Opening and Closing of the Bacterial RNA Polymerase Clamp
Chakraborty, Anirban, Wang, Dongye, Ebright, Yon W., Korlann, You, Kortkhonjia, Ekaterine, Kim, Taiho, Chowdhury, Saikat, Wigneshweraraj, Sivaramesh, Irschik, Herbert, Jansen, Rolf, Nixon, B. Tracy, Knight, Jennifer, Weiss, Shimon, Ebright, Richard H.
Published in Science (American Association for the Advancement of Science) (03.08.2012)
Published in Science (American Association for the Advancement of Science) (03.08.2012)
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Journal Article
A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin
Menchon, Grégory, Prota, Andrea E., Lucena-Agell, Daniel, Bucher, Pascal, Jansen, Rolf, Irschik, Herbert, Müller, Rolf, Paterson, Ian, Díaz, J. Fernando, Altmann, Karl-Heinz, Steinmetz, Michel O.
Published in Nature communications (29.05.2018)
Published in Nature communications (29.05.2018)
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Journal Article
New target for inhibition of bacterial RNA polymerase: ‘switch region’
Srivastava, Aashish, Talaue, Meliza, Liu, Shuang, Degen, David, Ebright, Richard Y, Sineva, Elena, Chakraborty, Anirban, Druzhinin, Sergey Y, Chatterjee, Sujoy, Mukhopadhyay, Jayanta, Ebright, Yon W, Zozula, Alex, Shen, Juan, Sengupta, Sonali, Niedfeldt, Rui Rong, Xin, Cai, Kaneko, Takushi, Irschik, Herbert, Jansen, Rolf, Donadio, Stefano, Connell, Nancy, Ebright, Richard H
Published in Current opinion in microbiology (01.10.2011)
Published in Current opinion in microbiology (01.10.2011)
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Journal Article
Damage of Streptococcus mutans biofilms by carolacton, a secondary metabolite from the myxobacterium Sorangium cellulosum
Kunze, Brigitte, Reck, Michael, Dötsch, Andreas, Lemme, André, Schummer, Dietmar, Irschik, Herbert, Steinmetz, Heinrich, Wagner-Döbler, Irene
Published in BMC microbiology (26.07.2010)
Published in BMC microbiology (26.07.2010)
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Journal Article
Sandaracinus amylolyticus gen. nov., sp. nov., a starch-degrading soil myxobacterium, and description of Sandaracinaceae fam. nov
Mohr, Kathrin I, Garcia, Ronald O, Gerth, Klaus, Irschik, Herbert, Müller, Rolf
Published in International journal of systematic and evolutionary microbiology (01.05.2012)
Published in International journal of systematic and evolutionary microbiology (01.05.2012)
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Journal Article
Analysis of the Sorangicin Gene Cluster Reinforces the Utility of a Combined Phylogenetic/Retrobiosynthetic Analysis for Deciphering Natural Product Assembly by trans-AT PKS
Irschik, Herbert, Kopp, Maren, Weissman, Kira J, Buntin, Kathrin, Piel, Jörn, Müller, Rolf
Published in Chembiochem : a European journal of chemical biology (03.09.2010)
Published in Chembiochem : a European journal of chemical biology (03.09.2010)
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Journal Article
Solving the Puzzle of One‐Carbon Loss in Ripostatin Biosynthesis
Fu, Chengzhang, Auerbach, David, Li, Yanyan, Scheid, Ullrich, Luxenburger, Eva, Garcia, Ronald, Irschik, Herbert, Müller, Rolf
Published in Angewandte Chemie International Edition (13.02.2017)
Published in Angewandte Chemie International Edition (13.02.2017)
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Journal Article
The RNA Polymerase “Switch Region” Is a Target for Inhibitors
Mukhopadhyay, Jayanta, Das, Kalyan, Ismail, Sajida, Koppstein, David, Jang, Minyoung, Hudson, Brian, Sarafianos, Stefan, Tuske, Steven, Patel, Jay, Jansen, Rolf, Irschik, Herbert, Arnold, Eddy, Ebright, Richard H.
Published in Cell (17.10.2008)
Published in Cell (17.10.2008)
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Journal Article
GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides
Zhang, Yu, Degen, David, Ho, Mary X, Sineva, Elena, Ebright, Katherine Y, Ebright, Yon W, Mekler, Vladimir, Vahedian-Movahed, Hanif, Feng, Yu, Yin, Ruiheng, Tuske, Steve, Irschik, Herbert, Jansen, Rolf, Maffioli, Sonia, Donadio, Stefano, Arnold, Eddy, Ebright, Richard H
Published in eLife (22.04.2014)
Published in eLife (22.04.2014)
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Journal Article
The Disorazole Z Family of Highly Potent Anticancer Natural Products from Sorangium cellulosum: Structure, Bioactivity, Biosynthesis, and Heterologous Expression
Gao, Yunsheng, Birkelbach, Joy, Fu, Chengzhang, Herrmann, Jennifer, Irschik, Herbert, Morgenstern, Bernd, Hirschfelder, Kerstin, Li, Ruijuan, Zhang, Youming, Jansen, Rolf, Müller, Rolf
Published in Microbiology spectrum (17.08.2023)
Published in Microbiology spectrum (17.08.2023)
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Journal Article
Isolation and Biosynthesis of Aurachin P and 5-Nitroresorcinol from Stigmatella erecta
Höfle, Gerhard, Irschik, Herbert
Published in Journal of natural products (Washington, D.C.) (01.11.2008)
Published in Journal of natural products (Washington, D.C.) (01.11.2008)
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Journal Article
Rifamycins do not function by allosteric modulation of binding of Mg²⁺ to the RNA polymerase active center
Feklistov, Andrey, Mekler, Vladimir, Jiang, Qiaorong, Westblade, Lars F, Irschik, Herbert, Jansen, Rolf, Mustaev, Arkady, Darst, Seth A, Ebright, Richard H
Published in Proceedings of the National Academy of Sciences - PNAS (30.09.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (30.09.2008)
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Journal Article
Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Campbell, Elizabeth A, Pavlova, Olga, Zenkin, Nikolay, Leon, Fred, Irschik, Herbert, Jansen, Rolf, Severinov, Konstantin, Darst, Seth A
Published in The EMBO journal (23.02.2005)
Published in The EMBO journal (23.02.2005)
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Journal Article
The Thuggacins, Novel Antibacterial Macrolides from Sorangium cellulosum Acting against Selected Gram-positive Bacteria: Production, Antimicrobial Activity and Mechanism of Action
Irschik, Herbert, Reichenbach, Hans, Höfle, Gerhard, Jansen, Rolf
Published in Journal of antibiotics (01.12.2007)
Published in Journal of antibiotics (01.12.2007)
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Journal Article
Sulfangolids, Macrolide Sulfate Esters from Sorangium cellulosum
Zander, Wiebke, Irschik, Herbert, Augustiniak, Hermann, Herrmann, Martina, Jansen, Rolf, Steinmetz, Heinrich, Gerth, Klaus, Kessler, Wolfgang, Kalesse, Markus, Höfle, Gerhard, Müller, Rolf
Published in Chemistry : a European journal (14.05.2012)
Published in Chemistry : a European journal (14.05.2012)
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Journal Article
Epothilons A and B: Antifungal and Cytotoxic Compounds from Sorangium cellulosum (Myxobacteria): Production, Physico-chemical and Biological Properties
GERTH, KLAUS, BEDORF, NORBERT, HÖFLE, GERHARD, IRSCHIK, HERBERT, REICHENBACH, HANS
Published in Journal of antibiotics (01.06.1996)
Published in Journal of antibiotics (01.06.1996)
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Journal Article
Isolierung und Totalsynthese der Icumazole und Noricumazole – antimykotische Antibiotika und Kationenkanalblocker aus Sorangium cellulosum
Barbier, Jenny, Jansen, Rolf, Irschik, Herbert, Benson, Stefan, Gerth, Klaus, Böhlendorf, Bettina, Höfle, Gerhard, Reichenbach, Hans, Wegner, Jens, Zeilinger, Carsten, Kirschning, Andreas, Müller, Rolf
Published in Angewandte Chemie (27.01.2012)
Published in Angewandte Chemie (27.01.2012)
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Journal Article
Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes
Altendorfer, Mario, Raja, Aruna, Sasse, Florenz, Irschik, Herbert, Menche, Dirk
Published in Organic & biomolecular chemistry (07.04.2013)
Published in Organic & biomolecular chemistry (07.04.2013)
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Journal Article
The Jerangolids: A Family of New Antifungal Compounds from Sorangium cellulosum (Myxobacteria): Production, Physico-chemical and Biological Properties of Jerangolid A
GERTH, KLAUS, WASHAUSEN, PETER, HÖFLE, GERHARD, IRSCHIK, HERBERT, REICHENBACH, HANS
Published in Journal of antibiotics (01.01.1996)
Published in Journal of antibiotics (01.01.1996)
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