Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)
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Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase
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Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
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SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors
Heron, Nicola M., Anderson, Malcolm, Blowers, David P., Breed, Jason, Eden, Jonathan M., Green, Stephen, Hill, George B., Johnson, Trevor, Jung, Frederic H., McMiken, Helen H.J., Mortlock, Andrew A., Pannifer, Andrew D., Pauptit, Richard A., Pink, Jennifer, Roberts, Nicola J., Rowsell, Siân
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor
Finlay, M. Raymond V, Anderton, Mark, Ashton, Susan, Ballard, Peter, Bethel, Paul A, Box, Matthew R, Bradbury, Robert H, Brown, Simon J, Butterworth, Sam, Campbell, Andrew, Chorley, Christopher, Colclough, Nicola, Cross, Darren A. E, Currie, Gordon S, Grist, Matthew, Hassall, Lorraine, Hill, George B, James, Daniel, James, Michael, Kemmitt, Paul, Klinowska, Teresa, Lamont, Gillian, Lamont, Scott G, Martin, Nathaniel, McFarland, Heather L, Mellor, Martine J, Orme, Jonathon P, Perkins, David, Perkins, Paula, Richmond, Graham, Smith, Peter, Ward, Richard A, Waring, Michael J, Whittaker, David, Wells, Stuart, Wrigley, Gail L
Published in Journal of medicinal chemistry (23.10.2014)
Published in Journal of medicinal chemistry (23.10.2014)
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Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors
Jung, Frédéric H, Pasquet, Georges, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques M, Warin, Nicolas, Renaud, Fabrice, Germain, Hervé, De Savi, Chris, Roberts, Nicola, Johnson, Trevor, Dousson, Cyril, Hill, George B, Mortlock, Andrew A, Heron, Nicola, Wilkinson, Robert W, Wedge, Stephen R, Heaton, Simon P, Odedra, Rajesh, Keen, Nicholas J, Green, Stephen, Brown, Elaine, Thompson, Katherine, Brightwell, Stephen
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: Selective inhibitors of Aurora B kinase with potent anti-tumor activity
Foote, Kevin M., Mortlock, Andrew A., Heron, Nicola M., Jung, Frédéric H., Hill, George B., Pasquet, Georges, Brady, Madeleine C., Green, Stephen, Heaton, Simon P., Kearney, Sarah, Keen, Nicholas J., Odedra, Rajesh, Wedge, Stephen R., Wilkinson, Robert W.
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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SARr and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors
HERON, Nicola M, ANDERSON, Malcolm, MORTLOCK, Andrew A, PANNIFER, Andrew D, PAUPTIT, Richard A, PINK, Jennifer, ROBERTS, Nicola J, ROWSELL, Sian, BLOWERS, David P, BREED, Jason, EDEN, Jonathan M, GREEN, Stephen, HILL, George B, JOHNSON, Trevor, JUNG, Frederic H, MCMIKEN, Helen H. J
Published in Bioorganic & medicinal chemistry letters (2006)
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Published in Bioorganic & medicinal chemistry letters (2006)
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Approaches to the design of anti-fibrotic drugs
Franklin, T J, Hales, N J, Johnstone, D, Morris, W B, Cunliffe, C J, Millest, A J, Hill, G B
Published in Biochemical Society transactions (01.11.1991)
Published in Biochemical Society transactions (01.11.1991)
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