Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation
Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas
Published in Nature communications (14.09.2015)
Published in Nature communications (14.09.2015)
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Journal Article
Inducing protein aggregation by extensional flow
Dobson, John, Kumar, Amit, Willis, Leon F., Tuma, Roman, Higazi, Daniel R., Turner, Richard, Lowe, David C., Ashcroft, Alison E., Radford, Sheena E., Kapur, Nikil, Brockwell, David J.
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2017)
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Journal Article
Rate of Asparagine Deamidation in a Monoclonal Antibody Correlating with Hydrogen Exchange Rate at Adjacent Downstream Residues
Phillips, Jonathan J, Buchanan, Andrew, Andrews, John, Chodorge, Matthieu, Sridharan, Sudharsan, Mitchell, Laura, Burmeister, Nicole, Kippen, Alistair D, Vaughan, Tristan J, Higazi, Daniel R, Lowe, David
Published in Analytical chemistry (Washington) (21.02.2017)
Published in Analytical chemistry (Washington) (21.02.2017)
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Journal Article
Investigating the Structural Compaction of Biomolecules Upon Transition to the Gas-Phase Using ESI-TWIMS-MS
Devine, Paul W. A., Fisher, Henry C., Calabrese, Antonio N., Whelan, Fiona, Higazi, Daniel R., Potts, Jennifer R., Lowe, David C., Radford, Sheena E., Ashcroft, Alison E.
Published in Journal of the American Society for Mass Spectrometry (01.09.2017)
Published in Journal of the American Society for Mass Spectrometry (01.09.2017)
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Journal Article
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo
Dobson, Claire L., Devine, Paul W. A., Phillips, Jonathan J., Higazi, Daniel R., Lloyd, Christopher, Popovic, Bojana, Arnold, Joanne, Buchanan, Andrew, Lewis, Arthur, Goodman, Joanne, van der Walle, Christopher F., Thornton, Peter, Vinall, Lisa, Lowne, David, Aagaard, Anna, Olsson, Lise-Lotte, Ridderstad Wollberg, Anna, Welsh, Fraser, Karamanos, Theodoros K., Pashley, Clare L., Iadanza, Matthew G., Ranson, Neil A., Ashcroft, Alison E., Kippen, Alistair D., Vaughan, Tristan J., Radford, Sheena E., Lowe, David C.
Published in Scientific reports (20.12.2016)
Published in Scientific reports (20.12.2016)
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Journal Article
Elucidation of critical pH-dependent structural changes in Botulinum Neurotoxin E
Lalaurie, Christophe J., Splevins, Andrew, Barata, Teresa S., Bunting, Karen A., Higazi, Daniel R., Zloh, Mire, Spiteri, Valentina A., Perkins, Stephen J., Dalby, Paul A.
Published in Journal of structural biology (01.09.2022)
Published in Journal of structural biology (01.09.2022)
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Journal Article
Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase
Klein, Tobias, Vajpai, Navratna, Phillips, Jonathan J., Davies, Gareth, Holdgate, Geoffrey A., Phillips, Chris, Tucker, Julie A., Norman, Richard A., Scott, Andrew D., Higazi, Daniel R., Lowe, David, Thompson, Gary S., Breeze, Alexander L.
Published in Nature communications (23.07.2015)
Published in Nature communications (23.07.2015)
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Journal Article
Replacement of the Mouse LD50 Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations
Fonfria, Elena, Marks, Elizabeth, Foulkes, Lisa-Marie, Schofield, Rebecca, Higazi, Daniel, Coward, Sam, Kippen, Alistair
Published in Toxins (29.04.2023)
Published in Toxins (29.04.2023)
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Journal Article
Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability
Edgeworth, Matthew J., Phillips, Jonathan J., Lowe, David C., Kippen, Alistair D., Higazi, Daniel R., Scrivens, James H.
Published in Angewandte Chemie International Edition (07.12.2015)
Published in Angewandte Chemie International Edition (07.12.2015)
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Journal Article
Calcium signalling during excitation-contraction coupling in mammalian atrial myocytes
Bootman, Martin D, Higazi, Daniel R, Coombes, Stephen, Roderick, H Llewelyn
Published in Journal of cell science (01.10.2006)
Published in Journal of cell science (01.10.2006)
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Journal Article
An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag: Short title: Controlled bioconjugation via O-glycan engineering
Murray, Thomas V., Kozakowska-McDonnell, Kasia, Tibbles, Adam, Taylor, Annabel, Higazi, Daniel, Rossy, Emmanuel, Rossi, Alessandra, Genapathy, Sivaneswary, Tamburrino, Giulia, Rath, Nicola, Tigue, Natalie, Lindo, Vivian, Vaughan, Tristan, Papworth, Monika A.
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Journal Article
MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential
Tigue, Natalie J., Bamber, Lisa, Andrews, John, Ireland, Samantha, Hair, James, Carter, Edward, Sridharan, Sudharsan, Jovanović, Jelena, Rees, D. Gareth, Springall, Jeremy S., Solier, Emilie, Li, Yi-Ming, Chodorge, Matthieu, Perez-Martinez, David, Higazi, Daniel R., Oberst, Michael, Kennedy, Maureen, Black, Chelsea M., Yan, Li, Schwickart, Martin, Maguire, Shaun, Cann, Jennifer A., de Haan, Lolke, Young, Lesley L., Vaughan, Tristan, Wilkinson, Robert W., Stewart, Ross
Published in Oncoimmunology (04.03.2017)
Published in Oncoimmunology (04.03.2017)
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Journal Article
The TGF-β inhibitory activity of antibody 37E1B5 depends on its H-CDR2 glycan
Tsui, Ping, Higazi, Daniel R, Wu, Yanli, Dunmore, Rebecca, Solier, Emilie, Kasali, Toyin, Bond, Nicholas J, Huntington, Catherine, Carruthers, Alan, Hood, John, Borrok, M Jack, Barnes, Arnita, Rickert, Keith, Phipps, Sandrina, Shirinian, Lena, Zhu, Jie, Bowen, Michael A, Dall'Acqua, William, Murray, Lynne A
Published in mAbs (01.01.2017)
Published in mAbs (01.01.2017)
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Journal Article
Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability
Edgeworth, Matthew J., Phillips, Jonathan J., Lowe, David C., Kippen, Alistair D., Higazi, Daniel R., Scrivens, James H.
Published in Angewandte Chemie (07.12.2015)
Published in Angewandte Chemie (07.12.2015)
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Journal Article
Endothelin-1-Stimulated InsP3-Induced Ca2+ Release Is a Nexus for Hypertrophic Signaling in Cardiac Myocytes
Higazi, Daniel R., Fearnley, Claire J., Drawnel, Faye M., Talasila, Amarnath, Corps, Elaine M., Ritter, Oliver, McDonald, Fraser, Mikoshiba, Katsuhiko, Bootman, Martin D., Roderick, H. Llewelyn
Published in Molecular cell (27.02.2009)
Published in Molecular cell (27.02.2009)
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Journal Article
Quantity of prabotulinumtoxinA in 100-U vials
Allcock, David, Splevins, Andrew, Baig, Hamzah, Higazi, Daniel
Published in Toxicon (Oxford) (01.01.2021)
Published in Toxicon (Oxford) (01.01.2021)
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Journal Article
Cell-Penetrating Peptides: Are They Useful Excipients in Botulinum Toxin Formulations?
Austerberry, James, Morrison, Julia, Shubber, Saif, Parreirinha, Daniel, Baig, Hamzah, Lima, Rubens, Fox, Ian, Wegner, Katarzyna, Molloy, Eoghan, Higazi, Daniel
Published in Toxicon (Oxford) (01.07.2022)
Published in Toxicon (Oxford) (01.07.2022)
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Journal Article
Replacement of the Mouse LD[sub.50] Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations
Fonfria, Elena, Marks, Elizabeth, Foulkes, Lisa-Marie, Schofield, Rebecca, Higazi, Daniel, Coward, Sam, Kippen, Alistair
Published in Toxins (01.04.2023)
Published in Toxins (01.04.2023)
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Journal Article
Replacement of the Mouse LD 50 Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations
Fonfria, Elena, Marks, Elizabeth, Foulkes, Lisa-Marie, Schofield, Rebecca, Higazi, Daniel, Coward, Sam, Kippen, Alistair
Published in Toxins (29.04.2023)
Get full text
Published in Toxins (29.04.2023)
Journal Article
An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag: Controlled bioconjugation via
Murray, Thomas V., Kozakowska-McDonnell, Kasia, Tibbles, Adam, Taylor, Annabel, Higazi, Daniel, Rossy, Emmanuel, Rossi, Alessandra, Genapathy, Sivaneswary, Tamburrino, Giulia, Rath, Nicola, Tigue, Natalie, Lindo, Vivian, Vaughan, Tristan, Papworth, Monika A.
Published in mAbs (16.11.2021)
Published in mAbs (16.11.2021)
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Journal Article