Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation
Primiano, Michael J, Lefker, Bruce A, Bowman, Michael R, Bree, Andrea G, Hubeau, Cedric, Bonin, Paul D, Mangan, Matthew, Dower, Ken, Monks, Brian G, Cushing, Leah, Wang, Stephen, Guzova, Julia, Jiao, Aiping, Lin, Lih-Ling, Latz, Eicke, Hepworth, David, Hall, J Perry
Published in The Journal of immunology (1950) (15.09.2016)
Published in The Journal of immunology (1950) (15.09.2016)
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Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
Hall, Justin, Brault, Amy, Vincent, Fabien, Weng, Shawn, Wang, Hong, Dumlao, Darren, Aulabaugh, Ann, Aivazian, Dikran, Castro, Dana, Chen, Ming, Culp, Jeffrey, Dower, Ken, Gardner, Joseph, Hawrylik, Steven, Golenbock, Douglas, Hepworth, David, Horn, Mark, Jones, Lyn, Jones, Peter, Latz, Eicke, Li, Jing, Lin, Lih-Ling, Lin, Wen, Lin, David, Lovering, Frank, Niljanskul, Nootaree, Nistler, Ryan, Pierce, Betsy, Plotnikova, Olga, Schmitt, Daniel, Shanker, Suman, Smith, James, Snyder, William, Subashi, Timothy, Trujillo, John, Tyminski, Edyta, Wang, Guoxing, Wong, Jimson, Lefker, Bruce, Dakin, Leslie, Leach, Karen
Published in PloS one (21.09.2017)
Published in PloS one (21.09.2017)
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Error reporting in a large animal veterinary teaching hospital identifies medication errors occur most often in the prescribing phase of therapy
Hepworth-Warren, Kate L, Maynard-Swift, Emily, Prange, Timo, Colwell, Curtis, Stallings, Olivia, Derks, Kobi G, Love, Kim, Hepworth, David A, Marks, Steven L
Published in Journal of the American Veterinary Medical Association (01.03.2024)
Published in Journal of the American Veterinary Medical Association (01.03.2024)
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Discovery and Preclinical Characterization of 6‑Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]‑1H‑indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy
Cameron, Kimberly O, Kung, Daniel W, Kalgutkar, Amit S, Kurumbail, Ravi G, Miller, Russell, Salatto, Christopher T, Ward, Jessica, Withka, Jane M, Bhattacharya, Samit K, Boehm, Markus, Borzilleri, Kris A, Brown, Janice A, Calabrese, Matthew, Caspers, Nicole L, Cokorinos, Emily, Conn, Edward L, Dowling, Matthew S, Edmonds, David J, Eng, Heather, Fernando, Dilinie P, Frisbie, Richard, Hepworth, David, Landro, James, Mao, Yuxia, Rajamohan, Francis, Reyes, Allan R, Rose, Colin R, Ryder, Tim, Shavnya, Andre, Smith, Aaron C, Tu, Meihua, Wolford, Angela C, Xiao, Jun
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification
Nolte, Whitney M, Fortin, Jean-Philippe, Stevens, Benjamin D, Aspnes, Gary E, Griffith, David A, Hoth, Lise R, Ruggeri, Roger B, Mathiowetz, Alan M, Limberakis, Chris, Hepworth, David, Carpino, Philip A
Published in Nature chemical biology (01.08.2014)
Published in Nature chemical biology (01.08.2014)
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Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin‑1
Casimiro-Garcia, Agustin, Allais, Christophe, Brennan, Agnes, Choi, Chulho, Dower, Gabriela, Farley, Kathleen A, Fleming, Margaret, Flick, Andrew, Frisbie, Richard K, Hall, Justin, Hepworth, David, Jones, Hannah, Knafels, John D, Kortum, Steve, Lovering, Frank E, Mathias, John P, Mohan, Sashi, Morgan, Paul M, Parng, Chuenlei, Parris, Kevin, Pullen, Nick, Schlerman, Franklin, Stansfield, John, Strohbach, Joseph W, Vajdos, Felix F, Vincent, Fabien, Wang, Hong, Wang, Xiaolun, Webster, Robert, Wright, Stephen W
Published in Journal of medicinal chemistry (13.01.2022)
Published in Journal of medicinal chemistry (13.01.2022)
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Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)
Futatsugi, Kentaro, Kung, Daniel W, Orr, Suvi T. M, Cabral, Shawn, Hepworth, David, Aspnes, Gary, Bader, Scott, Bian, Jianwei, Boehm, Markus, Carpino, Philip A, Coffey, Steven B, Dowling, Matthew S, Herr, Michael, Jiao, Wenhua, Lavergne, Sophie Y, Li, Qifang, Clark, Ronald W, Erion, Derek M, Kou, Kou, Lee, Kyuha, Pabst, Brandon A, Perez, Sylvie M, Purkal, Julie, Jorgensen, Csilla C, Goosen, Theunis C, Gosset, James R, Niosi, Mark, Pettersen, John C, Pfefferkorn, Jeffrey A, Ahn, Kay, Goodwin, Bryan
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Discovery of 2‑(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)‑yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases
Ruggeri, Roger B, Buckbinder, Leonard, Bagley, Scott W, Carpino, Philip A, Conn, Edward L, Dowling, Matthew S, Fernando, Dilinie P, Jiao, Wenhua, Kung, Daniel W, Orr, Suvi T. M, Qi, Yingmei, Rocke, Benjamin N, Smith, Aaron, Warmus, Joseph S, Zhang, Yan, Bowles, Daniel, Widlicka, Daniel W, Eng, Heather, Ryder, Tim, Sharma, Raman, Wolford, Angela, Okerberg, Carlin, Walters, Karen, Maurer, Tristan S, Zhang, Yanwei, Bonin, Paul D, Spath, Samantha N, Xing, Gang, Hepworth, David, Ahn, Kay, Kalgutkar, Amit S
Published in Journal of medicinal chemistry (12.11.2015)
Published in Journal of medicinal chemistry (12.11.2015)
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Virus-Like Particle Facilitated Deposition of Hydroxyapatite Bone Mineral on Nanocellulose after Exposure to Phosphate and Calcium Precursors
Sinitsyna, Olga V, Makarov, Valentine V, McGeachy, Kara, Bukharova, Tatyana, Whale, Eric, Hepworth, David, Yaminsky, Igor V, Kalinina, Natalia O, Taliansky, Michael E, Love, Andrew J
Published in International journal of molecular sciences (12.04.2019)
Published in International journal of molecular sciences (12.04.2019)
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Total Synthesis of Apoptolidin: Construction of Enantiomerically Pure Fragments
Nicolaou, K. C, Fylaktakidou, Konstantina C, Monenschein, Holger, Li, Yiwei, Weyershausen, Bernd, Mitchell, Helen J, Wei, Heng-xu, Guntupalli, Prasuna, Hepworth, David, Sugita, Kazuyuki
Published in Journal of the American Chemical Society (17.12.2003)
Published in Journal of the American Chemical Society (17.12.2003)
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Optimization of triazole-based TGR5 agonists towards orally available agents
Futatsugi, Kentaro, Bahnck, Kevin B., Brenner, Martin B., Buxton, Joanne, Chin, Janice E., Coffey, Steven B., Dubins, Jeffrey, Flynn, Declan, Gautreau, Denise, Guzman-Perez, Angel, Hadcock, John R., Hepworth, David, Herr, Michael, Hinchey, Terri, Janssen, Ann M., Jennings, Sandra M., Jiao, Wenhua, Lavergne, Sophie Y., Li, Bryan, Li, Mei, Munchhof, Michael J., Orr, Suvi T. M., Piotrowski, David W., Roush, Nicole S., Sammons, Matthew, Stevens, Benjamin D., Storer, Gregory, Wang, Jian, Warmus, Joseph S., Wei, Liuqing, Wolford, Angela C.
Published in MedChemComm (2013)
Published in MedChemComm (2013)
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Biophysical consequences of remodeling the neutral side chains of rhamnogalacturonan I in tubers of transgenic potatoes
Ulvskov, P, Wium, H, Bruce, D, Jorgensen, B, Qvist, K.B, Skjot, M, Hepworth, D, Borkhardt, B, Sorensen, S.O
Published in Planta (01.02.2005)
Published in Planta (01.02.2005)
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Variations in the morphology of wood structure can explain why hardwood species of similar density have very different resistances to impact and compressive loading
Smith, C. W., Hepworth, David G., Vincent, J. F. V., Stringer, G., Jeronimidis, G.
Published in Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences (15.02.2002)
Published in Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences (15.02.2002)
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A Call for Systematic Research on Solute Carriers
César-Razquin, Adrián, Snijder, Berend, Frappier-Brinton, Tristan, Isserlin, Ruth, Gyimesi, Gergely, Bai, Xiaoyun, Reithmeier, Reinhart A., Hepworth, David, Hediger, Matthias A., Edwards, Aled M., Superti-Furga, Giulio
Published in Cell (30.07.2015)
Published in Cell (30.07.2015)
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2D bio-based nanomaterial as a green route to amplify the formation of hydrate phases of cement composites: Atomistic simulations and analytical characterization
Chi, Yin, Huang, Bo, Saafi, Mohamed, Fullwood, Nigel, Lambert, Colin, Whale, Eric, Hepworth, David, Ye, Jianqiao
Published in Construction & building materials (13.09.2021)
Published in Construction & building materials (13.09.2021)
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Mechanical and fracture properties of sugar beetroot-based nanosheets (SNS) doped cementitious composites
Huang, Bo, Chi, Yin, Wang, Jianqun, Wang, Gongxun, Ye, Junjie, Whale, Eric, Hepworth, David, Ye, Jianqiao, Saafi, Mohamed
Published in Construction & building materials (15.12.2023)
Published in Construction & building materials (15.12.2023)
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Designing small molecules for therapeutic success: A contemporary perspective
Maurer, Tristan S., Edwards, Martin, Hepworth, David, Verhoest, Patrick, Allerton, Charlotte M.N.
Published in Drug discovery today (01.02.2022)
Published in Drug discovery today (01.02.2022)
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