)
Published in Neuron (Cambridge, Mass.) (07.05.2014)
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Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists
Nagahara, Takashi, Saitoh, Tsuyoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Kuroda, Daisuke, Gouda, Hiroaki, Kumagai, Hidetoshi, Fujii, Hideaki, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
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Design and Synthesis of Orexin 1 Receptor-Selective Agonists
Iio, Keita, Hashimoto, Kao, Nagumo, Yasuyuki, Amezawa, Mao, Hasegawa, Taisei, Yamamoto, Naoshi, Kutsumura, Noriki, Takeuchi, Katsuhiko, Ishikawa, Yukiko, Yamamoto, Hikari, Tokuda, Akihisa, Sato, Tetsu, Uchida, Yasuo, Inoue, Asuka, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi, Saitoh, Tsuyoshi
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy
Yamamoto, Hikari, Nagumo, Yasuyuki, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Namekawa, Yukiko, Nemoto, Tsuyoshi, Tanaka, Hiromu, Takahashi, Genki, Tokuda, Akihisa, Saitoh, Tsuyoshi, Nagase, Hiroshi, Funato, Hiromasa, Yanagisawa, Masashi
Published in PloS one (22.07.2022)
Published in PloS one (22.07.2022)
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Role for μ-opioid receptor in antidepressant effects of δ-opioid receptor agonist KNT-127
Moriya, Yuki, Kasahara, Yoshiyuki, Shimada, Masafumi, Sakakibara, Yasufumi, Fujii, Hideaki, Nagase, Hiroshi, Ide, Soichiro, Ikeda, Kazutaka, Hall, F. Scott, Uhl, George R., Sora, Ichiro
Published in Journal of pharmacological sciences (01.03.2023)
Published in Journal of pharmacological sciences (01.03.2023)
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Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation
Shokirova, Hurramhon, Inomata, Takenori, Saitoh, Tsuyoshi, Zhu, Jun, Fujio, Kenta, Okumura, Yuichi, Yanagawa, Ai, Fujimoto, Keiichi, Sung, Jaemyoung, Eguchi, Atsuko, Miura, Maria, Nagino, Ken, Hirosawa, Kunihiko, Kuwahara, Mizu, Akasaki, Yasutsugu, Nagase, Hiroshi, Murakami, Akira
Published in Scientific reports (21.04.2021)
Published in Scientific reports (21.04.2021)
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Cold-Restraint Stress-Induced Ultrasonic Vocalization as a Novel Tool to Measure Anxiety in Mice
Yamauchi, Tsugumi, Yoshioka, Toshinori, Yamada, Daisuke, Hamano, Takumi, Ohashi, Misaki, Matsumoto, Maki, Iio, Keita, Ikeda, Maika, Kamei, Masato, Otsuki, Takaya, Sato, Yasuo, Nii, Kyoko, Suzuki, Masashi, Ichikawa, Hiroko, Nagase, Hiroshi, Iriyama, Satoshi, Yoshizawa, Kazumi, Nishino, Shoichi, Miyazaki, Satoru, Saitoh, Akiyoshi
Published in Biological & pharmaceutical bulletin (01.03.2022)
Published in Biological & pharmaceutical bulletin (01.03.2022)
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Selective δ-Opioid Receptor Agonist, KNT-127, Facilitates Contextual Fear Extinction via Infralimbic Cortex and Amygdala in Mice
Kawaminami, Ayako, Yamada, Daisuke, Yanagisawa, Shoko, Shirakata, Motoki, Iio, Keita, Nagase, Hiroshi, Saitoh, Akiyoshi
Published in Frontiers in behavioral neuroscience (21.02.2022)
Published in Frontiers in behavioral neuroscience (21.02.2022)
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Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring
Iio, Keita, Saitoh, Tsuyoshi, Ohshita, Ryuichiro, Hino, Tsubasa, Amezawa, Mao, Takayama, Yoshiaki, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (15.03.2022)
Published in Bioorganic & medicinal chemistry letters (15.03.2022)
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Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton
Hino, Tsubasa, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
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Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
Wang, Yibing, Cao, Liqin, Lee, Chia-Ying, Matsuo, Tomohiko, Wu, Kejia, Asher, Greg, Tang, Lijun, Saitoh, Tsuyoshi, Russell, Jamie, Klewe-Nebenius, Daniela, Wang, Li, Soya, Shingo, Hasegawa, Emi, Chérasse, Yoan, Zhou, Jiamin, Li, Yuwenbin, Wang, Tao, Zhan, Xiaowei, Miyoshi, Chika, Irukayama, Yoko, Cao, Jie, Meeks, Julian P., Gautron, Laurent, Wang, Zhiqiang, Sakurai, Katsuyasu, Funato, Hiromasa, Sakurai, Takeshi, Yanagisawa, Masashi, Nagase, Hiroshi, Kobayakawa, Reiko, Kobayakawa, Ko, Beutler, Bruce, Liu, Qinghua
Published in Nature communications (23.05.2018)
Published in Nature communications (23.05.2018)
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Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives
Katoh, Koki, Kutsumura, Noriki, Yamamoto, Naoshi, Nagumo, Yasuyuki, Saitoh, Tsuyoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
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Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands
Iio, Keita, Kutsumura, Noriki, Nagumo, Yasuyuki, Saitoh, Tsuyoshi, Tokuda, Akihisa, Hashimoto, Kao, Yamamoto, Naoshi, Kise, Ryoji, Inoue, Asuka, Mizoguchi, Hirokazu, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (15.01.2022)
Published in Bioorganic & medicinal chemistry letters (15.01.2022)
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Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors
Roy, Koustav, Zhou, Xuzhao, Otani, Rintaro, Yuan, Ping-Chuan, Ioka, Shuji, Vogt, Kaspar E., Kondo, Tamae, Farag, Nouran H. T., Ijiri, Haruto, Wu, Zhaofa, Chitose, Youhei, Amezawa, Mao, Uygun, David S., Cherasse, Yoan, Nagase, Hiroshi, Li, Yulong, Yanagisawa, Masashi, Abe, Manabu, Basheer, Radhika, Wang, Yi-Qun, Saitoh, Tsuyoshi, Lazarus, Michael
Published in Nature communications (30.04.2024)
Published in Nature communications (30.04.2024)
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