Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis
Marmor-Kollet, Hagai, Siany, Aviad, Kedersha, Nancy, Knafo, Naama, Rivkin, Natalia, Danino, Yehuda M., Moens, Thomas G., Olender, Tsviya, Sheban, Daoud, Cohen, Nir, Dadosh, Tali, Addadi, Yoseph, Ravid, Revital, Eitan, Chen, Toth Cohen, Beata, Hofmann, Sarah, Riggs, Claire L., Advani, Vivek M., Higginbottom, Adrian, Cooper-Knock, Johnathan, Hanna, Jacob H., Merbl, Yifat, Van Den Bosch, Ludo, Anderson, Paul, Ivanov, Pavel, Geiger, Tamar, Hornstein, Eran
Published in Molecular cell (03.12.2020)
Published in Molecular cell (03.12.2020)
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Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions
COOPER-KNOCK, Johnathan, WALSH, Matthew J, HAUTBERGUE, Guillaume M, SHAW, Pamela J, HIGGINBOTTOM, Adrian, HIGHLEY, J. Robin, DICKMAN, Mark J, EDBAUER, Dieter, INCE, Paul G, WHARTON, Stephen B, WILSON, Stuart A, KIRBY, Janine
Published in Brain (London, England : 1878) (01.07.2014)
Published in Brain (London, England : 1878) (01.07.2014)
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C9orf72 expansion disrupts ATM-mediated chromosomal break repair
Walker, Callum, Herranz-Martin, Saul, Karyka, Evangelia, Liao, Chunyan, Lewis, Katherine, Elsayed, Waheba, Lukashchuk, Vera, Chiang, Shih-Chieh, Ray, Swagat, Mulcahy, Padraig J, Jurga, Mateusz, Tsagakis, Ioannis, Iannitti, Tommaso, Chandran, Jayanth, Coldicott, Ian, De Vos, Kurt J, Hassan, Mohamed K, Higginbottom, Adrian, Shaw, Pamela J, Hautbergue, Guillaume M, Azzouz, Mimoun, El-Khamisy, Sherif F
Published in Nature neuroscience (01.09.2017)
Published in Nature neuroscience (01.09.2017)
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Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis
Ferraiuolo, Laura, Higginbottom, Adrian, Heath, Paul R., Barber, Sian, Greenald, David, Kirby, Janine, Shaw, Pamela J.
Published in Brain (London, England : 1878) (01.09.2011)
Published in Brain (London, England : 1878) (01.09.2011)
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SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
Hautbergue, Guillaume M., Castelli, Lydia M., Ferraiuolo, Laura, Sanchez-Martinez, Alvaro, Cooper-Knock, Johnathan, Higginbottom, Adrian, Lin, Ya-Hui, Bauer, Claudia S., Dodd, Jennifer E., Myszczynska, Monika A., Alam, Sarah M., Garneret, Pierre, Chandran, Jayanth S., Karyka, Evangelia, Stopford, Matthew J., Smith, Emma F., Kirby, Janine, Meyer, Kathrin, Kaspar, Brian K., Isaacs, Adrian M., El-Khamisy, Sherif F., De Vos, Kurt J., Ning, Ke, Azzouz, Mimoun, Whitworth, Alexander J., Shaw, Pamela J.
Published in Nature communications (05.07.2017)
Published in Nature communications (05.07.2017)
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C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis
Cooper-Knock, Johnathan, Bury, Joanna J, Heath, Paul R, Wyles, Matthew, Higginbottom, Adrian, Gelsthorpe, Catherine, Highley, J Robin, Hautbergue, Guillaume, Rattray, Magnus, Kirby, Janine, Shaw, Pamela J
Published in PloS one (27.05.2015)
Published in PloS one (27.05.2015)
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Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer’s pathology and dementia in the CFAS population-derived neuropathology cohort
Mistry, Hemant, Richardson, Connor D., Higginbottom, Adrian, Ashford, Bridget, Ahamed, Saif U., Moore, Zoe, Matthews, Fiona E., Brayne, Carol, Simpson, Julie E., Wharton, Stephen B.
Published in Neuroscience research (01.07.2024)
Published in Neuroscience research (01.07.2024)
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Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis
Allen, Scott P, Rajan, Sandeep, Duffy, Lynn, Mortiboys, Heather, Higginbottom, Adrian, Grierson, Andrew J, Shaw, Pamela J
Published in Neurobiology of aging (01.06.2014)
Published in Neurobiology of aging (01.06.2014)
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Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease
Xia, Zengjie, Prescott, Emily E., Urbanek, Agnieszka, Wareing, Hollie E., King, Marianne C., Olerinyova, Anna, Dakin, Helen, Leah, Tom, Barnes, Katy A., Matuszyk, Martyna M., Dimou, Eleni, Hidari, Eric, Zhang, Yu P., Lam, Jeff Y. L., Danial, John S. H., Strickland, Michael R., Jiang, Hong, Thornton, Peter, Crowther, Damian C., Ohtonen, Sohvi, Gómez-Budia, Mireia, Bell, Simon M., Ferraiuolo, Laura, Mortiboys, Heather, Higginbottom, Adrian, Wharton, Stephen B., Holtzman, David M., Malm, Tarja, Ranasinghe, Rohan T., Klenerman, David, De, Suman
Published in Nature communications (01.06.2024)
Published in Nature communications (01.06.2024)
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Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features
Shaw, Matthew P, Higginbottom, Adrian, McGown, Alexander, Castelli, Lydia M, James, Evlyn, Hautbergue, Guillaume M, Shaw, Pamela J, Ramesh, Tennore M
Published in Acta neuropathologica communications (19.11.2018)
Published in Acta neuropathologica communications (19.11.2018)
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Pre-clinical development of AP4B1 gene replacement therapy for hereditary spastic paraplegia type 47
Wiseman, Jessica P, Scarrott, Joseph M, Alves-Cruzeiro, João, Saffari, Afshin, Böger, Cedric, Karyka, Evangelia, Dawes, Emily, Davies, Alexandra K, Marchi, Paolo M, Graves, Emily, Fernandes, Fiona, Yang, Zih-Liang, Coldicott, Ian, Hirst, Jennifer, Webster, Christopher P, Highley, J Robin, Hackett, Neil, Angyal, Adrienn, Silva, Thushan de, Higginbottom, Adrian, Shaw, Pamela J, Ferraiuolo, Laura, Ebrahimi-Fakhari, Darius, Azzouz, Mimoun
Published in EMBO molecular medicine (11.11.2024)
Published in EMBO molecular medicine (11.11.2024)
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Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)
Cox, Laura E, Ferraiuolo, Laura, Goodall, Emily F, Heath, Paul R, Higginbottom, Adrian, Mortiboys, Heather, Hollinger, Hannah C, Hartley, Judith A, Brockington, Alice, Burness, Christine E, Morrison, Karen E, Wharton, Stephen B, Grierson, Andrew J, Ince, Paul G, Kirby, Janine, Shaw, Pamela J
Published in PloS one (24.03.2010)
Published in PloS one (24.03.2010)
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CD81 Is Required for Hepatitis C Virus Glycoprotein-Mediated Viral Infection
Zhang, Jie, Randall, Glenn, Higginbottom, Adrian, Monk, Peter, Rice, Charles M, McKeating, Jane A
Published in Journal of Virology (01.02.2004)
Published in Journal of Virology (01.02.2004)
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C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten
Stopford, Matthew J, Higginbottom, Adrian, Hautbergue, Guillaume M, Cooper-Knock, Johnathan, Mulcahy, Padraig J, De Vos, Kurt J, Renton, Alan E, Pliner, Hannah, Calvo, Andrea, Chio, Adriano, Traynor, Bryan J, Azzouz, Mimoun, Heath, Paul R, Kirby, Janine, Shaw, Pamela J
Published in Human molecular genetics (15.03.2017)
Published in Human molecular genetics (15.03.2017)
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Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS
Iannitti, Tommaso, Scarrott, Joseph M., Likhite, Shibi, Coldicott, Ian R.P., Lewis, Katherine E., Heath, Paul R., Higginbottom, Adrian, Myszczynska, Monika A., Milo, Marta, Hautbergue, Guillaume M., Meyer, Kathrin, Kaspar, Brian K., Ferraiuolo, Laura, Shaw, Pamela J., Azzouz, Mimoun
Published in Molecular therapy. Nucleic acids (07.09.2018)
Published in Molecular therapy. Nucleic acids (07.09.2018)
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Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation
Bauer, Claudia S, Webster, Christopher P, Shaw, Allan C, Kok, Jannigje R, Castelli, Lydia M, Lin, Ya-Hui, Smith, Emma F, Illanes-Álvarez, Francisco, Higginbottom, Adrian, Shaw, Pamela J, Azzouz, Mimoun, Ferraiuolo, Laura, Hautbergue, Guillaume M, Grierson, Andrew J, De Vos, Kurt J
Published in Frontiers in cellular neuroscience (16.12.2022)
Published in Frontiers in cellular neuroscience (16.12.2022)
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A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screening
Da Costa, Marc M J, Allen, Claire E, Higginbottom, Adrian, Ramesh, Tennore, Shaw, Pamela J, McDermott, Christopher J
Published in Disease models & mechanisms (01.01.2014)
Published in Disease models & mechanisms (01.01.2014)
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Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits
Herranz-Martin, Saul, Chandran, Jayanth, Lewis, Katherine, Mulcahy, Padraig, Higginbottom, Adrian, Walker, Callum, Valenzuela, Isabel Martinez-Pena Y, Jones, Ross A, Coldicott, Ian, Iannitti, Tommaso, Akaaboune, Mohammed, El-Khamisy, Sherif F, Gillingwater, Thomas H, Shaw, Pamela J, Azzouz, Mimoun
Published in Disease models & mechanisms (01.07.2017)
Published in Disease models & mechanisms (01.07.2017)
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Journal Article
Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation
Barreiro, Olga, Yáñez-Mó, María, Sala-Valdés, Mónica, Gutiérrez-López, María Dolores, Ovalle, Susana, Higginbottom, Adrian, Monk, Peter N., Cabañas, Carlos, Sánchez-Madrid, Francisco
Published in Blood (01.04.2005)
Published in Blood (01.04.2005)
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