Iba-1-/CD68+ microglia are a prominent feature of age-associated deep subcortical white matter lesions
Waller, Rachel, Baxter, Lynne, Fillingham, Daniel J, Coelho, Santiago, Pozo, Jose M, Mozumder, Meghdoot, Frangi, Alejandro F, Ince, Paul G, Simpson, Julie E, Highley, J Robin
Published in PloS one (2019)
Published in PloS one (2019)
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Journal Article
Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions
COOPER-KNOCK, Johnathan, WALSH, Matthew J, HAUTBERGUE, Guillaume M, SHAW, Pamela J, HIGGINBOTTOM, Adrian, HIGHLEY, J. Robin, DICKMAN, Mark J, EDBAUER, Dieter, INCE, Paul G, WHARTON, Stephen B, WILSON, Stuart A, KIRBY, Janine
Published in Brain (London, England : 1878) (01.07.2014)
Published in Brain (London, England : 1878) (01.07.2014)
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Journal Article
ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles
An, Haiyan, Skelt, Lucy, Notaro, Antonietta, Highley, J Robin, Fox, Archa H, La Bella, Vincenzo, Buchman, Vladimir L, Shelkovnikova, Tatyana A
Published in Acta neuropathologica communications (14.01.2019)
Published in Acta neuropathologica communications (14.01.2019)
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Journal Article
Spinal muscular atrophy: Factors that modulate motor neurone vulnerability
Tu, Wen-Yo, Simpson, Julie E, Robin Highley, J, Heath, Paul R
Published in Neurobiology of disease (01.06.2017)
Published in Neurobiology of disease (01.06.2017)
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Journal Article
Proteinopathies as Hallmarks of Impaired Gene Expression, Proteostasis and Mitochondrial Function in Amyotrophic Lateral Sclerosis
Benson, Bridget C, Shaw, Pamela J, Azzouz, Mimoun, Highley, J Robin, Hautbergue, Guillaume M
Published in Frontiers in neuroscience (23.12.2021)
Published in Frontiers in neuroscience (23.12.2021)
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Journal Article
C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis
Cooper-Knock, Johnathan, Bury, Joanna J, Heath, Paul R, Wyles, Matthew, Higginbottom, Adrian, Gelsthorpe, Catherine, Highley, J Robin, Hautbergue, Guillaume, Rattray, Magnus, Kirby, Janine, Shaw, Pamela J
Published in PloS one (27.05.2015)
Published in PloS one (27.05.2015)
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Journal Article
Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology
Ince, Paul G., Highley, J. Robin, Kirby, Janine, Wharton, Stephen B., Takahashi, Hitoshi, Strong, Michael J., Shaw, Pamela J.
Published in Acta neuropathologica (01.12.2011)
Published in Acta neuropathologica (01.12.2011)
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Journal Article
Pre-clinical development of AP4B1 gene replacement therapy for hereditary spastic paraplegia type 47
Wiseman, Jessica P, Scarrott, Joseph M, Alves-Cruzeiro, João, Saffari, Afshin, Böger, Cedric, Karyka, Evangelia, Dawes, Emily, Davies, Alexandra K, Marchi, Paolo M, Graves, Emily, Fernandes, Fiona, Yang, Zih-Liang, Coldicott, Ian, Hirst, Jennifer, Webster, Christopher P, Highley, J Robin, Hackett, Neil, Angyal, Adrienn, Silva, Thushan de, Higginbottom, Adrian, Shaw, Pamela J, Ferraiuolo, Laura, Ebrahimi-Fakhari, Darius, Azzouz, Mimoun
Published in EMBO molecular medicine (11.11.2024)
Published in EMBO molecular medicine (11.11.2024)
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Journal Article
Concomitant idiopathic hypertrophic spinal pachymeningitis and Guillain-Barré syndrome in a patient: coincidence or a triggering mechanism?
Olubajo, Farouk, Yermakova, Tatyana, Highley, J Robin, Arzoglou, Vasileios
Published in Journal of neurosurgery. Spine (01.09.2017)
Published in Journal of neurosurgery. Spine (01.09.2017)
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Journal Article
A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis
Cooper-Knock, Johnathan, Green, Claire, Altschuler, Gabriel, Wei, Wenbin, Bury, Joanna J, Heath, Paul R, Wyles, Matthew, Gelsthorpe, Catherine, Highley, J Robin, Lorente-Pons, Alejandro, Beck, Tim, Doyle, Kathryn, Otero, Karel, Traynor, Bryan, Kirby, Janine, Shaw, Pamela J, Hide, Winston
Published in Acta neuropathologica communications (16.03.2017)
Published in Acta neuropathologica communications (16.03.2017)
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Journal Article
A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations
Allen, Scott P, Al Sultan, Afnan, Kabucho Kibirige, Elaine, Tonkiss, Erin, Hamer, Keaton J, Castelli, Lydia M, Lin, Ya-Hui, Roscoe, Sarah, Stefanidis, Nikolaos, Mead, Richard J, Highley, J Robin, Cooper-Knock, Johnathan, Hautbergue, Guillaume M, Heath, Paul R, Kirby, Janine, Shaw, Pamela J
Published in Frontiers in aging neuroscience (11.05.2023)
Published in Frontiers in aging neuroscience (11.05.2023)
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Journal Article
Quantitative histomorphometry of capillary microstructure in deep white matter
Mozumder, Meghdoot, Pozo, Jose M, Coelho, Santiago, Costantini, Marina, Simpson, Julie, Highley, J Robin, Ince, Paul G, Frangi, Alejandro F
Published in NeuroImage clinical (01.01.2019)
Published in NeuroImage clinical (01.01.2019)
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Journal Article
Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy
Boyd, Penelope J, Tu, Wen-Yo, Shorrock, Hannah K, Groen, Ewout J N, Carter, Roderick N, Powis, Rachael A, Thomson, Sophie R, Thomson, Derek, Graham, Laura C, Motyl, Anna A L, Wishart, Thomas M, Highley, J Robin, Morton, Nicholas M, Becker, Thomas, Becker, Catherina G, Heath, Paul R, Gillingwater, Thomas H
Published in PLoS genetics (20.04.2017)
Published in PLoS genetics (20.04.2017)
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Journal Article
Histological data of axons, astrocytes, and myelin in deep subcortical white matter populations
Coelho, Santiago, Pozo, Jose M., Costantini, Marina, Highley, J. Robin, Mozumder, Meghdoot, Simpson, Julie E., Ince, Paul G., Frangi, Alejandro F.
Published in Data in brief (01.04.2019)
Published in Data in brief (01.04.2019)
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Journal Article
Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy
Cooper-Knock, Johnathan, Higginbottom, Adrian, Stopford, Matthew J., Highley, J. Robin, Ince, Paul G., Wharton, Stephen B., Pickering-Brown, Stuart, Kirby, Janine, Hautbergue, Guillaume M., Shaw, Pamela J.
Published in Acta neuropathologica (01.07.2015)
Published in Acta neuropathologica (01.07.2015)
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Journal Article
Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72
COOPER-KNOCK, Johnathan, HEWITT, Christopher, BAXTER, Lynne, FORSTER, Gillian, FOX, Melanie, BURY, Joanna, MOK, Kin, MCDERMOTT, Christopher J, TRAYNOR, Bryan J, KIRBY, Janine, WHARTON, Stephen B, INCE, Paul G, HIGHLY, J. Robin, HARDY, John, SHAW, Pamela J, BROCKINGTON, Alice, MILANO, Antonio, MAN, Somai, MARTINDALE, Joanne, HARTLEY, Judith, WALSH, Theresa, GELSTHORPE, Catherine
Published in Brain (London, England : 1878) (01.03.2012)
Published in Brain (London, England : 1878) (01.03.2012)
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Journal Article
Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis
Lorente Pons, Alejandro, Higginbottom, Adrian, Cooper‐Knock, Johnathan, Alrafiah, Aziza, Alofi, Ebtisam, Kirby, Janine, Shaw, Pamela J, Wood, Jonathan D, Highley, J Robin
Published in The Journal of pathology (01.07.2020)
Published in The Journal of pathology (01.07.2020)
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Journal Article
Anomalous Asymmetry of Fusiform and Parahippocampal Gyrus Gray Matter in Schizophrenia: A Postmortem Study
McDonald, Brendan, Highley, J. Robin, Walker, Mary A., Herron, Brian M., Cooper, Stephen J., Esiri, Margaret M., Crow, Timothy J.
Published in The American journal of psychiatry (01.01.2000)
Published in The American journal of psychiatry (01.01.2000)
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Journal Article
Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death
Keatinge, Marcus, Bui, Hai, Menke, Aswin, Chen, Yu-Chia, Sokol, Anna M, Bai, Qing, Ellett, Felix, Da Costa, Marc, Burke, Derek, Gegg, Matthew, Trollope, Lisa, Payne, Thomas, McTighe, Aimee, Mortiboys, Heather, de Jager, Sarah, Nuthall, Hugh, Kuo, Ming-Shang, Fleming, Angeleen, Schapira, Anthony H V, Renshaw, Stephen A, Highley, J Robin, Chacinska, Agnieszka, Panula, Pertti, Burton, Edward A, O'Neill, Michael J, Bandmann, Oliver
Published in Human molecular genetics (01.12.2015)
Published in Human molecular genetics (01.12.2015)
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