Establishment of a novel in vitro co-culture system of enteric neurons and Caco-2 cells for evaluating the effect of enteric nervous system on transepithelial transport of drugs
Maruyama, Masato, Yoshikata, Minami, Sakaguchi, Mana, Wakushima, Shizuka, Higaki, Kazutaka
Published in International journal of pharmaceutics (25.02.2023)
Published in International journal of pharmaceutics (25.02.2023)
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Possible Regulation of P-glycoprotein Function by Adrenergic Agonists in a Vascular-luminal Perfused Preparation of Small Intestine
Mukai, Hironori, Takanashi, Masashi, Ogawara, Ken-ichi, Maruyama, Masato, Higaki, Kazutaka
Published in Journal of pharmaceutical sciences (01.12.2021)
Published in Journal of pharmaceutical sciences (01.12.2021)
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Journal Article
Effect of Doxorubicin Release Rate From Polyethylene Glycol-Modified Liposome on Anti-tumor Activity in B16-BL6 Tumor-Bearing Mice
Maruyama, Masato, Tojo, Haruka, Toi, Keita, Ienaka, Yusuke, Hyodo, Kenji, Kikuchi, Hiroshi, Ogawara, Ken-ichi, Higaki, Kazutaka
Published in Journal of pharmaceutical sciences (01.02.2022)
Published in Journal of pharmaceutical sciences (01.02.2022)
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Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs
Jinno, Jun-ichi, Kamada, Naoki, Miyake, Masateru, Yamada, Keigo, Mukai, Tadashi, Odomi, Masaaki, Toguchi, Hajime, Liversidge, Gary G., Higaki, Kazutaka, Kimura, Toshikiro
Published in Journal of controlled release (10.03.2006)
Published in Journal of controlled release (10.03.2006)
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Pharmacokinetics and Safety of Resveratrol Derivatives in Humans after Oral Administration of Melinjo (Gnetum gnemon L.) Seed Extract Powder
Tani, Hiroko, Hikami, Susumu, Iizuna, Sanae, Yoshimatsu, Maiko, Asama, Takashi, Ota, Hidetaka, Kimura, Yuka, Tatefuji, Tomoki, Hashimoto, Ken, Higaki, Kazutaka
Published in Journal of agricultural and food chemistry (26.02.2014)
Published in Journal of agricultural and food chemistry (26.02.2014)
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The relationship between in vivo nasal drug clearance and in vitro nasal mucociliary clearance: Application to the prediction of nasal drug absorption
Inoue, Daisuke, Tanaka, Akiko, Kimura, Shunsuke, Kiriyama, Akiko, Katsumi, Hidemasa, Yamamoto, Akira, Ogawara, Ken-ichi, Kimura, Toshikiro, Higaki, Kazutaka, Yutani, Reiko, Sakane, Toshiyasu, Furubayashi, Tomoyuki
Published in European journal of pharmaceutical sciences (30.05.2018)
Published in European journal of pharmaceutical sciences (30.05.2018)
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Journal Article
Formulation and Evaluation of Paclitaxel-Loaded Polymeric Nanoparticles Composed of Polyethylene Glycol and Polylactic Acid Block Copolymer
Araki, Tomoya, Kono, Yusuke, Ogawara, Ken-ichi, Watanabe, Takaichi, Ono, Tsutomu, Kimura, Toshikiro, Higaki, Kazutaka
Published in Biological & pharmaceutical bulletin (01.08.2012)
Published in Biological & pharmaceutical bulletin (01.08.2012)
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In vivo anti-tumor effect of PEG liposomal doxorubicin (DOX) in DOX-resistant tumor-bearing mice: Involvement of cytotoxic effect on vascular endothelial cells
Ogawara, Ken-ichi, Un, Keita, Tanaka, Ken-ichi, Higaki, Kazutaka, Kimura, Toshikiro
Published in Journal of controlled release (05.01.2009)
Published in Journal of controlled release (05.01.2009)
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Quantitative Estimation of the Effect of Nasal Mucociliary Function on in Vivo Absorption of Norfloxacin after Intranasal Administration to Rats
Inoue, Daisuke, Kimura, Shunsuke, Kiriyama, Akiko, Katsumi, Hidemasa, Yamamoto, Akira, Ogawara, Ken-ichi, Higaki, Kazutaka, Tanaka, Akiko, Yutani, Reiko, Sakane, Toshiyasu, Furubayashi, Tomoyuki
Published in Molecular pharmaceutics (01.10.2018)
Published in Molecular pharmaceutics (01.10.2018)
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In Vitro Evaluation of the Ciliary Beat Frequency of the Rat Nasal Epithelium Using a High-Speed Digital Imaging System
Inoue, Daisuke, Furubayashi, Tomoyuki, Ogawara, Ken-ichi, Kimura, Toshikiro, Higaki, Kazutaka, Shingaki, Tomotaka, Kimura, Shunsuke, Tanaka, Akiko, Katsumi, Hidemasa, Sakane, Toshiyasu, Yamamoto, Akira, Higashi, Yutaka
Published in Biological & pharmaceutical bulletin (2013)
Published in Biological & pharmaceutical bulletin (2013)
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Journal Article
A novel approach to overcome multidrug resistance: Utilization of P-gp mediated efflux of paclitaxel to attack neighboring vascular endothelial cells in tumors
Yoshizawa, Yuta, Ogawara, Ken-ichi, Kimura, Toshikiro, Higaki, Kazutaka
Published in European journal of pharmaceutical sciences (01.10.2014)
Published in European journal of pharmaceutical sciences (01.10.2014)
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Journal Article
Determinants for in vivo anti-tumor effects of PEG liposomal doxorubicin: Importance of vascular permeability within tumors
Ogawara, Ken-ichi, Un, Keita, Minato, Keiko, Tanaka, Ken-ichi, Higaki, Kazutaka, Kimura, Toshikiro
Published in International journal of pharmaceutics (09.07.2008)
Published in International journal of pharmaceutics (09.07.2008)
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Establishment of new preparation method for solid dispersion formulation of tacrolimus
Yamashita, Kazunari, Nakate, Toshiomi, Okimoto, Kazuto, Ohike, Atsuo, Tokunaga, Yuji, Ibuki, Rinta, Higaki, Kazutaka, Kimura, Toshikiro
Published in International journal of pharmaceutics (28.11.2003)
Published in International journal of pharmaceutics (28.11.2003)
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