The synthesis and structure–activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-Dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection
Hewawasam, Piyasena, Fan, Wenhong, Knipe, Jay, Moon, Sandra L, Boissard, Christopher G, Gribkoff, Valentin K, Starrett, John E
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
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The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels
HEWAWASAM, Piyasena, GRIBKOFF, Valentin K, PAJOR, Lorraine M, KNIPE, Jay, QI GAO, PERRONE, Robert, STARRETT, John E, PENDRI, Yadagiri, DWORETZKY, Steven I, MEANWELL, Nicholas A, MARTINEZ, Eduardo, BOISSARD, Christopher G, POST-MUNSON, Debra J, TROJNACKI, Joanne T, YELESWARAM, Krishnaswamy
Published in Bioorganic & medicinal chemistry letters (08.04.2002)
Published in Bioorganic & medicinal chemistry letters (08.04.2002)
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Effect of 4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a Novel Opener of Large Conductance Ca2+-Activated K+ (Maxi-K) Channels on Normal and Stress-Aggravated Colonic Motility and Visceral Nociception
Sivarao, Digavalli V, Newberry, Kimberly, Langdon, Shaun, Lee, Alicia V, Hewawasam, Piyasena, Plym, Mary Jane, Signor, Laura, Myers, Robert, Lodge, Nicholas J
Published in The Journal of pharmacology and experimental therapeutics (01.05.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2005)
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Journal Article
Synthesis of water-Soluble prodrugs of BMS-191011: A maxi-K channel opener targeted for post-stroke neuroprotection
Hewawasam, Piyasena, Ding, Min, Chen, Nathan, King, Dalton, Knipe, Jay, Pajor, Lorraine, Ortiz, Astrid, Gribkoff, Valentin K., Starrett, John
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
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Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
Scola, Paul M., Wang, Alan Xiangdong, Good, Andrew C., Sun, Li-Qiang, Combrink, Keith D., Campbell, Jeffrey A., Chen, Jie, Tu, Yong, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley, Zheng, Barbara, Hewawasam, Piyasena, Ding, Min, Thuring, Jan, Li, Jianqing, Hernandez, Dennis, Yu, Fei, Falk, Paul, Zhai, Guangzhi, Sheaffer, Amy K., Chen, Chaoqun, Lee, Min S., Barry, Diana, Knipe, Jay O., Li, Wenying, Han, Yong-Hae, Jenkins, Susan, Gesenberg, Christoph, Gao, Qi, Sinz, Michael W., Santone, Kenneth S., Zvyaga, Tatyana, Rajamani, Ramkumar, Klei, Herbert E., Colonno, Richard J., Grasela, Dennis M., Hughes, Eric, Chien, Caly, Adams, Stephen, Levesque, Paul C., Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
Scola, Paul M., Sun, Li-Qiang, Wang, Alan Xiangdong, Chen, Jie, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley V., Zheng, Barbara, Hewawasam, Piyasena, Tu, Yong, Friborg, Jacques, Falk, Paul, Hernandez, Dennis, Levine, Steven, Chen, Chaoqun, Yu, Fei, Sheaffer, Amy K., Zhai, Guangzhi, Barry, Diana, Knipe, Jay O., Han, Yong-Hae, Schartman, Richard, Donoso, Maria, Mosure, Kathy, Sinz, Michael W., Zvyaga, Tatyana, Good, Andrew C., Rajamani, Ramkumar, Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E., Gao, Qi, Mueller, Luciano, Colonno, Richard J., Grasela, Dennis M., Adams, Stephen P., Loy, James, Levesque, Paul C., Sun, Huabin, Shi, Hong, Sun, Lucy, Warner, William, Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore
Paradkar, Sateja, Herrington, James, Hendricson, Adam, Hewawasam, Piyasena, Plummer, Mark, Hoyer, Denton, Sundaram, Ranjini K, Surovtseva, Yulia V, Bindra, Ranjit S
Published in Oncotarget (27.04.2021)
Published in Oncotarget (27.04.2021)
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Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A
Sun, Jin-Hua, O’Boyle II, Donald R., Fridell, Robert A., Langley, David R., Wang, Chunfu, Roberts, Susan B., Nower, Peter, Johnson, Benjamin M., Moulin, Frederic, Nophsker, Michelle J., Wang, Ying-Kai, Liu, Mengping, Rigat, Karen, Tu, Yong, Hewawasam, Piyasena, Kadow, John, Meanwell, Nicholas A., Cockett, Mark, Lemm, Julie A., Kramer, Melissa, Belema, Makonen, Gao, Min
Published in Nature (London) (12.11.2015)
Published in Nature (London) (12.11.2015)
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Journal Article
Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase
Gentles, Robert G., Ding, Min, Bender, John A., Bergstrom, Carl P., Grant-Young, Katharine, Hewawasam, Piyasena, Hudyma, Thomas, Martin, Scott, Nickel, Andrew, Regueiro-Ren, Alicia, Tu, Yong, Yang, Zhong, Yeung, Kap-Sun, Zheng, Xiaofan, Chao, Sam, Sun, Jung-Hui, Beno, Brett R., Camac, Daniel M., Chang, Chong-Hwan, Gao, Mian, Morin, Paul E., Sheriff, Steven, Tredup, Jeff, Wan, John, Witmer, Mark R., Xie, Dianlin, Hanumegowda, Umesh, Knipe, Jay, Mosure, Kathy, Santone, Kenneth S., Parker, Dawn D., Zhuo, Xiaoliang, Lemm, Julie, Liu, Mengping, Pelosi, Lenore, Rigat, Karen, Voss, Stacey, Wang, Yi, Wang, Ying-Kai, Colonno, Richard J., Gao, Min, Roberts, Susan B., Gao, Qi, Ng, Alicia, Meanwell, Nicholas A, Kadow, John F.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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A practical and efficient synthesis of 6-carboalkoxy-13-cycloalkyl-5H-indolo[2,1-a][2]benzazepine-10-carboxylic acid derivatives
Hewawasam, Piyasena, Tu, Yong, Hudyma, Thomas W., Zhang, Xiaofan, Gentles, Robert G., Kadow, John F., Meanwell, Nicholas A.
Published in Tetrahedron letters (05.02.2014)
Published in Tetrahedron letters (05.02.2014)
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Journal Article
A practical and efficient synthesis of 6-carboalkoxy-13-cycloalkyl-5H-indolo[2,1-a][2]benzazepine-10-carb o xylic acid derivatives
Hewawasam, Piyasena, Tu, Yong, Hudyma, Thomas, Zhang, Xiaofan, Gentles, Robert, Kadow, John, Meanwell, Nicholas
Published in Tetrahedron letters (01.01.2014)
Published in Tetrahedron letters (01.01.2014)
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Journal Article
Synergistic Activity of Combined NS5A Inhibitors
O'Boyle, 2nd, Donald R, Nower, Peter T, Gao, Min, Fridell, Robert, Wang, Chunfu, Hewawasam, Piyasena, Lopez, Omar, Tu, Yong, Meanwell, Nicholas A, Belema, Makonen, Roberts, Susan B, Cockett, Mark, Sun, Jin-Hua
Published in Antimicrobial agents and chemotherapy (01.03.2016)
Published in Antimicrobial agents and chemotherapy (01.03.2016)
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Journal Article
Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase
Hewawasam, Piyasena, Tu, Yong, Gao, Min, Hanumegowda, Umesh, Knipe, Jay, Lemm, Julie A., Parker, Dawn D., Rigat, Karen L., Roberts, Susan B., Meanwell, Nicholas A., Kadow, John F.
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
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Journal Article
Synthesis and Structure−Activity Relationships of 3-Aryloxindoles: A New Class of Calcium-Dependent, Large Conductance Potassium (Maxi-K) Channel Openers with Neuroprotective Properties
Hewawasam, Piyasena, Erway, Matthew, Moon, Sandra L, Knipe, Jay, Weiner, Harvey, Boissard, Christopher G, Post-Munson, Debra J, Gao, Qi, Huang, Stella, Gribkoff, Valentin K, Meanwell, Nicholas A
Published in Journal of medicinal chemistry (28.03.2002)
Published in Journal of medicinal chemistry (28.03.2002)
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Journal Article
Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels
Gribkoff, Valentin K, Starrett, John E, Dworetzky, Steven I, Hewawasam, Piyasena, Boissard, Christopher G, Cook, Deborah A, Frantz, Stephen W, Heman, Karen, Hibbard, Jeffrey R, Huston, Kevin, Johnson, Graham, Krishnan, Bala S, Kinney, Gene G, Lombardo, Lynn A, Meanwell, Nicholas A, Molinoff, Perry B, Myers, Robert A, Moon, Sandra L, Ortiz, Astrid, Pajor, Lorraine, Pieschl, Rick L, Post-Munson, Debra J, Signor, Laura J, Srinivas, Nugehally, Taber, Matthew T, Thalody, George, Trojnacki, Joanne T, Wiener, Harvey, Yeleswaram, Krishnaswamy, Yeola, Sarita W
Published in Nature medicine (01.04.2001)
Published in Nature medicine (01.04.2001)
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Inhibitors of blood platelet cAMP phosphodiesterase. 4. Structural variation of the side-chain terminus of water-soluble 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives
Meanwell, Nicholas A, Hewawasam, Piyasena, Thomas, Jeanine A, Wright, J. J. Kim, Russell, John W, Gamberdella, Marianne, Goldenberg, Harold J, Seiler, Steven M, Zavoico, George B
Published in Journal of medicinal chemistry (01.10.1993)
Published in Journal of medicinal chemistry (01.10.1993)
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Journal Article
Regiospecific preparation of the benz[b]xanthen-12-one ring system. Total synthesis of bikaverin
Hauser, Frank M, Hewawasam, Piyasena, Baghdanov, Vaceli M
Published in Journal of organic chemistry (01.01.1988)
Published in Journal of organic chemistry (01.01.1988)
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Journal Article
면역조정제로서 유용한 비아릴 화합물
YEUNG KAP SUN, ZHU JULIANG, MULL ERIC, SAULNIER MARK G, WANG TAO, SCOLA PAUL MICHAEL, HEWAWASAM PIYASENA, MENG ZHAOXING, GRANT YOUNG KATHARINE A, FRENNESSON DAVID B, SUN LI QIANG, LANGLEY DAVID R, ZHANG ZHONGXING
Year of Publication 26.04.2019
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Year of Publication 26.04.2019
Patent
Stereospecific syntheses of (E)-1,3-disubstituted dienes
Hauser, Frank M, Tommasi, Ruben, Hewawasam, Piyasena, Rho, Young S
Published in Journal of organic chemistry (01.09.1988)
Published in Journal of organic chemistry (01.09.1988)
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Journal Article
4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction
Hewawasam, Piyasena, Fan, Wenhong, Ding, Min, Flint, Kim, Cook, Deborah, Goggins, Gregory D, Myers, Robert A, Gribkoff, Valentin K, Boissard, Christopher G, Dworetzky, Steven I, Starrett, John E, Lodge, Nicholas J
Published in Journal of medicinal chemistry (03.07.2003)
Published in Journal of medicinal chemistry (03.07.2003)
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