Ten things you should know about protein kinases: IUPHAR Review 14
Fabbro, Doriano, Cowan‐Jacob, Sandra W, Moebitz, Henrik
Published in British journal of pharmacology (01.06.2015)
Published in British journal of pharmacology (01.06.2015)
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Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties
Gao, Yijun, Chang, Matthew T, McKay, Daniel, Na, Na, Zhou, Bing, Yaeger, Rona, Torres, Neilawattie M, Muniz, Keven, Drosten, Matthias, Barbacid, Mariano, Caponigro, Giordano, Stuart, Darrin, Moebitz, Henrik, Solit, David B, Abdel-Wahab, Omar, Taylor, Barry S, Yao, Zhan, Rosen, Neal
Published in Cancer discovery (01.05.2018)
Published in Cancer discovery (01.05.2018)
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Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides
Rueeger, Heinrich, Lueoend, Rainer, Rogel, Olivier, Rondeau, Jean-Michel, Möbitz, Henrik, Machauer, Rainer, Jacobson, Laura, Staufenbiel, Matthias, Desrayaud, Sandrine, Neumann, Ulf
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
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Type II Inhibitors Targeting CDK2
Alexander, Leila T, Möbitz, Henrik, Drueckes, Peter, Savitsky, Pavel, Fedorov, Oleg, Elkins, Jonathan M, Deane, Charlotte M, Cowan-Jacob, Sandra W, Knapp, Stefan
Published in ACS chemical biology (18.09.2015)
Published in ACS chemical biology (18.09.2015)
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Paradoxical Increase of Permeability and Lipophilicity with the Increasing Topological Polar Surface Area within a Series of PRMT5 Inhibitors
Argikar, Upendra, Blatter, Markus, Bednarczyk, Dallas, Chen, Zhuoliang, Cho, Young Shin, Doré, Michaël, Dumouchel, Jennifer L., Ho, Samuel, Hoegenauer, Klemens, Kawanami, Toshio, Mathieu, Simon, Meredith, Erik, Möbitz, Henrik, Murphy, Stephen K., Parthasarathy, Saravanan, Soldermann, Carole Pissot, Santos, Jobette, Silver, Serena, Skolnik, Suzanne, Stojanovic, Aleksandar
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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Journal Article
Ten things you should know about protein kinases: IUPHAR R eview 14
Fabbro, Doriano, Cowan‐Jacob, Sandra W, Moebitz, Henrik
Published in British journal of pharmacology (01.06.2015)
Published in British journal of pharmacology (01.06.2015)
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Journal Article
The Discovery of SWI/SNF Chromatin Remodeling Activity as a Novel and Targetable Dependency in Uveal Melanoma
Rago, Florencia, Elliott, GiNell, Li, Ailing, Sprouffske, Kathleen, Kerr, Grainne, Desplat, Aurore, Abramowski, Dorothee, Chen, Julie T., Farsidjani, Ali, Xiang, Kay X., Bushold, Geoffrey, Feng, Yun, Shirley, Matthew D., Bric, Anka, Vattay, Anthony, Möbitz, Henrik, Nakajima, Katsumasa, Adair, Christopher D., Mathieu, Simon, Ntaganda, Rukundo, Smith, Troy, Papillon, Julien P.N., Kauffmann, Audrey, Ruddy, David A., Bhang, Hyo-eun C., Castelletti, Deborah, Jagani, Zainab
Published in Molecular cancer therapeutics (01.10.2020)
Published in Molecular cancer therapeutics (01.10.2020)
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New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse
Stauffer, Frédéric, Weiss, Andreas, Scheufler, Clemens, Möbitz, Henrik, Ragot, Christian, Beyer, Kim S, Calkins, Keith, Guthy, Daniel, Kiffe, Michael, Van Eerdenbrugh, Bernard, Tiedt, Ralph, Gaul, Christoph
Published in ACS medicinal chemistry letters (12.12.2019)
Published in ACS medicinal chemistry letters (12.12.2019)
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The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold
Gutmann, Sascha, Hinniger, Alexandra, Fendrich, Gabriele, Drückes, Peter, Antz, Sylvie, Mattes, Henri, Möbitz, Henrik, Ofner, Silvio, Schmiedeberg, Niko, Stojanovic, Aleksandar, Rieffel, Sebastien, Strauss, André, Troxler, Thomas, Glatthar, Ralf, Sparrer, Helmut
Published in The Journal of biological chemistry (12.06.2015)
Published in The Journal of biological chemistry (12.06.2015)
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Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides
Rueeger, Heinrich, Lueoend, Rainer, Machauer, Rainer, Veenstra, Siem Jacob, Jacobson, Laura Helen, Staufenbiel, Matthias, Desrayaud, Sandrine, Rondeau, Jean-Michel, Möbitz, Henrik, Neumann, Ulf
Published in Bioorganic & medicinal chemistry letters (01.10.2013)
Published in Bioorganic & medicinal chemistry letters (01.10.2013)
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Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor
Karpov, Alexei S, Amiri, Payman, Bellamacina, Cornelia, Bellance, Marie-Helene, Breitenstein, Werner, Daniel, Dylan, Denay, Regis, Fabbro, Doriano, Fernandez, Cesar, Galuba, Inga, Guerro-Lagasse, Stephanie, Gutmann, Sascha, Hinh, Linda, Jahnke, Wolfgang, Klopp, Julia, Lai, Albert, Lindvall, Mika K, Ma, Sylvia, Möbitz, Henrik, Pecchi, Sabina, Rummel, Gabriele, Shoemaker, Kevin, Trappe, Joerg, Voliva, Charles, Cowan-Jacob, Sandra W, Marzinzik, Andreas L
Published in ACS medicinal chemistry letters (09.07.2015)
Published in ACS medicinal chemistry letters (09.07.2015)
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Perspective on computational and structural aspects of kinase discovery from IPK2014
Martin, Eric, Knapp, Stefan, Engh, Richard A., Moebitz, Henrik, Varin, Thibault, Roux, Benoit, Meiler, Jens, Berdini, Valerio, Baumann, Alexander, Vieth, Michal
Published in Biochimica et biophysica acta (01.10.2015)
Published in Biochimica et biophysica acta (01.10.2015)
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Abstract B143: HRO761, a first-in-class, clinical stage WRN inhibitor with potent preclinical anti-tumor activity in MSIhigh models
Ferretti, Stephane, Jaco, Isabel, Decker, Andrea, Hemmerlin, Christelle, Scheufler, Clemens, Quadt, Cornelia, Sterker, Dario, Gavioli, Elena, Nunez, Eloisa Jimenez, Dammassa, Ernesta, Schaeffer, Fanny, Albrecht, Genevieve, Clementi, Giorgia, Martus, Hansjoerg, Hamon, Jacques, Hinrichs, Juergen, Laborde, Laurent, Dourdoigne, Marion, Moschetta, Michele, Stump, Ramona, Andraos-Rey, Rita, Welly, Sarah, Barbe, Stephanie, Romanet, Vincent, Reschke, Markus, Kanter, Ruben De, Jensen, Michael, Moebitz, Henrik, Cros, Marta Cortes
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Structural biology contributions to tyrosine kinase drug discovery
Cowan-Jacob, Sandra W, Möbitz, Henrik, Fabbro, Doriano
Published in Current opinion in cell biology (01.04.2009)
Published in Current opinion in cell biology (01.04.2009)
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Abstract PR007: Discovery of HRO761, a novel, first-in-class clinical stage WRN inhibitor with potent and selective anti-tumor activity in cancers with microsatellite instability
Cortes-Cros, Marta, Moebitz, Henrik, Barbe, Stephanie, Blank, Jutta, Bordas, Vincent, Clementi, Giorgia, Dammassa, Ernesta, Decker, Andrea, Nanni, Noemi Di, de Kanter, Ruben, Dourdoigne, Marion, Gavioli, Elena, Ferretti, Stephane, Hattenberger, Marc, Hemmerlin, Christelle, Hamon, Jacques, Hinrichs, Juergen, Jaco, Isabel, Jankovic, Dragana, Nunez, Eloisa Jimenez, Li, Yifang, Martus, Hans-Joerg, Moschetta, Michele, Quadt, Cornelia, Reschke, Markus, Romanet, Vincent, Scheufler, Clemens, Schoepfer, Joseph, Strang, Ross, Therier, Maxime, Voshol, Hans, Wartmann, Markus, Welly, Sarah, Pham, Monica, Laborde, Laurent
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
Velcicky, Juraj, Feifel, Roland, Hawtin, Stuart, Heng, Richard, Huppertz, Christine, Koch, Guido, Kroemer, Markus, Moebitz, Henrik, Revesz, Laszlo, Scheufler, Clemens, Schlapbach, Achim
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: A proof-of-concept study
Chapelat, Julien, Berst, Frédéric, Marzinzik, Andreas L., Moebitz, Henrik, Drueckes, Peter, Trappe, Joerg, Fabbro, Doriano, Seebach, Dieter
Published in European journal of medicinal chemistry (01.11.2012)
Published in European journal of medicinal chemistry (01.11.2012)
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Journal Article
Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors
Rueeger, Heinrich, Rondeau, Jean-Michel, McCarthy, Clive, Möbitz, Henrik, Tintelnot-Blomley, Marina, Neumann, Ulf, Desrayaud, Sandrine
Published in Bioorganic & medicinal chemistry letters (01.04.2011)
Published in Bioorganic & medicinal chemistry letters (01.04.2011)
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Pyrrolo-pyrimidones : A novel class of MK2 inhibitors with potent cellular activity
SCHLAPBACH, Achim, FEIFEL, Roland, HUPPERTZ, Christine, HAWTIN, Stuart, HENG, Richard, KOCH, Guido, MOEBITZ, Henrik, REVESZ, Laszlo, SCHEUFLER, Clemens, VELCICKY, Juraj, WAELCHLI, Rudolf
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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