The discovery of GSK221149A: A potent and selective oxytocin antagonist
Liddle, John, Allen, Michael J., Borthwick, Alan D., Brooks, David P., Davies, David E., Edwards, Richard M., Exall, Anne M., Hamlett, Chris, Irving, Wendy R., Mason, Andrew M., McCafferty, Gerald P., Nerozzi, Fabrizio, Peace, Simon, Philp, Joanne, Pollard, Derek, Pullen, Mark A., Shabbir, Shaila S., Sollis, Steve L., Westfall, Timothy D., Woollard, Pat M., Wu, Charlene, Hickey, Deirdre M.B.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor
McKeown, Stephen C., Corbett, David F., Goetz, Aaron S., Littleton, Thomas R., Bigham, Eric, Briscoe, Celia P., Peat, Andrew J., Watson, Steve P, Hickey, Deirdre M.B.
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Synthesis and properties of macrolones characterized by two ether bonds in the linker
Jakopović, Ivana Palej, Kragol, Goran, Forrest, Andrew K., Frydrych, Catherine S.V., Štimac, Vlado, Kapić, Samra, Škugor, Maja Matanović, Ilijaš, Marina, Paljetak, Hana Čipčić, Jelić, Dubravko, Holmes, David J., Hickey, Deirdre M.B., Verbanac, Donatella, Eraković Haber, Vesna, Alihodžić, Sulejman
Published in Bioorganic & medicinal chemistry (01.09.2010)
Published in Bioorganic & medicinal chemistry (01.09.2010)
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Use of a novel and highly selective oxytocin receptor antagonist to characterize uterine contractions in the rat
McCafferty, Gerald P, Pullen, Mark A, Wu, Charlene, Edwards, Richard M, Allen, Michael J, Woollard, Patrick M, Borthwick, Alan D, Liddle, John, Hickey, Deirdre M. B, Brooks, David P, Westfall, Timothy D
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.07.2007)
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.07.2007)
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5-Aryl-pyrazolo[3,4- b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
Witherington, Jason, Bordas, Vincent, Garland, Stephen L, Hickey, Deirdre M.B, Ife, Robert J, Liddle, John, Saunders, Martin, Smith, David G, Ward, Robert W
Published in Bioorganic & medicinal chemistry letters (05.05.2003)
Published in Bioorganic & medicinal chemistry letters (05.05.2003)
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The identification of clinical candidate SB-480848 : A potent inhibitor of lipoprotein-associated phospholipase A2
BLACKIE, Josie A, BLOOMER, Jackie C, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L, SMITH, Stephen A, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, BROWN, Murray J. B, CHENG, Hung-Yuan, HAMMOND, Beverley, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
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5-Aryl-pyrazolo[3,4- b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
Witherington, Jason, Bordas, Vincent, Haigh, David, Hickey, Deirdre M.B, Ife, Robert J, Rawlings, Anthony D, Slingsby, Brian P, Smith, David G, Ward, Robert W
Published in Bioorganic & medicinal chemistry letters (05.05.2003)
Published in Bioorganic & medicinal chemistry letters (05.05.2003)
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Inhibitors of CoA-independent transacylase block the movement of arachidonate into 1-ether-linked phospholipids of human neutrophils
Chilton, Floyd H, Fonteh, Alfred N, Sung, Chiu-Mei, Hickey, Deirdre M. B, Torphy, Theodore J, Mayer, Ruth J, Marshall, Lisa A, Heravi, Javid D, Winkler, James D
Published in Biochemistry (Easton) (25.04.1995)
Published in Biochemistry (Easton) (25.04.1995)
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Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor
MACPHEE, Colin H., MOORES, Kitty E., BOYD, Helen F., DHANAK, Dash, IFE, Robert J., LEACH, Colin A., LEAKE, David S., MILLINER, Kevin J., PATTERSON, Rebecca A., SUCKLING, Keith E., TEW, David G., HICKEY, Deirdre M. B.
Published in Biochemical journal (01.03.1999)
Published in Biochemical journal (01.03.1999)
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Vinyl azides in heterocyclic synthesis. Part 6. Synthesis of isoquinolines by intramolecular aza-Wittig reaction
Hickey, Deirdre M. B., MacKenzie, A. Roderick, Moody, Christopher J., Rees, Charles W.
Published in Journal of the Chemical Society, Perkin Transactions 1 (1987)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1987)
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Vinyl azides in heterocyclic synthesis. Part 3. Isolation of azirine trimers (1,3,8-triazatricyclo[4.3.0.0 3,5 ]non-7-enes) and intramolecular interception of nitrile ylides by neighbouring π-bonds or nucleophiles
Hickey, Deirdre M. B., Moody, Christopher J., Rees, Charles W.
Published in J. Chem. Soc., Perkin Trans. 1 (1986)
Published in J. Chem. Soc., Perkin Trans. 1 (1986)
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Vinyl azides in heterocyclic synthesis. Part 2. Selectivity in the decomposition of azidocinnamates with olefinic ortho-substituents
Hickey, Deirdre M. B., Moody, Christopher J., Rees, Charles W.
Published in Journal of the Chemical Society, Perkin Transactions 1 (1986)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1986)
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Use of a novel and highly selective oxytocin receptor antagonist to characterize uterine contractions in the rat
MCCAFFERTY, Gerald P, PULLEN, Mark A, WESTFALL, Timothy D, WU, Charlene, EDWARDS, Richard M, ALLEN, Michael J, WOOLLARD, Patrick M, BORTHWICK, Alan D, LIDDLE, John, HICKEY, Deirdre M. B, BROOKS, David P
Published in American journal of physiology. Regulatory, integrative and comparative physiology (2007)
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Published in American journal of physiology. Regulatory, integrative and comparative physiology (2007)
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Synthesis of thyroid hormone analogues. Part 3. Iodonium salt approaches to SK&F L-94901
Hickey, Deirdre M. B., Leeson, Paul D., Novelli, Riccardo, Shah, Virendra P., Burpitt, Brian E., Crawford, Lynne P., Davies, Bryan J., Mitchell, Michael B., Pancholi, Kirit D., Tuddenham, David, Lewis, Norman J., O'Farrell, Clare
Published in J. Chem. Soc., Perkin Trans. 1 (1988)
Published in J. Chem. Soc., Perkin Trans. 1 (1988)
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Synthesis of thyroid hormone analogues. Part 2. Oxidative coupling approach to SK&F L-94901
Hickey, Deirdre M. B., Leeson, Paul D., Carter, Steven D., Goodyear, Michael D., Jones, Sarah J., Lewis, Norman J., Morgan, Ian T., Mullane, M. Valerie, Tricker, Jane Y.
Published in J. Chem. Soc., Perkin Trans. 1 (1988)
Published in J. Chem. Soc., Perkin Trans. 1 (1988)
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Journal Article
The discovery of SB-435495: A potent, orally active inhibitor of lipoprotein-associated phospholipase A2 for evaluation in man
BLACKIE, Josie A, BLOOMER, Jackie C, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L, SMITH, Stephen A, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, BROWN, Murray J. B, CHENG, Hung-Yuan, ELLIOTT, Richard L, HAMMOND, Beverley, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
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Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones
BOYD, Helen F, FELL, Stephen C. M, STANSFIELD, Ian G, STANWAY, Steven J, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
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Journal Article
Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones
Boyd, Helen F, Fell, Stephen C M, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Macphee, Colin H, Milliner, Kevin J, Pinto, Ivan L, Rawlings, D Anthony, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Theobald, Colin J, Whittaker, Caroline M
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
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Journal Article
N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2
BOYD, Helen F, FELL, Stephen C. M, PORTER, Rod A, RAWLINGS, D. Anthony, SMITH, Stephen A, STANSFIELD, Ian G, TEW, David G, THEOBALD, Colin J, WHITTAKER, Caroline M, FLYNN, Sean T, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L
Published in Bioorganic & medicinal chemistry letters (20.11.2000)
Published in Bioorganic & medicinal chemistry letters (20.11.2000)
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