Use of broadly neutralizing antibodies for HIV‐1 prevention
Pegu, Amarendra, Hessell, Ann J., Mascola, John R., Haigwood, Nancy L.
Published in Immunological reviews (01.01.2017)
Published in Immunological reviews (01.01.2017)
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Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers
Hessell, Ann J, Rakasz, Eva G, Poignard, Pascal, Hangartner, Lars, Landucci, Gary, Forthal, Donald N, Koff, Wayne C, Watkins, David I, Burton, Dennis R
Published in PLoS pathogens (01.05.2009)
Published in PLoS pathogens (01.05.2009)
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Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor
Saphire, Erica Ollmann, Lee, Jeffrey E, Fusco, Marnie L, Hessell, Ann J, Oswald, Wendelien B, Burton, Dennis R
Published in Nature (10.07.2008)
Published in Nature (10.07.2008)
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Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
Hessell, Ann J, Poignard, Pascal, Hunter, Meredith, Hangartner, Lars, Tehrani, David M, Bleeker, Wim K, Parren, Paul W H I, Marx, Preston A, Burton, Dennis R
Published in Nature medicine (01.08.2009)
Published in Nature medicine (01.08.2009)
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Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody
Burton, Dennis R, Hessell, Ann J, Keele, Brandon F, Klasse, Per Johan, Ketas, Thomas A, Moldt, Brian, Dunlop, D. Cameron, Poignard, Pascal, Doyle, Lara A, Cavacini, Lisa, Veazey, Ronald S, Moore, John P
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2011)
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Passive and active antibody studies in primates to inform HIV vaccines
Hessell, Ann J, Malherbe, Delphine C, Haigwood, Nancy L
Published in Expert review of vaccines (01.02.2018)
Published in Expert review of vaccines (01.02.2018)
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Broadly Neutralizing Monoclonal Antibodies 2F5 and 4E10 Directed against the Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Protect against Mucosal Challenge by Simian-Human Immunodeficiency Virus SHIVBa-L
HESSELL, Ann J, RAKASZ, Eva G, BURTON, Dennis R, TEHRANI, David M, HUBER, Michael, WEISGRAU, Kimberly L, LANDUCCI, Gary, FORTHAL, Donald N, KOFF, Wayne C, POIGNARD, Pascal, WATKINS, David I
Published in Journal of Virology (01.02.2010)
Published in Journal of Virology (01.02.2010)
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Structural definition of a conserved neutralization epitope on HIV-1 gp120
Van Ryk, Donald, Wyatt, Richard, Dey, Barna, Zhang, Mei-Yun, Nabel, Gary J, Xu, Ling, Xiang, Shi-Hua, Dimitrov, Dimiter S, Sodroski, Joseph, Arthos, James, Yang, Xinzhen, Zhou, Tongqing, Kwong, Peter D, Hessell, Ann J, Burton, Dennis R, Zwick, Michael B
Published in Nature (15.02.2007)
Published in Nature (15.02.2007)
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Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis
Spencer, David A., Goldberg, Benjamin S., Pandey, Shilpi, Ordonez, Tracy, Dufloo, Jérémy, Barnette, Philip, Sutton, William F., Henderson, Heidi, Agnor, Rebecca, Gao, Lina, Bruel, Timothée, Schwartz, Olivier, Haigwood, Nancy L., Ackerman, Margaret E., Hessell, Ann J.
Published in Nature communications (03.02.2022)
Published in Nature communications (03.02.2022)
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Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity
Shapiro, Mariya B., Cheever, Tracy, Malherbe, Delphine C., Pandey, Shilpi, Reed, Jason, Yang, Eun Sung, Wang, Keyun, Pegu, Amarendra, Chen, Xuejun, Siess, Don, Burke, David, Henderson, Heidi, Lewinsohn, Rebecca, Fischer, Miranda, Stanton, Jeffrey J., Axthelm, Michael K., Kahl, Christoph, Park, Byung, Lewis, Anne D., Sacha, Jonah B., Mascola, John R., Hessell, Ann J., Haigwood, Nancy L.
Published in Nature communications (07.01.2020)
Published in Nature communications (07.01.2020)
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Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120
Chen, Lei, Do Kwon, Young, Zhou, Tongqing, Wu, Xueling, O'Dell, Sijy, Cavacini, Lisa, Hessell, Ann J, Pancera, Marie, Tang, Min, Xu, Ling, Yang, Zhi-Yong, Zhang, Mei-Yun, Arthos, James, Burton, Dennis R, Dimitrov, Dimiter S, Nabel, Gary J, Posner, Marshall R, Sodroski, Joseph, Wyatt, Richard, Mascola, John R, Kwong, Peter D
Published in Science (American Association for the Advancement of Science) (20.11.2009)
Published in Science (American Association for the Advancement of Science) (20.11.2009)
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Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir
Prévost, Jérémie, Chen, Yaozong, Zhou, Fei, Tolbert, William D., Gasser, Romain, Medjahed, Halima, Nayrac, Manon, Nguyen, Dung N., Gottumukkala, Suneetha, Hessell, Ann J., Rao, Venigalla B., Pozharski, Edwin, Huang, Rick K., Matthies, Doreen, Finzi, Andrés, Pazgier, Marzena
Published in Nature communications (23.10.2023)
Published in Nature communications (23.10.2023)
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Differential V2-directed antibody responses in non-human primates infected with SHIVs or immunized with diverse HIV vaccines
Weiss, Svenja, Itri, Vincenza, Pan, Ruimin, Jiang, Xunqing, Luo, Christina C., Morris, Lynn, Malherbe, Delphine C., Barnette, Philip, Alexander, Jeff, Kong, Xiang-Peng, Haigwood, Nancy L., Hessell, Ann J., Duerr, Ralf, Zolla-Pazner, Susan
Published in Nature communications (16.02.2022)
Published in Nature communications (16.02.2022)
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Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice
Hioe, Catarina E, Li, Guangming, Liu, Xiaomei, Tsahouridis, Ourania, He, Xiuting, Funaki, Masaya, Klingler, Jéromine, Tang, Alex F, Feyznezhad, Roya, Heindel, Daniel W, Wang, Xiao-Hong, Spencer, David A, Hu, Guangnan, Satija, Namita, Prévost, Jérémie, Finzi, Andrés, Hessell, Ann J, Wang, Shixia, Lu, Shan, Chen, Benjamin K, Zolla-Pazner, Susan, Upadhyay, Chitra, Alvarez, Raymond, Su, Lishan
Published in PLoS pathogens (01.01.2022)
Published in PLoS pathogens (01.01.2022)
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Journal Article
Advancing HIV Broadly Neutralizing Antibodies: From Discovery to the Clinic
Spencer, David A., Shapiro, Mariya B., Haigwood, Nancy L., Hessell, Ann J.
Published in Frontiers in public health (26.05.2021)
Published in Frontiers in public health (26.05.2021)
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Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity
Goldberg, Benjamin S, Kaku, Chengzi I, Dufloo, Jérémy, Bruel, Timothée, Schwartz, Olivier, Spencer, David A, Hessell, Ann J, Ackerman, Margaret E
Published in mBio (26.10.2021)
Published in mBio (26.10.2021)
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Vaccination with immune complexes modulates the elicitation of functional antibodies against HIV-1
Hioe, Catarina E, Liu, Xiaomei, Banin, Andrew N, Heindel, Daniel W, Klingler, Jéromine, Rao, Priyanka G, Luo, Christina C, Jiang, Xunqing, Pandey, Shilpi, Ordonez, Tracy, Barnette, Philip, Totrov, Maxim, Zhu, Jiang, Nádas, Arthur, Zolla-Pazner, Susan, Upadhyay, Chitra, Shen, Xiaoying, Kong, Xiang-Peng, Hessell, Ann J
Published in Frontiers in immunology (03.10.2023)
Published in Frontiers in immunology (03.10.2023)
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A Nonfucosylated Variant of the anti-HIV-1 Monoclonal Antibody b12 Has Enhanced FcγRIIIa-Mediated Antiviral Activity In Vitro but Does Not Improve Protection against Mucosal SHIV Challenge in Macaques
MOLDT, Brian, SHIBATA-KOYAMA, Mami, DUGAST, Anne-Sophie, PARREN, Paul W. H. I, NIMMERJAHN, Falk, EVANS, David T, ALTER, Galit, FORTHAL, Donald N, SCHMITZ, Jörn E, IIDA, Shigeru, POIGNARD, Pascal, WATKINS, David I, RAKASZ, Eva G, HESSELL, Ann J, BURTONA, Dennis R, SCHULTZ, Niccole, KANDA, Yutaka, CAMERON DUNLOP, D, FINSTAD, Samantha L, CHENGGANG JIN, LANDUCCI, Gary, ALPERT, Michael D
Published in Journal of Virology (01.06.2012)
Published in Journal of Virology (01.06.2012)
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Polyfunctional Tier 2-Neutralizing Antibodies Cloned following HIV-1 Env Macaque Immunization Mirror Native Antibodies in a Human Donor
Spencer, David A, Malherbe, Delphine C, Vázquez Bernat, Néstor, Ádori, Monika, Goldberg, Benjamin, Dambrauskas, Nicholas, Henderson, Heidi, Pandey, Shilpi, Cheever, Tracy, Barnette, Philip, Sutton, William F, Ackerman, Margaret E, Kobie, James J, Sather, D Noah, Karlsson Hedestam, Gunilla B, Haigwood, Nancy L, Hessell, Ann J
Published in The Journal of immunology (1950) (01.03.2021)
Published in The Journal of immunology (1950) (01.03.2021)
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