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Published in The Journal of biological chemistry (18.02.2005)
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Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo
Lewis, Nuruddeen D, Patnaude, Lori A, Pelletier, Josephine, Souza, Donald J, Lukas, Susan M, King, F James, Hill, Jonathan D, Stefanopoulos, Dimitria E, Ryan, Kelli, Desai, Sudha, Skow, Donna, Kauschke, Stefan G, Broermann, Andre, Kuzmich, Daniel, Harcken, Christian, Hickey, Eugene R, Modis, Louise K
Published in PloS one (26.06.2014)
Published in PloS one (26.06.2014)
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An in Silico Method for Predicting Ames Activities of Primary Aromatic Amines by Calculating the Stabilities of Nitrenium Ions
Bentzien, Jörg, Hickey, Eugene R, Kemper, Raymond A, Brewer, Mark L, Dyekjær, Jane D, East, Stephen P, Whittaker, Mark
Published in Journal of chemical information and modeling (22.02.2010)
Published in Journal of chemical information and modeling (22.02.2010)
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Reversal of H3K9me2 by a Small-Molecule Inhibitor for the G9a Histone Methyltransferase
Kubicek, Stefan, O'Sullivan, Roderick J., August, E. Michael, Hickey, Eugene R., Zhang, Qiang, Teodoro, Miguel L., Rea, Stephen, Mechtler, Karl, Kowalski, Jennifer A., Homon, Carol Ann, Kelly, Terence A., Jenuwein, Thomas
Published in Molecular cell (09.02.2007)
Published in Molecular cell (09.02.2007)
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X‐ray crystal structure localizes the mechanism of inhibition of an IL‐36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains
Larson, Eric T., Brennan, Debra L., Hickey, Eugene R., Ganesan, Raj, Kroe‐Barrett, Rachel, Farrow, Neil A.
Published in Protein science (01.07.2020)
Published in Protein science (01.07.2020)
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Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
Pargellis, Christopher, Tong, Liang, Churchill, Laurie, Cirillo, Pier F, Gilmore, Thomas, Graham, Anne G, Grob, Peter M, Hickey, Eugene R, Moss, Neil, Pav, Susan, Regan, John
Published in Nature structural & molecular biology (01.04.2002)
Published in Nature structural & molecular biology (01.04.2002)
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Selective CB2 receptor agonists. Part 3: The optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model
Bartolozzi, Alessandra, Cirillo, Pier Francesco, Berry, Angela K., Hickey, Eugene R., Thomson, David S., Wu, Lifen, Zindell, Renee, Albrecht, Claudia, Ceci, Angelo, Gemkow, Mark J., Nagaraja, Nelamangala V., Romig, Helmut, Sauer, Achim, Riether, Doris
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Identification of a Potent Sodium Hydrogen Exchanger Isoform 1 (NHE1) Inhibitor with a Suitable Profile for Chronic Dosing and Demonstrated Cardioprotective Effects in a Preclinical Model of Myocardial Infarction in the Rat
Huber, John D, Bentzien, Jörg, Boyer, Stephen J, Burke, Jennifer, De Lombaert, Stéphane, Eickmeier, Christian, Guo, Xin, Haist, James V, Hickey, Eugene R, Kaplita, Paul, Karmazyn, Morris, Kemper, Raymond, Kennedy, Charles A, Kirrane, Thomas, Madwed, Jeffrey B, Mainolfi, Elizabeth, Nagaraja, Nelamangara, Soleymanzadeh, Fariba, Swinamer, Alan, Eldrup, Anne B
Published in Journal of medicinal chemistry (23.08.2012)
Published in Journal of medicinal chemistry (23.08.2012)
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Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 3, aryl substituted pyrrolidines
Bosanac, Todd, Hickey, Eugene R., Ginn, John, Kashem, Mohammed, Kerr, Steven, Kugler, Stanley, Li, Xiang, Olague, Alan, Schlyer, Sabine, Young, Erick R.R.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Exploration of cathepsin S inhibitors characterized by a triazole P1–P2 amide replacement
Moss, Neil, Xiong, Zhaoming, Burke, Mike, Cogan, Derek, Gao, Donghong A., Haverty, Kathleen, Heim-Riether, Alexander, Hickey, Eugene R., Nagaraja, Raj, Netherton, Matthew, O’Shea, Kathy, Ramsden, Philip, Schwartz, Racheline, Shih, Daw-Tsun, Ward, Yancey, Young, Erick, Zhang, Qing
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
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New modifications to the area of pyrazole-naphthyl urea based p38 MAP kinase inhibitors that bind to the adenine/ATP site
Moss, Neil, Breitfelder, Steffen, Betageri, Raj, Cirillo, Pier F., Fadra, Tazmeen, Hickey, Eugene R., Kirrane, Thomas, Kroe, Rachel R., Madwed, Jeffrey, Nelson, Richard M., Pargellis, Christopher A., Qian, Kevin C., Regan, John, Swinamer, Alan, Torcellini, Carol
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Discovery and characterization of the N-phenyl- N′-naphthylurea class of p38 kinase inhibitors
Cirillo, Pier F., Hickey, Eugene R., Moss, Neil, Breitfelder, Steffen, Betageri, Raj, Fadra, Tazmeen, Gaenzler, Faith, Gilmore, Thomas, Goldberg, Daniel R., Kamhi, Victor, Kirrane, Thomas, Kroe, Rachel R., Madwed, Jeffrey, Moriak, Monica, Netherton, Matthew, Pargellis, Christopher A., Patel, Usha R., Qian, Kevin C., Sharma, Rajiv, Sun, Sanxing, Swinamer, Alan, Torcellini, Carol, Takahashi, Hidenori, Tsang, Michele, Xiong, Zhaoming
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
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암의 치료를 위한 포스포이노시티드 3-키나제 (PI3K)의 알로스테릭 크로메논 억제제
DAWADI SURENDRA, WIDJAJA TIEN, LONG KATELYN FRANCES, ARONOW SEAN DOUGLAS, KNIGHT JENNIFER LYNN, KOLAKOWSKI GABRIELLE R, WANG HUA YU, ANDERSON ERIN DANIELLE, HICKEY EUGENE R, IRVIN THOMAS COMBS, MCLEAN JOHNATHAN ALEXANDER, WELCH MICHAEL BRIAN, MAYNE CHRISTOPHER GLENN, KUMAR MANOJ, CHEN XIAOHONG, BOYLES NICHOLAS A, POTOTSCHNIG GERIT MARIA, KESICKI EDWARD A
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Year of Publication 31.01.2024
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질환의 치료를 위한 포스포이노시티드 3-키나제 (PI3K)의 알로스테릭 크로메논 억제제
DAWADI SURENDRA, PICADO ALFREDO, WIDJAJA TIEN, LONG KATELYN FRANCES, ARONOW SEAN DOUGLAS, KNIGHT JENNIFER LYNN, KOLAKOWSKI GABRIELLE R, WANG HUA YU, ANDERSON ERIN DANIELLE, HICKEY EUGENE R, WRIGHT NATHAN EDWARD, IRVIN THOMAS COMBS, WELCH MICHAEL BRIAN, MAYNE CHRISTOPHER GLENN, KUMAR MANOJ, CHEN XIAOHONG, BOYLES NICHOLAS A, POTOTSCHNIG GERIT MARIA, KESICKI EDWARD A
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질환의 치료를 위한 포스포이노시티드 3-키나제 (PI3K)의 알로스테릭 크로메논 억제제
DAWADI SURENDRA, PICADO ALFREDO, WIDJAJA TIEN, LONG KATELYN FRANCES, ARONOW SEAN DOUGLAS, KNIGHT JENNIFER LYNN, KOLAKOWSKI GABRIELLE R, WANG HUA YU, ANDERSON ERIN DANIELLE, HICKEY EUGENE R, WRIGHT NATHAN EDWARD, IRVIN THOMAS COMBS, WELCH MICHAEL BRIAN, MAYNE CHRISTOPHER GLENN, KUMAR MANOJ, CHEN XIAOHONG, BOYLES NICHOLAS A, POTOTSCHNIG GERIT MARIA, KESICKI EDWARD A
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포스포이노시티드 3-키나제 (PI3K) 조정과 연관된 질환의 치료를 위한 PI3K의 알로스테릭 크로메논 억제제
DAHLGREN MARKUS K, WIDJAJA TIEN, LONG KATELYN FRANCES, MCELLIGOTT DAVID L, ARONOW SEAN DOUGLAS, KNIGHT JENNIFER LYNN, KOLAKOWSKI GABRIELLE R, KLIPPEL GIESE ANKE, ANDERSON ERIN DANIELLE, FENG SHULU, HICKEY EUGENE R, SEVERANCE DANIEL LEE, IRVIN THOMAS COMBS, PUCA LOREDANA, MCLEAN JOHNATHAN ALEXANDER, WELCH MICHAEL BRIAN, MAYNE CHRISTOPHER GLENN, GERASYUTO ALEKSEY I, KUMAR MANOJ, RAVI KANNAN KARUKURICHI, BOYLES NICHOLAS A, KESICKI EDWARD A
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A Belted Monofacial Ionophore Featuring High Selectivity for Lithium Ion Complexation
Paquette, Leo A., Tae, Jinsung, Hickey, Eugene R., Rogers, Robin D.
Published in Angewandte Chemie (International ed.) (17.05.1999)
Published in Angewandte Chemie (International ed.) (17.05.1999)
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