Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations
McInnes, Iain B, Byers, Nicole L, Higgs, Richard E, Lee, Jonathan, Macias, William L, Na, Songqing, Ortmann, Robert A, Rocha, Guilherme, Rooney, Terence P, Wehrman, Thomas, Zhang, Xin, Zuckerman, Steven H, Taylor, Peter C
Published in Arthritis research & therapy (02.08.2019)
Published in Arthritis research & therapy (02.08.2019)
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Journal Article
Identification of druggable cancer driver genes amplified across TCGA datasets
Chen, Ying, McGee, Jeremy, Chen, Xianming, Doman, Thompson N, Gong, Xueqian, Zhang, Youyan, Hamm, Nicole, Ma, Xiwen, Higgs, Richard E, Bhagwat, Shripad V, Buchanan, Sean, Peng, Sheng-Bin, Staschke, Kirk A, Yadav, Vipin, Yue, Yong, Kouros-Mehr, Hosein
Published in PloS one (29.05.2014)
Published in PloS one (29.05.2014)
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Journal Article
Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry
Kellie, John F., Higgs, Richard E., Ryder, John W., Major, Anthony, Beach, Thomas G., Adler, Charles H., Merchant, Kalpana, Knierman, Michael D.
Published in Scientific reports (23.07.2014)
Published in Scientific reports (23.07.2014)
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Journal Article
Assessment and Clinical Relevance of Serum IL-19 Levels in Psoriasis and Atopic Dermatitis Using a Sensitive and Specific Novel Immunoassay
Konrad, Robert J., Higgs, Richard E., Rodgers, George H., Ming, Wenyu, Qian, Yue-Wei, Bivi, Nicoletta, Mack, Justin K., Siegel, Robert W., Nickoloff, Brian J.
Published in Scientific reports (26.03.2019)
Published in Scientific reports (26.03.2019)
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Journal Article
Relationship between gene expression patterns from nasopharyngeal swabs and serum biomarkers in patients hospitalized with COVID-19, following treatment with the neutralizing monoclonal antibody bamlanivimab
Sims, Jonathan T, Poorbaugh, Josh, Chang, Ching-Yun, Holzer, Timothy R, Zhang, Lin, Engle, Sarah M, Beasley, Stephanie, Doman, Thompson N, Naughton, Lynn, Higgs, Richard E, Kallewaard, Nicole, Benschop, Robert J
Published in Journal of translational medicine (18.03.2022)
Published in Journal of translational medicine (18.03.2022)
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Journal Article
A Bayesian gene network reveals insight into the JAK-STAT pathway in systemic lupus erythematosus
Li, Yupeng, Higgs, Richard E, Hoffman, Robert W, Dow, Ernst R, Liu, Xiong, Petri, Michelle, Wallace, Daniel J, Dörner, Thomas, Eastwood, Brian J, Miller, Bradley B, Liu, Yushi
Published in PloS one (02.12.2019)
Published in PloS one (02.12.2019)
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Journal Article
Endogenous Antibody Responses to SARS-CoV-2 in Patients With Mild or Moderate COVID-19 Who Received Bamlanivimab Alone or Bamlanivimab and Etesevimab Together
Zhang, Lin, Poorbaugh, Josh, Dougan, Michael, Chen, Peter, Gottlieb, Robert L, Huhn, Gregory, Beasley, Stephanie, Daniels, Montanea, Ngoc Vy Trinh, Thi, Crisp, Melissa, Freitas, Joshua Joaquin, Vaillancourt, Peter, Patel, Dipak R, Nirula, Ajay, Kallewaard, Nicole L, Higgs, Richard E, Benschop, Robert J
Published in Frontiers in immunology (09.12.2021)
Published in Frontiers in immunology (09.12.2021)
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Journal Article
Baricitinib-associated changes in global gene expression during a 24-week phase II clinical systemic lupus erythematosus trial implicates a mechanism of action through multiple immune-related pathways
Dörner, Thomas, Tanaka, Yoshiya, Petri, Michelle A, Smolen, Josef S, Wallace, Daniel J, Dow, Ernst R, Higgs, Richard E, Rocha, Guilherme, Crowe, Brenda, Benschop, Robert J, Byers, Nicole L, Silk, Maria E, de Bono, Stephanie, Fantini, Damiano, Hoffman, Robert W
Published in Lupus science & medicine (09.10.2020)
Published in Lupus science & medicine (09.10.2020)
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Journal Article
Evaluation of the Relative Performance of Drug-Induced Skeletal Muscle Injury Biomarkers in Rats
Burch, Peter M, Greg Hall, David, Walker, Elizabeth G, Bracken, William, Giovanelli, Richard, Goldstein, Richard, Higgs, Richard E, King, Nicholas M P, Lane, Pamela, Sauer, John-Michael, Michna, Laura, Muniappa, Nagaraja, Pritt, Michael L, Vlasakova, Katerina, Watson, David E, Wescott, Debra, Zabka, Tanja S, Glaab, Warren E
Published in Toxicological sciences (01.03.2016)
Published in Toxicological sciences (01.03.2016)
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Journal Article
Further Evaluation of Mechanisms Associated with the Antidepressantlike Signature of Scopolamine in Mice
Martin, Anna E, Schober, Douglas A, Nikolayev, Alexander, Tolstikov, Vladimir V, Anderson, Wesley H, Higgs, Richard E, Kuo, Ming-Shang, Laksmanan, Anastasia, Catlow, John T, Li, Xia, Felder, Christian C, Witkin, Jeffrey M
Published in CNS & neurological disorders drug targets (01.01.2017)
Published in CNS & neurological disorders drug targets (01.01.2017)
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Journal Article
Characteristic Physical Properties and Structural Fragments of Marketed Oral Drugs
Vieth, Michal, Siegel, Miles G, Higgs, Richard E, Watson, Ian A, Robertson, Daniel H, Savin, Kenneth A, Durst, Gregory L, Hipskind, Philip A
Published in Journal of medicinal chemistry (01.01.2004)
Published in Journal of medicinal chemistry (01.01.2004)
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Journal Article
Kinomics—structural biology and chemogenomics of kinase inhibitors and targets
Vieth, Michal, Higgs, Richard E., Robertson, Daniel H., Shapiro, Michael, Gragg, Ellen A., Hemmerle, Horst
Published in BBA - Proteins and Proteomics (11.03.2004)
Published in BBA - Proteins and Proteomics (11.03.2004)
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Book Review
Journal Article
Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial
Gottlieb, Robert L, Nirula, Ajay, Chen, Peter, Boscia, Joseph, Heller, Barry, Morris, Jason, Huhn, Gregory, Cardona, Jose, Mocherla, Bharat, Stosor, Valentina, Shawa, Imad, Kumar, Princy, Adams, Andrew C, Van Naarden, Jacob, Custer, Kenneth L, Durante, Michael, Oakley, Gerard, Schade, Andrew E, Holzer, Timothy R, Ebert, Philip J, Higgs, Richard E, Kallewaard, Nicole L, Sabo, Janelle, Patel, Dipak R, Klekotka, Paul, Shen, Lei, Skovronsky, Daniel M
Published in JAMA : the journal of the American Medical Association (16.02.2021)
Published in JAMA : the journal of the American Medical Association (16.02.2021)
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Journal Article
SeedMatchR: identify off-target effects mediated by siRNA seed regions in RNA-seq experiments
Cazares, Tareian, Higgs, Richard E, Wang, Jibo, Ozer, Hatice Gulcin
Published in Bioinformatics (Oxford, England) (02.01.2024)
Published in Bioinformatics (Oxford, England) (02.01.2024)
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Journal Article
Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19
Sims, Jonathan T., Krishnan, Venkatesh, Chang, Ching-Yun, Engle, Sarah M., Casalini, Giacomo, Rodgers, George H., Bivi, Nicoletta, Nickoloff, Brian J., Konrad, Robert J., de Bono, Stephanie, Higgs, Richard E., Benschop, Robert J., Ottaviani, Silvia, Cardoso, Anabela, Nirula, Ajay, Corbellino, Mario, Stebbing, Justin
Published in Journal of allergy and clinical immunology (01.01.2021)
Published in Journal of allergy and clinical immunology (01.01.2021)
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Journal Article
Neutrophil activation markers can predict rheumatoid arthritis treatment response to the Janus Kinase 1/2 inhibitor baricitinib
Kuley, Runa, Duvvuri, Bhargavi, Hasnain, Sabeeha, Dow, Ernst R, Koch, Alisa E, Higgs, Richard E, Krishnan, Venkatesh, Lood, Christian
Published in Arthritis & rheumatology (Hoboken, N.J.) (21.10.2024)
Published in Arthritis & rheumatology (Hoboken, N.J.) (21.10.2024)
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Journal Article
Mechanism of baricitinib supports artificial intelligence-predicted testing inCOVID-19 patients
Stebbing, J, Krishnan, V, de, Bono S, Ottaviani, S, Casalini, G, Richardson, PJ, Monteil, V, Lauschke, VM, Mirazimi, A, Youhanna, S
Published in EMBO molecular medicine (07.08.2020)
Published in EMBO molecular medicine (07.08.2020)
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Journal Article
Proteomic Analysis of Demyelinated and Remyelinating Brain Tissue following Dietary Cuprizone Administration
Werner, Sean R., Saha, Joy K., Broderick, Carol L., Zhen, Eugene Y., Higgs, Richard E., Duffin, Kevin L., Smith, Rosamund C.
Published in Journal of molecular neuroscience (01.10.2010)
Published in Journal of molecular neuroscience (01.10.2010)
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Journal Article
Changes in Osteoblast, Chondrocyte, and Adipocyte Lineages Mediate the Bone Anabolic Actions of PTH and Small Molecule GSK-3 Inhibitor
Kulkarni, Nalini H., Wei, Tao, Kumar, Amar, Dow, Ernst R., Stewart, Trent R., Shou, Jianyong, N'cho, Mathias, Sterchi, Diane L., Gitter, Bruce D., Higgs, Richard E., Halladay, David L., Engler, Thomas A., Martin, T. John, Bryant, Henry U., Ma, Yanfei L., Onyia, Jude E.
Published in Journal of cellular biochemistry (15.12.2007)
Published in Journal of cellular biochemistry (15.12.2007)
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Journal Article
Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients
Stebbing, Justin, Krishnan, Venkatesh, de Bono, Stephanie, Ottaviani, Silvia, Casalini, Giacomo, Richardson, Peter J, Monteil, Vanessa, Lauschke, Volker M, Mirazimi, Ali, Youhanna, Sonia, Tan, Yee‐Joo, Baldanti, Fausto, Sarasini, Antonella, Terres, Jorge A Ross, Nickoloff, Brian J, Higgs, Richard E, Rocha, Guilherme, Byers, Nicole L, Schlichting, Douglas E, Nirula, Ajay, Cardoso, Anabela, Corbellino, Mario
Published in EMBO molecular medicine (07.08.2020)
Published in EMBO molecular medicine (07.08.2020)
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Journal Article