Optimization of Drug-Linker to Enable Long-term Storage of Antibody–Drug Conjugate for Subcutaneous Dosing
Hobson, Adrian D., Xu, Jianwen, Marvin, Christopher C., McPherson, Michael J., Hollmann, Markus, Gattner, Michael, Dzeyk, Kristina, Fettis, Margaret M., Bischoff, Agnieszka K., Wang, Lu, Fitzgibbons, Julia, Wang, Lu, Salomon, Paulin, Hernandez, Axel, Jia, Ying, Sarvaiya, Hetal, Goess, Christian A., Mathieu, Suzanne L., Santora, Ling C.
Published in Journal of medicinal chemistry (13.07.2023)
Published in Journal of medicinal chemistry (13.07.2023)
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Journal Article
Impact of dipeptide on ADC physicochemical properties and efficacy identifies Ala-Ala as the optimal dipeptide
Wang, Lu, Hobson, Adrian D, Fitzgibbons, Julia, Hernandez, Axel, Jia, Ying, Xu, Zhou, Wang, Zhongyuan, Yu, Yajie, Li, Xiang
Published in MedChemComm (25.01.2024)
Published in MedChemComm (25.01.2024)
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Journal Article
Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads
Hobson, Adrian D, McPherson, Michael J, Waegell, Wendy, Goess, Christian A, Stoffel, Robert H, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Hernandez, Axel, Bryant, Shaughn H, Mathieu, Suzanne L, Bischoff, Agnieszka K, Fitzgibbons, Julia, Pawlikowska, Martyna, Puthenveetil, Sujiet, Santora, Ling C, Wang, Lu, Wang, Lu, Marvin, Christopher C, Hayes, Martin E, Shrestha, Anurupa, Sarris, Kathy A, Li, Biqin
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
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Journal Article
Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC)
Hobson, Adrian D., Xu, Jianwen, Welch, Dennie S., Marvin, Christopher C., McPherson, Michael J., Gates, Bradley, Liao, Xiaoli, Hollmann, Markus, Gattner, Michael J., Dzeyk, Kristina, Sarvaiya, Hetal, Shenoy, Vikram M., Fettis, Margaret M., Bischoff, Agnieszka K., Wang, Lu, Santora, Ling C., Wang, Lu, Fitzgibbons, Julia, Salomon, Paulin, Hernandez, Axel, Jia, Ying, Goess, Christian A., Mathieu, Suzanne L., Bryant, Shaughn H., Larsen, Mary E., Cui, Baoliang, Tian, Yu
Published in Journal of medicinal chemistry (14.09.2023)
Published in Journal of medicinal chemistry (14.09.2023)
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Journal Article
Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model
Marvin, Christopher C., Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Bischoff, Agnieszka K., Fitzgibbons, Julia, Wang, Lu, Wang, Lu, Hernandez, Axel, Jia, Ying, Goess, Christian A., Bryant, Shaughn H., Mathieu, Suzanne L., Xu, Jianwen
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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Journal Article
Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate
Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Goess, Christian, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Yang, Jindong, Sun, Liang, Zhang, Qiang, Qu, Pei, Yang, Shi, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Santora, Ling C., Wang, Lu, Wang, Lu, Fettis, Margaret M., Li, Xiaofeng, Marvin, Christopher C., Wang, Zhi, Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Henry, Rodger F., Graff, Candace, Tian, Yu, Aguirre, Ana L., Shrestha, Anurupa
Published in Journal of medicinal chemistry (08.12.2022)
Published in Journal of medicinal chemistry (08.12.2022)
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Journal Article
ABBV-319: a CD19-targeting glucocorticoid receptor modulator antibody-drug conjugate therapy for B-cell malignancies
Chang, Chewei Anderson, Emberley, Ethan, D'Souza, Aloma L., Zhao, Weilong, Cosgrove, Cormac, Parrish, Karen, Mitra, Diya, Payson, Elmer, Oleksijew, Anatol, Ellis, Paul, Rodriguez, Luis, Duggan, Ryan, Hrusch, Cara, Lasko, Loren, Assaily, Wissam, Zheng, Pingping, Liu, Wei, Hernandez, Axel, McCarthy, Kimberley, Zhang, Zhaomei, Rha, Geunbae, Cao, Zhensheng, Li, Yingchun, Perng, Olivia, Campbell, Jos, Zhang, Gloria, Curran, Tyler, Bruncko, Milan, Marvin, Christopher C., Hobson, Adrian, McPherson, Michael, Uziel, Tamar, Pysz, Marybeth A., Zhao, Xi, Bankovich, Alex, Hayflick, Joel, McDevitt, Michael, Freise, Kevin J., Morgan-Lappe, Susan, Purcell, James W.
Published in Blood (15.08.2024)
Published in Blood (15.08.2024)
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Journal Article
An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases
McPherson, Michael J, Hobson, Adrian D, Hernandez, Jr, Axel, Marvin, Christopher C, Waegell, Wendy, Goess, Christian, Oh, Jason Z, Shi, Dan, Hayes, Martin E, Wang, Lu, Wang, Lu, Schmidt, Diana, Wang, Zhi, Pitney, Victoria, McCarthy, Kimberley, Jia, Ying, Wang, Ce, Kang, Bit Na, Bryant, Shaughn, Mathieu, Suzanne, Ruzek, Melanie, Parmentier, Julie, D'Cunha, Ronilda R, Pang, Yinuo, Phillips, Lucy, Brown, Nathan J, Xu, Jianwen, Graff, Candace, Tian, Yu, Longenecker, Kenton L, Qiu, Wei, Zhu, Haizhong, Liu, Wei, Zheng, Pingping, Bi, Yingtao, Stoffel, Robert
Published in Science translational medicine (20.03.2024)
Published in Science translational medicine (20.03.2024)
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Journal Article
Correction to “Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads”
Hobson, Adrian D., McPherson, Michael J., Waegell, Wendy, Goess, Christian A., Stoffel, Robert H., Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Pawlikowska, Martyna, Puthenveetil, Sujiet, Santora, Ling C., Wang, Lu, Wang, Lu, Marvin, Christopher C., Hayes, Martin E., Shrestha, Anurupa, Sarris, Kathy A., Li, Biqin
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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Journal Article
Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates
Wang, Lu, Hobson, Adrian D, Salomon, Paulin L, Fitzgibbons, Julia, Xu, Jianwen, McCarthy, Sean, Wu, Kan, Jia, Ying, Hernandez, Axel, Li, Xiang, Xu, Zhou, Wang, Zhongyuan, Yu, Yajie, Li, Junxian, Tao, Lin
Published in MedChemComm (21.02.2024)
Published in MedChemComm (21.02.2024)
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Journal Article
Correction to “Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate”
Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Goess, Christian, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Yang, Jindong, Sun, Liang, Zhang, Qiang, Qu, Pei, Yang, Shi, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Santora, Ling C., Wang, Lu, Wang, Lu, Fettis, Margaret M., Li, Xiaofeng, Marvin, Christopher C., Wang, Zhi, Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Henry, Rodger F., Graff, Candace, Tian, Yu, Aguirre, Ana L., Shrestha, Anurupa
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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Journal Article
Abstract 6308: Preclinical development of ABBV-319: a CD19-targeting glucocorticoid receptor modulator (GRM) agonist antibody-drug conjugate (ADC) for the treatment of B-cell malignancies
Chang, Chewei Anderson, Emberley, Ethan, D'Souza, Aloma L., Zhao, Weilong, Cosgrove, Cormac, Jr, Axel Hernandez, Oleksijew, Anatol, Ellis, Paul, Rodriguez, Luis, Bukofzer, Gail, Peetz, David, Assaily, Wissam, Mali, Raghuveer Singh, Liu, Wei, Xu, Danqing, Potts, Gregory K., McLoughlin, Shaun, McCarthy, Kimberley, Zhang, Zhaomei, Campbell, Jos, Sturdevant, Isabella, Zhang, Gloria, Curran, Tyler, Williams, Jon D., Boghaert, Erwin, Bruncko, Milan, Marvin, Christopher C., Hobson, Adrian, Mcpherson, Michael, Uziel, Tamar, Pysz, Marybeth, Zhao, Xi, Bankovich, Alex, Freise, Kevin J., Morgan-Lappe, Susan, Purcell, James W.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Anti-alpha-4-beta-7 antibodies
Dong, Feng, Miller, Renee, Ng, Teresa (Iok-Chan), Hernandez, Jr., Axel, Bixby, Jacqueline, Benatuil, Lorenzo, Dekhtyar, Tatyana, Krishnan, Preethi, Mensa, Federico, Min, Jing, Lu, Liangjun, Sahu, Gautam
Year of Publication 02.05.2023
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Year of Publication 02.05.2023
Patent
ANTI-ΑLPHA-4-ΒETA-7 ANTIBODIES
BENATUIL, Lorenzo, DEKHTYAR, Tatyana, NG, Teresa (Iok-Chan), KRISHNAN, Preethi, DONG, Feng, BIXBY, Jacqueline, LU, Liangjun, MIN, Jing, MENSA, Federico, HERNANDEZ Jr., Axel, MILLER, Renee, SAHU, Gautam
Year of Publication 27.09.2023
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Year of Publication 27.09.2023
Patent
Anti-alpha-4-beta-7 antibodies
BENATUIL, Lorenzo, DEKHTYAR, Tatyana, NG, Teresa (Iok-Chan), KRISHNAN, Preethi, DONG, Feng, BIXBY, Jacqueline, LU, Liangjun, MIN, Jing, MENSA, Federico, HERNANDEZ Jr., Axel, MILLER, Renee, SAHU, Gautam
Year of Publication 02.02.2023
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Year of Publication 02.02.2023
Patent
ANTI-ALPHA-4-BETA-7 ANTIBODIES
Dong, Feng, Miller, Renee, Ng, Teresa (Iok-Chan), Hernandez, Jr., Axel, Bixby, Jacqueline, Benatuil, Lorenzo, Dekhtyar, Tatyana, Krishnan, Preethi, Mensa, Federico, Min, Jing, Lu, Liangjun, Sahu, Gautam
Year of Publication 20.01.2022
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Year of Publication 20.01.2022
Patent
GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF
HOBSON, ADRIAN D, MCPHERSON, MICHAEL J, GOESS, CHRISTIAN, WAEGELL, WENDY, HERNANDEZ, AXEL JR, SANTORA, LING C, MARVIN, CHRISTOPHER C, WANG, LU
Year of Publication 18.10.2021
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Year of Publication 18.10.2021
Patent
ANTI-CD40 ANTIBODY DRUG CONJUGATES
Oh, Jason Z, Marvin, Christopher C, Perng, Olivia A, Hobson, Adrian D, Santora, Ling C, Bryant, Shaughn H, Hernandez, Jr., Axel, Ihle, Claire L, Waegell, Wendy, Wang, Lu, McPherson, Michael J
Year of Publication 25.08.2022
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Year of Publication 25.08.2022
Patent
GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF
Marvin, Christopher C, Hobson, Adrian D, Santora, Ling C, Waegell, Wendy, Goess, Christian, Hernandez, Axel, Jr, Wang, Lu, McPherson, Michael J
Year of Publication 03.09.2021
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Year of Publication 03.09.2021
Patent