Structure-activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as K(ATP) channel openers
Drizin, Irene, Altenbach, Robert J, Buckner, Steven A, Whiteaker, Kristi L, Scott, Victoria E, Darbyshire, John F, Jayanti, Venkata, Henry, Rodger F, Coghlan, Michael J, Gopalakrishnan, Murali, Carroll, William A
Published in Bioorganic & medicinal chemistry (15.04.2004)
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Published in Bioorganic & medicinal chemistry (15.04.2004)
Journal Article
Structure–activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as K ATP channel openers
Drizin, Irene, Altenbach, Robert J., Buckner, Steven A., Whiteaker, Kristi L., Scott, Victoria E., Darbyshire, John F., Jayanti, Venkata, Henry, Rodger F., Coghlan, Michael J., Gopalakrishnan, Murali, Carroll, William A.
Published in Bioorganic & medicinal chemistry (2004)
Published in Bioorganic & medicinal chemistry (2004)
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Synthesis of 1 H-pyridin-2-one derivatives as potent and selective farnesyltransferase inhibitors
Wang, Le, Lin, Nan-Horng, Li, Qun, Henry, Rodger F., Zhang, Haiying, Cohen, Jerome, Gu, Wen-Zhen, Marsh, Kennan C., Bauch, Joy L., Rosenberg, Saul H., Sham, Hing L.
Published in Bioorganic & medicinal chemistry letters (2004)
Published in Bioorganic & medicinal chemistry letters (2004)
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Carbidopa and l-dopa prodrugs and their use to treat parkinson's disease
Henry, Rodger F, Ho, Raimundo, Huang, Ye, Dempah, Kassibla E, Chan, Vincent S, Cardinal-David, Benoit, Wang, Zhi, Zhang, Geoff G, Stella, Valentino J, Huters, Alexander D, Krabbe, Scott W, Lao, Yanbin, Mayer, Peter T, Enright, Brian P, Lou, Xiaochun, Mackey, Sean E, Matulenko, Mark A, Stambuli, James, Miller, Christopher P, Voight, Eric A, Klix, Russell C, Kym, Philip R
Year of Publication 26.04.2024
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Year of Publication 26.04.2024
Patent
Carbidopa and l-dopa prodrugs and their use to treat parkinson's disease
Henry, Rodger F, Ho, Raimundo, Huang, Ye, Dempah, Kassibla E, Chan, Vincent S, Cardinal-David, Benoit, Wang, Zhi, Zhang, Geoff G, Stella, Valentino J, Huters, Alexander D, Krabbe, Scott W, Lao, Yanbin, Mayer, Peter T, Enright, Brian P, Lou, Xiaochun, Mackey, Sean E, Matulenko, Mark A, Stambuli, James, Miller, Christopher P, Voight, Eric A, Klix, Russell C, Kym, Philip R
Year of Publication 26.04.2024
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Year of Publication 26.04.2024
Patent
Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K(ATP) opener that selectively inhibits spontaneous bladder contractions
Carroll, William A, Altenbach, Robert J, Bai, Hao, Brioni, Jorge D, Brune, Michael E, Buckner, Steven A, Cassidy, Christopher, Chen, Yiyuan, Coghlan, Michael J, Daza, Anthony V, Drizin, Irene, Fey, Thomas A, Fitzgerald, Michael, Gopalakrishnan, Murali, Gregg, Robert J, Henry, Rodger F, Holladay, Mark W, King, Linda L, Kort, Michael E, Kym, Philip R, Milicic, Ivan, Tang, Rui, Turner, Sean C, Whiteaker, Kristi L, Yi, Lin, Zhang, Henry, Sullivan, James P
Published in Journal of medicinal chemistry (03.06.2004)
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Published in Journal of medicinal chemistry (03.06.2004)
Journal Article
CARBIDOPA AND L-DOPA PRODRUGS AND METHODS OF USE
Henry, Rodger F, Ho, Raimundo, Huang, Ye, Dempah, Kassibla E, Chan, Vincent S, Cardinal-David, Benoit, Wang, Zhi, Stella, Valentino J, Zhang, Geoff G, Huters, Alexander D, Krabbe, Scott W, Lao., Yanbin, Mayer, Peter T, Enright, Brian P, Lou, Xiaochun, Matulenko, Mark A, Stambuli, James, Miller, Christopher P, Voight, Eric A, Klix, Russell C, Kym, Philip R, Mackey, Sean
Year of Publication 25.01.2024
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Year of Publication 25.01.2024
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Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist
Altenbach, RJ, Khilevich, A, Kolasa, T, Rohde, JJ, Bhatia, PA, Patel, MV, Searle, XB, Yang, F, Bunnelle, WH, Tietje, K, Bayburt, EK, Carroll, WA, Meyer, MD, Henry, R, Buckner, SA, Kuk, J, Daza, AV, Milicic, Cain, JC, Kang, CH, Ireland, LM, Carr, TL, Miller, TR, Hancock, AA, Nakane, M, Esbenshade, TA, Brune, ME, O'Neill, AB, Gauvin, DM, Katwala, SP, Holladay, MW, Brioni, JD, Sullivan, JP
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C
HENRY RODGER F, LIU YAYA, LOU XIAOCHUN, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, FRANCZYK II THADDEUS S, ROCKWAY TODD W, HUANG PEGGY P, FLENTGE CHARLES A, SARRIS KATHY, GAO YI, DEGOEY DAVID A, KATI WARREN M, MARING CLARENCE J, BARNES DAVID M, PRATT JOHN K, DONNER PAMELA L, CHEN SHUANG, WAGNER ROLF, HENGEVELD JOHN E, RANDOLPH JOHN T, TUFANO MICHAEL D, LONGENECKER KENTON L, MOTTER CHRISTOPHER E, LIU DACHUN, KRUEGER ALLAN C, KOTECKI BRIAN J, HAIGHT ANTHONY R, ZHANG GEOFF G. Z, STEWART KENT D
Year of Publication 22.06.2010
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Year of Publication 22.06.2010
Patent
Synthesis and Structure−Activity Studies on N -[5-(1 H -Imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an Imidazole-Containing α 1A -Adrenoceptor Agonist
Altenbach, Robert J., Khilevich, Albert, Kolasa, Teodozyj, Rohde, Jeffrey J., Bhatia, Pramila A., Patel, Meena V., Searle, Xenia B., Yang, Fan, Bunnelle, William H., Tietje, Karin, Bayburt, Erol K., Carroll, William A., Meyer, Michael D., Henry, Rodger, Buckner, Steven A., Kuk, Jane, Daza, Anthony V., Milicic, Ivan V., Cain, John C., Kang, Chae H., Ireland, Lynne M., Carr, Tracy L., Miller, Thomas R., Hancock, Arthur A., Nakane, Masaki, Esbenshade, Timothy A., Brune, Michael E., O'Neill, Alyssa B., Gauvin, Donna M., Katwala, Sweta P., Holladay, Mark W., Brioni, Jorge D., Sullivan, James P.
Published in Journal of medicinal chemistry (01.06.2004)
Published in Journal of medicinal chemistry (01.06.2004)
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Carbidopa and L-dopa prodrugs and their use to treat Parkinson's disease
MAYER, Peter T, ZHANG, Geoff G, DEMPAH, Kassibla E, KRABBE, Scott W, KYM, Philip R, HUTERS, Alexander D, MILLER, Christopher P, HENRY, Rodger F, HUANG, Ye, MACKEY, Sean E, CARDINAL-DAVID, Benoit, ENRIGHT, Brian P, KLIX, Russell C, LAO, Yanbin, LOU, Xiaochun, MATULENKO, Mark A, STELLA, Valentino J, HO, Raimundo, WANG, Zhi, STAMBULI, James, CHAN, Vincent S, VOIGHT, Eric A
Year of Publication 24.08.2023
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Year of Publication 24.08.2023
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INTERMEDIATES AND PROCESS FOR PREPARING L-DOPA DIPHOSPHATE
MAYER, Peter T, ZHANG, Geoff G, DEMPAH, Kassibla E, KRABBE, Scott W, KYM, Philip R, HUTERS, Alexander D, MILLER, Christopher P, HENRY, Rodger F, HUANG, Ye, MACKEY, Sean E, CARDINAL-DAVID, Benoit, ENRIGHT, Brian P, KLIX, Russell C, LAO, Yanbin, LOU, Xiaochun, MATULENKO, Mark A, STELLA, Valentino J, HO, Raimundo, WANG, Zhi, STAMBULI, James, CHAN, Vincent S, VOIGHT, Eric A
Year of Publication 31.05.2023
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Year of Publication 31.05.2023
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Carbidopa and L-dopa prodrugs and their use to treat Parkinson's disease
Henry, Rodger F, Ho, Raimundo, Huang, Ye, Dempah, Kassibla E, Chan, Vincent S, Cardinal-David, Benoit, Wang, Zhi, Zhang, Geoff G, Stella, Valentino J, Huters, Alexander D, Krabbe, Scott W, Lao, Yanbin, Mayer, Peter T, Enright, Brian P, Lou, Xiaochun, Mackey, Sean E, Matulenko, Mark A, Stambuli, James, Miller, Christopher P, Voight, Eric A, Klix, Russell C, Kym, Philip R
Year of Publication 11.05.2023
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Year of Publication 11.05.2023
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METHODS OF TREATING PARKINSON'S DISEASE
Henry, Rodger F, Ho, Raimundo, Huang, Ye, Dempah, Kassibla E, Chan, Vincent S, Cardinal-David, Benoit, Wang, Zhi, Stella, Valentino J, Zhang, Geoff G, Huters, Alexander D, Krabbe, Scott W, Lao, Yanbin, Mayer, Peter T, Enright, Brian P, Lou, Xiaochun, Mackey, Sean E, Matulenko, Mark A, Stambuli, James, Miller, Christopher P, Voight, Eric A, Klix, Russell C, Kym, Philip R
Year of Publication 06.04.2023
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Year of Publication 06.04.2023
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Salt and crystalline forms thereof of a drug
Barnes, David M, Henry, Rodger, Zhang, Geoff G. Z, Bradley, Michael F
Year of Publication 25.06.2019
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Year of Publication 25.06.2019
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CARBIDOPA AND L-DOPA PRODRUGS AND THEIR USE TO TREAT PARKINSON'S DISEASE
MAYER, Peter T, ZHANG, Geoff G, DEMPAH, Kassibla E, KRABBE, Scott W, KYM, Philip R, HUTERS, Alexander D, MILLER, Christopher P, HENRY, Rodger F, HUANG, Ye, MACKEY, Sean E, CARDINAL-DAVID, Benoit, ENRIGHT, Brian P, KLIX, Russell C, LAO, Yanbin, LOU, Xiaochun, MATULENKO, Mark A, STELLA, Valentino J, HO, Raimundo, WANG, Zhi, STAMBULI, James, CHAN, Vincent S, VOIGHT, Eric A
Year of Publication 25.05.2022
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Year of Publication 25.05.2022
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METHODS OF TREATING PARKINSON'S DISEASE
Henry, Rodger F, Ho, Raimundo, Huang, Ye, Chan, Vincent S, Cardinal-David, Benoit, Wang, Zhi, Stella, Valentino J, Zhang, Geoff G, Huters, Alexander D, Krabbe, Scott W, Lao, Yanbin, Dempah, Kassibla, Mayer, Peter T, Enright, Brian P, Lou, Xiaochun, Mackey, Sean E, Matulenko, Mark A, Stambuli, James, Miller, Christopher P, Voight, Eric A, Klix, Russell C, Kym, Philip R
Year of Publication 19.05.2022
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Year of Publication 19.05.2022
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