Syntheses of 10-Oxo, 10α-Hydroxy, and 10β-Hydroxy Derivatives of a Potent κ-Opioid Receptor Agonist, TRK-820
Horikiri, Hiromasa, Hirano, Noriyuki, Tanaka, Yoichiro, Oishi, Junji, Hatakeyama, Hitoshi, Kawamura, Kuniaki, Nagase, Hiroshi
Published in Chemical & pharmaceutical bulletin (01.06.2004)
Published in Chemical & pharmaceutical bulletin (01.06.2004)
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Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epox-ymorphinan derivatives for orexin and opioid receptors
Katoh, Koki, Yamamoto, Naoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Tanimura, Ryuji, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Kutsumura, Noriki, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
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Delta-1 Opioid Receptor-Mediated Antinociceptive Properties of a Nonpeptidic Delta Opioid Receptor Agonist, (â)TAN-67, in the Mouse Spinal Cord
Tseng, L F, Narita, M, Mizoguchi, H, Kawai, K, Mizusuna, A, Kamei, J, Suzuki, T, Nagase, H
Published in The Journal of pharmacology and experimental therapeutics (01.02.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.02.1997)
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Syntheses of 10-Oxo, 10.ALPHA.-Hydroxy, and 10.BETA.-Hydroxy Derivatives of a Potent .KAPPA.-Opioid Receptor Agonist, TRK-820
Horikiri, Hiromasa, Hirano, Noriyuki, Tanaka, Yoichiro, Oishi, Junji, Hatakeyama, Hitoshi, Kawamura, Kuniaki, Nagase, Hiroshi
Published in Chemical & pharmaceutical bulletin (2004)
Published in Chemical & pharmaceutical bulletin (2004)
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Non-peptidic δ opioid receptor agonists and antagonists (2000 - 2012)
Fujii, Hideaki, Takahashi, Toshihiro, Nagase, Hiroshi
Published in Expert opinion on therapeutic patents (01.09.2013)
Published in Expert opinion on therapeutic patents (01.09.2013)
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The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions
Saitoh, Akiyoshi, Sugiyama, Azusa, Nemoto, Toru, Fujii, Hideaki, Wada, Keiji, Oka, Jun-Ichiro, Nagase, Hiroshi, Yamada, Mitsuhiko
Published in Behavioural brain research (01.10.2011)
Published in Behavioural brain research (01.10.2011)
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Asymmetric induction in cyclohexadienones carrying α-d-glucopyranosyl moiety
Yajima, Saki, Saitoh, Tsuyoshi, Kawa, Kohei, Nakamura, Kensuke, Nagase, Hiroshi, Einaga, Yasuaki, Nishiyama, Shigeru
Published in Tetrahedron (22.12.2016)
Published in Tetrahedron (22.12.2016)
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Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine
Nagumo, Yasuyuki, Katoh, Koki, Iio, Keita, Saitoh, Tsuyoshi, Kutsumura, Noriki, Yamamoto, Naoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Baba, Takeshi, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
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Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatri-quinane bearing multiple effective residues (TriMER) library
Saitoh, Tsuyoshi, Amezawa, Mao, Horiuchi, Jumpei, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Ohshita, Ryuichiro, Tokuda, Akihisa, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Hasegawa, Emi, Sakurai, Takeshi, Uchida, Yasuo, Sato, Tetsu, Gouda, Hiroaki, Tanimura, Ryuji, Yangisawa, Masashi, Nagase, Hiroshi
Published in European journal of medicinal chemistry (05.10.2022)
Published in European journal of medicinal chemistry (05.10.2022)
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Antinociceptive effects of (+)-matrine in mice
Kamei, Junzo, Xiao, Ping, Ohsawa, Masahiro, Kubo, Hajime, Higashiyama, Kimio, Takahashi, Hiroshi, Li, Jiashi, Nagase, Hiroshi, Ohmiya, Shigeru
Published in European journal of pharmacology (22.10.1997)
Published in European journal of pharmacology (22.10.1997)
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Antinociceptive effect of buprenorphine in μ1-opioid receptor deficient CXBK mice
Kamei, Junzo, Sodeyama, Midori, Tsuda, Makoto, Suzuki, Tsutomu, Nagase, Hiroshi
Published in Life sciences (1973) (01.04.1997)
Published in Life sciences (1973) (01.04.1997)
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Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function
Korkutata, Mustafa, Saitoh, Tsuyoshi, Cherasse, Yoan, Ioka, Shuji, Duo, Feng, Qin, Rujie, Murakoshi, Nobuyuki, Fujii, Shinya, Zhou, Xuzhao, Sugiyama, Fumihiro, Chen, Jiang-Fan, Kumagai, Hidetoshi, Nagase, Hiroshi, Lazarus, Michael
Published in Neuropharmacology (01.01.2019)
Published in Neuropharmacology (01.01.2019)
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Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies
Nagase, Hiroshi, Yamamoto, Naoshi, Yata, Masahiro, Ohrui, Sayaka, Okada, Takahiro, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Ogawa, Yasuhiro, Hirayama, Shigeto, Kuroda, Daisuke, Watanabe, Yurie, Gouda, Hiroaki, Yanagisawa, Masashi
Published in Journal of medicinal chemistry (09.02.2017)
Published in Journal of medicinal chemistry (09.02.2017)
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Synthesis of optically active cyclopenta[b]benzofuran as a precursor of m-phenyleneprostacyclin
Nishiyama, H, Sakata, N, Sugimoto, H, Motoyama, Y, Wakita, H, Nagase, H
Published in Synlett (01.08.1998)
Published in Synlett (01.08.1998)
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Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists
Nemoto, Toru, Iihara, Yusuke, Hirayama, Shigeto, Iwai, Takashi, Higashi, Eika, Fujii, Hideaki, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.08.2015)
Published in Bioorganic & medicinal chemistry letters (01.08.2015)
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