PI3K inhibitors in inflammation, autoimmunity and cancer
Stark, Anne-Katrien, Sriskantharajah, Srividya, Hessel, Edith M, Okkenhaug, Klaus
Published in Current opinion in pharmacology (01.08.2015)
Published in Current opinion in pharmacology (01.08.2015)
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Journal Article
Histamine-secreting microbes are increased in the gut of adult asthma patients
Barcik, Weronika, MSc, Pugin, Benoit, PhD, Westermann, Patrick, MSc, Perez, Noelia Rodriguez, PhD, Ferstl, Ruth, PhD, Wawrzyniak, Marcin, PhD, Smolinska, Sylwia, PhD, Jutel, Marek, MD, PhD, Hessel, Edith M., PhD, Michalovich, David, PhD, Akdis, Cezmi A., MD, Frei, Remo, PhD, O'Mahony, Liam, PhD
Published in Journal of allergy and clinical immunology (01.11.2016)
Published in Journal of allergy and clinical immunology (01.11.2016)
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Journal Article
Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients
Michalovich, David, Rodriguez-Perez, Noelia, Smolinska, Sylwia, Pirozynski, Michal, Mayhew, David, Uddin, Sorif, Van Horn, Stephanie, Sokolowska, Milena, Altunbulakli, Can, Eljaszewicz, Andrzej, Pugin, Benoit, Barcik, Weronika, Kurnik-Lucka, Magdalena, Saunders, Ken A., Simpson, Karen D., Schmid-Grendelmeier, Peter, Ferstl, Ruth, Frei, Remo, Sievi, Noriane, Kohler, Malcolm, Gajdanowicz, Pawel, Graversen, Katrine B., Lindholm Bøgh, Katrine, Jutel, Marek, Brown, James R., Akdis, Cezmi A., Hessel, Edith M., O’Mahony, Liam
Published in Nature communications (13.12.2019)
Published in Nature communications (13.12.2019)
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Journal Article
IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment
Davidson, Sophia, McCabe, Teresa M, Crotta, Stefania, Gad, Hans Henrik, Hessel, Edith M, Beinke, Soren, Hartmann, Rune, Wack, Andreas
Published in EMBO molecular medicine (01.09.2016)
Published in EMBO molecular medicine (01.09.2016)
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Journal Article
Airway host-microbiome interactions in chronic obstructive pulmonary disease
Wang, Zhang, Maschera, Barbara, Lea, Simon, Kolsum, Umme, Michalovich, David, Van Horn, Stephanie, Traini, Christopher, Brown, James R, Hessel, Edith M, Singh, Dave
Published in Respiratory research (06.06.2019)
Published in Respiratory research (06.06.2019)
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Journal Article
Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition
Juss, Jatinder K, House, David, Amour, Augustin, Begg, Malcolm, Herre, Jurgen, Storisteanu, Daniel M L, Hoenderdos, Kim, Bradley, Glyn, Lennon, Mark, Summers, Charlotte, Hessel, Edith M, Condliffe, Alison, Chilvers, Edwin R
Published in American journal of respiratory and critical care medicine (15.10.2016)
Published in American journal of respiratory and critical care medicine (15.10.2016)
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Journal Article
Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model
Edwards, Chris D., Luscombe, Chris, Eddershaw, Peter, Hessel, Edith M.
Published in Pharmaceutical research (01.11.2016)
Published in Pharmaceutical research (01.11.2016)
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Journal Article
PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
Stark, Anne-Katrien, Chandra, Anita, Chakraborty, Krishnendu, Alam, Rafeah, Carbonaro, Valentina, Clark, Jonathan, Sriskantharajah, Srividya, Bradley, Glyn, Richter, Alex G., Banham-Hall, Edward, Clatworthy, Menna R., Nejentsev, Sergey, Hamblin, J. Nicole, Hessel, Edith M., Condliffe, Alison M., Okkenhaug, Klaus
Published in Nature communications (09.08.2018)
Published in Nature communications (09.08.2018)
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Journal Article
Intranasal Bifidobacterium longum protects against viral-induced lung inflammation and injury in a murine model of lethal influenza infection
Groeger, David, Schiavi, Elisa, Grant, Ray, Kurnik-Łucka, Magdalena, Michalovich, David, Williamson, Rick, Beinke, Soren, Kiely, Barry, Akdis, Cezmi A, Hessel, Edith M, Shanahan, Fergus, O’ Mahony, Liam
Published in EBioMedicine (01.10.2020)
Published in EBioMedicine (01.10.2020)
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Journal Article
PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation
Uddin, Sorif, Amour, Augustin, Lewis, David J, Edwards, Chris D, Williamson, Matthew G, Hall, Simon, Lione, Lisa A, Hessel, Edith M
Published in BMC immunology (17.12.2021)
Published in BMC immunology (17.12.2021)
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Journal Article
Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection
Aegerter, Helena, Kulikauskaite, Justina, Crotta, Stefania, Patel, Harshil, Kelly, Gavin, Hessel, Edith M., Mack, Matthias, Beinke, Soren, Wack, Andreas
Published in Nature immunology (01.02.2020)
Published in Nature immunology (01.02.2020)
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Journal Article
Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction
Hessel, Edith M, Chu, Mabel, Lizcano, Jennifer O, Chang, Bonnie, Herman, Nancy, Kell, Sariah A, Wills-Karp, Marsha, Coffman, Robert L
Published in The Journal of experimental medicine (05.12.2005)
Published in The Journal of experimental medicine (05.12.2005)
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Journal Article
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
Kanzler, Holger, Barrat, Franck J, Hessel, Edith M, Coffman, Robert L
Published in Nature medicine (01.05.2007)
Published in Nature medicine (01.05.2007)
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Journal Article
Membrane-Bound TNF Supports Secondary Lymphoid Organ Structure but Is Subservient to Secreted TNF in Driving Autoimmune Inflammation
Ruuls, Sigrid R, Hoek, Robert M, Ngo, Vu N, McNeil, Tom, Lucian, Linda A, Janatpour, Mary J, Körner, Heinrich, Scheerens, Heleen, Hessel, Edith M, Cyster, Jason G, McEvoy, Leslie M, Sedgwick, Jonathon D
Published in Immunity (Cambridge, Mass.) (01.10.2001)
Published in Immunity (Cambridge, Mass.) (01.10.2001)
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Journal Article
Safety, Tolerability, and Pharmacokinetics of a New Formulation of Nemiralisib Administered via a Dry Powder Inhaler to Healthy Individuals
Wilson, Robert, Templeton, Alison, Leemereise, Claudia, Eames, Rhena, Banham-Hall, Edward, Hessel, Edith M., Cahn, Anthony
Published in Clinical therapeutics (01.06.2019)
Published in Clinical therapeutics (01.06.2019)
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Journal Article
Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages
Lopes, Filipa B, Bálint, Štefan, Valvo, Salvatore, Felce, James H, Hessel, Edith M, Dustin, Michael L, Davis, Daniel M
Published in The Journal of cell biology (03.04.2017)
Published in The Journal of cell biology (03.04.2017)
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Journal Article
Corrected Super-Resolution Microscopy Enables Nanoscale Imaging of Autofluorescent Lung Macrophages
Ambrose, Ashley R., Dechantsreiter, Susanne, Shah, Rajesh, Montero, M. Angeles, Quinn, Anne Marie, Hessel, Edith M., Beinke, Soren, Tannahill, Gillian M., Davis, Daniel M.
Published in Biophysical journal (15.12.2020)
Published in Biophysical journal (15.12.2020)
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Journal Article
In situ targeted base editing of bacteria in the mouse gut
Brödel, Andreas K., Charpenay, Loïc H., Galtier, Matthieu, Fuche, Fabien J., Terrasse, Rémi, Poquet, Chloé, Havránek, Jan, Pignotti, Simone, Krawczyk, Antonina, Arraou, Marion, Prevot, Gautier, Spadoni, Dalila, Yarnall, Matthew T. N., Hessel, Edith M., Fernandez-Rodriguez, Jesus, Duportet, Xavier, Bikard, David
Published in Nature (London) (22.08.2024)
Published in Nature (London) (22.08.2024)
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Journal Article