The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies
Copin, Richard, Baum, Alina, Wloga, Elzbieta, Pascal, Kristen E., Giordano, Stephanie, Fulton, Benjamin O., Zhou, Anbo, Negron, Nicole, Lanza, Kathryn, Chan, Newton, Coppola, Angel, Chiu, Joyce, Ni, Min, Wei, Yi, Atwal, Gurinder S., Hernandez, Annabel Romero, Saotome, Kei, Zhou, Yi, Franklin, Matthew C., Hooper, Andrea T., McCarthy, Shane, Hamon, Sara, Hamilton, Jennifer D., Staples, Hilary M., Alfson, Kendra, Carrion, Ricardo, Ali, Shazia, Norton, Thomas, Somersan-Karakaya, Selin, Sivapalasingam, Sumathi, Herman, Gary A., Weinreich, David M., Lipsich, Leah, Stahl, Neil, Murphy, Andrew J., Yancopoulos, George D., Kyratsous, Christos A.
Published in Cell (22.07.2021)
Published in Cell (22.07.2021)
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Comparison of PET/CT versus CT only in the assessment of new heterotopic ossification bone lesions in patients with fibrodysplasia ossificans progressiva
González Trotter, Dinko, McGinniss, Jennifer, Mohammadi, Kusha, Musser, Bret J., Herman, Gary A., Mellis, Scott, Economides, Aris N.
Published in Bone (New York, N.Y.) (01.01.2025)
Published in Bone (New York, N.Y.) (01.01.2025)
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Examining protective effects of SARS-CoV-2 neutralizing antibodies after vaccination or monoclonal antibody administration
Follmann, Dean, O’Brien, Meagan P., Fintzi, Jonathan, Fay, Michael P., Montefiori, David, Mateja, Allyson, Herman, Gary A., Hooper, Andrea T., Turner, Kenneth C., Chan, Kuo- Chen, Forleo-Neto, Eduardo, Isa, Flonza, Baden, Lindsey R., El Sahly, Hana M., Janes, Holly, Doria-Rose, Nicole, Miller, Jacqueline, Zhou, Honghong, Dang, Weiping, Benkeser, David, Fong, Youyi, Gilbert, Peter B., Marovich, Mary, Cohen, Myron S.
Published in Nature communications (17.06.2023)
Published in Nature communications (17.06.2023)
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Casirivimab and Imdevimab for the Treatment of Hospitalized Patients With COVID-19
Somersan-Karakaya, Selin, Mylonakis, Eleftherios, Menon, Vidya P, Wells, Jason C, Ali, Shazia, Sivapalasingam, Sumathi, Sun, Yiping, Bhore, Rafia, Mei, Jingning, Miller, Jutta, Cupelli, Lisa, Forleo-Neto, Eduardo, Hooper, Andrea T, Hamilton, Jennifer D, Pan, Cynthia, Pham, Viet, Zhao, Yuming, Hosain, Romana, Mahmood, Adnan, Davis, John D, Turner, Kenneth C, Kim, Yunji, Cook, Amanda, Kowal, Bari, Soo, Yuhwen, DiCioccio, A Thomas, Geba, Gregory P, Stahl, Neil, Lipsich, Leah, Braunstein, Ned, Herman, Gary A, Yancopoulos, George D, Weinreich, David M
Published in The Journal of infectious diseases (28.12.2022)
Published in The Journal of infectious diseases (28.12.2022)
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34-OR: The Effect of Combined Activin A and Myostatin Blockade on Body Composition—A Phase 1 Trial
GONZALEZ TROTTER, DINKO, DONAHUE, STEPHEN, WYNNE, CHRIS, ALI, SHAZIA, PARASOGLOU, PRODROMOS, BOYAPATI, ANITA, MOHAMMADI, KUSHA, MUSSER, BRET J., MEIER, PRETTY, MASTAITIS, JASON, GASPARINO, EVELYN, TREJOS, JESUS, DAVIS, JOHN D., HERMAN, GARY A., PORDY, ROBERT
Published in Diabetes (New York, N.Y.) (14.06.2024)
Published in Diabetes (New York, N.Y.) (14.06.2024)
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Efficacy and Safety of Sarilumab in Hospitalized Patients With Coronavirus Disease 2019: A Randomized Clinical Trial
Sivapalasingam, Sumathi, Lederer, David J, Bhore, Rafia, Hajizadeh, Negin, Criner, Gerard, Hosain, Romana, Mahmood, Adnan, Giannelou, Angeliki, Somersan-Karakaya, Selin, O’Brien, Meagan P, Boyapati, Anita, Parrino, Janie, Musser, Bret J, Labriola-Tompkins, Emily, Ramesh, Divya, Purcell, Lisa A, Gulabani, Daya, Kampman, Wendy, Waldron, Alpana, Ng Gong, Michelle, Saggar, Suraj, Sperber, Steven J, Menon, Vidya, Stein, David K, Sobieszczyk, Magdalena E, Park, William, Aberg, Judith A, Brown, Samuel M, Kosmicki, Jack A, Horowitz, Julie E, Ferreira, Manuel A, Baras, Aris, Kowal, Bari, Thomas DiCioccio, A, Akinlade, Bolanle, Nivens, Michael C, Braunstein, Ned, Herman, Gary A, Yancopoulos, George D, Weinreich, David M
Published in Clinical infectious diseases (24.08.2022)
Published in Clinical infectious diseases (24.08.2022)
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Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial
Di Rocco, Maja, Forleo-Neto, Eduardo, Pignolo, Robert J., Keen, Richard, Orcel, Philippe, Funck-Brentano, Thomas, Roux, Christian, Kolta, Sami, Madeo, Annalisa, Bubbear, Judith S., Tabarkiewicz, Jacek, Szczepanek, Małgorzata, Bachiller-Corral, Javier, Cheung, Angela M., Dahir, Kathryn M., Botman, Esmée, Raijmakers, Pieter G., Al Mukaddam, Mona, Tile, Lianne, Portal-Celhay, Cynthia, Sarkar, Neena, Hou, Peijie, Musser, Bret J., Boyapati, Anita, Mohammadi, Kusha, Mellis, Scott J., Rankin, Andrew J., Economides, Aris N., Trotter, Dinko Gonzalez, Herman, Gary A., O’Meara, Sarah J., DelGizzi, Richard, Weinreich, David M., Yancopoulos, George D., Eekhoff, E. Marelise W., Kaplan, Frederick S.
Published in Nature medicine (01.10.2023)
Published in Nature medicine (01.10.2023)
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Repeat subcutaneous administration of casirivimab and imdevimab in adults is well-tolerated and prevents the occurrence of COVID-19
Isa, Flonza, Forleo-Neto, Eduardo, Meyer, Jonathan, Zheng, Wenjun, Rasmussen, Scott, Armas, Danielle, Oshita, Masaru, Brinson, Cynthia, Folkerth, Steven, Faria, Lori, Heirman, Ingeborg, Sarkar, Neena, Musser, Bret J., Bansal, Shikha, O'Brien, Meagan P., Turner, Kenneth C., Ganguly, Samit, Mahmood, Adnan, Dupljak, Ajla, Hooper, Andrea T., Hamilton, Jennifer D., Kim, Yunji, Kowal, Bari, Soo, Yuhwen, Geba, Gregory P., Lipsich, Leah, Braunstein, Ned, Yancopoulos, George D., Weinreich, David M., Herman, Gary A.
Published in International journal of infectious diseases (01.09.2022)
Published in International journal of infectious diseases (01.09.2022)
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Casirivimab and Imdevimab Treatment Reduces Viral Load and Improves Clinical Outcomes in Seropositive Hospitalized COVID-19 Patients with Nonneutralizing or Borderline Neutralizing Antibodies
Hooper, Andrea T, Somersan-Karakaya, Selin, McCarthy, Shane E, Mylonakis, Eleftherios, Ali, Shazia, Mei, Jingning, Bhore, Rafia, Mahmood, Adnan, Geba, Gregory P, Dakin, Paula, Weinreich, David M, Yancopoulos, George D, Herman, Gary A, Hamilton, Jennifer D
Published in mBio (20.12.2022)
Published in mBio (20.12.2022)
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1198-P: Prevention of COVID-with Subcutaneous Administration of CAS+IMD in Individuals with Diabetes and Other Risk Factors for Severe Disease
O'BRIEN, MEAGAN, FORLEO-NETO, EDUARDO, ORTA, ERNESTO OVIEDO, MCGINNISS, JENNIFER, HOU, PEIJIE, ISA, FLONZA, CHAN, KUO-CHEN, SARKAR, NEENA, MUSSER, BRET J., BARNABAS, RUANNE V., COHEN, MYRON S., MAHMOOD, ADNAN, HERMAN, GARY A., YANCOPOULOS, GEORGE D., WEINREICH, DAVID M.
Published in Diabetes (New York, N.Y.) (01.06.2022)
Published in Diabetes (New York, N.Y.) (01.06.2022)
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Effect of Renal Insufficiency on the Pharmacokinetics of Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor
Bergman, Arthur J, Cote, Josee, Yi, Bingming, Marbury, Thomas, Swan, Suzanne K, Smith, William, Gottesdiener, Keith, Wagner, John, Herman, Gary A
Published in Diabetes care (01.07.2007)
Published in Diabetes care (01.07.2007)
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Effect of Single Oral Doses of Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, on Incretin and Plasma Glucose Levels after an Oral Glucose Tolerance Test in Patients with Type 2 Diabetes
Herman, Gary A., Bergman, Arthur, Stevens, Catherine, Kotey, Paul, Yi, Bingming, Zhao, Peng, Dietrich, Bruno, Golor, George, Schrodter, Andreas, Keymeulen, Bart, Lasseter, Kenneth C., Kipnes, Mark S., Snyder, Karen, Hilliard, Deborah, Tanen, Michael, Cilissen, Caroline, De Smet, Marina, de Lepeleire, Inge, Van Dyck, Kristien, Wang, Amy Q., Zeng, Wei, Davies, Michael J., Tanaka, Wesley, Holst, Jens J., Deacon, Carolyn F., Gottesdiener, Keith M., Wagner, John A.
Published in The journal of clinical endocrinology and metabolism (01.11.2006)
Published in The journal of clinical endocrinology and metabolism (01.11.2006)
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Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency
Altarejos, Judith Y, Pangilinan, Jeffrey, Podgrabinska, Simona, Akinci, Baris, Foss-Freitas, Maria, Neidert, Adam H, Ray, Yonaton, Zheng, Wenjun, Kim, Steven, Kamat, Vishal, Huang, Meilin, Min, Soo, Mastaitis, Jason, Dominguez-Gutierrez, Giselle, Kim, Jee-Hae, Stevis, Panayiotis, Huang, Tammy, Zambrowicz, Brian, Olson, William C, Godin, Stephen, Bradley, Elizabeth, Gewitz, Andrew D, Baker, Mark, Hench, Rita, Davenport, Matthew S, Chenevert, Thomas L, DiPaola, Frank, Yancopoulos, George D, Murphy, Andrew J, Herman, Gary A, Musser, Bret J, Dansky, Hayes, Harp, Joyce, Gromada, Jesper, Sleeman, Mark W, Oral, Elif A, Olenchock, Benjamin A
Published in Science translational medicine (22.11.2023)
Published in Science translational medicine (22.11.2023)
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Assessing the safety and pharmacokinetics of casirivimab and imdevimab (CAS+IMD) in a cohort of pregnant outpatients with COVID-19: results from an adaptive, multicentre, randomised, double-blind, phase 1/2/3 study
Norton, Thomas D, Thakur, Mazhar, Ganguly, Samit, Ali, Shazia, Chao, Jesse, Waldron, Alpana, Xiao, Jing, Patel, Yogesh, Turner, Kenneth C, Davis, John D, Irvin, Susan C, Pan, Cynthia, Atmodjo-Watkins, Dominique, Hooper, Andrea T, Hamilton, Jennifer D, Subramaniam, Danise, Bocchini, Joseph A, Kowal, Bari, DiCioccio, A. Thomas, Bhore, Rafia, Geba, Gregory P, Cox, Edward, Braunstein, Ned, Dakin, Paula, Herman, Gary A
Published in BMJ open (08.10.2024)
Published in BMJ open (08.10.2024)
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The Acyclic CB1R Inverse Agonist Taranabant Mediates Weight Loss by Increasing Energy Expenditure and Decreasing Caloric Intake
Addy, Carol, Wright, Hamish, Van Laere, Koen, Gantz, Ira, Erondu, Ngozi, Musser, Bret J., Lu, Kaifeng, Yuan, Jinyu, Sanabria-Bohórquez, Sandra M., Stoch, Aubrey, Stevens, Cathy, Fong, Tung M., De Lepeleire, Inge, Cilissen, Caroline, Cote, Josee, Rosko, Kim, Gendrano, Isaias N., Nguyen, Allison Martin, Gumbiner, Barry, Rothenberg, Paul, de Hoon, Jan, Bormans, Guy, Depré, Marleen, Eng, Wai-si, Ravussin, Eric, Klein, Samuel, Blundell, John, Herman, Gary A., Burns, H. Donald, Hargreaves, Richard J., Wagner, John, Gottesdiener, Keith, Amatruda, John M., Heymsfield, Steven B.
Published in Cell metabolism (01.01.2008)
Published in Cell metabolism (01.01.2008)
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Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension
Mistry, Goutam C, Maes, Andrea L, Lasseter, Kenneth C, Davies, Michael J, Gottesdiener, Keith M, Wagner, John A, Herman, Gary A
Published in Journal of clinical pharmacology (01.05.2008)
Published in Journal of clinical pharmacology (01.05.2008)
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Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses
Herman, Gary A, Stevens, Cathy, Van Dyck, Kristien, Bergman, Arthur, Yi, Bingming, De Smet, Marina, Snyder, Karen, Hilliard, Deborah, Tanen, Michael, Tanaka, Wesley, Wang, Amy Q, Zeng, Wei, Musson, Donald, Winchell, Gregory, Davies, Michael J, Ramael, Steven, Gottesdiener, Keith M, Wagner, John A
Published in Clinical pharmacology and therapeutics (01.12.2005)
Published in Clinical pharmacology and therapeutics (01.12.2005)
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Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: A double-blind, randomized, placebo-controlled study in healthy male volunteers
Bergman, Arthur J., Stevens, Catherine, Zhou, YanYan, Yi, Bingming, Laethem, Martine, De Smet, Marina, Snyder, Karen, Hilliard, Deborah, Tanaka, Wesley, Zeng, Wei, Tanen, Michael, Wang, Amy Q., Chen, Li, Winchell, Gregory, Davies, Michael J., Ramael, Steven, Wagner, John A., Herman, Gary A.
Published in Clinical therapeutics (2006)
Published in Clinical therapeutics (2006)
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