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McNae, Iain W., Kinkead, James, Malik, Divya, Yen, Li-Hsuan, Walker, Martin K., Swain, Chris, Webster, Scott P., Gray, Nick, Fernandes, Peter M., Myburgh, Elmarie, Blackburn, Elizabeth A., Ritchie, Ryan, Austin, Carol, Wear, Martin A., Highton, Adrian J., Keats, Andrew J., Vong, Antonio, Dornan, Jacqueline, Mottram, Jeremy C., Michels, Paul A. M., Pettit, Simon, Walkinshaw, Malcolm D.
Published in Nature communications (16.02.2021)
Published in Nature communications (16.02.2021)
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Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides
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Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle
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Pharmacokinetic Benefits of 3,4-Dimethoxy Substitution of a Phenyl Ring and Design of Isosteres Yielding Orally Available Cathepsin K Inhibitors
Crawford, James J, Kenny, Peter W, Bowyer, Jonathan, Cook, Calum R, Finlayson, Jonathan E, Heyes, Christine, Highton, Adrian J, Hudson, Julian A, Jestel, Anja, Krapp, Stephan, Martin, Scott, MacFaul, Philip A, McDermott, Benjamin P, McGuire, Thomas M, Morley, Andrew D, Morris, Jeffrey J, Page, Ken M, Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline, Dossetter, Alexander G
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
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Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition
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Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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(1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor for the Treatment of Osteoarthritis
Dossetter, Alexander G, Beeley, Howard, Bowyer, Jonathan, Cook, Calum R, Crawford, James J, Finlayson, Jonathan E, Heron, Nicola M, Heyes, Christine, Highton, Adrian J, Hudson, Julian A, Jestel, Anja, Kenny, Peter W, Krapp, Stephan, Martin, Scott, MacFaul, Philip A, McGuire, Thomas M, Gutierrez, Pablo Morentin, Morley, Andrew D, Morris, Jeffrey J, Page, Ken M, Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline, Vickers, Madeleine
Published in Journal of medicinal chemistry (26.07.2012)
Published in Journal of medicinal chemistry (26.07.2012)
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Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis
Cumming, John G., Tucker, Howard, Oldfield, John, Fielding, Colin, Highton, Adrian, Faull, Alan, Wild, Martin, Brown, Dearg, Wells, Stuart, Shaw, John
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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(1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b)indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor for the Treatment of Osteoarthritis
Dossetter, Alexander G., Beeley, Howard, Bowyer, Jonathan, Cook, Calum R., Crawford, James J., Finlayson, Jonathan E., Heron, Nicola M., Heyes, Christine, Highton, Adrian J., Hudson, Julian A., Jestel, Anja, Kenny, Peter W., Krapp, Stephan, Martin, Scott, MacFaul, Philip A., McGuire, Thomas M., Gutierrez, Pablo Morentin, Morley, Andrew D., Morris, Jeffrey J., Page, Ken M., Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline, Vickers, Madeleine
Published in Journal of medicinal chemistry (26.07.2012)
Published in Journal of medicinal chemistry (26.07.2012)
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A Total Synthesis of Galbonolide B
Parsons, Philip J, Pennicott, Lewis, Eshelby, James, Goessman, Matthias, Highton, Adrian, Hitchcock, Peter
Published in Journal of organic chemistry (23.11.2007)
Published in Journal of organic chemistry (23.11.2007)
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Model studies for the synthesis of galbonolide B
Eshelby, J, Goessman, M, Parsons, PJ, Pennicotta, L, Highton, A
Published in Organic & biomolecular chemistry (21.08.2005)
Published in Organic & biomolecular chemistry (21.08.2005)
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Year of Publication 25.08.2021
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Macrocyclic inhibitors of flaviviridae viruses
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Year of Publication 12.11.2019
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Macrocyclic inhibitors of flaviviridae viruses
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Year of Publication 02.04.2019
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