Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
Solca, Flavio, Dahl, Goeran, Zoephel, Andreas, Bader, Gerd, Sanderson, Michael, Klein, Christian, Kraemer, Oliver, Himmelsbach, Frank, Haaksma, Eric, Adolf, Guenther R
Published in The Journal of pharmacology and experimental therapeutics (01.11.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2012)
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Journal Article
(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a Novel Xanthine-Based Dipeptidyl Peptidase 4 Inhibitor, Has a Superior Potency and Longer Duration of Action Compared with Other Dipeptidyl Peptidase-4 Inhibitors
Thomas, Leo, Eckhardt, Matthias, Langkopf, Elke, Tadayyon, Moh, Himmelsbach, Frank, Mark, Michael
Published in The Journal of pharmacology and experimental therapeutics (01.04.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2008)
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Journal Article
Inhibition of Epidermal Growth Factor Receptor Activity by Two Pyrimidopyrimidine Derivatives
Solca, Flavio F, Baum, Anke, Langkopf, Elke, Dahmann, Georg, Heider, Karl-Heinz, Himmelsbach, Frank, van Meel, Jacques C A
Published in The Journal of pharmacology and experimental therapeutics (01.11.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2004)
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Journal Article
Sequential C–H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD‑1 Inhibitor
Wei, Xudong, Qu, Bo, Zeng, Xingzhong, Savoie, Jolaine, Fandrick, Keith R, Desrosiers, Jean-Nicolas, Tcyrulnikov, Sergei, Marsini, Maurice A, Buono, Frederic G, Li, Zhibin, Yang, Bing-Shiou, Tang, Wenjun, Haddad, Nizar, Gutierrez, Osvaldo, Wang, Jun, Lee, Heewon, Ma, Shengli, Campbell, Scot, Lorenz, Jon C, Eckhardt, Matthias, Himmelsbach, Frank, Peters, Stefan, Patel, Nitinchandra D, Tan, Zhulin, Yee, Nathan K, Song, Jinhua J, Roschangar, Frank, Kozlowski, Marisa C, Senanayake, Chris H
Published in Journal of the American Chemical Society (30.11.2016)
Published in Journal of the American Chemical Society (30.11.2016)
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SYNTHESIS OF 1:1:1 CO-CRYSTAL OF 1-CYANO-2-(4-CYCLOPROPYL-BENZYL)-4-(β-D-GLUCOPYRANOS-1-YL)-BENZENE, L-PROLINE AND WATER
ECKHARDT MATTHIAS, SHU CHUTIAN, WANG XIAO-JUN, STEFAN SAHLI, BEAT THEODOR WEBER, MONIKA BRINK, HIMMELSBACH FRANK, YANG BING-SHIOU
Year of Publication 21.11.2023
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Year of Publication 21.11.2023
Patent
Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes
Hamilton, Bradford S., Himmelsbach, Frank, Nar, Herbert, Schuler-Metz, Annette, Krosky, Paula, Guo, Joan, Guo, Rong, Meng, Shi, Zhao, Yi, Lala, Deepak S., Zhuang, Linghang, Claremon, David A., McGeehan, Gerard M.
Published in European journal of pharmacology (05.01.2015)
Published in European journal of pharmacology (05.01.2015)
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8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes
Eckhardt, Matthias, Langkopf, Elke, Mark, Michael, Tadayyon, Moh, Thomas, Leo, Nar, Herbert, Pfrengle, Waldemar, Guth, Brian, Lotz, Ralf, Sieger, Peter, Fuchs, Holger, Himmelsbach, Frank
Published in Journal of medicinal chemistry (27.12.2007)
Published in Journal of medicinal chemistry (27.12.2007)
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SYNTHESIS OF 1: 1: 1 CO-CRYSTAL CONSISTING OF 1-CYANO-2-(4-CYCLOPROPYL-BENZYL)-4-(β-D-GLUCOPYRANOS-1-YL)-BENZENE, L-PROLINE AND WATER
ECKHARDT MATTHIAS, SHU CHUTIAN, WANG XIAO-JUN, STEFAN SAHLI, BEAT THEODOR WEBER, MONIKA BRINK, HIMMELSBACH FRANK, YANG BING-SHIOU
Year of Publication 23.12.2021
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Year of Publication 23.12.2021
Patent
Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor
Zhuang, Linghang, Tice, Colin M., Xu, Zhenrong, Zhao, Wei, Cacatian, Salvacion, Ye, Yuan-Jie, Singh, Suresh B., Lindblom, Peter, McKeever, Brian M., Krosky, Paula M., Zhao, Yi, Lala, Deepak, Kruk, Barbara A., Meng, Shi, Howard, Lamont, Johnson, Judith A., Bukhtiyarov, Yuri, Panemangalore, Reshma, Guo, Joan, Guo, Rong, Himmelsbach, Frank, Hamilton, Bradford, Schuler-Metz, Annette, Schauerte, Heike, Gregg, Richard, McGeehan, Gerard M., Leftheris, Katerina, Claremon, David A.
Published in Bioorganic & medicinal chemistry (15.07.2017)
Published in Bioorganic & medicinal chemistry (15.07.2017)
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