Small Molecule Inhibitors of IκB Kinase Are Selectively Toxic for Subgroups of Diffuse Large B-Cell Lymphoma Defined by Gene Expression Profiling
LAM, Lloyd T, DAVIS, R. Eric, STAUDT, Louis M, PIERCE, Jackie, HEPPERLE, Michael, YAJUN XU, HOTTELET, Maria, YUHUA NONG, DANYI WEN, ADAMS, Julian, DANG, Lenny
Published in Clinical cancer research (01.01.2005)
Published in Clinical cancer research (01.01.2005)
Get full text
Journal Article
Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase
Walker, John K., Selness, Shaun R., Devraj, Rajesh V., Hepperle, Michael E., Naing, Win, Shieh, Huey, Kurambail, Ravi, Yang, Syaulan, Flynn, Daniel L., Benson, Alan G., Messing, Dean M., Dice, Tom, Kim, Tina, Lindmark, R.J., Monahan, Joseph B., Portanova, Joseph
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Get full text
Journal Article
Synthesis and antiviral activity of HCV NS3/4A peptidomimetic boronic acid inhibitors
Boloor, Amogh, Hanway, Denise, Joshi, Maria, Winn, David T., Mendez, Gabriel, Walls, Marlena, Wei, Ping, Qian, Fuxin, Zhang, Xiaoli, Zhang, Yuliang, Hepperle, Michael E., Li, Xinqiang, Campbell, David A., Betancort, Juan M.
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Get full text
Journal Article
Discovery of 5-substituted- N-arylpyridazinones as inhibitors of p38 MAP kinase
Jerome, Kevin D., Hepperle, Michael E., Walker, John K., Xing, Li, Devraj, Rajesh V., Benson, Alan G., Baldus, John E., Selness, Shaun R.
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Get full text
Journal Article
Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase
Selness, Shaun R., Devraj, Rajesh V., Monahan, Joseph B., Boehm, Terri L., Walker, John K., Devadas, Balekudru, Durley, Richard C., Kurumbail, Ravi, Shieh, Huey, Xing, Li, Hepperle, Michael, Rucker, Paul V., Jerome, Kevin D., Benson, Alan G., Marrufo, Laura D., Madsen, Heather M., Hitchcock, Jeff, Owen, Tom J., Christie, Lance, Promo, Michele A., Hickory, Brian S., Alvira, Edgardo, Naing, Win, Blevis-Bal, Radhika
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Get full text
Journal Article
An efficient semisynthesis of taxol from (3 R,4 S)- N-Benzoyl-3-[( t-butyldimethylsilyl)oxy]-4-phenyl-2-azetidinone and 7-(Triethylsilyl)baccatin III
Georg, Gunda I., Cheruvallath, Zacharia S., Harriman, Geraldine C.B., Hepperle, Michael, Park, Haeil
Published in Bioorganic & medicinal chemistry letters (01.11.1993)
Published in Bioorganic & medicinal chemistry letters (01.11.1993)
Get full text
Journal Article
A Selective Small Molecule IκB Kinase β Inhibitor Blocks Nuclear Factor κB-Mediated Inflammatory Responses in Human Fibroblast-Like Synoviocytes, Chondrocytes, and Mast Cells
Wen, Danyi, Nong, Yuhua, Morgan, Jennifer G., Gangurde, Pranoti, Bielecki, Andrew, DaSilva, Jennifer, Keaveney, Marie, Cheng, Hong, Fraser, Chris, Schopf, Lisa, Hepperle, Michael, Harriman, Geraldine, Jaffee, Bruce D., Ocain, Timothy D., Xu, Yajun
Published in The Journal of pharmacology and experimental therapeutics (01.06.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2006)
Get full text
Journal Article
Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKβ
Nagashima, Kumiko, Sasseville, Vito G., Wen, Danyi, Bielecki, Andrew, Yang, Hua, Simpson, Chris, Grant, Ethan, Hepperle, Michael, Harriman, Gerry, Jaffee, Bruce, Ocain, Tim, Xu, Yajun, Fraser, Christopher C.
Published in Blood (01.06.2006)
Published in Blood (01.06.2006)
Get full text
Journal Article
Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase
Selness, Shaun R, Boehm, Terri L, Walker, John K, Devadas, Balekudru, Durley, Richard C, Kurumbail, Ravi, Shieh, Huey, Xing, Li, Hepperle, Michael, Rucker, Paul V, Jerome, Kevin D, Benson, Alan G, Marrufo, Laura D, Madsen, Heather M, Hitchcock, Jeff, Owen, Tom J, Christie, Lance, Promo, Michele A, Hickory, Brian S, Alvira, Edgardo, Naing, Win, Blevis-Bal, Radhika, Devraj, Rajesh V, Messing, Dean, Schindler, John F, Hirsch, Jeffrey, Saabye, Matthew, Bonar, Sheri, Webb, Elizabeth, Anderson, Gary, Monahan, Joseph B
Published in Bioorganic & medicinal chemistry letters (01.07.2011)
Published in Bioorganic & medicinal chemistry letters (01.07.2011)
Get full text
Journal Article
SD0006: A Potent, Selective and Orally Available Inhibitor of p38 Kinase
Burnette, Barry L., Selness, Shaun, Devraj, Raj, Jungbluth, Gail, Kurumbail, Ravi, Stillwell, Loreen, Anderson, Gary, Mnich, Stephen, Hirsch, Jeffrey, Compton, Robert, De Ciechi, Pamela, Hope, Heidi, Hepperle, Michael, Keith, Robert H., Naing, Win, Shieh, Huey, Portanova, Joseph, Zhang, Yan, Zhang, Jian, Leimgruber, Richard M., Monahan, Joseph
Published in Pharmacology (01.01.2009)
Published in Pharmacology (01.01.2009)
Get full text
Journal Article
Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta
Nagashima, Kumiko, Sasseville, Vito G, Wen, Danyi, Bielecki, Andrew, Yang, Hua, Simpson, Chris, Grant, Ethan, Hepperle, Michael, Harriman, Gerry, Jaffee, Bruce, Ocain, Tim, Xu, Yajun, Fraser, Christopher C
Published in Blood (01.06.2006)
Get full text
Published in Blood (01.06.2006)
Journal Article
A Selective Small Molecule IκB Kinase β Inhibitor Blocks Nuclear Factor κB-Mediated Inflammatory Responses in Human Fibroblast-Like Synoviocytes, Chondrocytes, and Mast Cells
Danyi Wen, Yuhua Nong, Jennifer G. Morgan, Pranoti Gangurde, Andrew Bielecki, Jennifer DaSilva, Marie Keaveney, Hong Cheng, Chris Fraser, Lisa Schopf, Michael Hepperle, Geraldine Harriman, Bruce D. Jaffee, Timothy D. Ocain, Yajun Xu
Published in The Journal of pharmacology and experimental therapeutics (01.06.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2006)
Get full text
Journal Article
A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells
Wen, Danyi, Nong, Yuhua, Morgan, Jennifer G, Gangurde, Pranoti, Bielecki, Andrew, Dasilva, Jennifer, Keaveney, Marie, Cheng, Hong, Fraser, Chris, Schopf, Lisa, Hepperle, Michael, Harriman, Geraldine, Jaffee, Bruce D, Ocain, Timothy D, Xu, Yajun
Published in The Journal of pharmacology and experimental therapeutics (01.06.2006)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.06.2006)
Journal Article
Mono N-arylation of piperazine(III): metal-catalyzed N-arylation and its application to the novel preparations of the antifungal posaconazole and its advanced intermediate
Hepperle, Michael, Eckert, Jeffrey, Gala, Dinesh, Shen, Lan, Anderson Evans, C, Goodman, Andrew
Published in Tetrahedron letters (29.04.2002)
Published in Tetrahedron letters (29.04.2002)
Get full text
Journal Article
Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling
Lam, Lloyd T, Davis, R Eric, Pierce, Jackie, Hepperle, Michael, Xu, Yajun, Hottelet, Maria, Nong, Yuhua, Wen, Danyi, Adams, Julian, Dang, Lenny, Staudt, Louis M
Published in Clinical cancer research (01.01.2005)
Get full text
Published in Clinical cancer research (01.01.2005)
Journal Article